AutismKB 2.0

Annotation Detail for USP18


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Basic Information Top
Gene Symbol:USP18 ( ISG43,UBP43 )
Gene Full Name: ubiquitin specific peptidase 18
Band: 22q11.2
Quick LinksEntrez ID:11274; OMIM: 607057; Uniprot ID:UBP18_HUMAN; ENSEMBL ID: ENSG00000184979; HGNC ID: 12616
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of USP18 mRNAaffects expression 21346803
C026114 2-xylene 2-xylene results in increased expression of USP18 mRNAincreases expression 20359517
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of USP18 mRNAaffects expression 18648102
D001554 Benzene Benzene results in increased expression of USP18 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of USP18 mRNAdecreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of USP18 mRNAincreases expression 15003993
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of USP18 mRNAaffects cotreatment|affects expression 17602206
D004041 Dietary Fats Dietary Fats affects the expression of USP18 mRNAaffects expression 17086191
D004041 Dietary Fats Dietary Fats results in decreased expression of USP18 mRNAdecreases expression 18042831
D004041 Dietary Fats resveratrol inhibits the reaction [Dietary Fats affects the expression of USP18 mRNA]affects expression|decreases reaction 17086191
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of USP18 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of USP18 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of USP18 mRNAincreases expression 19619570
C004912 ethylbenzene ethylbenzene results in increased expression of USP18 mRNAincreases expression 20359517
C056933 fumonisin B1 fumonisin B1 results in increased expression of USP18 mRNAincreases expression 16221962
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of USP18 mRNAdecreases expression 20713471
D008752 Methylene Chloride Methylene Chloride results in increased expression of USP18 mRNAincreases expression 20359517
C041786 palm oil palm oil results in decreased expression of USP18 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of USP18 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of USP18 mRNAincreases expression 19482888
C059514 resveratrol resveratrol inhibits the reaction [Dietary Fats affects the expression of USP18 mRNA]affects expression|decreases reaction 17086191
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of USP18 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of USP18 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of USP18 mRNAaffects binding|increases expression 16214954
D014050 Toluene Toluene results in increased expression of USP18 mRNAincreases expression 20359517
D014212 Tretinoin Tretinoin results in decreased expression of USP18 mRNAdecreases expression 16249480
D014241 Trichloroethylene Trichloroethylene results in increased expression of USP18 mRNAincreases expression 20359517
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.866195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8614514962 11752688 15322242
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.699612607
MESH:D058186 Acute Kidney Injury resveratrol 3.7316538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1720464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.1711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 20.233712494
MESH:D000236 Adenoma Benzo(a)pyrene 20.236695378
MESH:D000236 Adenoma Diethylnitrosamine 20.236695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 20.2310545420 6695378
MESH:D000236 Adenoma resveratrol 20.2315688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.5917162532 19061943 18056438 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5916835633
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000544 Alzheimer Disease resveratrol 2.5416183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000741 Anemia, Aplastic Benzene 4.2717661222 11369114 14761424
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.7615238619
MESH:D001169 Arthritis, Experimental resveratrol 7.2517115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D050197 Atherosclerosis Methylcholanthrene 6.7111922910
MESH:D050197 Atherosclerosis resveratrol 6.7117967414 16873680
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5416206674 16197459
MESH:D001836 Body Weight Changes 2-xylene 11.677457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.6715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001855 Bone Marrow Diseases Benzene 5.1016183116
MESH:D002545 Brain Ischemia resveratrol 4.1517600658
MESH:D001943 Breast Neoplasms Benzene 8.1917162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.1917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 8.1920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.1917474063
MESH:D001943 Breast Neoplasms Estradiol 8.1918497071 12948864 17289903 16675129 17018787 14630087 19861407 17261762
MESH:D001943 Breast Neoplasms Methylcholanthrene 8.1917474063
MESH:D001943 Breast Neoplasms Methylene Chloride 8.1915986119
MESH:D001943 Breast Neoplasms resveratrol 8.1916393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.1920435547
MESH:D001943 Breast Neoplasms Tretinoin 8.1916873071 16443354 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 8.1915986119
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002277 Carcinoma Methylcholanthrene 7.9910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.7716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.777296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7716502159 20512989 16328049 19701751 19208518 17162532 16569478 17978847 20214788 18785209 18788625 19539802 19418558 19107877 17055752 19383236 10672840 16807293 18056438 16779866 10737359 18506893 18691550 18494052 18665156 20524982 18971187 19052882 20727157 19519916 19919837 19335982 16935385 17138121 16878318 3581430 20432363 16288022 20514400 18978308 16681979 16698587 19822196 19171122 21159647 16540662 3084413 16830150 20084675 19394651 18393292 17428255 11831363 20007298 20101231 18210153 17173139 20935162 17761372
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.7716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.7717173139 1701930 20935162 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.7719321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.771917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4616675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3320419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.3316227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3316096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.3815458977
