AutismKB 2.0

Annotation Detail for EGLN3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EGLN3 ( FLJ21620,HIFPH3,MGC125998,MGC125999,PHD3 )
Gene Full Name: egl nine homolog 3 (C. elegans)
Band: 14q13.1
Quick LinksEntrez ID:112399; OMIM: 606426; Uniprot ID:EGLN3_HUMAN; ENSEMBL ID: ENSG00000129521; HGNC ID: 14661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
Pathway IDPathway Name
P00030Hypoxia response via HIF activation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of EGLN3 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of EGLN3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EGLN3 proteinaffects expression 20106945
D019386 Alendronate Alendronate affects the expression of EGLN3 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EGLN3 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 17639512
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in increased expression of EGLN3 mRNAincreases expression 15901920
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of EGLN3 mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of EGLN3 mRNAincreases expression 20105288
D003345 Corticosterone Corticosterone results in increased expression of EGLN3 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of EGLN3 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of EGLN3 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of EGLN3 mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of EGLN3 mRNAincreases expression 19371625
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of EGLN3 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of EGLN3 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EGLN3 mRNAincreases expression 16872691
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EGLN3 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EGLN3 mRNAincreases expression 15576828
15901920
D019266 Iron, Dietary Iron, Dietary affects the expression of EGLN3 mRNAaffects expression 15637178
C041786 palm oil palm oil results in increased expression of EGLN3 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of EGLN3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of EGLN3 mRNAincreases expression 19482888
D010656 Phenylephrine Phenylephrine results in increased expression of EGLN3 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in decreased expression of EGLN3 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of EGLN3 mRNAincreases expression 18301758
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 17639512
D020849 Raloxifene Raloxifene affects the expression of EGLN3 mRNAaffects expression 16079270
C009277 sodium arsenate sodium arsenate results in increased expression of EGLN3 mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EGLN3 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EGLN3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EGLN3 mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in decreased expression of EGLN3 mRNAdecreases expression 18230668
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of EGLN3 mRNAaffects binding|increases expression 20105288
C002802 tungsten carbide tungsten carbide results in increased expression of EGLN3 mRNAincreases expression 20105288
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Estradiol 4.0011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0014692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.4119389873
MESH:D000236 Adenoma Diethylnitrosamine 6.416695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.8216434500 19052882 19061943 18056438 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.8216835633
MESH:D000419 Albuminuria Raloxifene 4.3617308373 17451421
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4915800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0217084956
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9017460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7315336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1719761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D001930 Brain Injuries Raloxifene 4.2316580743
MESH:D001943 Breast Neoplasms Ascorbic Acid 8.0216443354
MESH:D001943 Breast Neoplasms bisphenol A 8.0217123778
MESH:D001943 Breast Neoplasms Cobalt 8.0215986119
MESH:D001943 Breast Neoplasms Dietary Fats 8.0220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.0217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 8.0217289903 14630087 12948864 19861407 18497071 17261762 17018787 16675129
MESH:D001943 Breast Neoplasms Quercetin 8.0218628248
MESH:D001943 Breast Neoplasms Raloxifene 8.0217261762 16912660 17242785 15572757 17049068 17595753 17952589 16837676 17440819 17893378 15758505 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0220435547
MESH:D001943 Breast Neoplasms Tretinoin 8.0216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.193084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.1912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.1917162532 18506893 20007298 16807293 19107877 17055752 19383236 18785209 20935162 19701751 16698587 20514400 20524982 16288022 17428255 19052882 18494052 19539802 20432363 17173139 16681979 20084675 18691550 19335982 18056438 18788625 21159647 18393292 16540662 17978847 16830150 19394651 16779866 3581430 11831363 17138121 20512989 19519916 18978308 19208518 19822196 16878318 20101231 18210153 10737359 19919837 19418558 10672840 18665156 19171122 16502159 3084413 20727157 17761372 20214788 16328049 16935385 16569478 18971187
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.1916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.1916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.1917173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.1919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.191917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7117234771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8617572228
MESH:D006332 Cardiomegaly Phenylephrine 10.6915728586 11179087 17124262 17287366 11754973 16170337
MESH:D006332 Cardiomegaly Quercetin 10.6919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.6918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2815775269
