AutismKB 2.0

Annotation Detail for SLC46A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC46A1 ( FLJ39875,HCP1,MGC9564,PCFT )
Gene Full Name: solute carrier family 46 (folate transporter), member 1
Band: 17q11.2
Quick LinksEntrez ID:113235; OMIM: 611672; Uniprot ID:PCFT_HUMAN; ENSEMBL ID: ENSG00000076351; HGNC ID: 30521
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
501009Metabolism of folate and pterines
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Folate malabsorption, hereditary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C005984 5-methyltetrahydrofolate 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
C005984 5-methyltetrahydrofolate 5-methyltetrahydrofolate results in decreased activity of SLC46A1 proteindecreases activity 17475902
D000082 Acetaminophen Acetaminophen affects the expression of SLC46A1 mRNAaffects expression 17562736
D006710 Homocysteine SLC46A1 protein affects the abundance of Homocysteine metaboliteaffects abundance 19204075
D000638 Amiodarone Amiodarone affects the expression of SLC46A1 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of SLC46A1 mRNAaffects expression 19483382
D002104 Cadmium Cadmium results in increased expression of SLC46A1 mRNAincreases expression 17156779
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of SLC46A1 mRNAincreases expression 17156779
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC46A1 mRNAdecreases expression 17484886
D002994 Clofibrate Clofibrate affects the expression of SLC46A1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC46A1 mRNAdecreases expression 20106945
C014347 decitabine [decitabine affects the methylation of SLC46A1 promoter] which affects the expression of SLC46A1 mRNAaffects expression|affects methylation 18817749
D002117 Calcitriol Calcitriol results in increased expression of SLC46A1 mRNAincreases expression 16002434
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC46A1 proteindecreases activity 17475902
D005001 Ethionine Ethionine affects the expression of SLC46A1 mRNAaffects expression 19483382
D005492 Folic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D005492 Folic Acid 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D005492 Folic Acid Folic Acid results in decreased expression of SLC46A1 mRNAdecreases expression 17616776
D005492 Folic Acid Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D005492 Folic Acid Methotrexate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D005492 Folic Acid SLC46A1 protein results in increased transport of Folic Acidincreases transport 17129779
17475902
17446347
D005492 Folic Acid Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D005492 Folic Acid SLC46A1 protein results in increased uptake of Folic Acidincreases uptake 21346251
D002955 Leucovorin Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D002955 Leucovorin Leucovorin results in decreased activity of SLC46A1 proteindecreases activity 17475902
D006418 Heme SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]increases expression|increases reaction 17156779
D006418 Heme SLC46A1 protein results in increased uptake of Hemeincreases uptake 17156779
D008727 Methotrexate Methotrexate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D008727 Methotrexate Methotrexate results in decreased activity of SLC46A1 proteindecreases activity 17475902
D008727 Methotrexate SLC46A1 protein results in increased transport of Methotrexateincreases transport 17475902
D008727 Methotrexate Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]decreases reaction|increases transport 17475902
D009853 Omeprazole Omeprazole affects the expression of SLC46A1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of SLC46A1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of SLC46A1 mRNAaffects expression 19483382
D012460 Sulfasalazine Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]decreases reaction|increases transport 17475902
D012460 Sulfasalazine Sulfasalazine results in decreased activity of SLC46A1 proteindecreases activity 17475902
D013448 Sulfobromophthalein Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]decreases reaction|increases transport 17475902
D013448 Sulfobromophthalein Sulfobromophthalein results in decreased activity of SLC46A1 proteindecreases activity 17475902
D013853 Thioacetamide Thioacetamide affects the expression of SLC46A1 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.0812039119
MESH:D058186 Acute Kidney Injury Folic Acid 4.1717003819 16316344 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000236 Adenoma Folic Acid 3.7016963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3116434500
MESH:D000544 Alzheimer Disease Folic Acid 3.0117116317
MESH:D000740 Anemia marker/mechanism 21346251
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6518218290 20041841 18057881
MESH:D001172 Arthritis, Rheumatoid Methotrexate 5.4417286800
MESH:D001172 Arthritis, Rheumatoid Sulfasalazine 5.449133974
