Annotation Detail for CHRM4
Basic Information Top
| Gene Symbol: | CHRM4 ( HM4,M4R ) |
|---|---|
| Gene Full Name: | cholinergic receptor, muscarinic 4 |
| Band: | 11p11.2 |
| Quick Links | Entrez ID:1132; OMIM: 118495; Uniprot ID:ACM4_HUMAN; ENSEMBL ID: ENSG00000180720; HGNC ID: 1953 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04810 | Regulation of actin cytoskeleton |
| Pathway ID | Pathway Name |
|---|---|
| Signaling by GPCR |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| P00003 | Alzheimer disease-amyloid secretase pathway |
| P00026 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway |
| P00043 | Muscarinic acetylcholine receptor 2 and 4 signaling pathway |
| P00027 | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CHRM4 mRNA | affects expression | 16483693 |
| D001285 | Atropine | Atropine binds to and results in decreased activity of CHRM4 protein | affects binding|decreases activity | 17613726 |
| C018465 | bioallethrin | [DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA | affects cotreatment|increases expression | 10192214 |
| D002217 | Carbachol | Carbachol results in increased activity of CHRM4 protein | increases activity | 15955028 |
| D002330 | Carmustine | Carmustine results in decreased expression of CHRM4 mRNA | decreases expression | 15980968 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased activity of CHRM4 protein | decreases activity | 17666426 |
| D003435 | Crotalid Venoms | Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 10845706 |
| D003634 | DDT | [DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA | affects cotreatment|increases expression | 10192214 |
| D003976 | Diazinon | Diazinon results in increased expression of CHRM4 mRNA | increases expression | 18812211 |
| D004026 | Dieldrin | Dieldrin affects the expression of CHRM4 mRNA | affects expression | 18812211 |
| D005703 | Gallamine Triethiodide | Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| C048172 | himbacine | himbacine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 8744975 |
| C048172 | himbacine | himbacine binds to and results in decreased activity of CHRM4 protein | affects binding|decreases activity | 8744975 |
| C054938 | methoctramine | methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] | affects binding|decreases reaction | 11306684 |
| D008743 | Methyl Parathion | Methyl Parathion results in decreased activity of CHRM4 protein | decreases activity | 17666426 |
| D019832 | N-Methylscopolamine | Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D019832 | N-Methylscopolamine | N-Methylscopolamine binds to CHRM4 protein | affects binding | 9846649 |
| D019832 | N-Methylscopolamine | Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D019832 | N-Methylscopolamine | Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D019832 | N-Methylscopolamine | rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D019832 | N-Methylscopolamine | Tropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D019832 | N-Methylscopolamine | Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D008799 | Mevinphos | Mevinphos results in increased activity of CHRM4 protein | increases activity | 17395621 |
| D009532 | Nickel | Nickel results in decreased expression of CHRM4 mRNA | decreases expression | 18812211 |
| D010197 | Pancuronium | Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D017300 | Pipecuronium | Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D011813 | Quinuclidinyl Benzilate | Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 10845706 |
| D011813 | Quinuclidinyl Benzilate | Quinuclidinyl Benzilate binds to CHRM4 protein | affects binding | 10845706 |
| D011813 | Quinuclidinyl Benzilate | himbacine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 8744975 |
| D011813 | Quinuclidinyl Benzilate | Quinuclidinyl Benzilate binds to CHRM4 protein | affects binding | 8744975 |
| D011813 | Quinuclidinyl Benzilate | Tropicamide inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 8744975 |
| C061870 | rocuronium | rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D012602 | Scopolamine Derivatives | Scopolamine Derivatives binds to CHRM4 protein | affects binding | 12507038 |
| D012602 | Scopolamine Derivatives | methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] | affects binding|decreases reaction | 11306684 |
| D014236 | Trichlorfon | Trichlorfon affects the expression of CHRM4 mRNA | affects expression | 12093157 |
