AutismKB 2.0

Annotation Detail for CHRM3


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Basic Information Top
Gene Symbol:CHRM3 ( HM3 )
Gene Full Name: cholinergic receptor, muscarinic 3
Band: 1q43
Quick LinksEntrez ID:1131; OMIM: 118494; Uniprot ID:ACM3_HUMAN; ENSEMBL ID: ENSG00000133019; HGNC ID: 1952
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04971Gastric acid secretion
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Integration of energy metabolism
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500136Regulation of Insulin Secretion by Acetylcholine
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
2074Asthma
2151Neuroblastoma
Desease Name
CARDIOVASCULAR
asthma and atopy
hypertension
diabetes, type 2 insulin
IMMUNE
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 11306684
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 15251036
9287041
10353596
15955028
17180451
17403421
17438462
17613726
17872906
C058297 4-fluorohexahydrosiladifenidol 4-fluorohexahydrosiladifenidol binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 10353596
D000109 Acetylcholine CHRM3 protein affects the susceptibility to Acetylcholineaffects response to substance 18367213
D000109 Acetylcholine CHRM3 protein results in increased susceptibility to Acetylcholineincreases response to substance 19407017
D000109 Acetylcholine Acetylcholine results in increased activity of CHRM3 proteinincreases activity 11755166
D000109 Acetylcholine Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]affects binding|decreases reaction 15900516
D000109 Acetylcholine Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]affects binding|decreases reaction 15900516
D000171 Acrolein Acrolein results in increased expression of CHRM3 proteinincreases expression 17941892
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CHRM3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRM3 mRNAaffects expression 16483693
D001285 Atropine Atropine binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 15140916
D001285 Atropine Atropine binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 17613726
D002217 Carbachol CHRM3 protein results in increased susceptibility to Carbacholincreases response to substance 19407017
D002217 Carbachol Carbachol results in increased activity of CHRM3 proteinincreases activity 15955028
15255942
D002217 Carbachol Ethanol inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]decreases reaction|increases activity 15255942
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CHRM3 mRNAincreases expression 16644059
D004390 Chlorpyrifos Chlorpyrifos results in decreased activity of CHRM3 proteindecreases activity 17666426
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of CHRM3 mRNAdecreases expression 18812211
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 10845706
C101207 darifenacin darifenacin binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 15140916
C101207 darifenacin darifenacin binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 11488427
D003976 Diazinon Diazinon results in increased expression of CHRM3 mRNAincreases expression 16207942
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of CHRM3 mRNAincreases expression 15620428
D004117 Dimethoate Dimethoate results in increased expression of CHRM3 mRNAincreases expression 15033005
D004117 Dimethoate Dimethoate results in decreased expression of CHRM3 mRNAdecreases expression 15033006
D000431 Ethanol Ethanol inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]decreases reaction|increases activity 15255942
C044894 ethylcholine aziridinium ethylcholine aziridinium results in increased expression of CHRM3 mRNAincreases expression 10733153
C044894 ethylcholine aziridinium ethylcholine aziridinium results in increased expression of CHRM3 proteinincreases expression 10733153
D005632 Fructose Fructose results in increased expression of CHRM3 mRNAincreases expression 17707055
D005632 Fructose Fructose results in increased expression of CHRM3 proteinincreases expression 17707055
D005703 Gallamine Triethiodide Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
C046773 hexahydrosiladifenidol hexahydrosiladifenidol inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 8744975
C046773 hexahydrosiladifenidol hexahydrosiladifenidol binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 8744975
9287041
D006851 Hydrochloric Acid CHRM3 protein affects the susceptibility to Hydrochloric Acidaffects response to substance 18367213
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of CHRM3 proteindecreases expression 20719367
D007649 Ketamine Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12456425
C054938 methoctramine methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12507038