MESH:D053627 Asthenozoospermia Sulfasalazine 6.1010689203
MESH:D050197 Atherosclerosis Cadmium 3.5415687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.7818651412 19698954
MESH:D001321 Autistic Disorder 5-methyltetrahydrofolate 2.8018461502
MESH:D001321 Autistic Disorder Acetaminophen 2.8018445737
MESH:D001321 Autistic Disorder Folic Acid 2.8021388746
MESH:D001321 Autistic Disorder Homocysteine 2.8020468076 16297937
MESH:D001528 Behcet Syndrome Sulfasalazine 6.0815870978
MESH:D001778 Blood Coagulation Disorders Amiodarone 47.9219483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 47.9219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 47.9219483382
MESH:D001778 Blood Coagulation Disorders Ethionine 47.9219483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 47.9219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 47.9219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 47.9219483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 47.9219483382
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D001943 Breast Neoplasms decitabine 2.3619208741 18320071
MESH:D001943 Breast Neoplasms Folic Acid 2.3616777985
MESH:D001943 Breast Neoplasms Methotrexate 2.3616978400
MESH:D001943 Breast Neoplasms Sulfasalazine 2.3617356269
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116227642 16124888 15721981 16011737 10355542 16097048 15673190 16050911 3786805 18705752 15700767 16192424
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.393084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.391701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3918788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.3917997003
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7211237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7219215824
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8319225199 15710769
MESH:D002318 Cardiovascular Diseases Folic Acid 3.8316755160
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9118974383
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.6917332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.691399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6912371664
MESH:D002637 Chest Pain Omeprazole 4.9315447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.1418291259
MESH:D002779 Cholestasis Cyclosporine 7.3419486331
MESH:D002779 Cholestasis pirinixic acid 7.3419176532
MESH:D002971 Cleft Lip Folic Acid 3.8921254359
MESH:D002972 Cleft Palate Folic Acid 3.508946559 21254359
MESH:D003093 Colitis, Ulcerative Sulfasalazine 4.4815955209 17339853
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms decitabine 3.7118981723
MESH:D015179 Colorectal Neoplasms Folic Acid 3.7117245555 16963246 17087956 17116713 16985020
MESH:D015179 Colorectal Neoplasms Leucovorin 3.7117401013 20501625 16303861 17255274 17594712 17454858
MESH:D003324 Coronary Artery Disease Homocysteine 3.7016379339
MESH:D019465 Craniofacial Abnormalities Leucovorin 3.5516925845
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.5512039119 9562676
MESH:D003550 Cystic Fibrosis Methotrexate 4.0919747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003882 Dermatomyositis Methotrexate 4.9620191521
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.0916886840
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5917522070 19164858 15968718 11461765 12705907 17906064 15619225 16485898 19085960 12153990 11421492 14550746 14725611 11287661 11834606 10663392 12392966 18071297 10774834 12594235 16109766 10915739 12958197 11739529 16081117 19416960 16781746 19370779 16227642 12540782 16177239 19420014 14986274 19923254 2444490 16393943 18713872 11743745 19739265 17562736 11529661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.5918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.592869522 17522070 21278145 19336974 15968718 11566570 19085960 6623471 16177239 3732212 10915739 4309450 10092053 15027814 7179309 6884620 16227642 7440962 7120509 15998439 9327722 3786805
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.5912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.1615991576 16613094 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.9416707586
MESH:D004487 Edema pirinixic acid 2.3312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7715138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9419294695
MESH:D016889 Endometrial Neoplasms Folic Acid 3.9017301261
MESH:D017889 Exfoliation Syndrome Folic Acid 12.8116504073
MESH:D017889 Exfoliation Syndrome Homocysteine 12.8116504073
MESH:D005218 Fat Necrosis Thioacetamide 5.5516456712
MESH:D005234 Fatty Liver Amiodarone 23.0014986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.0012795759 16045604 12631006 16239168 61145 17595544 19224547 15959796
MESH:D005234 Fatty Liver Clofibrate 23.0019224547
MESH:D005234 Fatty Liver Cyclosporine 23.0019224547
MESH:D005234 Fatty Liver pirinixic acid 23.0020131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Cyclosporine 8.1012639820 12168785
