AutismKB 2.0

Annotation Detail for CHP


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Basic Information Top
Gene Symbol:CHP ( SLC9A1BP )
Gene Full Name: -
Band: 15q13.3
Quick LinksEntrez ID:11261; OMIM: 606988; Uniprot ID:CHP1_HUMAN; ENSEMBL ID: ENSG00000187446; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa04114Oocyte meiosis
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
No data
Pathway IDPathway Name
200159Calcium signaling in the CD4+ TCR pathway
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CHP mRNAaffects expression 21346803
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of CHP mRNAincreases expression 19643169
D000638 Amiodarone Amiodarone affects the expression of CHP mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHP mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of CHP mRNAaffects expression 19483382
D001554 Benzene Benzene affects the expression of CHP mRNAaffects expression 15878777
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CHP mRNAaffects cotreatment|increases expression 17905399
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CHP mRNAincreases expression 19150397
D002994 Clofibrate Clofibrate affects the expression of CHP mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of CHP mRNAaffects expression 17602206
C014347 decitabine decitabine affects the methylation of CHP geneaffects methylation 17630775
D005001 Ethionine Ethionine affects the expression of CHP mRNAaffects expression 19483382
C005219 methyl cellosolve methyl cellosolve results in increased expression of CHP mRNAincreases expression 19643169
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CHP mRNAaffects cotreatment|increases expression 17905399
D009853 Omeprazole Omeprazole affects the expression of CHP mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of CHP mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of CHP mRNAaffects expression 19483382
D013853 Thioacetamide Thioacetamide affects the expression of CHP mRNAaffects expression 19483382
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CHP mRNAaffects cotreatment|increases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 9.316499820 6499812 7151721 6499823 6499796
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 9.313652986 6499812 6474471
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4416434500
MESH:D000741 Anemia, Aplastic Benzene 4.3311369114 17661222 14761424
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.323699323
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7620041841 18218290 18057881
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 12.4910689203 6499807 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 12.493987992
MESH:D001259 Ataxia 2-ethoxyethanol 5.417151721
MESH:D001281 Atrial Fibrillation Amiodarone 3.8719698954 18651412
MESH:D001284 Atrophy 2-ethoxyethanol 11.2715850284 6499799
MESH:D001284 Atrophy methyl cellosolve 11.272626667 6705890 3699323
MESH:D053713 Azoospermia 2-ethoxyethanol 5.546499807 6492198
MESH:D001724 Birth Weight 2-ethoxyethanol 6.482884743 6499823
MESH:D001778 Blood Coagulation Disorders Amiodarone 50.0819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 50.0819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 50.0819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 50.0819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 50.0819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 50.0819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 50.0819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 50.0819483382
MESH:D001836 Body Weight Changes 2-ethoxyethanol 5.687151721 6499796
MESH:D001855 Bone Marrow Diseases Benzene 5.2016183116
MESH:D001943 Breast Neoplasms Benzene 2.1911921183 17162533
MESH:D001943 Breast Neoplasms decitabine 2.1918320071 19208741
MESH:D001943 Breast Neoplasms Trichloroethylene 2.1915986119
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.741701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7417997003
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5819215824
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.096135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0920889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.091399818
MESH:D002637 Chest Pain Omeprazole 5.0815447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.2518291259
MESH:D002764 Cholecystitis 2-ethoxyethanol 13.566499794
MESH:D002764 Cholecystitis methyl cellosolve 13.566499794
MESH:D002779 Cholestasis pirinixic acid 2.7919176532
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.7712530607 6499821
MESH:D019465 Craniofacial Abnormalities Benzene 2.4415643154
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D003643 Death 2-ethoxyethanol 5.946499796
MESH:D003872 Dermatitis Benzene 4.7315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.9918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.9912963478
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 8.997120509
MESH:D004381 Duodenal Ulcer Omeprazole 4.2916613094 17151854 21218061 15991576
MESH:D050171 Dyslipidemias Clofibrate 4.0316707586
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.486499796
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0919294695
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0620426865
MESH:D005218 Fat Necrosis Thioacetamide 5.6916456712
MESH:D005234 Fatty Liver Amiodarone 13.0014986274
MESH:D005234 Fatty Liver Clofibrate 13.0019224547
MESH:D005234 Fatty Liver pirinixic acid 13.0020131406 19236843
MESH:D005313 Fetal Death 2-ethoxyethanol 5.346499820 7198755 6499823 7151721 2884743
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.376499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 12.586499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 12.586499821 6499812 6474471 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 13.567151721 6499820 2884743
MESH:D020567 Fetal Weight methyl cellosolve 13.566499821 6474471 6499812
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.443652986
MESH:D006258 Head and Neck Neoplasms decitabine 3.4619215824