| D014236 | Trichlorfon | Trichlorfon affects the expression of CHRM4 protein | affects expression | 12093157 |
| D014331 | Tropicamide | Tropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| D014331 | Tropicamide | Tropicamide inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein] | affects binding|decreases reaction | 8744975 |
| D014331 | Tropicamide | Tropicamide binds to and results in decreased activity of CHRM4 protein | affects binding|decreases activity | 10353596 15251036 9287041 15955028 17040474 17180451 8744975 17403421 17438462 17594079 17613726 17872906 |
| D014673 | Vecuronium Bromide | Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] | affects binding|decreases reaction | 9846649 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.37 | 18287403 | |
| MESH:D055371 | Acute Lung Injury | Nickel | 4.41 | 16166738 | |
| MESH:D018248 | Adenoma, Liver Cell | DDT | 5.03 | 12597452 | |
| MESH:D000382 | Agricultural Workers' Diseases | Chlorpyrifos | 13.57 | 17119214 11874814 16611668 | |
| MESH:D000382 | Agricultural Workers' Diseases | DDT | 13.57 | 12584743 16487989 | |
| MESH:D000382 | Agricultural Workers' Diseases | Diazinon | 13.57 | 16487989 | |
| MESH:D000544 | Alzheimer Disease | Trichlorfon | 4.13 | 11419566 | |
| MESH:D001919 | Bradycardia | Carbachol | 5.71 | 12411408 | |
| MESH:D001932 | Brain Neoplasms | Carmustine | 4.22 | 16187019 | |
| MESH:D001943 | Breast Neoplasms | Atropine | 2.19 | 12762645 | |
| MESH:D001943 | Breast Neoplasms | DDT | 2.19 | 12709520 16792888 | |
| MESH:D001943 | Breast Neoplasms | Dieldrin | 2.19 | 15770527 11859874 | |
| MESH:D001943 | Breast Neoplasms | Nickel | 2.19 | 15986119 | |
| MESH:D006528 | Carcinoma, Hepatocellular | DDT | 3.15 | 12597452 | |
| MESH:D002418 | Cattle Diseases | Trichlorfon | 5.95 | 14651886 | |
| MESH:D000013 | Congenital Abnormalities | DDT | 4.74 | 15095906 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Nickel | 3.77 | 17244072 17100760 19470301 | |
| MESH:D003877 | Dermatitis, Contact | Nickel | 4.46 | 2952479 | |
| MESH:D003967 | Diarrhea | Atropine | 4.77 | 10867622 | |
| MESH:D004381 | Duodenal Ulcer | Atropine | 5.11 | 11595415 | |
| MESH:D004417 | Dyspnea | DDT | 10.23 | 16487989 | |
| MESH:D004417 | Dyspnea | Diazinon | 10.23 | 16487989 | |
| MESH:D004487 | Edema | Crotalid Venoms | 5.19 | 19703484 | |
| MESH:D005909 | Glioblastoma | Carmustine | 3.81 | 16187019 | |
| MESH:D006470 | Hemorrhage | Crotalid Venoms | 6.14 | 17537475 | |
| MESH:D006505 | Hepatitis | DDT | 9.49 | 16487989 | |
| MESH:D006505 | Hepatitis | Diazinon | 9.49 | 16487989 | |
| MESH:D006529 | Hepatomegaly | DDT | 4.55 | 2387028 | |
| MESH:D015658 | HIV Infections | Nickel | 3.72 | 17263646 | |
| MESH:D007247 | Infertility, Female | Dieldrin | 4.76 | 10630421 | |
| MESH:D007248 | Infertility, Male | DDT | 7.15 | 17192596 17157474 | |
| MESH:D007248 | Infertility, Male | Diazinon | 7.15 | 12948887 16466525 | |
| MESH:D007249 | Inflammation | Crotalid Venoms | 6.05 | 17537475 | |
| MESH:D007249 | Inflammation | Nickel | 6.05 | 16166738 | |
| MESH:D007859 | Learning Disorders | bioallethrin | 10.22 | 7589230 | |
| MESH:D007859 | Learning Disorders | DDT | 10.22 | 7589230 | |
| MESH:D008107 | Liver Diseases | Chlorpyrifos | 4.76 | 15991261 | |
| MESH:D008107 | Liver Diseases | DDT | 4.76 | 15729006 | |
| MESH:D008113 | Liver Neoplasms | DDT | 5.25 | 15975961 11948501 | |
| MESH:D008113 | Liver Neoplasms | Dieldrin | 5.25 | 9539021 8742319 | |
| MESH:D008545 | Melanoma | Carmustine | 2.84 | 12393984 | |
| MESH:D008569 | Memory Disorders | Trichlorfon | 5.52 | 15957009 | |
| MESH:D015878 | Mydriasis | Tropicamide | 7.16 | 16308726 | |
| MESH:D009216 | Myopia | Atropine | 9.29 | 12601066 | |
| MESH:D009216 | Myopia | himbacine | 9.29 | 12601066 | |
| MESH:D009369 | Neoplasms | DDT | 5.63 | 8820588 | |
| MESH:D009369 | Neoplasms | Dieldrin | 5.63 | 8820588 | |
| MESH:D020258 | Neurotoxicity Syndromes | Chlorpyrifos | 8.40 | 15081274 | |
| MESH:D020258 | Neurotoxicity Syndromes | Methyl Parathion | 8.40 | 19784758 | |
| MESH:D010300 | Parkinson Disease | Dieldrin | 3.46 | 17291500 11181820 11445065 16112328 16809432 | |
| MESH:D020734 | Parkinsonian Disorders | Tropicamide | 5.59 | 17594079 | |
| MESH:D011041 | Poisoning | Atropine | 13.89 | 18072136 17849254 | |
| MESH:D011041 | Poisoning | Diazinon | 13.89 | 17603234 | |
| MESH:D011041 | Poisoning | Methyl Parathion | 13.89 | 17603234 | |