OMIM:229050 FOLATE MALABSORPTION, HEREDITARY marker/mechanism
MESH:D005756 Gastritis Acetaminophen 10.7016983495
MESH:D005756 Gastritis Folic Acid 10.7017171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005901 Glaucoma Folic Acid 11.3116504073
MESH:D005901 Glaucoma Homocysteine 11.3116504073
MESH:D006086 Graft vs Host Disease Methotrexate 4.9816518429
MESH:D006258 Head and Neck Neoplasms decitabine 3.3719215824
MESH:D006330 Heart Defects, Congenital Folic Acid 7.1917286298 16524890
MESH:D006330 Heart Defects, Congenital Homocysteine 7.1919638421
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4218665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9319110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.9316456712
MESH:D006529 Hepatomegaly Amiodarone 8.0115265979
MESH:D006529 Hepatomegaly pirinixic acid 8.0118467677 19176532 19772884 16221962
MESH:D006679 HIV Seropositivity Folic Acid 5.3217209195
MESH:D006712 Homocystinuria 5-methyltetrahydrofolate 6.6517413090
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.729751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D020138 Hyperhomocysteinemia marker/mechanism 19204075
MESH:D020138 Hyperhomocysteinemia Folic Acid 9.3516433478 16865747 16755160 16395265 16397167
MESH:D020138 Hyperhomocysteinemia Homocysteine 9.3518234410 17292331 17369066
MESH:D006973 Hypertension Cyclosporine 2.0410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007037 Hypothyroidism Amiodarone 11.0417991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.048137927 18031379
MESH:D007248 Infertility, Male decitabine 7.2117581917
MESH:D007248 Infertility, Male Sulfasalazine 7.2110689203
MESH:D007249 Inflammation Heme 4.2412649161
MESH:D015212 Inflammatory Bowel Diseases Sulfasalazine 4.6115339030
MESH:D007333 Insulin Resistance pirinixic acid 2.5216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.6912587719 15629191
MESH:D007674 Kidney Diseases Cadmium 13.6916226777 16962696 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 13.6916962696
MESH:D007674 Kidney Diseases Cyclosporine 13.698314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6012371664
MESH:D007805 Language Development Disorders Methotrexate 4.949562676
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9619248655
MESH:D007938 Leukemia decitabine 2.9918980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.8517236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3518704418 18460780 19387464 19010910 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2918055864
MESH:D008064 Lipidoses Amiodarone 3.3915342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6217157831 11408273 16943688 11903743 21278145 16221502 16239168 17334410 17174718
MESH:D008103 Liver Cirrhosis Methotrexate 6.6214986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9018420326 12445421 14512876 16136751 15057751 18412020 18395095 15338365 10355542 17708605 12389079 15876570 17565644 18472332 18006644 17869086 18481824 12898905 15370692 12632514 15052691 12667390 17698563 14716496 17944888 17557913 16011737 12546737 18054572 18429990 15931870 17481882 18166357 17525996 12609069 15673190 16097048 18187930 20821823 12649538 16116963 17714472 12445418 18156304 16033810 15362042 13678700 12586293 15650968 18277467 17976157 18418968 18705752 12632512 17900296 18472094 15925388 18251166 18263696 12666154 18279442 17823541 14724832 16192424 17721639 15996030 15959796 18395914 18317297 12741479 14620537 16248980 15893842 17761835 11481614 15818738 18205269 18210741 16638106 17766677 14716833 12958196 17922224 16015684 17640975 18339082 14748882 17631135 15730626 16027843 15123356 17805973 18376398
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9015474484
MESH:D008106 Liver Cirrhosis, Experimental Sulfasalazine 4.9015633128
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.9018606216 15075984 18031379 16098781 12085344 15288473 11172339 18263696 15716488 12679928 12557150 11682029 17292413 14739098 15095483 11481614 18615449 18395095 15288472 17127702 12891558 16097051 15158331 12531686 15465738 15078482 17629604 17050028 16248980 10677585 17355460 18416461 16343077 16126171 18380797 16489207 18458672 15334695 18032466 18295389 12175628 15474484 16511523 15362042 15316131
MESH:D008107 Liver Diseases Acetaminophen 9.0719460945 11587558 12969438 16610002 19784758 19014921 12587719 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.0716964402 17285989 16246199 15830285 15720792
MESH:D008107 Liver Diseases Folic Acid 9.0716877991
MESH:D008107 Liver Diseases Thioacetamide 9.0716337175 18374380 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.3816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.3814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.3815633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.2219294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.2216377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.5112014681 15583823
