AutismKB 2.0

Annotation Detail for CHRM2


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Basic Information Top
Gene Symbol:CHRM2 ( FLJ43243,HM2,MGC120006,MGC120007 )
Gene Full Name: cholinergic receptor, muscarinic 2
Band: 7q33
Quick LinksEntrez ID:1129; OMIM: 118493; Uniprot ID:ACM2_HUMAN; ENSEMBL ID: ENSG00000181072; HGNC ID: 1951
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200046Arf6 trafficking events
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
2045Bipolar disorder
2125Bladder cancer
2221Behavior disease
2223Central nervous system disease
Desease Name
Cardiomyopathy, Dilated
CARDIOVASCULAR
PSYCH
intelligence
major depression
heart rate
depression
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C420024 1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane [N-Methylscopolamine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]affects binding|affects reaction 16362429
C420024 1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane [Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]affects binding|affects reaction 16362429
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of CHRM2 mRNAdecreases expression 20406850
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 11306684
D000171 Acrolein Acrolein results in decreased expression of CHRM2 proteindecreases expression 17941892
C065959 AFDX 384 AFDX 384 binds to CHRM2 proteinaffects binding 14751452
C065959 AFDX 384 DEET promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 11248143
C065959 AFDX 384 Permethrin promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 11248143
C065959 AFDX 384 [Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
C065959 AFDX 384 [Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
C065959 AFDX 384 Pyridostigmine Bromide promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 14751452
11248143
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRM2 mRNAaffects expression 16483693
C015688 arecaidine arecaidine binds to and results in increased activity of CHRM2 proteinaffects binding|increases activity 15251036
C015000 arecaidine esters arecaidine esters binds to and results in increased activity of CHRM2 proteinaffects binding|increases activity 18603373
D001285 Atropine Atropine binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 15140916
D001285 Atropine Atropine binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 17613726
D001374 Azacitidine Azacitidine affects the expression of CHRM2 mRNAaffects expression 19002953
D002217 Carbachol Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]increases abundance|increases reaction 19002953
D002217 Carbachol otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]decreases reaction|increases abundance|increases reaction 19002953
D002217 Carbachol Carbachol binds to and results in increased activity of CHRM2 proteinaffects binding|increases activity 17021048
D002217 Carbachol [Carbachol binds to and results in increased activity of CHRM2 protein] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]affects binding|increases activity 17021048
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CHRM2 mRNAdecreases expression 12832660
D004390 Chlorpyrifos Chlorpyrifos results in decreased activity of CHRM2 proteindecreases activity 15470232
D004390 Chlorpyrifos Chlorpyrifos inhibits the reaction [ADRBK1 protein results in increased phosphorylation of CHRM2 protein]decreases reaction|increases phosphorylation 16824341
D004390 Chlorpyrifos Chlorpyrifos results in decreased activity of CHRM2 proteindecreases activity 17666426
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of CHRM2 mRNAincreases expression 18812211
17452286
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 10845706
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 10845706
C101207 darifenacin darifenacin binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 15140916
D003671 DEET DEET affects the activity of CHRM2 proteinaffects activity 14713564
D003671 DEET DEET promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 11248143
D003671 DEET [Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
D003976 Diazinon Diazinon results in decreased activity of CHRM2 proteindecreases activity 15470232
D003976 Diazinon Diazinon results in increased expression of CHRM2 mRNAincreases expression 16207942
D003976 Diazinon Diazinon affects the expression of CHRM2 mRNAaffects expression 17452286
D003976 Diazinon Diazinon results in decreased expression of CHRM2 mRNAdecreases expression 18812211
D004026 Dieldrin Dieldrin affects the expression of CHRM2 mRNAaffects expression 18812211
