AutismKB 2.0

Annotation Detail for SLCO2B1


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Basic Information Top
Gene Symbol:SLCO2B1 ( DKFZp686E0517,KIAA0880,OATP-B,OATP2B1,OATPB,SLC21A9 )
Gene Full Name: solute carrier organic anion transporter family, member 2B1
Band: 11q13
Quick LinksEntrez ID:11309; OMIM: 604988; Uniprot ID:SO2B1_HUMAN; ENSEMBL ID: ENSG00000137491; HGNC ID: 10962
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLCO2B1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLCO2B1 mRNAaffects expression 21346803
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLCO2B1 mRNAincreases expression 15919853
D000082 Acetaminophen Acetaminophen affects the expression of SLCO2B1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLCO2B1 proteinaffects expression 20106945
D000638 Amiodarone SLCO2B1 protein results in increased uptake of Amiodaroneincreases uptake 19285480
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLCO2B1 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of SLCO2B1 mRNAincreases expression 15919853
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLCO2B1 mRNAdecreases expression 20106945
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of SLCO2B1 mRNAdecreases expression 15912405
D002083 Butylated Hydroxyanisole Butylated Hydroxyanisole results in increased expression of SLCO2B1 mRNAincreases expression 15919853
D002220 Carbamazepine Carbamazepine results in increased expression of SLCO2B1 mRNAincreases expression 17112801
C019304 ciprofibrate ciprofibrate results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D002994 Clofibrate Clofibrate results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D002995 Clofibric Acid Clofibric Acid affects the expression of SLCO2B1 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SLCO2B1 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D004041 Dietary Fats Dietary Fats results in decreased expression of SLCO2B1 mRNAdecreases expression 18042831
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D004958 Estradiol Estradiol results in decreased expression of SLCO2B1 mRNAdecreases expression 20106945
D005015 Ethoxyquin Ethoxyquin results in increased expression of SLCO2B1 mRNAincreases expression 15919853
C065180 fluvastatin SLCO2B1 protein affects the import of fluvastatinaffects import 16046661
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SLCO2B1 mRNAdecreases expression 16807920
C026209 oltipraz oltipraz results in increased expression of SLCO2B1 mRNAincreases expression 15919853
C041786 palm oil palm oil results in decreased expression of SLCO2B1 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of SLCO2B1 mRNAdecreases expression 16837569
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLCO2B1 mRNAaffects binding|increases activity|increases expression 19710929
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D013148 Spironolactone Spironolactone results in decreased expression of SLCO2B1 mRNAdecreases expression 15919853
D013448 Sulfobromophthalein SLCO2B1 protein affects the import of Sulfobromophthaleinaffects import 16046661
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLCO2B1 mRNAdecreases expression 16837569
20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 18.008986270
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 18.006734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.006195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.0015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0211473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.246695378
MESH:D000236 Adenoma beta-Naphthoflavone 6.2419389873
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 22.4916628245
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.4917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.4916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5518057881 18218290 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 3.6015238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3617659584
MESH:D001281 Atrial Fibrillation Amiodarone 3.6918651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001714 Bipolar Disorder Carbamazepine 3.9820046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 19.8219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 19.8219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.8219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.8212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8720435547
MESH:D001943 Breast Neoplasms Estradiol 1.8717261762 12948864 14630087 16675129 17289903 17018787 19861407 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.2816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.2816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.283084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.2821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.2816924424
MESH:D006528 Carcinoma, Hepatocellular Ethoxyquin 13.283084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.2820935162 1701930 6705139 17173139 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7919225199 15710769
MESH:D002318 Cardiovascular Diseases Spironolactone 4.5711230374
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7918974383
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.386135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.381399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.964080065
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.9916628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9916835633
MESH:D002779 Cholestasis Cyclosporine 7.0419486331
MESH:D002779 Cholestasis pirinixic acid 7.0419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9816354765 8697196 15340226 12621046 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D003327 Coronary Disease fluvastatin 4.6216142594
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 5.2417686920
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.249014606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.2417728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2415322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.9318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.9318551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1312438553
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.5116882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D003967 Diarrhea Dexamethasone 3.427237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.1611748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.2320216337 15057820 16538176 16538175