MESH:D008133 Long QT Syndrome Amiodarone 3.4515350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.9718516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 10.9718516814
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2917718048
MESH:D008223 Lymphoma decitabine 7.5019470736
MESH:D008223 Lymphoma Methotrexate 7.5017352296
MESH:D008286 Malabsorption Syndromes marker/mechanism 17129779 17446347
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5216832597
MESH:D008545 Melanoma decitabine 2.2217785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008591 Meningomyelocele Homocysteine 5.3716602021
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D052016 Mucositis Methotrexate 5.1117488658
MESH:D009101 Multiple Myeloma decitabine 3.2318172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009181 Mycoses Amiodarone 4.7312754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2916882708 19157545 18608210 19010910
MESH:D009203 Myocardial Infarction Homocysteine 5.7617412321
MESH:D009203 Myocardial Infarction pirinixic acid 5.7619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8116411023
MESH:D009369 Neoplasms decitabine 4.7419116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 4.7417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009436 Neural Tube Defects 5-methyltetrahydrofolate 8.0617413090
MESH:D009436 Neural Tube Defects Folic Acid 8.0617438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D009503 Neutropenia Folic Acid 4.3416322990
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.779802331
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010051 Ovarian Neoplasms decitabine 2.6019259094 19331143
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7119294695
MESH:D010198 Pancytopenia marker/mechanism 21346251
MESH:D010300 Parkinson Disease Homocysteine 3.5116275827
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.2115687053
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D055728 Primary Myelofibrosis decitabine 4.5617616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6115572423
MESH:D011471 Prostatic Neoplasms Cadmium 3.7117075824
MESH:D011471 Prostatic Neoplasms Calcitriol 3.7116289102 15754350 16644109 18247401 12479363
MESH:D011565 Psoriasis Cyclosporine 5.7116882103
MESH:D011565 Psoriasis Methotrexate 5.7117410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7911597910 12490602 12832656
MESH:D051437 Renal Insufficiency Folic Acid 10.1315728788
MESH:D051437 Renal Insufficiency Methotrexate 10.1317352296
MESH:D015427 Reperfusion Injury Leucovorin 6.7817295595
MESH:D015427 Reperfusion Injury pirinixic acid 6.7819058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.2419155313
MESH:D012559 Schizophrenia Folic Acid 4.1816641680
MESH:D012559 Schizophrenia Homocysteine 4.1816641680
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9118724381
MESH:D012871 Skin Diseases Folic Acid 3.2118709164
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3216361298
MESH:D013272 Stomach Diseases Omeprazole 4.4418545984
MESH:D013274 Stomach Neoplasms decitabine 2.8319037991
MESH:D013274 Stomach Neoplasms Folic Acid 2.8317171786
MESH:D013276 Stomach Ulcer Amiodarone 7.0618087811
MESH:D013276 Stomach Ulcer Omeprazole 7.0616755016 18237397 10750652 17977527 11906479 15991576
MESH:D020521 Stroke Folic Acid 4.1916517955
MESH:D013576 Syndactyly Methotrexate 4.879562676
MESH:D013610 Tachycardia Amiodarone 4.1211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0219225199
MESH:D013959 Thyroid Diseases Amiodarone 4.5919731979
MESH:D013964 Thyroid Neoplasms decitabine 7.1117967635
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.1115710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6919584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.0217467628 11989578
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.6617616700 19087683
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014604 Uveal Neoplasms decitabine 4.7417785578
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014947 Wounds and Injuries Heme 5.1412649161
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
REACT:11193 Metabolism of vitamins and cofactors
KEGG:04978 Mineral absorption
REACT:15518 Transmembrane transport of small molecules
KEGG:04977 Vitamin digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162403775
    • No data
    Releated disease ID Related disease Name
    PA444857Malabsorption Syndromes
    Releated drug ID Related drug Name
    PA449789glycine
    PA451330l-serine
    PA450428methotrexate
    PA449692folic acid
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00158 substrate Folic Acid Dietary supplement;Micronutrient;Vitamin B Complex;Hematinics
    DB00563 inhibitor Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB00795 inhibitor Sulfasalazine Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved