AutismKB 2.0

Annotation Detail for CHRM1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CHRM1 ( HM1,M1,M1R,MGC30125 )
Gene Full Name: cholinergic receptor, muscarinic 1
Band: 11q12.3
Quick LinksEntrez ID:1128; OMIM: 118510; Uniprot ID:ACM1_HUMAN; ENSEMBL ID: ENSG00000168539; HGNC ID: 1950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2071Supranuclear palsy, progressive
2069Schizophrenia
2074Asthma
2151Neuroblastoma
Desease Name
CHEMDEPENDENCY
PSYCH
Asthma
IMMUNE
nicotine
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CHRM1 mRNAincreases expression 18648102
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
C496641 4-(N-(4-chlorophenyl)carbamoyloxy)-4-pent-2-ammonium iodide 4-(N-(4-chlorophenyl)carbamoyloxy)-4-pent-2-ammonium iodide binds to and results in increased activity of CHRM1 proteinaffects binding|increases activity 15251036
C041594 4-nonylphenol 4-nonylphenol results in decreased expression of CHRM1decreases expression 9827057
C041594 4-nonylphenol 4-nonylphenol results in decreased expression of CHRM1decreases expression 9827057
C041594 4-nonylphenol 4-nonylphenol results in decreased expression of CHRM1decreases expression 9827057
D000109 Acetylcholine CHRM1 protein affects the susceptibility to Acetylcholineaffects response to substance 18367213
D000109 Acetylcholine Acetylcholine results in increased activity of CHRM1 proteinincreases activity 11527950
D000109 Acetylcholine [Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D000109 Acetylcholine Acetylcholine results in increased activity of CHRM1 proteinincreases activity 14534362
D000109 Acetylcholine Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]affects binding|decreases reaction 15900516
D000109 Acetylcholine Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]affects binding|decreases reaction 15900516
D000109 Acetylcholine Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]decreases reaction|increases activity 14534362
D013196 Dihydrotestosterone Cycloheximide inhibits the reaction [Dihydrotestosterone results in decreased expression of CHRM1 mRNA]decreases expression|decreases reaction 17624924
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of CHRM1 mRNAdecreases expression 17624924
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRM1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]decreases expression|decreases reaction 18806925
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of CHRM1 proteindecreases expression 18806925
D001285 Atropine Atropine binds to and results in decreased activity of CHRM1 proteinaffects binding|decreases activity 17613726
D001374 Azacitidine Azacitidine affects the expression of CHRM1 mRNAaffects expression 19002953
D002118 Calcium [Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D002118 Calcium [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D002118 Calcium CHRM1 protein promotes the reaction [Methacholine Compounds results in increased abundance of Calcium]increases abundance|increases reaction 12456425
D002118 Calcium [Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D002217 Carbachol Carbachol results in increased activity of CHRM1 proteinincreases activity 11527950
D002217 Carbachol [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D012721 Carbaryl Carbaryl results in decreased expression of CHRM1decreases expression 9827057
D012721 Carbaryl Carbaryl results in decreased expression of CHRM1decreases expression 9827057
D012721 Carbaryl Carbaryl results in decreased expression of CHRM1decreases expression 9827057
D004390 Chlorpyrifos Chlorpyrifos affects the expression of CHRM1 mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in decreased activity of CHRM1 proteindecreases activity 17666426
D003024 Clozapine Clozapine analog binds to CHRM1 proteinaffects binding 11997696
D003024 Clozapine Clozapine binds to CHRM1 proteinaffects binding 11997696
16983399
D003024 Clozapine Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]decreases expression|decreases reaction 18806925
D003024 Clozapine Clozapine results in increased expression of CHRM1 proteinincreases expression 18806925
D003300 Copper Copper results in decreased expression of CHRM1decreases expression 9827057
D003300 Copper Copper results in decreased expression of CHRM1decreases expression 9827057
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 10845706
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 10845706
D003513 Cycloheximide Cycloheximide inhibits the reaction [Dihydrotestosterone results in decreased expression of CHRM1 mRNA]decreases expression|decreases reaction 17624924
D003976 Diazinon Diazinon affects the expression of CHRM1 mRNAaffects expression 17452286