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.1817174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.1818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3016919318 16105132 15861022 17681005 17333356 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 8697196 16354765 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003072 Cognition Disorders Raloxifene 4.3815800139
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms Quercetin 2.3811134977 19056647 17148506 16640504 19440933 15741050 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.2317323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.7110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7117551590 9664655 10589399 9142499 16925845 14991402 8800419 9224671 9125849 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3212952375 16002989
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9617474826
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8016823706 15059100 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5319496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.8116506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.3217308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3716227642 17562736 11834606 19164858 14725611 19370779 15968718 2444490 11421492 11739529 17522070 19923254 19085960 16081117 12958197 11743745 12705907 16109766 11287661 12392966 14986274 10774834 18071297 16393943 16177239 11529661 10915739 18713872 17906064 16485898 16781746 12594235 19416960 15619225 12540782 19420014 14550746 12153990 11461765 19739265 10663392
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3719107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.3718186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:C538011 Eales disease Ascorbic Acid 5.239068938
MESH:D004487 Edema pirinixic acid 10.1612083418
MESH:D004487 Edema Raloxifene 10.1615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3315845917
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.5616804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 11.5619148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 27.8419224547
MESH:D005234 Fatty Liver Dietary Fats 27.8417967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8415345470
MESH:D005234 Fatty Liver pirinixic acid 27.8420131406 19236843
MESH:D005234 Fatty Liver Raloxifene 27.8417473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116611131 16534752 16513791 15751030 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Cyclosporine 25.1612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 25.1618296743
MESH:D005355 Fibrosis Quercetin 25.1619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.1620067830
MESH:D005355 Fibrosis Tretinoin 25.1617994277
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Quercetin 6.7319804834
MESH:D005909 Glioblastoma Tretinoin 6.7317312396
MESH:D005910 Glioma Quercetin 2.9617643826
MESH:D018149 Glucose Intolerance sodium arsenate 4.8519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.4916080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4914991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.3711110106
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9818467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9812621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3916490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.0916870215
MESH:D006930 Hyperalgesia Alendronate 12.0916769263
MESH:D006930 Hyperalgesia Tretinoin 12.0916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 8.5320558911
MESH:D006943 Hyperglycemia Quercetin 8.5318262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1914722030 12960047
MESH:D006973 Hypertension Cobalt 19.3817039479
MESH:D006973 Hypertension Cyclosporine 19.3810903974
MESH:D006973 Hypertension Phenylephrine 19.388949925 12717712
MESH:D006973 Hypertension Quercetin 19.3818356687
MESH:D006973 Hypertension Raloxifene 19.3815787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 19.3818850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.3318502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Dietary Fats 7.5320412841
MESH:D007249 Inflammation Diethylnitrosamine 7.5318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5312878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.2616624496
MESH:D007333 Insulin Resistance bisphenol A 16.3316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.3311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.3316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2017551590 15992940
MESH:D007627 Keloid Quercetin 4.7117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.2715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.2718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.2715618244
MESH:D007674 Kidney Diseases Quercetin 13.2716962696
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.2814681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.2815610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D007889 Leiomyoma Raloxifene 4.2716973256
MESH:D007938 Leukemia Quercetin 6.0517468513
MESH:D007938 Leukemia Tretinoin 6.0517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9917217047 16788101 15748426 19035177 19225113 9834237 19029980 17712046 17107899 17649720 17301526 16823087 16766008 19642359 16935935 17294898 17368321 16891316 17339181 19075265 16140955 17361223 16331271 17506722 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2518665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2521047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.3812741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.0919014921 12587719 19784758 16610002 19460945 16611625 12969438 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0917034775