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.0518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.0512153990 16109766 17906064 16485898 19923254 19420014 12540782 16227642 15619225 19085960 12705907 19370779 18713872 16393943 11287661 14986274 10915739 10774834 11739529 12392966 14550746 19739265 11743745 17562736 2444490 15968718 10663392 16781746 11529661 11461765 18071297 19416960 16177239 19164858 11834606 17522070 12594235 11421492 14725611 12958197 16081117
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.0518218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 14.0517465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.0520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Carbamazepine 7.6820216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6811462148
MESH:D050171 Dyslipidemias Clofibrate 8.1216707586
MESH:D050171 Dyslipidemias Dietary Fats 8.1218367378
MESH:D004421 Dystonia Phenobarbital 3.731851702
MESH:D004485 Eczema Dexamethasone 4.1812438553
MESH:D004487 Edema Dexamethasone 9.9319703484
MESH:D004487 Edema pirinixic acid 9.9312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9312711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 11.4217686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.4215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.4517654737
MESH:D016889 Endometrial Neoplasms Estradiol 2.7919148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.9716538176 19915237 16415921 18855540 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.2217275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.223659116
MESH:D004828 Epilepsies, Partial Carbamazepine 9.3615008574 16628512 17116037
MESH:D004828 Epilepsies, Partial Phenobarbital 9.3611558140 3922381
MESH:D004827 Epilepsy Carbamazepine 6.559014606 18234410 17178248 17465707 20417680 821787 19620853 7988514 19439326 19700373
MESH:D004827 Epilepsy Phenobarbital 6.5520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.306401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 10.737750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.737750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 9.883659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.883659116
MESH:D004916 Erythromelalgia Carbamazepine 5.4319549232
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9316530937
MESH:D005076 Exanthema Carbamazepine 5.1720485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Amiodarone 21.8614986274
MESH:D005234 Fatty Liver Clofibrate 21.8619224547
MESH:D005234 Fatty Liver Cyclosporine 21.8619224547
MESH:D005234 Fatty Liver Dietary Fats 21.8619004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 21.8620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005355 Fibrosis Cyclosporine 13.0412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.0418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0420067830
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D015432 Glomerulonephritis, Membranoproliferative Spironolactone 5.7316928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.3620471113 17686920
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006529 Hepatomegaly Amiodarone 18.3015265979
MESH:D006529 Hepatomegaly Phenobarbital 18.3016109766
MESH:D006529 Hepatomegaly pirinixic acid 18.3019176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.3015340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006937 Hypercholesterolemia Amiodarone 8.298137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.2921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.4810459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006965 Hyperplasia Carbamazepine 4.9218773962
MESH:D006973 Hypertension Cyclosporine 7.9110903974
MESH:D006973 Hypertension Dexamethasone 7.9117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9118670907 18850075
MESH:D020514 Hypokalemic Periodic Paralysis Spironolactone 5.8719822448
MESH:D007037 Hypothyroidism Amiodarone 4.2218020914 17991464
MESH:D007249 Inflammation Dexamethasone 7.4511099482 8960868
MESH:D007249 Inflammation Dietary Fats 7.4520412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.4512200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.1811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.1816627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.1816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.9918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.7916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.7916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.7912371664
MESH:D007680 Kidney Neoplasms Estradiol 15.7915610895
MESH:D008064 Lipidoses Amiodarone 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.1221047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.3316718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 6.3316544323
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3312878042
MESH:D008107 Liver Diseases Acetaminophen 3.6612969438 16611625 19014921 19784758 19460945 11587558 12587719 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.6619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 31.967678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 31.9618177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 31.9620195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 31.9619389873 21295105
MESH:D008113 Liver Neoplasms ciprofibrate 31.9612771043
MESH:D008113 Liver Neoplasms Clofibric Acid 31.9617602206
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 31.9611940454
MESH:D008113 Liver Neoplasms Phenobarbital 31.9619812893 19482888 15975961 8742319 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 31.9616377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.9616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.702876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.708603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.7018164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.702563599 6150874 18308698 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.7012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3611989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.1812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1818516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.5414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.5420464547 6695378 18520028 20064080 18569708 20869020 18816296 17053015 20135361
MESH:D008175 Lung Neoplasms Dexamethasone 4.5411195469 15824018
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5419555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4816628512
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3811807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008607 Mental Retardation Carbamazepine 3.629014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D009101 Multiple Myeloma Dexamethasone 7.2715867202 16118317 15744524
MESH:D009101 Multiple Myeloma fluvastatin 7.2716996129
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009181 Mycoses Amiodarone 4.6012754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.379809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1817484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.1720399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.3618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.367678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.3311141357
MESH:D009369 Neoplasms pirinixic acid 4.3317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 14.8516990009
MESH:D009421 Nervous System Malformations Estradiol 14.8511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.659802331
MESH:D009765 Obesity Dietary Fats 4.1718457598 17217161 16723640 20518802 18674790 20132043 11836018 19632207 21332399
MESH:D009765 Obesity pirinixic acid 4.1720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0416049721
MESH:D010018 Osteomalacia Carbamazepine 11.1117016548
MESH:D010018 Osteomalacia Phenobarbital 11.1117016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1319401270
MESH:D010146 Pain Acetaminophen 6.2216870215
MESH:D010146 Pain Carbamazepine 6.2215215642
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.3916965848
MESH:D010267 Parapsoriasis Carbamazepine 5.4116538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.6317679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1512371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.152563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3821297632
MESH:D011248 Pregnancy Complications Carbamazepine 4.869014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 8.879014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8711896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.2216740699
MESH:D019310 Pseudolymphoma Carbamazepine 11.589591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 11.5812752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7411597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7518379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 12.4918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 12.4918551238
MESH:D012640 Seizures Carbamazepine 12.499046859 15946322 16180713 16938433 9844417 19414003 16876388
MESH:D012640 Seizures Phenobarbital 12.4911442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.536407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7918724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.0010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0016192470
MESH:D012893 Sleep Disorders Carbamazepine 4.8319414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.9216415921 16538176 19915237 15057820 20485159 18855540 19694795
MESH:D013272 Stomach Diseases Dexamethasone 4.0315472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.8220155912 2093021
MESH:D013274 Stomach Neoplasms Butylated Hydroxyanisole 2.821399818 3581430
MESH:D013276 Stomach Ulcer Amiodarone 6.6118087811
MESH:D013276 Stomach Ulcer Dexamethasone 6.6115138204
MESH:D013610 Tachycardia Amiodarone 4.0111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9119225199
MESH:D013959 Thyroid Diseases Amiodarone 11.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.841399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.5718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9017467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.0016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.0017053015
MESH:D001749 Urinary Bladder Neoplasms Butylated Hydroxyanisole 11.001399818
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.0010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.0010091137
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D014605 Uveitis Cyclosporine 10.771336536
MESH:D014605 Uveitis Dexamethasone 10.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35845
    • Releated gene ID Related gene Name
    PA35845SLCO2B1
    Releated disease ID Related disease Name
    PA443450Asthma
    PA443632Cardiomyopathy, Dilated
    Releated drug ID Related drug Name
    PA143487910aliskiren
    PA449512estrone
    PA450842penicillin g
    PA142650384pitavastatin
    PA449688fluvastatin
    PA451089pravastatin
    PA134308647rosuvastatin
    PA450546montelukast
    PA448500atorvastatin
    PA448897cerivastatin
    PA449750gemfibrozil
    PA449782glibenclamide
    PA451363simvastatin
    PA10034bosentan
    PA451250rifampin
    PA449621fexofenadine
    PA151958355grapefruit juice
    PA10816ezetimibe
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01049 antagonist Ergoloid mesylate Sympatholytics;Vasodilator Agents;Adrenergic alpha-Antagonists;Nootropic Agents
    No data
    Drugbank ID Action Drug Name Description
    DB00175 inhibitor Pravastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00286 substrate Prempro Estrogens
    DB00390 substrate Digoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB00471 substrate Montelukast Anti-Asthmatic Agents;Antiarrhythmic Agents;Leukotriene Antagonists
    DB00627 inhibitor Vitamin C with Niacin and Niacinamide-Liq Vitamins (Vitamin B Complex);Vasodilator Agents;Antilipemic Agents;Vitamin B Complex
    DB00654 substrate Xalacom Antihypertensive Agents;Neuroprotective Agents
    DB00655 inhibitor Holis 98 Antineoplastic Agents;Estrogens;Osteoporosis Prophylactic;Anti-menopausal Agents
    DB00770 inhibitor Caverject Sterile Powder - Kit 23.2mcg/Vial Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00783 inhibitor Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00917 substrate Dinoprostone Oxytocics;Prostaglandins
    DB00936 substrate Mobilat Anti-Infective Agents;Keratolytic Agents;Antifungal Agents
    DB00950 substrate Allegra-D Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB01016 substrate Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    DB01045 inhibitor Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01050 substrate Vicoprofen® Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01053 substrate Penicillin G Anti-Bacterial Agents;Penicillins
    DB01088 substrate Iloprost Antihypertensive Agents
    DB01124 substrate Tolbutamide Hypoglycemic Agents;Sulfonylureas
    DB02746 inhibitor Phthalic Acid
    DB03166 inhibitor Acetic acid Antibacterial Agents;Indicators and Reagents
    DB03467 inhibitor Naringenin Anti-Ulcer Agents;Estrogen Antagonists
    DB03793 inhibitor Benzoic Acid Food Preservatives
    DB03902 inhibitor Oxalic Acid Reducing Agents
    DB04216 inhibitor Quercetin Antioxidants
    DB04272 inhibitor Citric Acid Anticoagulants;Chelating Agents
    DB04348 substrate Taurocholic Acid Cholagogues and Choleretics;Detergents
    DB04398 inhibitor Lactic Acid
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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