D004117 Dimethoate Dimethoate results in decreased expression of CHRM2 mRNAdecreases expression 15033006
D004117 Dimethoate Dimethoate results in decreased expression of CHRM2 proteindecreases expression 14694657
C113497 dimethyl-W84 CHRM2 protein binds to dimethyl-W84affects binding 16641315
C113497 dimethyl-W84 [CHRM2 protein binds to dimethyl-W84] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
C044894 ethylcholine aziridinium ethylcholine aziridinium results in increased expression of CHRM2 mRNAincreases expression 10733153
C044894 ethylcholine aziridinium ethylcholine aziridinium results in increased expression of CHRM2 proteinincreases expression 10733153
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in decreased expression of CHRM2 mRNAdecreases expression 19490752
D005632 Fructose Fructose results in increased expression of CHRM2 mRNAincreases expression 17707055
D005632 Fructose Fructose results in increased expression of CHRM2 proteinincreases expression 17707055
D005703 Gallamine Triethiodide CHRM2 protein binds to Gallamine Triethiodideaffects binding 16641315
D005703 Gallamine Triethiodide [CHRM2 protein binds to Gallamine Triethiodide] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D005703 Gallamine Triethiodide [CHRM2 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|increases reaction 15937215
D005703 Gallamine Triethiodide Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D005947 Glucose Glucose results in increased expression of CHRM2 mRNAincreases expression 18715473
C048172 himbacine himbacine binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 17180451
D007649 Ketamine Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 12456425
C054938 methoctramine methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
C054938 methoctramine methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 8744975
C054938 methoctramine methoctramine binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 17613726
8744975
9287041
17872906
10353596
17438462
17403421
17180451
D008743 Methyl Parathion Methyl Parathion results in decreased activity of CHRM2 proteindecreases activity 17666426
D008743 Methyl Parathion Methyl Parathion results in decreased expression of CHRM2 proteindecreases expression 14746346
16645783
D019832 N-Methylscopolamine [CHRM2 protein binds to dimethyl-W84] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D019832 N-Methylscopolamine [CHRM2 protein binds to Gallamine Triethiodide] affects the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D019832 N-Methylscopolamine [CHRM2 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM2 protein binds to N-Methylscopolamine]affects binding|increases reaction 15937215
D019832 N-Methylscopolamine CHRM2 protein binds to N-Methylscopolamineaffects binding 16641315
D019832 N-Methylscopolamine Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 10845706
D019832 N-Methylscopolamine Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine N-Methylscopolamine binds to CHRM2 proteinaffects binding 10845706
9846649
D019832 N-Methylscopolamine Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine [N-Methylscopolamine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]affects binding|affects reaction 16362429
D008799 Mevinphos Mevinphos results in increased activity of CHRM2 proteinincreases activity 17395621
D015544 Inositol 1,4,5-Trisphosphate Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]increases abundance|increases reaction 19002953
D015544 Inositol 1,4,5-Trisphosphate CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphateincreases abundance 19002953
D015544 Inositol 1,4,5-Trisphosphate otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]decreases reaction|increases abundance|increases reaction 19002953
D009532 Nickel Nickel affects the expression of CHRM2 mRNAaffects expression 18812211
C025256 nonylphenol nonylphenol results in decreased expression of CHRM2 mRNAdecreases expression 15620428
C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [ADRBK1 protein results in increased phosphorylation of CHRM2 protein]decreases reaction|increases phosphorylation 16824341
C048593 otenzepad otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]decreases reaction|increases abundance|increases reaction 19002953
C048593 otenzepad otenzepad inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 8744975
C048593 otenzepad otenzepad binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 11804996
17040474
8744975
15251036