D003976 Diazinon Diazinon results in decreased expression of CHRM1 mRNAdecreases expression 18812211
D004026 Dieldrin Dieldrin results in decreased expression of CHRM1 mRNAdecreases expression 18812211
D004117 Dimethoate Dimethoate results in decreased expression of CHRM1 mRNAdecreases expression 15033006
D004117 Dimethoate Dimethoate results in decreased expression of CHRM1 proteindecreases expression 14694657
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in decreased expression of CHRM1 mRNAdecreases expression 19490752
D005703 Gallamine Triethiodide Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D006851 Hydrochloric Acid CHRM1 protein affects the susceptibility to Hydrochloric Acidaffects response to substance 18367213
D007649 Ketamine Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 12456425
D008688 Methacholine Compounds CHRM1 protein promotes the reaction [Methacholine Compounds results in increased abundance of Calcium]increases abundance|increases reaction 12456425
C054938 methoctramine methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
D008743 Methyl Parathion Methyl Parathion results in decreased activity of CHRM1 proteindecreases activity 17666426
D008743 Methyl Parathion Methyl Parathion results in decreased expression of CHRM1 proteindecreases expression 16645783
14746346
D019832 N-Methylscopolamine Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 10845706
D019832 N-Methylscopolamine Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine N-Methylscopolamine binds to CHRM1 proteinaffects binding 9846649
10845706
D019832 N-Methylscopolamine Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D015544 Inositol 1,4,5-Trisphosphate CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphateaffects abundance 19002953
D009532 Nickel Nickel results in decreased expression of CHRM1 mRNAdecreases expression 18812211
C076029 olanzapine olanzapine binds to CHRM1 proteinaffects binding 16983399
D010197 Pancuronium Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D026023 Permethrin Permethrin results in decreased expression of CHRM1decreases expression 9827057
D026023 Permethrin Permethrin results in decreased expression of CHRM1decreases expression 9827057
D026023 Permethrin Permethrin results in decreased expression of CHRM1decreases expression 9827057
D010852 Picrotoxin Picrotoxin results in increased expression of CHRM1 mRNAincreases expression 15170462
D010862 Pilocarpine Pilocarpine results in increased activity of CHRM1 proteinincreases activity 11527950
D010862 Pilocarpine [Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calciumincreases abundance|increases activity 11527950
D017300 Pipecuronium Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D010890 Pirenzepine Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D010890 Pirenzepine Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
D010890 Pirenzepine Pirenzepine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 8744975
D010890 Pirenzepine Pirenzepine binds to and results in decreased activity of CHRM1 proteinaffects binding|decreases activity 17180451
8744975
9287041
17403421
17872906
17613726
10353596
17438462
15251036
D011284 Pregnenolone Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]affects binding|decreases reaction 15900516
D011284 Pregnenolone Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 15900516
D011374 Progesterone Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]affects binding|decreases reaction 15900516
D011374 Progesterone Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 15900516
D015742 Propofol Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]decreases reaction|increases activity 14534362
D015742 Propofol Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein]decreases reaction|increases activity 14534362
D011813 Quinuclidinyl Benzilate Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 10845706
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM1 proteinaffects binding 10845706
D011813 Quinuclidinyl Benzilate Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 15900516
D011813 Quinuclidinyl Benzilate Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 15900516
D011813 Quinuclidinyl Benzilate Pirenzepine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]affects binding|decreases reaction 8744975
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM1 proteinaffects binding 8744975
C061870 rocuronium rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
D012602 Scopolamine Derivatives 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
D012602 Scopolamine Derivatives Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 12456425
D012602 Scopolamine Derivatives methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