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHRM3 mRNAincreases expression 19285098
D008743 Methyl Parathion Methyl Parathion results in decreased activity of CHRM3 proteindecreases activity 17666426
D019832 N-Methylscopolamine 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine N-Methylscopolamine binds to CHRM3 proteinaffects binding 9846649
D019832 N-Methylscopolamine Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
C074183 N-(2-chloroethyl)-4-piperidinyl diphenylacetate N-(2-chloroethyl)-4-piperidinyl diphenylacetate binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 10353596
D009255 Nafenopin Nafenopin results in increased expression of CHRM3 proteinincreases expression 10903494
C005419 oxybutynin oxybutynin binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 15140916
D010197 Pancuronium Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D010852 Picrotoxin Picrotoxin results in increased expression of CHRM3 mRNAincreases expression 15170462
D017300 Pipecuronium Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D011284 Pregnenolone Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]affects binding|decreases reaction 15900516
D011284 Pregnenolone Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 15900516
D011374 Progesterone Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]affects binding|decreases reaction 15900516
D011374 Progesterone Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 15900516
C441209 quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 11488427
D011813 Quinuclidinyl Benzilate Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 10845706
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM3 proteinaffects binding 10845706
D011813 Quinuclidinyl Benzilate Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 15900516
D011813 Quinuclidinyl Benzilate Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 15900516
D011813 Quinuclidinyl Benzilate hexahydrosiladifenidol inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein]affects binding|decreases reaction 8744975
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM3 proteinaffects binding 8744975
C059514 resveratrol resveratrol promotes the reaction [CHRM3 protein binds to GJA1 protein]affects binding|increases reaction 17520802
C061870 rocuronium rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D012602 Scopolamine Derivatives methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12507038
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to CHRM3 proteinaffects binding 12507038
D012602 Scopolamine Derivatives 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 11306684
D012602 Scopolamine Derivatives Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12456425
D012602 Scopolamine Derivatives Scopolamine Derivatives binds to CHRM3 proteinaffects binding 11306684
12456425
D012602 Scopolamine Derivatives Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12456425
D012602 Scopolamine Derivatives Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 11306684
D013874 Thiopental Thiopental binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 12456425
D013874 Thiopental Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 12456425
C099041 tolterodine tolterodine binds to and results in decreased activity of CHRM3 proteinaffects binding|decreases activity 15140916
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CHRM3 mRNAaffects expression 21346803
D014331 Tropicamide Tropicamide inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]affects binding|decreases reaction 11306684
D014673 Vecuronium Bromide Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]affects binding|decreases reaction 9846649
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of CHRM3 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.3918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.397525203
MESH:D000138 Acidosis Ammonium Chloride 21.5518287403
MESH:D000138 Acidosis Ethanol 21.5511192467
MESH:D000138 Acidosis Hydrochloric Acid 21.5519262391 20872349 15920416 11574821 16144966 12771618
MESH:D000138 Acidosis Zinc Sulfate 21.557265320
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.3117183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.3320597076
MESH:D058186 Acute Kidney Injury resveratrol 3.4316538975
MESH:D055371 Acute Lung Injury Acrolein 8.4521297076 20525806
MESH:D055371 Acute Lung Injury Hydrochloric Acid 8.4519060228 11953099 11850527 19094174 15970105 16759491 19760209
MESH:D000236 Adenoma resveratrol 3.0315688382
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.6017119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.6016487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8315451040 15451039
MESH:D000544 Alzheimer Disease Acrolein 4.2614715435 17570602 15207723
MESH:D000544 Alzheimer Disease resveratrol 4.2616162502 16183991
MESH:D000853 Anophthalmos Ethanol 4.3515513904
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 4.9115146954
MESH:D000860 Anoxia Hydrochloric Acid 10.0215090967
MESH:D000860 Anoxia Zinc Sulfate 10.027265320
MESH:D001008 Anxiety Disorders Ethanol 3.6311141031
MESH:D001161 Arteriosclerosis Acrolein 4.5415014928
MESH:D001169 Arthritis, Experimental resveratrol 3.2017115116
MESH:D050197 Atherosclerosis Acrolein 6.1816037261 17363696 16126721
MESH:D050197 Atherosclerosis resveratrol 6.1817967414 16873680
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 4.3915920416
MESH:D001919 Bradycardia Carbachol 5.4312411408
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8517868700
MESH:D001930 Brain Injuries Progesterone 3.7915665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 3.8117600658
MESH:D001943 Breast Neoplasms Atropine 2.2512762645
MESH:D001943 Breast Neoplasms Progesterone 2.2517614352 16175315 15562024
MESH:D001943 Breast Neoplasms resveratrol 2.2517534123 16393696 17651959
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.2112378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 4.9815578804
MESH:D002056 Burns Ethanol 4.1916374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3216011737 16192424 16124888 16050911 15673190 16097048 3786805 18705752 15721981 10355542 15700767 16227642
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 5.8612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 5.8618788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 5.8618788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular resveratrol 5.8619321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1216675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.5716227395
MESH:D006332 Cardiomegaly Ethanol 3.1619332462
MESH:D002318 Cardiovascular Diseases resveratrol 3.1415458977
MESH:D002386 Cataract Trinitrotoluene 3.5814694615 15817613
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 2.9615513904
MESH:D003092 Colitis resveratrol 3.6716474422
MESH:D003110 Colonic Neoplasms resveratrol 2.3716338953
MESH:D015179 Colorectal Neoplasms Acrolein 2.8817597105
MESH:D015179 Colorectal Neoplasms resveratrol 2.8816550006
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.0015095906
MESH:D003248 Constipation quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate 7.2211488427
MESH:D003327 Coronary Disease Fructose 7.7318504504
MESH:D003327 Coronary Disease resveratrol 7.7316507316
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3115451039 15513904 19302082 15451040 11198716 10194807 11873399
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.9916037377
MESH:D003490 Cyanosis Trinitrotoluene 4.4618551238
MESH:D003556 Cystitis Acrolein 10.6512161096
MESH:D003556 Cystitis Hydrochloric Acid 10.6520719367 12853844 19279288 12599022
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.3317714534
MESH:D003921 Diabetes Mellitus, Experimental Fructose 7.5518603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 3.2518603373
MESH:D003928 Diabetic Nephropathies resveratrol 3.5616286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.0317187935
MESH:D003967 Diarrhea Atropine 8.1110867622
MESH:D003967 Diarrhea quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate 8.1111488427
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.5019336974 4309450 7120509 9327722 6884620 16177239 7179309 16227642 6623471 17522070 10092053 10915739 11566570 15968718 2869522 19085960 15027814 7440962 21278145 15998439 3786805 3732212
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.5011566570
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 5.5021346803 18551238
MESH:D004381 Duodenal Ulcer Atropine 4.8511595415
MESH:D004417 Dyspnea Diazinon 4.3216487989
MESH:D004487 Edema Crotalid Venoms 6.5819703484
MESH:D004487 Edema resveratrol 6.588985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.8517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.8517872969
MESH:D004715 Endometriosis Progesterone 3.3516134523
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3817923197
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.3219566590
MESH:D004938 Esophageal Neoplasms Ethanol 2.6216704527
MESH:D004941 Esophagitis Hydrochloric Acid 5.5212928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 5.5311346197 14621274 20516732
MESH:D005234 Fatty Liver Carbon Tetrachloride 10.9312795759 16239168 15959796 61145 12631006 16045604 17595544 19224547
MESH:D005234 Fatty Liver Ethanol 10.9318620774 19236843 16409862
MESH:D005234 Fatty Liver Fructose 10.9319196556 18395287 18641190
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8216946407 15451040 15513904 10194807
MESH:D005355 Fibrosis Carbon Tetrachloride 12.4718705752
MESH:D005355 Fibrosis Fructose 12.4718504504