D010095 Oxotremorine [Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]affects binding|affects reaction 16362429
C005419 oxybutynin oxybutynin binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 15140916
D010197 Pancuronium Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D010278 Parathion Parathion results in decreased activity of CHRM2 proteindecreases activity 15470232
D026023 Permethrin Permethrin promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 11248143
D026023 Permethrin [Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
D026023 Permethrin [Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
D010695 Phlorhizin Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]decreases reaction|increases expression 18715473
D010695 Phlorhizin Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]decreases reaction|increases expression 18715473
D010852 Picrotoxin Picrotoxin results in increased expression of CHRM2 mRNAincreases expression 15170462
D010862 Pilocarpine Pilocarpine binds to and results in increased activity of CHRM2 proteinaffects binding|increases activity 15470232
D017300 Pipecuronium Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D011729 Pyridostigmine Bromide [Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
D011729 Pyridostigmine Bromide [Pyridostigmine Bromide co-treated with Permethrin] promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|affects cotreatment|increases reaction 14751452
D011729 Pyridostigmine Bromide Pyridostigmine Bromide promotes the reaction [AFDX 384 binds to CHRM2 protein]affects binding|increases reaction 11248143
14751452
D011813 Quinuclidinyl Benzilate Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 10845706
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM2 proteinaffects binding 10845706
D011813 Quinuclidinyl Benzilate methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 8744975
D011813 Quinuclidinyl Benzilate otenzepad inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]affects binding|decreases reaction 8744975
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM2 proteinaffects binding 8744975
C061870 rocuronium rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to CHRM2 proteinaffects binding 12507038
D012602 Scopolamine Derivatives 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 11306684
D012602 Scopolamine Derivatives Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 12456425
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to CHRM2 proteinaffects binding 11306684
12456425
D012602 Scopolamine Derivatives Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 11306684
D013311 Streptozocin Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]decreases reaction|increases expression 18715473
D013311 Streptozocin Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]decreases reaction|increases expression 18715473
D013311 Streptozocin Streptozocin results in increased expression of CHRM2 mRNAincreases expression 18715473
D013311 Streptozocin Streptozocin results in increased expression of CHRM2 proteinincreases expression 18715473
C099041 tolterodine tolterodine binds to and results in decreased activity of CHRM2 proteinaffects binding|decreases activity 15140916
D014236 Trichlorfon [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 proteinaffects localization|decreases activity 12794734
D014331 Tropicamide Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]affects binding|decreases reaction 11306684
D014673 Vecuronium Bromide Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]affects binding|decreases reaction 9846649
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.0018287403
MESH:D055371 Acute Lung Injury Acrolein 8.1020525806 21297076
MESH:D055371 Acute Lung Injury Nickel 8.1016166738
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.4816611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.4816487989
MESH:D000382 Agricultural Workers' Diseases Parathion 11.4811874814 17119214
MESH:D000544 Alzheimer Disease Acrolein 4.7417570602 15207723 14715435
MESH:D000544 Alzheimer Disease Trichlorfon 4.7411419566
MESH:D001161 Arteriosclerosis Acrolein 4.4615014928
MESH:D050197 Atherosclerosis Acrolein 3.6316037261 17363696 16126721
MESH:D001919 Bradycardia Carbachol 5.3412411408
MESH:D001943 Breast Neoplasms Atropine 2.1412762645
MESH:D001943 Breast Neoplasms Dieldrin 2.1411859874 15770527
MESH:D001943 Breast Neoplasms Nickel 2.1415986119
MESH:D001943 Breast Neoplasms Parathion 2.1412762645
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2316097048 15721981 16124888 16192424 3786805 16050911 10355542 15673190 16011737 15700767 18705752 16227642
