AutismKB 2.0

Annotation Detail for MAN1B1


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Basic Information Top
Gene Symbol:MAN1B1 ( ERMan1,MANA-ER )
Gene Full Name: mannosidase, alpha, class 1B, member 1
Band: 9q34.3
Quick LinksEntrez ID:11253; OMIM: 604346; Uniprot ID:MA1B1_HUMAN; ENSEMBL ID: ENSG00000177239; HGNC ID: 6823
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
2149Pelvic inflammatory disease
2252Female reproductive cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MAN1B1 mRNAdecreases expression 12958071
C099555 CD 437 CD 437 results in decreased expression of MAN1B1 mRNAdecreases expression 12958071
C014347 decitabine decitabine results in increased expression of MAN1B1 mRNAincreases expression 17908484
D012643 Selenium Selenium results in increased expression of MAN1B1 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAN1B1 mRNAdecreases expression 19465110
D014810 Vitamin E Vitamin E results in increased expression of MAN1B1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms decitabine 2.0719208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6619215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 16354765 15340226 12621046
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0616080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 15340226 16959395 8697196 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007938 Leukemia decitabine 3.2119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.3318454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4217679729 19010910 18460780 18206229 18704418 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4216169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3811062179
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008545 Melanoma decitabine 2.2817785578 16505122
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5419157545 19010910 16882708 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms decitabine 2.8417925555 19116145 19470736
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D010051 Ovarian Neoplasms CD 437 5.5917474084
MESH:D010051 Ovarian Neoplasms decitabine 5.5919331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8519294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11222880 11896295 11118676
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.9216720286
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.9217616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30572
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    Releated drug ID Related drug Name
    PA449212daunorubicin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01955 - 1,4-Butanediol
    DB02422 - Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside
    DB02742 - Kifunensine Enzyme Inhibitors
    DB02944 - Alpha-D-Mannose
    DB03206 - 1-Deoxynojirimycin Antiviral Agents;Enzyme Inhibitors;Beta-Glucosidase A Inhibitors
    No data
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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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