MESH:D005355 Fibrosis Hydrochloric Acid 12.4718497604
MESH:D005739 Gas Poisoning Hydrochloric Acid 4.9812378975
MESH:D005756 Gastritis Ethanol 4.2115046732
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 4.8719951613 20616304 20516732 19957777 12212954 20545468
MESH:D018149 Glucose Intolerance Fructose 4.8819165636
MESH:D006261 Headache Ketamine 5.5311554966
MESH:D006356 Heartburn Hydrochloric Acid 5.3219566590
MESH:D006470 Hemorrhage Crotalid Venoms 5.8917537475
MESH:D006505 Hepatitis Carbon Tetrachloride 8.1219900420 19110552
MESH:D006505 Hepatitis Diazinon 8.1216487989
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.5317063115
MESH:D006529 Hepatomegaly Trinitrotoluene 3.7815817613
MESH:D006561 Herpes Simplex resveratrol 3.7116876885
MESH:D006930 Hyperalgesia Ethanol 3.3518783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0516899240
MESH:D006937 Hypercholesterolemia resveratrol 3.5817188708
MESH:D006940 Hyperemia Hydrochloric Acid 5.1712646421
MESH:D006946 Hyperinsulinism Fructose 4.5019008412 18360027 18563319 14757778 15752949
MESH:D006949 Hyperlipidemias Fructose 8.2515752949
MESH:D006949 Hyperlipidemias resveratrol 8.2516873680
MESH:D006973 Hypertension Fructose 3.4314573337 19008412 16843071 14568997 14633139
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 9.8615338365
MESH:D006975 Hypertension, Portal Hydrochloric Acid 9.8616984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.1119262391
MESH:D015228 Hypertriglyceridemia Fructose 4.6619342510 19799862
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8917488730
MESH:D007022 Hypotension Hydrochloric Acid 8.2911574821
MESH:D007022 Hypotension Zinc Sulfate 8.297265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.9415869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.9417600658
MESH:D007248 Infertility, Male Diazinon 6.3112948887 16466525
MESH:D007248 Infertility, Male Trinitrotoluene 6.3112150543
MESH:D007249 Inflammation Crotalid Venoms 10.0117537475
MESH:D007249 Inflammation Hydrochloric Acid 10.0111574821
MESH:D007249 Inflammation Progesterone 10.0115869954
MESH:D007249 Inflammation resveratrol 10.0116366677
MESH:D007251 Influenza, Human resveratrol 4.0616624496
MESH:D007333 Insulin Resistance Fructose 3.9217133782 14573337 18057795 19008412 19586609 19342510 18981581 14757778 19799862 18563319 14633139
MESH:D007410 Intestinal Diseases Hydrochloric Acid 4.5111574821
MESH:D007569 Jaw Abnormalities Ethanol 3.9815513904
MESH:D007674 Kidney Diseases Acrolein 3.5612488133
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 5.8816498863
MESH:D007826 Laryngismus Hydrochloric Acid 5.8811510729
MESH:D007859 Learning Disorders Ethanol 3.7515451040
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.8815237267
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2616087638
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4717676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.6416221502 21278145 11408273 17174718 16943688 17334410 16239168 11903743 17157831
MESH:D008103 Liver Cirrhosis Ethanol 9.6415289165
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 9.6416984587
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6218295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5012445418 17900296 12649538 15959796 12389079 12667390 17565644 16033810 14724832 13678700 15650968 18187930 16116963 14716833 15893842 17976157 20821823 18395095 14512876 18376398 18166357 18420326 18705752 17708605 15370692 12609069 17869086 18429990 18317297 18279442 18006644 17714472 18481824 12958196 17481882 15996030 17944888 12632512 16136751 16011737 15925388 16192424 11481614 15052691 15057751 10355542 18054572 12586293 17698563 18205269 14620537 16027843 18472094 17640975 12898905 12741479 12632514 17766677 17805973 16097048 15338365 18339082 18412020 18263696 17922224 18418968 16638106 18251166 16248980 15818738 18210741 12445421 18277467 17721639 18395914 15876570 15931870 17761835 15730626 17631135 18472332 18156304 14716496 15362042 12546737 17525996 17823541 15123356 12666154 15673190 14748882 17557913 16015684
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5018166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9616246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Chlorpyrifos 3.9615991261
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1917207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 6.3715890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.3719294768
MESH:D008113 Liver Neoplasms resveratrol 6.3719812893 20405173 19073162 19321006
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 4.988603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.9815583823 12014681
MESH:D008171 Lung Diseases Acrolein 7.1411504702
MESH:D008171 Lung Diseases Hydrochloric Acid 7.1416784557