MESH:D002276 Carcinoid Tumor Streptozocin 5.0216051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.6416705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.6418788625
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 4.088340253
MESH:D002418 Cattle Diseases Trichlorfon 5.5714651886
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.386135515
MESH:D015179 Colorectal Neoplasms Acrolein 3.0317597105
MESH:D015179 Colorectal Neoplasms Azacitidine 3.0319934284
MESH:D003327 Coronary Disease Fructose 4.0918504504
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1619861644
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4718551238
MESH:D003556 Cystitis Acrolein 4.8212161096
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.4319470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 8.362952479
MESH:D003877 Dermatitis, Contact Permethrin 8.3614617103
MESH:D003920 Diabetes Mellitus Streptozocin 4.2516285004
MESH:D003921 Diabetes Mellitus, Experimental marker/mechanism 18603373
MESH:D003921 Diabetes Mellitus, Experimental Fructose 7.5518603373
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 7.551374869 12446591 11055810 19586609 12093613 2177838 8740154 17874149 19298542 19496084 17442507 11260395 12644472 16286809 6379147 18715473 15298345 12083368 7637645 18603373 19960420 15862027 15831366 16684804
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 18603373
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4318603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.7018603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.7019647726 19586609
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.1616025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.2019960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 4.8917662242
MESH:D003967 Diarrhea Atropine 4.4310867622
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.2410915739 16177239 7179309 4309450 6884620 15968718 21278145 17522070 3786805 19085960 3732212 16227642 10092053 7440962 6623471 2869522 15027814 19336974 7120509 11566570 15998439 9327722
MESH:D004381 Duodenal Ulcer Atropine 4.7611595415
MESH:D004417 Dyspnea Diazinon 4.2316487989
MESH:D004487 Edema Crotalid Venoms 4.8819703484
MESH:D004827 Epilepsy Pilocarpine 4.3411162239 19439326 19700373
MESH:D005234 Fatty Liver Carbon Tetrachloride 6.6015959796 12795759 16239168 61145 12631006 19224547 17595544 16045604
MESH:D005234 Fatty Liver Fructose 6.6019196556 18395287 18641190
MESH:D005355 Fibrosis Carbon Tetrachloride 7.4118705752
MESH:D005355 Fibrosis Fructose 7.4118504504
MESH:D018149 Glucose Intolerance Fructose 4.8019165636
MESH:D006261 Headache Ketamine 5.4411554966
MESH:D006331 Heart Diseases Streptozocin 3.8712093613
MESH:D006470 Hemorrhage Crotalid Venoms 5.8117537475
MESH:D006505 Hepatitis Carbon Tetrachloride 7.8419900420 19110552
MESH:D006505 Hepatitis Diazinon 7.8416487989
MESH:D015658 HIV Infections Nickel 3.5017263646
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9716899240
MESH:D006946 Hyperinsulinism Fructose 4.4218360027 19008412 15752949 14757778 18563319
MESH:D006949 Hyperlipidemias Fructose 4.2315752949
MESH:D006973 Hypertension Fructose 3.3814633139 19008412 16843071 14568997 14573337
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5415338365
MESH:D015228 Hypertriglyceridemia Fructose 4.5819342510 19799862
MESH:D007247 Infertility, Female Dieldrin 4.4210630421
MESH:D007248 Infertility, Male Diazinon 6.3812948887 16466525
MESH:D007248 Infertility, Male Parathion 6.3816029889
MESH:D007249 Inflammation Crotalid Venoms 5.3317537475
MESH:D007249 Inflammation Nickel 5.3316166738
MESH:D007299 Insect Bites and Stings Permethrin 5.2512749493 15189238 12971516
MESH:D007333 Insulin Resistance Fructose 3.8618981581 17133782 14573337 19799862 19342510 19008412 14757778 19586609 18057795 18563319 14633139
MESH:D007674 Kidney Diseases Acrolein 8.6012488133
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 8.6018617210 15834431
MESH:D007674 Kidney Diseases Streptozocin 8.6012093613
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.4516705839
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 6.459667754 18055543
MESH:D007938 Leukemia Azacitidine 6.1219148494
MESH:D007938 Leukemia Permethrin 6.1212937054
MESH:D007951 Leukemia, Myeloid Azacitidine 4.1219077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.8918720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.6719299654