D012602 Scopolamine Derivatives Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]affects binding|decreases reaction 11306684
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to CHRM1 proteinaffects binding 12456425
11306684
D012602 Scopolamine Derivatives Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein]decreases reaction|increases activity 14534362
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to and results in increased activity of CHRM1 proteinaffects binding|increases activity 14534362
C046338 telenzepine telenzepine binds to and results in decreased activity of CHRM1 proteinaffects binding|decreases activity 17180451
D014673 Vecuronium Bromide Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]affects binding|decreases reaction 9846649
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 9.1118287403
MESH:D000138 Acidosis Hydrochloric Acid 9.1111574821 19262391 20872349 16144966 12771618 15920416
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.2917183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.3220597076
MESH:D055371 Acute Lung Injury Hydrochloric Acid 8.3719060228 19094174 11953099 19760209 16759491 11850527 15970105
MESH:D055371 Acute Lung Injury Nickel 8.3716166738
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.463712494
MESH:D000380 Agranulocytosis Clozapine 4.5814617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.5717119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.5716487989
MESH:D000544 Alzheimer Disease Copper 3.1216962711 16886094 16325427 16410023 17119284 16866297
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.9810694572
MESH:D018798 Anemia, Iron-Deficiency Copper 4.4516614410
MESH:D000860 Anoxia Hydrochloric Acid 4.8215090967
MESH:D001321 Autistic Disorder olanzapine 3.4317069543 18685284
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.521440618 11289319
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 4.3815920416
MESH:D001919 Bradycardia Carbachol 5.4212411408
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8417868700
MESH:D001930 Brain Injuries Progesterone 3.7815665606 15380490 15845082
MESH:D001932 Brain Neoplasms Copper 4.1417079463
MESH:D001943 Breast Neoplasms Atropine 2.2412762645
MESH:D001943 Breast Neoplasms Copper 2.2417079463 15986119
MESH:D001943 Breast Neoplasms Dieldrin 2.2415770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.2415986119
MESH:D001943 Breast Neoplasms Progesterone 2.2417614352 16175315 15562024
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 8.6112378975
MESH:D016535 Bronchial Hyperreactivity Methacholine Compounds 8.6112388339
MESH:D001986 Bronchial Spasm Hydrochloric Acid 4.9715578804
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.707296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.177296757
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 6.178340253
MESH:D006332 Cardiomegaly Copper 3.7417327471
MESH:D002389 Catatonia olanzapine 5.7518071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.437505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.789022650 19486331
MESH:D003072 Cognition Disorders Clozapine 4.4917123785
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1619861644
MESH:D003556 Cystitis Hydrochloric Acid 4.9712599022 19279288 12853844 20719367
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.3217714534
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.7111906362 18759878 11298694 12868966 8970840 2524372 14531868 8156756
MESH:D017449 Dermatitis, Allergic Contact Nickel 5.7117100760 17244072 19470301
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 13.253621924 2952479
MESH:D003877 Dermatitis, Contact Nickel 13.252952479
MESH:D003877 Dermatitis, Contact Permethrin 13.2514617103
MESH:D002658 Developmental Disabilities olanzapine 4.3617069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.8516402076
MESH:D003929 Diabetic Neuropathies Progesterone 4.0217187935
MESH:D003967 Diarrhea Atropine 4.5010867622
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.0615331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.8316192314 18692083 9328219 18648102 9022650 6482804 7440962 11289319 8291058 9653073 1440618 18289764 6679447
MESH:D004381 Duodenal Ulcer Atropine 9.0111595415
MESH:D004381 Duodenal Ulcer Pirenzepine 9.0116613094
MESH:D050171 Dyslipidemias Clozapine 3.8316402076
MESH:D004417 Dyspnea Diazinon 4.3116487989
MESH:D004487 Edema Crotalid Venoms 4.9519703484
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.3217692515
MESH:D004715 Endometriosis Progesterone 3.3416134523
MESH:D004827 Epilepsy Pilocarpine 4.3919439326 11162239 19700373
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.3119566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 1.973581430