MESH:D055370 Lung Injury Hydrochloric Acid 4.3021114838 19644408 11395602 16129981 15090967 15044056 18497604 18339021 19262391 20597076 18573544 17627322 21311175 15607125
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8614755239
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4814749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7715688416
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.2211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.228985016 11606380
MESH:D008545 Melanoma resveratrol 2.3017992120
MESH:D008546 Melanoma, Experimental Acrolein 4.7410803710
MESH:D008569 Memory Disorders Ethanol 3.7418411066 15451040
MESH:D008659 Metabolic Diseases resveratrol 3.9517112576
MESH:D024821 Metabolic Syndrome X Fructose 4.4317098227 18497449 19165636 16815490 17261469
MESH:D009101 Multiple Myeloma resveratrol 3.1317049120 17164350 14749477 16267019 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3917962980
MESH:D009175 Mycoplasma Infections Thiopental 6.1410773494
MESH:D015878 Mydriasis Tropicamide 6.8716308726
MESH:D009203 Myocardial Infarction Hydrochloric Acid 5.6318534312
MESH:D009203 Myocardial Infarction resveratrol 5.6316525036 17125593 17188708 17015251 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 3.6317125593 17015251
MESH:D009205 Myocarditis resveratrol 4.2817322642
MESH:D009216 Myopia Atropine 4.6912601066
MESH:D009336 Necrosis Trinitrotoluene 4.2918551238
MESH:D009369 Neoplasms Acrolein 3.3117329238
MESH:D009374 Neoplasms, Experimental resveratrol 3.548985016
MESH:D009393 Nephritis Acrolein 5.8012653641
MESH:D019636 Neurodegenerative Diseases Acrolein 7.6711342003
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6717652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9617929310
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.7315081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 7.7319784758
MESH:D009765 Obesity Fructose 3.2918585860 17707055
MESH:D009784 Occupational Diseases Hydrochloric Acid 8.3412378975
MESH:D009784 Occupational Diseases Trinitrotoluene 8.3417852074 14694615 12819281
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8217513867
MESH:D010051 Ovarian Neoplasms Progesterone 2.3716525653 17393432
MESH:D010149 Pain, Postoperative Ketamine 5.6411554966
MESH:D010190 Pancreatic Neoplasms Ethanol 2.7912384795
MESH:D010300 Parkinson Disease Acrolein 3.4017690948
MESH:D020734 Parkinsonian Disorders Tropicamide 5.3417594079
MESH:D010787 Photosensitivity Disorders Acrolein 5.2511550810
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 4.8915607125 18573544 15970105 18497604
MESH:D011041 Poisoning Atropine 12.4017849254 18072136
MESH:D011041 Poisoning Diazinon 12.4017603234
MESH:D011041 Poisoning Methyl Parathion 12.4017603234
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.7116679765
MESH:D011471 Prostatic Neoplasms resveratrol 3.8015767336 17804756 16731767 17636462 17718901 17675339
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.5320597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 4.7315090967
MESH:D051437 Renal Insufficiency Acrolein 4.5412732208
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1016325855
MESH:D015427 Reperfusion Injury resveratrol 3.0316314181 17520802 15827377 16317513 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.3217627322 18339021 18549715 16784557 16129981
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 3.929413022
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 5.8811510729
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.1716611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 9.5216611668 17119214
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 9.5220516732
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6718045962
MESH:D012559 Schizophrenia Ketamine 3.9320000043
MESH:D012640 Seizures Atropine 11.5811218047 12660363 17157343
MESH:D012640 Seizures Ethanol 11.589754883
MESH:D012640 Seizures Picrotoxin 11.588635557 8954991
MESH:D012640 Seizures Trinitrotoluene 11.5818551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.606418539
MESH:D012878 Skin Neoplasms resveratrol 2.808985016 15837718
MESH:D013119 Spinal Cord Injuries Progesterone 3.8015862959 16503802
MESH:D013163 Splenomegaly Trinitrotoluene 4.7415817613
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Atropine 10.0211595415
MESH:D013276 Stomach Ulcer Ethanol 10.0211906479 16755016 17918041 9562338 9211565 17189318
MESH:D013276 Stomach Ulcer Hydrochloric Acid 10.0216755016 17189318 15309881
MESH:D020521 Stroke Acrolein 4.1816269634
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0616321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.849754883
MESH:D013742 Tetanus Vecuronium Bromide 6.682903605
MESH:D014062 Tongue Neoplasms resveratrol 3.8016227395