| MESH:D011471 | Prostatic Neoplasms | DDT | 4.55 | 12584743 | |
| MESH:D012135 | Respiratory Sounds | Chlorpyrifos | 4.45 | 16611668 17119214 11874814 | |
| MESH:D012140 | Respiratory Tract Diseases | Chlorpyrifos | 4.70 | 16611668 17119214 | |
| MESH:D012640 | Seizures | Atropine | 4.26 | 11218047 17157343 12660363 | |
| MESH:D012729 | Sex Chromosome Aberrations | Chlorpyrifos | 5.90 | 6418539 | |
| MESH:D013276 | Stomach Ulcer | Atropine | 4.58 | 11595415 | |
| MESH:D013322 | Strongyloidiasis | Trichlorfon | 6.44 | 14651886 | |
| MESH:D013742 | Tetanus | Vecuronium Bromide | 6.97 | 2903605 | |
| MESH:D014202 | Tremor | Atropine | 11.31 | 17594079 | |
| MESH:D014202 | Tremor | Tropicamide | 11.31 | 17594079 19467297 | |
| MESH:D014570 | Urologic Diseases | DDT | 11.90 | 16487989 | |
| MESH:D014570 | Urologic Diseases | Diazinon | 11.90 | 16487989 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| KEGG:04810 | Regulation of actin cytoskeleton |
| REACT:14797 | Signaling by GPCR |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00246 | antagonist | Ziprasidone | Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents |
| DB00321 | antagonist | Triavil Tab | Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic |
| DB00334 | antagonist | Olanzapine | Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors |
| DB00340 | antagonist | Metixene | Antiparkinson Agents;Muscarinic Antagonists |
| DB00363 | antagonist | Clozapine | Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists |
| DB00376 | antagonist | Trihexyphenidyl | Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists |
| DB00387 | antagonist | Procyclidine | Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists |
| DB00420 | antagonist | Promazine | Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents |
| DB00424 | antagonist | Hyoscyamine | Antiarrhythmic Agents;Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Antispasmodics;Antimuscarinics;Parasympatholytics |
| DB00458 | antagonist | Imipramine | Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB00496 | antagonist | Darifenacin | Muscarinic Antagonists;Urinary antispasmodics |
| DB00540 | antagonist | Nortriptyline | Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB00572 | antagonist | Spascupreel Tablets | Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Parasympatholytics |
| DB00622 | antagonist | Nicardipine | Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines |
| DB00715 | antagonist | Paroxetine | Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation |
| DB00725 | antagonist | Debiline H | Anti-Ulcer Agents;Antispasmodics;Antimuscarinics |
| DB00747 | antagonist | Scopolamine | Mydriatics;Adjuvants, Anesthesia;Muscarinic Antagonists;Antispasmodics;Cholinergic Antagonists;Antimuscarinics;Adjuvants |
| DB00767 | antagonist | Benzquinamide | Antiemetics;Antipsychotics |
| DB00777 | antagonist | Propiomazine | Sedatives and Hypnotics |
| DB00785 | antagonist | Cryptenamine | Antihypertensive Agents |
| DB00809 | antagonist | Phenyltrope Oph Soln | Mydriatics;Muscarinic Antagonists;Diagnostic aid, cycloplegic;Diagnostic aid, mydriatic |
| DB00835 | antagonist | Tantapp Elixir | Anti-Allergic Agents;Histamine H1 Antagonists |
| DB00934 | antagonist | Maprotiline | Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation |
| DB01036 | antagonist | Tolterodine | Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents;Genitourinary Smooth Muscle Relaxants |
| DB01069 | antagonist | Phenergan VC Expectorant Syrup | Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives |
| DB01142 | antagonist | Doxepin | Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists |
| DB01151 | antagonist | Desipramine | Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors |
| DB01224 | antagonist | Quetiapine | Antipsychotics;Antipsychotic Agents |
| DB01238 | other/unknown | Aripiprazole | Antipsychotics;Antipsychotic Agents |
| DB01239 | antagonist | Chlorprothixene | Antipsychotics;Dopamine Antagonists;Antipsychotic Agents |
| DB01403 | antagonist | Methotrimeprazine | Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents |
| DB01591 | antagonist | Solifenacin | Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents |
| DB01625 | antagonist | Isopropamide | Gastrointestinal Agents |
| DB06702 | antagonist | Fesoterodine | Antispasmodics;Anti-Incontinence Agents;Antimuscarinics;Genitourinary Smooth Muscle Relaxants |
| No data |
| No data |
| No data |