AutismKB 2.0

Annotation Detail for ZHX1


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Basic Information Top
Gene Symbol:ZHX1 ( - )
Gene Full Name: zinc fingers and homeoboxes 1
Band: 8q24.13
Quick LinksEntrez ID:11244; OMIM: 604764; Uniprot ID:ZHX1_HUMAN; ENSEMBL ID: ENSG00000165156; HGNC ID: 12871
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ZHX1 mRNAincreases expression 16788091
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of ZHX1 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZHX1 mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in decreased expression of ZHX1 mRNAdecreases expression 19304788
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZHX1 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ZHX1 mRNAaffects cotreatment|decreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ZHX1 mRNAincreases expression 17011747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZHX1 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in decreased expression of ZHX1 mRNAdecreases expression 19304788
C017947 sodium arsenite sodium arsenite results in increased expression of ZHX1 mRNAincreases expression 17879257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9017162532 19052882 17620307 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2917474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2917129689 15324884
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8010672840 19335982 20084675 3084413 10737359 19052882 17138121 18506893 18665156 19701751 20512989 18393292 20935162 20007298 19919837 17761372 19394651 3581430 19418558 18210153 21159647 16502159 17173139 16878318 16288022 11831363 16779866 18785209 20514400 19519916 18494052 16540662 20432363 16328049 18978308 19208518 16681979 18691550 16807293 18056438 19171122 17055752 16698587 20524982 20101231 20727157 17162532 16830150 19822196 20214788 16935385 18788625 18971187 17978847 19107877 19539802 19383236 16569478 17428255
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8016507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4218572023
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.162727394 21159647 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.1620056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7512952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1019107877
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5716804899 15700306
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.2621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.2619236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7516611131 15751030 16002989 16534752 16513791
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.6216452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.6216452187
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2119772884 18467677 16221962 19176532
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6512960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male sodium arsenite 3.1015346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7510783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.7715369732
MESH:D007674 Kidney Diseases sodium arsenite 6.7720008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.6015003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1016766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9120032147 18522880 18665156 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2121047994 19996281 20137499 20118626 19427195 18978307 18644402 18648771 19812893 19850985 20452335 19255062 21278145 21167192 19426721 20434301 16942905 21071580 19499222 19551842 19638242 19256749 19833225 2422723 18754104 12771043 19294768 19690152 19073162 2862719 12112319 20583210 20405173 20101389 19642983 15175105 15885732 20492335 10737359 18977376 20501860 19090486 9163691 19254457
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.2115890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 11.2116377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 11.2116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7318544905 19539802 19126423 17854601 18079962 19009564 18093689 2563599 18775883 18164116 3124819 17942915 19519916 9362446 16842330 16267830 18308698 18253720 19004024 18282651 17174075 21159647
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5420970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 2.5419931552 15276417 16712894 17077188 17306315
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 8.7415313581
MESH:D009369 Neoplasms pirinixic acid 8.7417405874
MESH:D009369 Neoplasms sodium arsenite 8.7411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009410 Nerve Degeneration Rotenone 4.0115790535 17356569 18619942
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.3311399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4815276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010300 Parkinson Disease Rotenone 3.0315451049 11535288 18619942 11445065 19232380 16412576 16140633 19114014 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.2418197244 15927086 15574749 15795934
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8916977796 15687265
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.3517184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3715846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3716039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.7718572023 19524636
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4716452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4716452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.0916175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.0911813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2716690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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