AutismKB 2.0

Annotation Detail for GPR176


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Basic Information Top
Gene Symbol:GPR176 ( GPR,Gm1012 )
Gene Full Name: G protein-coupled receptor 176
Band: 15q14-q15.1
Quick LinksEntrez ID:11245; OMIM: 612183; Uniprot ID:GP176_HUMAN; ENSEMBL ID: ENSG00000166073; HGNC ID: 32370
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPR176 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GPR176 mRNAincreases expression 17879257
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GPR176 mRNAaffects expression 17484886
D004317 Doxorubicin GPR176 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of GPR176 mRNA]affects reaction|increases expression 14699072
D004958 Estradiol Estradiol affects the expression of GPR176 mRNAaffects expression 14699072
D014747 Vinblastine GPR176 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4920127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.4917418594
MESH:D000230 Adenocarcinoma Estradiol 7.4911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 1.9118628466 15634643 16264153 18234424 16096432 17983394 15939500 16935488 15136595 17369602 18695136 15994142 19526202 15993339 18382427 16595493 17426702 16322301 15567936 16826403 15692762 16115903 15668708 11325840
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 16675129 19861407 17261762 17289903 17018787 14630087 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2015700767 18705752 15721981 3786805 16227642 16124888 15673190 10355542 16050911 16011737 16097048 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8618788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8616023760 17876044 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8616924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.381485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.381485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.946189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7217329180 17974986 16651473 16455267 16109756 16612575 15476868 16278810 18627295 17351982 17519947 17382496 15505089 17007740 17308081 17928571 16731534 16242529 16364871 16952015 17131338 17924179 15811867 15792986 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0317334414 16243910
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9818566989
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9918259882 18802399
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9918802399
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.316623471 2869522 16177239 9327722 15998439 16227642 10092053 21278145 7179309 17522070 15968718 4309450 6884620 7440962 11566570 15027814 19336974 10915739 7120509 19085960 3786805 3732212
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.3117416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9018602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.1917359293
MESH:D016889 Endometrial Neoplasms Estradiol 8.1918566989 11473722 19148513
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4912795759 19224547 12631006 17595544 61145 15959796 16045604 16239168
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006331 Heart Diseases Doxorubicin 3.6917875725 18006777 16879835 16495754 16244372 16244371 16330681 16144979 14766674 16707910 12587719 18674790 17888722
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D006689 Hodgkin Disease Doxorubicin 8.7618501091 17606976 15147373
MESH:D006689 Hodgkin Disease Vinblastine 8.7618501091 18180244
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007333 Insulin Resistance Estradiol 3.1616393666 16627594
MESH:D007674 Kidney Diseases Doxorubicin 6.7515369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 6.7515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007680 Kidney Neoplasms Estradiol 3.2415610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9621278145 11408273 17334410 16943688 17174718 17157831 16239168 11903743 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.7117900296 15925388 18395095 16638106 14724832 12666154 20821823 12632514 18472094 17481882 14716833 16248980 18420326 16015684 11481614 17761835 18277467 18205269 16097048 18412020 16033810 12546737 12609069 18054572 12649538 17698563 18166357 17557913 16116963 17922224 18481824 18472332 12667390 13678700 17766677 14620537 17640975 17714472 15123356 18376398 15959796 15338365 18187930 18251166 18339082 18395914 18156304 12898905 15362042 14716496 17631135 15931870 16192424 15818738 12632512 18210741 18263696 14512876 18279442 17708605 18705752 18006644 15057751 15673190 15893842 16136751 15650968 17869086 15876570 12445418 18317297 15730626 17565644 12389079 17721639 15370692 18429990 17823541 10355542 14748882 15052691 17805973 17976157 16011737 15996030 12958196 12445421 18418968 17525996 17944888 12586293 12741479 16027843
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.7116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7114716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.7012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.7017085340 16842330
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5920464547 6695378 18569708 20064080 18816296 17053015 20869020 18520028 20135361
MESH:D008175 Lung Neoplasms Doxorubicin 2.5917418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.7611807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008545 Melanoma Doxorubicin 3.9316827129
MESH:D008545 Melanoma Vinblastine 3.9316809738 17761969 18505091 16248763 15577323 18176117 18332650 12374674 16432458 15577320
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0515857846 19429709
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009401 Nephrosis Doxorubicin 5.1916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2916889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D009503 Neutropenia Vinblastine 4.9217378895
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5017292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5016888761 15897917 15749863 18437689 16729912 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 2.5016740699
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012509 Sarcoma Doxorubicin 4.2915675481 15625365 18313854 16767912 17710206 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2319755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 6.2315692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9817203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6117909728 16010429
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4917053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.4917653716
MESH:D014625 Vaginal Neoplasms Vinblastine 5.4615577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417334414 16364871 17678736 17638931
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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