MESH:D002386 Cataract Tretinoin 3.0217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.317505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.317505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.3118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.3116192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D002547 Cerebral Palsy Toluene 5.729294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.0519486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5816354765 15340226 8697196 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.589407595
MESH:D003092 Colitis resveratrol 9.1916474422
MESH:D003092 Colitis Tretinoin 9.1917035595
MESH:D003110 Colonic Neoplasms resveratrol 2.4416338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6716507316
MESH:D019465 Craniofacial Abnormalities Benzene 5.3615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 5.369294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.3617551590 9125849 14991402 16925845 9224671 9664655 9142499 8800419 9211117 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8818551238
MESH:D003643 Death Toluene 5.546431079
MESH:D003872 Dermatitis Benzene 4.6415902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6812868966 11298694 2524372 8970840 14531868 8156756 11906362 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6616873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.6419279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.6416286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.7716192314 6482804 7440962 11289319 6679447 18648102 9328219 8291058 18692083 1440618 9022650 9653073 18289764
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.7719107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 14.7716221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.7720420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 14.777120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9111462148
MESH:D004362 Drug Toxicity Zidovudine 7.9115040536
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004421 Dystonia Phenobarbital 3.881851702
MESH:D004487 Edema resveratrol 6.478985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5116714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.9017872969
MESH:D016889 Endometrial Neoplasms Estradiol 7.1318566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7217923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.983659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.743922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.436401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.127750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.893659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.253581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.519664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 12.5618296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 12.5621071580 20387270
MESH:D005234 Fatty Liver Zidovudine 12.5618299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8114633661 10962813
MESH:D005355 Fibrosis Dietary Fats 14.0118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0120067830
MESH:D005355 Fibrosis Tretinoin 14.0117994277
MESH:D005909 Glioblastoma Tretinoin 2.9217312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.6920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.699664655 14991402
MESH:D006402 Hematologic Diseases Benzene 10.6716183116
MESH:D006402 Hematologic Diseases Zidovudine 10.6712579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.396705139
MESH:D006529 Hepatomegaly 2-xylene 19.737457028 7457013
MESH:D006529 Hepatomegaly fumonisin B1 19.7316221962
MESH:D006529 Hepatomegaly Phenobarbital 19.7316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.7315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D006561 Herpes Simplex resveratrol 4.0516876885
MESH:D015658 HIV Infections Zidovudine 3.4211141242 11698656 17358032 11363243 20032539
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9218606429 16959395 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.1116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8121332399
MESH:D006937 Hypercholesterolemia resveratrol 8.8117188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006949 Hyperlipidemias Dietary Fats 8.8821332399
MESH:D006949 Hyperlipidemias resveratrol 8.8816873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Benzene 5.1517940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1518850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1917488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5217600658
MESH:D007249 Inflammation Dietary Fats 11.4120412841
MESH:D007249 Inflammation Diethylnitrosamine 11.4118785209
MESH:D007249 Inflammation resveratrol 11.4116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4112200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.4216624496
MESH:D007333 Insulin Resistance Dietary Fats 7.0911836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.0916627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5317551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.5115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.9016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.906582329
MESH:D007680 Kidney Neoplasms Estradiol 16.9015610895
MESH:D007680 Kidney Neoplasms Zidovudine 16.9012579204
MESH:D007938 Leukemia Benzene 6.3315935818 18335105 17119257 14694614
MESH:D007938 Leukemia Tretinoin 6.3317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2920370541
MESH:D007951 Leukemia, Myeloid Benzene 9.2817506065
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.0119478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.4816087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4816788101 12679006 16766008 17301526 17107899 17506722 16823087 19225113 9834237 16891316 16331271 16935935 17217047 19029980 17294898 17361223 17339181 17649720 19075265 15748426 19035177 17368321 19642359 16140955 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.6119638242 18665156 20032147 18522880 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6121047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3518397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D008107 Liver Diseases Phenobarbital 3.9919363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.3521137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 17.3517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.3520101389 10737359 19642983 20492335 20118626 21071580 18977376 19256749 20501860 18644402 19551842 21047994 19294768 16942905 19254457 20137499 2422723 19812893 15175105 19638242 19090486 19427195 18978307 20434301 20405173 12771043 19426721 19850985 2862719 19499222 21278145 19073162 20583210 19996281 18754104 18648771 19255062 9163691 12112319 15885732 19833225 20452335 19690152 21167192
MESH:D008113 Liver Neoplasms Phenobarbital 17.358742319 19073162 21047994 15975961 19812893 19482888