MESH:D004941 Esophagitis Hydrochloric Acid 5.5112928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 5.5211346197 20516732 14621274
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.526705139
MESH:D005355 Fibrosis Hydrochloric Acid 4.2518497604
MESH:D005739 Gas Poisoning Hydrochloric Acid 4.9712378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 4.8619957777 20516732 20616304 12212954 19951613 20545468
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.597505956
MESH:D006261 Headache Ketamine 5.5211554966
MESH:D006356 Heartburn Hydrochloric Acid 5.3119566590
MESH:D006470 Hemorrhage Crotalid Venoms 5.8817537475
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.056705139
MESH:D006505 Hepatitis Diazinon 8.0516487989
MESH:D006521 Hepatitis, Chronic Copper 4.7817338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.6916607473 17109627 19888908 17182432 17276780
MESH:D015658 HIV Infections Nickel 3.5517263646
MESH:D006940 Hyperemia Hydrochloric Acid 5.1612646421
MESH:D006948 Hyperkinesis Clozapine 4.4216046005
MESH:D006963 Hyperphagia olanzapine 5.7417933447
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4615034207
MESH:D006975 Hypertension, Portal Hydrochloric Acid 4.8716984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.1019262391
MESH:D007022 Hypotension Hydrochloric Acid 4.3111574821
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9315869954
MESH:D007247 Infertility, Female Dieldrin 4.4910630421
MESH:D007248 Infertility, Male Diazinon 3.5012948887 16466525
MESH:D007249 Inflammation Crotalid Venoms 9.9817537475
MESH:D007249 Inflammation Hydrochloric Acid 9.9811574821
MESH:D007249 Inflammation Nickel 9.9816166738
MESH:D007249 Inflammation Progesterone 9.9815869954
MESH:D007299 Insect Bites and Stings Permethrin 5.3312971516 12749493 15189238
MESH:D007410 Intestinal Diseases Hydrochloric Acid 4.5011574821
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.529022650 8074119
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 3.9815834431 18617210
MESH:D007676 Kidney Failure, Chronic Copper 4.4616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.676582329
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 6.6718055543 9667754
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.5516316344
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 5.8616498863
MESH:D007826 Laryngismus Hydrochloric Acid 5.8611510729
MESH:D007859 Learning Disorders Copper 4.3217134702
MESH:D007938 Leukemia Azacitidine 6.2919148494
MESH:D007938 Leukemia Permethrin 6.2912937054
MESH:D007951 Leukemia, Myeloid Azacitidine 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9118720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7419299654
MESH:D008064 Lipidoses Clozapine 3.6117567588
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 3.7916984587
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.889327722 15034207
MESH:D008107 Liver Diseases Chlorpyrifos 2.9515991261
MESH:D008113 Liver Neoplasms Copper 4.7420302851
MESH:D008113 Liver Neoplasms Dieldrin 4.748742319 9539021
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.231399818 598648 3712494 6587162
MESH:D008133 Long QT Syndrome olanzapine 4.3520210726
MESH:D008171 Lung Diseases Hydrochloric Acid 3.9516784557
MESH:D055370 Lung Injury Hydrochloric Acid 4.2915607125 19644408 18497604 15044056 20597076 16129981 21311175 18339021 19262391 21114838 11395602 15090967 17627322 18573544
MESH:D008175 Lung Neoplasms Azacitidine 2.7221224363
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.5611408345 17203775
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.3917268249 17109627
MESH:D001523 Mental Disorders Clozapine 7.0016856516
MESH:D001523 Mental Disorders olanzapine 7.0016856516
MESH:D008659 Metabolic Diseases olanzapine 4.9519142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.0119142101
MESH:D009006 Monosomy Azacitidine 5.5819299654
MESH:D009041 Motion Sickness Dextroamphetamine 5.021613127
MESH:D009101 Multiple Myeloma Azacitidine 3.6219549372 18443271
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.7117596541 18720364 17611569 19805378
MESH:D009203 Myocardial Infarction Hydrochloric Acid 3.5918534312
MESH:D009216 Myopia Atropine 8.5012601066
MESH:D009216 Myopia Pirenzepine 8.5012601066
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.263581430
MESH:D009369 Neoplasms Dieldrin 3.248820588
MESH:D009389 Neovascularization, Pathologic Copper 4.4617308104
MESH:D009421 Nervous System Malformations Pilocarpine 5.1115987249
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.596679447
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.7015081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 7.7019784758