MESH:D008107 Liver Diseases Phenobarbital 6.0919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0216871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.319163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.3119389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.312862719 21167192 19294768 20501860 19642983 16942905 18977376 18978307 21071580 20118626 2422723 19427195 19551842 9163691 20101389 19833225 19090486 19255062 20492335 20583210 12112319 15885732 20452335 19256749 21278145 19850985 18644402 20434301 15175105 19073162 10737359 19996281 12771043 20137499 19426721 19638242 18648771 20405173 19254457 19690152 19812893 19499222 18754104 21047994
MESH:D008113 Liver Neoplasms Diethylstilbestrol 24.3115890375 16712894
MESH:D008113 Liver Neoplasms Phenobarbital 24.318742319 19812893 21047994 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 24.3120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 24.3118980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.3116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.948603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 25.9418544905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.9418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.9418308698 19539802 21159647 18544905 17174075 18079962 19126423 18775883 18253720 3124819 18164116 19009564 19004024 16267830 17854601 17942915 16842330 2563599 18093689 19519916 18282651 9362446
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.9417172636 2563599 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 25.9419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.9412151625
MESH:D008171 Lung Diseases Ascorbic Acid 3.7916863852
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.626434250
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.2714755239
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.2716401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.276695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Quercetin 6.2716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2719555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.8212807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8216891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6318186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.3819151258
MESH:D009203 Myocardial Infarction Quercetin 5.3819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.1119207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009232 Myxoma Raloxifene 5.3016343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.473581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 10.8815313581
MESH:D009369 Neoplasms pirinixic acid 10.8817405874
MESH:D009369 Neoplasms Quercetin 10.8815185748
MESH:D009369 Neoplasms Tretinoin 10.8816946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0818481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 28.2316427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.2311399458
MESH:D009421 Nervous System Malformations Estradiol 28.2316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2314600291
MESH:D009421 Nervous System Malformations Tretinoin 28.239125849
MESH:D009436 Neural Tube Defects sodium arsenate 7.0819446573 18186108 11749123 10525206
MESH:D009436 Neural Tube Defects Tretinoin 7.089142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5220387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.1317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity Ascorbic Acid 7.1117217161
MESH:D009765 Obesity Dietary Fats 7.1117217161 19632207 21332399 18674790 16723640 20518802 18457598 11836018 20132043
MESH:D009765 Obesity pirinixic acid 7.1120558911
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010024 Osteoporosis Alendronate 7.2917882678
MESH:D010024 Osteoporosis Raloxifene 7.2915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.4319495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.4315579764 17823083 17893378 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.4519401270
MESH:D010051 Ovarian Neoplasms Quercetin 7.4519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4516936753
MESH:D010146 Pain Acetaminophen 5.9416870215
MESH:D010146 Pain Tretinoin 5.9416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.6016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.6016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 11.6016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.6015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 20.1812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 20.182563599
MESH:D011230 Precancerous Conditions Phenobarbital 20.182563599
MESH:D011230 Precancerous Conditions Quercetin 20.1819056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.8510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.8517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.8511118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9017136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Quercetin 1.9017292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9016536755 16220300 15731164
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0814606601
MESH:D011658 Pulmonary Fibrosis Cobalt 3.916434250
MESH:D011693 Purpura Raloxifene 5.3015770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2416849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 5.3016862918
MESH:D012640 Seizures Phenobarbital 2.534039156 11442880 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012871 Skin Diseases Ascorbic Acid 3.1518709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.1816467112
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.6818726076
MESH:D020521 Stroke Ascorbic Acid 8.3616403987 16517955
MESH:D020521 Stroke Raloxifene 8.3616837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.907505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.901399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.8819048282
MESH:D013978 Tibial Fractures Raloxifene 12.8819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.9216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.9216720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.9217572228
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.8016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.8016129372
MESH:D014591 Uterine Diseases bisphenol A 12.9814652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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