AutismKB 2.0

Annotation Detail for KRT71


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Basic Information Top
Gene Symbol:KRT71 ( K6IRS1,KRT6IRS,KRT6IRS1,MGC119390,MGC119391 )
Gene Full Name: keratin 71
Band: 12q13.13
Quick LinksEntrez ID:112802; OMIM: 608245; Uniprot ID:K2C71_HUMAN; ENSEMBL ID: ENSG00000139648; HGNC ID: 28927
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of KRT71 mRNAaffects expression 18281256
D000082 Acetaminophen Acetaminophen affects the expression of KRT71 mRNAaffects expression 17562736
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of KRT71 geneincreases mutagenesis 17143583
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Ethylnitrosourea 3.946695378
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001927 Brain Diseases Ethylnitrosourea 5.3314991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.7415144691 16357521 16651633 18412241 16436596
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 4.0116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.8517160924
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6816485898 11287661 19164858 14725611 19370779 16177239 10663392 16109766 12594235 16081117 17562736 19739265 16393943 11743745 12958197 11739529 12392966 16781746 12153990 17522070 11529661 18071297 2444490 11461765 18713872 16227642 15619225 15968718 10774834 19416960 19420014 11834606 19923254 11421492 14550746 17906064 12540782 12705907 14986274 10915739 19085960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.8518357618
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1016436596
MESH:D005910 Glioma Ethylnitrosourea 3.6316357521 16651633 18412241
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 5.4016109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4212587719 15629191
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.3217379185
MESH:D008107 Liver Diseases Acetaminophen 1.7116611625 19784758 16610002 19014921 12587719 19460945 11587558 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316019985 17703301 6695378 16271038
MESH:D008223 Lymphoma Ethylnitrosourea 4.2515790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.7015375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7710838139 10767621 18041768
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008579 Meningioma Ethylnitrosourea 6.8517943659
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 5.0516707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.1616003739 16651423 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.8517160924
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.9015790496
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018