MESH:D009765 Obesity Clozapine 4.9218515891 19142110
MESH:D009765 Obesity olanzapine 4.9218515891
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.974026338 6482804
MESH:D009784 Occupational Diseases Hydrochloric Acid 7.9712378975
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.523988306
MESH:D010024 Osteoporosis Calcium 3.4717882678
MESH:D010051 Ovarian Neoplasms Progesterone 2.3617393432 16525653
MESH:D010149 Pain, Postoperative Ketamine 5.6311554966
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.017296757
MESH:D010300 Parkinson Disease Dieldrin 3.3311181820 16112328 17291500 16809432 11445065
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.976228378
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 4.8818573544 15970105 15607125 18497604
MESH:D011041 Poisoning Atropine 12.3417849254 18072136
MESH:D011041 Poisoning Diazinon 12.3417603234
MESH:D011041 Poisoning Methyl Parathion 12.3417603234
MESH:D011471 Prostatic Neoplasms Azacitidine 4.2018324645
MESH:D011471 Prostatic Neoplasms Copper 4.2017079463 17308104
MESH:D011595 Psychomotor Agitation olanzapine 5.1118685284
MESH:D011618 Psychotic Disorders Clozapine 3.8315331141
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.5220597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 4.7215090967
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.3116129981 16784557 18549715 18339021 17627322
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 3.919413022
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 5.8611510729
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.1616611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 9.4816611668 17119214
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 9.4820516732
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.013692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6718045962
MESH:D012559 Schizophrenia Clozapine 7.3317123785 20580759 17667964 20521326 19369910 20107430 20168265 18855531 20521320 16141801 11151749 11763009 18806925 17726453 20452607
MESH:D012559 Schizophrenia Copper 7.3316842975
MESH:D012559 Schizophrenia Ketamine 7.3320000043
MESH:D012559 Schizophrenia olanzapine 7.3320107430 17726453 20521326
MESH:D012640 Seizures Atropine 8.5411218047 17157343 12660363
MESH:D012640 Seizures Picrotoxin 8.548635557 8954991
MESH:D012640 Seizures Pilocarpine 8.5419660546 7750514
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.596418539
MESH:D013119 Spinal Cord Injuries Progesterone 3.7916503802 15862959
MESH:D013226 Status Epilepticus Pilocarpine 5.7619951488 19055492 11259499 19430551 15987249 15857427 19570321
MESH:D013276 Stomach Ulcer Atropine 6.8511595415
MESH:D013276 Stomach Ulcer Hydrochloric Acid 6.8515309881 17189318 16755016
MESH:D017180 Tachycardia, Ventricular olanzapine 4.8720210726
MESH:D013742 Tetanus Propofol 12.672903605
MESH:D013742 Tetanus Vecuronium Bromide 12.672903605
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.526587162 3712494 7505956 6582329 1399818
MESH:D014202 Tremor Atropine 10.1517594079
MESH:D014202 Tremor Pilocarpine 10.1517594079
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.088074119
MESH:D014570 Urologic Diseases Diazinon 4.7816487989
MESH:D015430 Weight Gain Clozapine 8.9816141801 20107430 16402076 17502770 20521320 20564506
MESH:D015430 Weight Gain olanzapine 8.9820107430 17933447 19434072
MESH:D015431 Weight Loss Clozapine 4.5917933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26484
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA449061clozapine
    PA164769056tiotropium
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00185 agonist Cevimeline Parasympathomimetics;Muscarinic Agonists
    DB00202 agonist Succinylcholine Skeletal Muscle Relaxants;Neuromuscular Depolarizing Agents
    DB00209 antagonist Trospium Analgesics;Parasympatholytics
    DB00219 antagonist Oxyphenonium Mydriatics;Muscarinic Antagonists;Parasympatholytics
    DB00245 antagonist Benztropine Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Parasympatholytics
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00280 antagonist Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00332 antagonist Ratio-Ipra SAL UDV Bronchodilator Agents;Antispasmodics;Cholinergic Antagonists;Antimuscarinics
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00340 antagonist Metixene Antiparkinson Agents;Muscarinic Antagonists
    DB00354 antagonist Buclizine Antiemetics;Antihistamines;Anticholinergic Agents
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00366 antagonist Tylenol Cold & Flu Nighttime Hypnotics and Sedatives;Antiemetics;Anti-Allergic Agents;Histamine H1 Antagonists;Antitussive Agents