MESH:D008113 Liver Neoplasms resveratrol 17.3519812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.3516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 27.043712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Benzene 27.0412562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.0416267830 3124819 19539802 18775883 19004024 21159647 19519916 17854601 17174075 18164116 2563599 18282651 19009564 16842330 9362446 18544905 19126423 18253720 18093689 18308698 17942915 18079962
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 27.041399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.042563599 6150874 1399818 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.0412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 27.047955063
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6814698565
MESH:D008175 Lung Neoplasms Benzene 10.4712562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.4720135361 18520028 6695378 18569708 20064080 17053015 18816296 20464547 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.4720970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.479230183 20512841 15390079 17909032 7750092 6695378 16271038 10545420 20970405 21163286 16337739 11893704 1399818
MESH:D008175 Lung Neoplasms Methylene Chloride 10.4715172992
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4719555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 10.4718800350
MESH:D008223 Lymphoma Benzene 3.6417584886 17119257
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1717088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7614749477
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.8212562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.8215688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.6111921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.6117203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.618985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma resveratrol 3.3917992120
MESH:D008545 Melanoma Tretinoin 3.3916752155
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008607 Mental Retardation Toluene 3.619294310
MESH:D008659 Metabolic Diseases resveratrol 4.2617112576
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7117358032
MESH:D019957 Motor Skills Disorders Toluene 5.119294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009101 Multiple Myeloma Benzene 7.3217119195
MESH:D009101 Multiple Myeloma resveratrol 7.3216490592 16267019 17935668 17164350 14749477 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7417962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0117596541
MESH:D009203 Myocardial Infarction resveratrol 2.9816456233 16317513 17015251 17188708 16525036 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.6617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1816810080
MESH:D009205 Myocarditis resveratrol 4.6317322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7318551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.533581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.533581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0311141357
MESH:D009369 Neoplasms Tretinoin 8.0316946489 16594593
MESH:D009369 Neoplasms Trichloroethylene 8.0311911487
MESH:D009374 Neoplasms, Experimental resveratrol 3.878985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009421 Nervous System Malformations Estradiol 15.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 15.599125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.716679447
MESH:D009436 Neural Tube Defects Benzene 11.7115643154
MESH:D009436 Neural Tube Defects Tretinoin 11.719142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1720387270
MESH:D019636 Neurodegenerative Diseases resveratrol 8.1717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity Dietary Fats 2.2617217161 21332399 18457598 20518802 16723640 19632207 18674790 11836018 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.4916049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.496482804 4026338
MESH:D009784 Occupational Diseases Benzene 14.4915612468 15935809 15727169 15576619 16737584 17479406 17119257 17178637 15913788
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1317513867
MESH:D010051 Ovarian Neoplasms Benzene 7.7112562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.7119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7116936753
MESH:D010146 Pain Tretinoin 2.8016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.3416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.3415976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.722563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.722563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.1616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1611222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6116740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.6117675339 15767336 17804756 17636462 17718901 16731767
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.3712752131
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2116317513 17520802 17058453 16314181 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9816283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 9.4518551238
MESH:D012640 Seizures Phenobarbital 9.453137016 16876388 4039156 11442880
MESH:D012640 Seizures Toluene 9.456431079 9294310
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.2719755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 17.2715837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.278532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 17.2716467112
MESH:D013274 Stomach Neoplasms Benzene 6.2712562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.272093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.2718456281
MESH:D013274 Stomach Neoplasms Tretinoin 6.2717261132
MESH:D013274 Stomach Neoplasms Zidovudine 6.2717696246
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3616321402
MESH:D013733 Testicular Diseases Toluene 4.8310048760 10514026
MESH:D013953 Thymus Neoplasms Benzene 4.8210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.271399818 7505956 6582329 3712494 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.277505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 16.271399818
MESH:D013964 Thyroid Neoplasms Tretinoin 16.2716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014062 Tongue Neoplasms resveratrol 9.5216227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.5216051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.978074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.1517473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1516129372
MESH:D014594 Uterine Neoplasms Benzene 9.4512562636
MESH:D014594 Uterine Neoplasms resveratrol 9.4517044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6312579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1717488730
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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