AutismKB 2.0

Annotation Detail for STX1B


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Basic Information Top
Gene Symbol:STX1B ( STX1B1,STX1B2 )
Gene Full Name: syntaxin 1B
Band: 16p11.2
Quick LinksEntrez ID:112755; OMIM: 601485; Uniprot ID:STX1B_HUMAN; ENSEMBL ID: ENSG00000099365; HGNC ID: 18539
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P05734Synaptic vesicle trafficking
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of STX1B mRNAdecreases expression 18648102
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of STX1B mRNAincreases expression 16359582
C096324 botulinum toxin type C botulinum toxin type C results in increased cleavage of STX1B proteinincreases cleavage 17666428
D002330 Carmustine Carmustine results in decreased expression of STX1B mRNAdecreases expression 15980968
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of STX1B mRNAaffects cotreatment|affects expression 18636392
D003024 Clozapine Clozapine results in increased expression of STX1B mRNAincreases expression 15860345
D005419 Flavonoids Flavonoids results in decreased expression of STX1B mRNAdecreases expression 18035473
D006220 Haloperidol Haloperidol affects the expression of STX1B mRNAaffects expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of STX1B mRNAincreases expression 16807920
15469884
C029938 nickel sulfate nickel sulfate results in increased expression of STX1B mRNAincreases expression 16780908
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of STX1B mRNAaffects cotreatment|affects expression 18636392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Chlorine 10.0920601635
MESH:D055371 Acute Lung Injury nickel sulfate 10.0912718980 19131640 11954676 16100012
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D000380 Agranulocytosis Clozapine 5.2316160616 14617031 12649775
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001321 Autistic Disorder Haloperidol 2.7319368416 18080171
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001932 Brain Neoplasms Carmustine 4.5216187019
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7919059883 16777450 14754758 17626835 15516495 18417511 18315731
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.763581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002375 Catalepsy Haloperidol 5.1015215559 1977408
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.259022650 19486331
MESH:D003072 Cognition Disorders Clozapine 5.1417123785
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9920210726
MESH:D003704 Dementia Haloperidol 4.7211575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.7311298694 12868966 8970840 11906362 18759878 2524372 8156756 14531868
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.7316780908 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0016402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.7715331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.999328219 18692083 1440618 11289319 6679447 8291058 9653073 16192314 7440962 6482804 18289764 9022650 18648102
MESH:D050171 Dyslipidemias Clozapine 4.2816402076
MESH:D004417 Dyspnea Chlorine 4.8420016425
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005739 Gas Poisoning Chlorine 5.2320016425
MESH:D005909 Glioblastoma Carmustine 4.0116187019
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006948 Hyperkinesis Clozapine 5.1016046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D007249 Inflammation Flavonoids 2.7117296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D008064 Lipidoses Clozapine 4.0617567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.611399818 598648 3712494 6587162
MESH:D008171 Lung Diseases Ozone 3.4719066396 8266340
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Ozone 2.107614698 8597069
MESH:D008545 Melanoma Carmustine 2.8812393984
MESH:D001523 Mental Disorders Clozapine 9.0216856516
MESH:D001523 Mental Disorders Haloperidol 9.0216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5319142101
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D009041 Motion Sickness Dextroamphetamine 5.741613127
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009765 Obesity Clozapine 3.0419142110 18515891
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011014 Pneumonia Ozone 4.5918929643 18007984 18381685
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Clozapine 9.4915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4911575062
MESH:D012120 Respiration Disorders Chlorine 5.4318579056
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012559 Schizophrenia Clozapine 4.1620168265 11151749 16141801 18855531 17667964 17726453 20521320 17123785 20452607 18806925 20521326 19369910 20107430 11763009 20580759
MESH:D012559 Schizophrenia Haloperidol 4.1619369910 1830565 18513383 20107430
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8720210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996587162 7505956 1399818 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.328074119
MESH:D015430 Weight Gain Clozapine 4.5920564506 20521320 16141801 17502770 16402076 20107430
MESH:D015431 Weight Loss Clozapine 5.2717933447
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
KEGG:04130 SNARE interactions in vesicular transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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