    DB00376 antagonist Trihexyphenidyl Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00383 antagonist Oxyphencyclimine Antispasmodics;Anticholinergic Agents
    DB00387 antagonist Procyclidine Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00392 antagonist Ethopropazine Antiparkinson Agents;Antidyskinetics
    DB00411 agonist Carbachol Cardiotonic Agents;Analgesics, Non-Narcotic;Cholinergic Agonists;Miotics
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00424 antagonist Hyoscyamine Antiarrhythmic Agents;Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Antispasmodics;Antimuscarinics;Parasympatholytics
    DB00434 antagonist Cyproheptadine Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00462 antagonist Scour solution coop Antispasmodics;Anticholinergic Agents;Parasympatholytics
    DB00496 antagonist Darifenacin Muscarinic Antagonists;Urinary antispasmodics
    DB00505 antagonist Tridihexethyl Antispasmodics;Anticholinergic Agents
    DB00508 antagonist Triflupromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00517 antagonist Anisotropine Methylbromide Anticholinergics;Parasympatholytics
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00543 antagonist Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00572 antagonist Spascupreel Tablets Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Parasympatholytics
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00670 antagonist Pirenzepine Anti-Ulcer Agents;Muscarinic Antagonists;Antispasmodics;Antimuscarinics
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00725 antagonist Debiline H Anti-Ulcer Agents;Antispasmodics;Antimuscarinics
    DB00747 antagonist Scopolamine Mydriatics;Adjuvants, Anesthesia;Muscarinic Antagonists;Antispasmodics;Cholinergic Antagonists;Antimuscarinics;Adjuvants
    DB00767 antagonist Benzquinamide Antiemetics;Antipsychotics
    DB00771 antagonist Pro Chlorax Antiarrhythmic Agents;Antispasmodics;Anticholinergic Agents;Parasympatholytics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00782 antagonist Propantheline Anti-Ulcer Agents;Muscarinic Antagonists;Antispasmodics;Antimuscarinics
    DB00785 antagonist Cryptenamine Antihypertensive Agents
    DB00804 antagonist Dicyclomine Muscarinic Antagonists;Antispasmodics;Antimuscarinics;Anticholinergic Agents;Parasympatholytics
    DB00805 agonist Minaprine Central Nervous System Agents;Antiparkinson Agents;Antidepressive Agents
    DB00809 antagonist Phenyltrope Oph Soln Mydriatics;Muscarinic Antagonists;Diagnostic aid, cycloplegic;Diagnostic aid, mydriatic
    DB00810 antagonist Biperiden Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Parasympatholytics
    DB00835 antagonist Tantapp Elixir Anti-Allergic Agents;Histamine H1 Antagonists
    DB00875 antagonist Flupenthixol Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB00907 antagonist Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00940 antagonist Methantheline Antispasmodics;Anticholinergic Agents
    DB00942 antagonist Cycrimine Antiparkinson Agents;Antidyskinetics
    DB00979 antagonist Cyclopentolate Mydriatics;Muscarinic Antagonists;Parasympatholytics;Antimuscarinic eye preparations
    DB00986 antagonist Glycopyrrolate Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-cholinergic Agents
    DB01036 antagonist Tolterodine Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents;Genitourinary Smooth Muscle Relaxants
    DB01062 antagonist Oxybutynin Muscarinic Antagonists;Antispasmodics;Anticholinergic Agents;Parasympatholytics;Genitourinary Smooth Muscle Relaxants
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01085 agonist Timpilo 4 Muscarinic Agonists;Miotics;Cholinergic Agents
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01148 antagonist Flavoxate Parasympatholytics
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01175 other/unknown Escitalopram Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01231 antagonist Diphenidol Antiemetics;Antivertigo Agents
    DB01233 agonist Metoclopramide Antiemetics;Dopamine Antagonists;Prokinetic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01409 antagonist Tiotropium Bronchodilator Agents;Muscarinic Antagonists;Cholinergic Antagonists;Anticholinergic Agents;Parasympatholytics
    DB01591 antagonist Solifenacin Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents
    DB01618 other/unknown Molindone Antipsychotic Agents
    DB04365 - Arecoline Cholinergic Agonists;Nootropics
    DB04843 antagonist Mepenzolate Anticholinergic Agents;Parasympatholytics
    DB06702 antagonist Fesoterodine Antispasmodics;Anti-Incontinence Agents;Antimuscarinics;Genitourinary Smooth Muscle Relaxants
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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