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.4816943688 21278145 11903743 11408273 16239168 17174718 17157831 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7312586293 12649538 16027843 12546737 15996030 14716496 18156304 17714472 18317297 14512876 16116963 15370692 20821823 12666154 18481824 17823541 18705752 17708605 12445421 16136751 12632514 15931870 11481614 17761835 17805973 15818738 17766677 17698563 18412020 12389079 18205269 15730626 15057751 18006644 15650968 14620537 17525996 18472094 17557913 15925388 17944888 18054572 15893842 15673190 13678700 12445418 17565644 17869086 16248980 17922224 12898905 16638106 18166357 18376398 12667390 18251166 17631135 17481882 18429990 18277467 18187930 16015684 17640975 15052691 18279442 15959796 15876570 14724832 15362042 16097048 10355542 18395095 15123356 14716833 12741479 17900296 18418968 18420326 16192424 18472332 12632512 18263696 18339082 17976157 18395914 14748882 18210741 16033810 17721639 16011737 12958196 12609069 15338365
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8415720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Chlorpyrifos 3.8415991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2014706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.167678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.1619294768
MESH:D008113 Liver Neoplasms Dieldrin 6.168742319 9539021
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 4.702876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.7015583823 12014681
MESH:D008171 Lung Diseases Acrolein 3.8211504702
MESH:D008175 Lung Neoplasms Azacitidine 2.7221224363
MESH:D008545 Melanoma Glucose 2.9914993021
MESH:D008546 Melanoma, Experimental Acrolein 4.6610803710
MESH:D008569 Memory Disorders Trichlorfon 5.1715957009
MESH:D024821 Metabolic Syndrome X Fructose 4.3516815490 18497449 17261469 19165636 17098227
MESH:D009006 Monosomy Azacitidine 5.5019299654
MESH:D009101 Multiple Myeloma Azacitidine 3.5619549372 18443271
MESH:D015878 Mydriasis Tropicamide 6.7816308726
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.6619805378 17611569 18720364 17596541
MESH:D009216 Myopia Atropine 8.4512601066
MESH:D009216 Myopia himbacine 8.4512601066
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.3018551238 7678174
MESH:D009369 Neoplasms Acrolein 4.8817329238
MESH:D009369 Neoplasms Dieldrin 4.888820588
MESH:D009393 Nephritis Acrolein 5.7112653641
MESH:D009421 Nervous System Malformations Pilocarpine 5.0415987249
MESH:D019636 Neurodegenerative Diseases Acrolein 4.0511342003
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.5015081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 7.5019784758
MESH:D009765 Obesity Fructose 3.2618585860 17707055
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9416049721
MESH:D010149 Pain, Postoperative Ketamine 5.5511554966
MESH:D010300 Parkinson Disease Acrolein 5.2517690948
MESH:D010300 Parkinson Disease Dieldrin 5.2511445065 17291500 16112328 16809432 11181820
MESH:D020734 Parkinsonian Disorders Tropicamide 5.2617594079
MESH:D010787 Photosensitivity Disorders Acrolein 5.1611550810
MESH:D011041 Poisoning Atropine 11.9217849254 18072136
MESH:D011041 Poisoning Diazinon 11.9217603234
MESH:D011041 Poisoning Methyl Parathion 11.9217603234
MESH:D011471 Prostatic Neoplasms Azacitidine 4.3518324645
MESH:D051437 Renal Insufficiency Acrolein 4.4612732208
MESH:D012135 Respiratory Sounds Chlorpyrifos 8.5717119214 16611668 11874814
MESH:D012135 Respiratory Sounds Parathion 8.5711874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 9.3617119214 16611668
MESH:D012140 Respiratory Tract Diseases Parathion 9.3617119214
MESH:D012559 Schizophrenia Ketamine 3.9120000043
MESH:D012640 Seizures 2,6-dinitrotoluene 11.0418551238
MESH:D012640 Seizures Atropine 11.0412660363 11218047 17157343
MESH:D012640 Seizures Picrotoxin 11.048635557 8954991
MESH:D012640 Seizures Pilocarpine 11.0419660546 7750514
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.516418539
MESH:D012878 Skin Neoplasms Glucose 3.4514993021
MESH:D013226 Status Epilepticus Pilocarpine 5.6819570321 19430551 15857427 19055492 15987249 19951488 11259499
MESH:D013276 Stomach Ulcer Atropine 4.2611595415
MESH:D020521 Stroke Acrolein 4.1016269634
MESH:D013322 Strongyloidiasis Trichlorfon 6.0614651886
MESH:D013742 Tetanus Vecuronium Bromide 6.592903605
MESH:D014202 Tremor Atropine 15.2817594079
MESH:D014202 Tremor Pilocarpine 15.2817594079
MESH:D014202 Tremor Tropicamide 15.2819467297 17594079
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.0516049721
MESH:D014570 Urologic Diseases Diazinon 4.7016487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7510091137
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA111