MESH:D014202 Tremor Atropine 10.3317594079
MESH:D014202 Tremor Tropicamide 10.3319467297 17594079
MESH:D014570 Urologic Diseases Diazinon 4.7916487989
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.6917473185
MESH:D014594 Uterine Neoplasms resveratrol 3.6917044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8417488730
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:15380 Diabetes pathways
KEGG:04971 Gastric acid secretion
REACT:1505 Integration of energy metabolism
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04972 Pancreatic secretion
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA112
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    PA164769056tiotropium
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00185 agonist Cevimeline Parasympathomimetics;Muscarinic Agonists
    DB00193 antagonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
    DB00202 agonist Succinylcholine Skeletal Muscle Relaxants;Neuromuscular Depolarizing Agents
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00280 antagonist Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00332 antagonist Ratio-Ipra SAL UDV Bronchodilator Agents;Antispasmodics;Cholinergic Antagonists;Antimuscarinics
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00340 antagonist Metixene Antiparkinson Agents;Muscarinic Antagonists
    DB00342 antagonist Terfenadine Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00376 antagonist Trihexyphenidyl Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00383 antagonist Oxyphencyclimine Antispasmodics;Anticholinergic Agents
    DB00387 antagonist Procyclidine Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00424 antagonist Hyoscyamine Antiarrhythmic Agents;Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Antispasmodics;Antimuscarinics;Parasympatholytics
    DB00434 antagonist Cyproheptadine Serotonin Antagonists;Antipruritics;Gastrointestinal Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamine derivatives
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00462 antagonist Scour solution coop Antispasmodics;Anticholinergic Agents;Parasympatholytics
    DB00496 antagonist Darifenacin Muscarinic Antagonists;Urinary antispasmodics
    DB00505 antagonist Tridihexethyl Antispasmodics;Anticholinergic Agents
    DB00517 antagonist Anisotropine Methylbromide Anticholinergics;Parasympatholytics
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00572 antagonist Spascupreel Tablets Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Parasympatholytics
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00725 antagonist Debiline H Anti-Ulcer Agents;Antispasmodics;Antimuscarinics
    DB00729 antagonist Diphemanil Methylsulfate Bronchodilator Agents;Muscarinic Antagonists;Parasympatholytics
    DB00747 antagonist Scopolamine Mydriatics;Adjuvants, Anesthesia;Muscarinic Antagonists;Antispasmodics;Cholinergic Antagonists;Antimuscarinics;Adjuvants
    DB00767 antagonist Benzquinamide Antiemetics;Antipsychotics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00785 antagonist Cryptenamine Antihypertensive Agents
    DB00809 antagonist Phenyltrope Oph Soln Mydriatics;Muscarinic Antagonists;Diagnostic aid, cycloplegic;Diagnostic aid, mydriatic
    DB00835 antagonist Tantapp Elixir Anti-Allergic Agents;Histamine H1 Antagonists
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01036 antagonist Tolterodine Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents;Genitourinary Smooth Muscle Relaxants
    DB01062 antagonist Oxybutynin Muscarinic Antagonists;Antispasmodics;Anticholinergic Agents;Parasympatholytics;Genitourinary Smooth Muscle Relaxants
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01085 agonist Timpilo 4 Muscarinic Agonists;Miotics;Cholinergic Agents
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01226 antagonist Mivacurium Neuromuscular Nondepolarizing Agents
    DB01231 antagonist Diphenidol Antiemetics;Antivertigo Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01337 antagonist Pancuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01338 antagonist Pipecuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01409 antagonist Tiotropium Bronchodilator Agents;Muscarinic Antagonists;Cholinergic Antagonists;Anticholinergic Agents;Parasympatholytics
    DB01591 antagonist Solifenacin Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents
    DB01625 antagonist Isopropamide Gastrointestinal Agents
    DB04843 antagonist Mepenzolate Anticholinergic Agents;Parasympatholytics
    DB06702 antagonist Fesoterodine Antispasmodics;Anti-Incontinence Agents;Antimuscarinics;Genitourinary Smooth Muscle Relaxants
    DB06709 agonist Methacholine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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