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.746499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 11.1910514026 20172899
MESH:D006402 Hematologic Diseases Benzene 11.1916183116
MESH:D006461 Hemolysis 2-ethoxyethanol 12.2517874071 19051582
MESH:D006461 Hemolysis methyl cellosolve 12.2517874071
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5315929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.1716456712
MESH:D006529 Hepatomegaly Amiodarone 8.4515265979
MESH:D006529 Hepatomegaly pirinixic acid 8.4519772884 18467677 19176532 16221962
MESH:D006937 Hypercholesterolemia Amiodarone 3.838137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Benzene 3.0717940673
MESH:D007037 Hypothyroidism Amiodarone 11.4818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.488137927 18031379
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.196499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 11.456499823
MESH:D007248 Infertility, Male decitabine 11.4517581917
MESH:D007248 Infertility, Male methyl cellosolve 11.453987992
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9416705839
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0619248655
MESH:D007938 Leukemia Benzene 6.5918335105 17119257 15935818 14694614
MESH:D007938 Leukemia decitabine 6.5919235587 18980019
MESH:D007951 Leukemia, Myeloid Benzene 9.6617506065
MESH:D007951 Leukemia, Myeloid decitabine 9.6617236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1719478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1719010910 17679729 19387464 18460780 18206229 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.466499821
MESH:D008064 Lipidoses Amiodarone 3.4817567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5415158331 11481614 12891558 12531686 10677585 12175628 16511523 18263696 12557150 17127702 17355460 15474484 16489207 18395095 12085344 11682029 16097051 12679928 18615449 15288473 18606216 15362042 18032466 17050028 15095483 17629604 16248980 15334695 15078482 18295389 11172339 16098781 18458672 15075984 15288472 18416461 18031379 14739098 16343077 15465738 18380797 15716488 15316131 16126171 17292413
MESH:D008107 Liver Diseases Thioacetamide 2.6915158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2717276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.367678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.3617602206
MESH:D008113 Liver Neoplasms pirinixic acid 7.3620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.942876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Benzene 9.9412562636
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 9.947955063
MESH:D008133 Long QT Syndrome Amiodarone 3.5415350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 11.3718516814
MESH:D017563 Lung Diseases, Interstitial Benzene 11.3714698565
MESH:D008175 Lung Neoplasms Benzene 2.4212562636
MESH:D008223 Lymphoma Benzene 7.7217584886 17119257
MESH:D008223 Lymphoma decitabine 7.7219470736
MESH:D008231 Lymphopenia methyl cellosolve 5.743699323
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4112562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.2811921183
MESH:D008545 Melanoma decitabine 2.2417785578 16505122
MESH:D009101 Multiple Myeloma Benzene 7.4817119195
MESH:D009101 Multiple Myeloma decitabine 7.4818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009181 Mycoses Amiodarone 4.8717974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3619157545 18608210 16882708 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.777678174 18551238
MESH:D009336 Necrosis 2-ethoxyethanol 10.7720172899
MESH:D009369 Neoplasms decitabine 8.2917925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 8.2917405874
MESH:D009369 Neoplasms Trichloroethylene 8.2911911487
MESH:D009436 Neural Tube Defects Benzene 3.6415643154
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.909802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0316049721
MESH:D009784 Occupational Diseases Benzene 9.0316737584 15727169 17479406 15935809 15576619 15612468 15913788 17119257 17178637
MESH:D009845 Oligospermia 2-ethoxyethanol 11.2620172899
MESH:D009845 Oligospermia methyl cellosolve 11.263987992
MESH:D010051 Ovarian Neoplasms Benzene 5.1512562636
MESH:D010051 Ovarian Neoplasms decitabine 5.1519331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.7519294695
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 10.466499817 2884743 7198755
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 10.467974496 12530607 6499817
MESH:D055728 Primary Myelofibrosis decitabine 4.6917616702
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8412832656 11597910 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.3619155313
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5018551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0518724381
MESH:D013272 Stomach Diseases Omeprazole 4.5818545984
MESH:D013274 Stomach Neoplasms Benzene 2.7612562636
MESH:D013274 Stomach Neoplasms decitabine 2.7619037991
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 12.096499799
MESH:D013276 Stomach Ulcer Amiodarone 12.0918087811
MESH:D013276 Stomach Ulcer Omeprazole 12.0918237397 11906479 16755016 17977527 10750652 15991576
MESH:D013610 Tachycardia Amiodarone 4.2511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1519225199
MESH:D013733 Testicular Diseases 2-ethoxyethanol 10.956499806 10514026 10048760
MESH:D013733 Testicular Diseases methyl cellosolve 10.956499806
MESH:D013953 Thymus Neoplasms Benzene 4.9210850423
MESH:D013959 Thyroid Diseases Amiodarone 4.7319731979
MESH:D013964 Thyroid Neoplasms decitabine 7.4217967635
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.4215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.1511989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1119087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014594 Uterine Neoplasms Benzene 4.2912562636
MESH:D014604 Uveal Neoplasms decitabine 4.8817785578
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04210 Apoptosis
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04114 Oocyte meiosis
KEGG:04660 T cell receptor signaling pathway
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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