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00202 agonist Succinylcholine Skeletal Muscle Relaxants;Neuromuscular Depolarizing Agents
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00280 antagonist Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00332 antagonist Ratio-Ipra SAL UDV Bronchodilator Agents;Antispasmodics;Cholinergic Antagonists;Antimuscarinics
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00340 antagonist Metixene Antiparkinson Agents;Muscarinic Antagonists
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00376 antagonist Trihexyphenidyl Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00383 antagonist Oxyphencyclimine Antispasmodics;Anticholinergic Agents
    DB00387 antagonist Procyclidine Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00392 antagonist Ethopropazine Antiparkinson Agents;Antidyskinetics
    DB00411 agonist Carbachol Cardiotonic Agents;Analgesics, Non-Narcotic;Cholinergic Agonists;Miotics
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00424 antagonist Hyoscyamine Antiarrhythmic Agents;Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Antispasmodics;Antimuscarinics;Parasympatholytics
    DB00434 antagonist Cyproheptadine Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00462 antagonist Scour solution coop Antispasmodics;Anticholinergic Agents;Parasympatholytics
    DB00483 antagonist Gallamine Triethiodide Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB00496 antagonist Darifenacin Muscarinic Antagonists;Urinary antispasmodics
    DB00505 antagonist Tridihexethyl Antispasmodics;Anticholinergic Agents
    DB00508 antagonist Triflupromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00517 antagonist Anisotropine Methylbromide Anticholinergics;Parasympatholytics
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00572 antagonist Spascupreel Tablets Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Parasympatholytics
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00725 antagonist Debiline H Anti-Ulcer Agents;Antispasmodics;Antimuscarinics
    DB00728 antagonist Rocuronium Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents
    DB00747 antagonist Scopolamine Mydriatics;Adjuvants, Anesthesia;Muscarinic Antagonists;Antispasmodics;Cholinergic Antagonists;Antimuscarinics;Adjuvants
    DB00767 antagonist Benzquinamide Antiemetics;Antipsychotics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00785 antagonist Cryptenamine Antihypertensive Agents
    DB00804 antagonist Dicyclomine Muscarinic Antagonists;Antispasmodics;Antimuscarinics;Anticholinergic Agents;Parasympatholytics
    DB00809 antagonist Phenyltrope Oph Soln Mydriatics;Muscarinic Antagonists;Diagnostic aid, cycloplegic;Diagnostic aid, mydriatic
    DB00835 antagonist Tantapp Elixir Anti-Allergic Agents;Histamine H1 Antagonists
    DB00907 antagonist Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01019 agonist Bethanechol Parasympathomimetics;Muscarinic Agonists
    DB01036 antagonist Tolterodine Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents;Genitourinary Smooth Muscle Relaxants
    DB01062 antagonist Oxybutynin Muscarinic Antagonists;Antispasmodics;Anticholinergic Agents;Parasympatholytics;Genitourinary Smooth Muscle Relaxants
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01085 agonist Timpilo 4 Muscarinic Agonists;Miotics;Cholinergic Agents
    DB01135 antagonist Doxacurium chloride Neuromuscular Nondepolarizing Agents
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01148 antagonist Flavoxate Parasympatholytics
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01226 partial agonist Mivacurium Neuromuscular Nondepolarizing Agents
    DB01231 antagonist Diphenidol Antiemetics;Antivertigo Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01336 antagonist Metocurine Neuromuscular Nondepolarizing Agents
    DB01337 antagonist Pancuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01338 antagonist Pipecuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01409 antagonist Tiotropium Bronchodilator Agents;Muscarinic Antagonists;Cholinergic Antagonists;Anticholinergic Agents;Parasympatholytics
    DB01591 antagonist Solifenacin Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents
    DB06702 antagonist Fesoterodine Antispasmodics;Anti-Incontinence Agents;Antimuscarinics;Genitourinary Smooth Muscle Relaxants
    DB08801 antagonist Dimethindene Antipruritics;Anti-Allergic Agents;Antihistamines;Anticholinergics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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