AutismKB 2.0

Annotation Detail for CHRM5


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Basic Information Top
Gene Symbol:CHRM5 ( HM5,MGC41838 )
Gene Full Name: cholinergic receptor, muscarinic 5
Band: 15q14
Quick LinksEntrez ID:1133; OMIM: 118496; Uniprot ID:ACM5_HUMAN; ENSEMBL ID: ENSG00000184984; HGNC ID: 1954
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
Desease Name
CHEMDEPENDENCY
alcohol consumption
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C042375 4-diphenylacetoxy-1,1-dimethylpiperidinium 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRM5 mRNAaffects expression 16483693
D000661 Amphetamine CHRM5 protein affects the susceptibility to Amphetamineaffects response to substance 15213703
D000661 Amphetamine CHRM5 protein mutant form results in decreased susceptibility to Amphetaminedecreases response to substance 15213703
D001285 Atropine Atropine binds to and results in decreased activity of CHRM5 proteinaffects binding|decreases activity 17613726
D004390 Chlorpyrifos Chlorpyrifos affects the expression of CHRM5 mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of CHRM5 mRNAdecreases expression 17452286
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 10845706
D003435 Crotalid Venoms Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM5 protein]affects binding|decreases reaction 10845706
D003976 Diazinon Diazinon affects the expression of CHRM5 mRNAaffects expression 17452286
D004026 Dieldrin Dieldrin results in increased expression of CHRM5 mRNAincreases expression 18812211
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of CHRM5 mRNAdecreases expression 15620428
C113497 dimethyl-W84 CHRM5 protein binds to dimethyl-W84affects binding 16641315
C113497 dimethyl-W84 [CHRM5 protein binds to dimethyl-W84] affects the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D004298 Dopamine CHRM5 gene mutant form results in decreased secretion of Dopaminedecreases secretion 15213703
D004298 Dopamine CHRM5 protein affects the secretion of Dopamineaffects secretion 15213703
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of CHRM5 geneincreases mutagenesis 16495775
D005703 Gallamine Triethiodide CHRM5 protein binds to Gallamine Triethiodideaffects binding 16641315
D005703 Gallamine Triethiodide [CHRM5 protein binds to Gallamine Triethiodide] affects the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D005703 Gallamine Triethiodide [CHRM5 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|increases reaction 15937215
D005703 Gallamine Triethiodide Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
C054938 methoctramine methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine [CHRM5 protein binds to dimethyl-W84] affects the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D019832 N-Methylscopolamine [CHRM5 protein binds to Gallamine Triethiodide] affects the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|affects reaction 16641315
D019832 N-Methylscopolamine [CHRM5 protein binds to Gallamine Triethiodide] promotes the reaction [CHRM5 protein binds to N-Methylscopolamine]affects binding|increases reaction 15937215
D019832 N-Methylscopolamine CHRM5 protein binds to N-Methylscopolamineaffects binding 16641315
D019832 N-Methylscopolamine Crotalid Venoms inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 10845706
D019832 N-Methylscopolamine Gallamine Triethiodide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine N-Methylscopolamine binds to CHRM5 proteinaffects binding 10845706
9846649
D019832 N-Methylscopolamine Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Tropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D019832 N-Methylscopolamine Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D010197 Pancuronium Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D017300 Pipecuronium Pipecuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D010890 Pirenzepine Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D011813 Quinuclidinyl Benzilate Crotalid Venoms inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM5 protein]affects binding|decreases reaction 10845706
D011813 Quinuclidinyl Benzilate Quinuclidinyl Benzilate binds to CHRM5 proteinaffects binding 10845706
C061870 rocuronium rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CHRM5 mRNAdecreases expression 20055451
D014331 Tropicamide Tropicamide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
D014673 Vecuronium Bromide Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]affects binding|decreases reaction 9846649
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.206734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000236 Adenoma Ethylnitrosourea 3.636695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.6717119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.6716487989
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.9018475255 16916582 16459022 15010207
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000855 Anorexia Amphetamine 4.8812005258 16101753 12183048 16084549
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7514991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1616357521 16651633 15144691 16436596 18412241
MESH:D001943 Breast Neoplasms Atropine 2.2212762645
MESH:D001943 Breast Neoplasms Dieldrin 2.2215770527 11859874
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.6216003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8317160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 12621046 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.9816882537
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003967 Diarrhea Atropine 4.8110867622
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004381 Duodenal Ulcer Atropine 10.0511595415
MESH:D004381 Duodenal Ulcer Pirenzepine 10.0516613094
MESH:D004417 Dyspnea Diazinon 4.6516487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8318357618
MESH:D004487 Edema Crotalid Venoms 7.1419703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005221 Fatigue Amphetamine 5.4519890266
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005909 Glioblastoma Ethylnitrosourea 3.7316436596
MESH:D005910 Glioma Ethylnitrosourea 3.4316651633 16357521 18412241
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006470 Hemorrhage Crotalid Venoms 10.3617537475
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 10.3611000095
MESH:D006505 Hepatitis Diazinon 4.4316487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 15340226 16354765 18606429 16959395
MESH:D006948 Hyperkinesis Amphetamine 5.281977408 14960337
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518850075 18670907
MESH:D007022 Hypotension Dopamine 4.876740701
MESH:D007247 Infertility, Female Dieldrin 4.7910630421
MESH:D007248 Infertility, Male Diazinon 3.7212948887 16466525
MESH:D007249 Inflammation Crotalid Venoms 5.5417537475
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.8117379185
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2312878042
MESH:D008107 Liver Diseases Chlorpyrifos 3.0415991261
MESH:D008113 Liver Neoplasms Dieldrin 7.378742319 9539021
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 7.3711940454
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0212151625
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.5316271038 17703301 16019985 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5319555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 3.8315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.9015375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.4218041768 10767621 10838139
MESH:D008579 Meningioma Ethylnitrosourea 5.8317943659
MESH:D015878 Mydriasis Tropicamide 7.2016308726
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D009216 Myopia Atropine 9.2212601066
MESH:D009216 Myopia Pirenzepine 9.2212601066
MESH:D009369 Neoplasms Dieldrin 3.408820588
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.2516707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2617160924 16651423 16003739
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.5215183010
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0615081274
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8317160924
MESH:D010300 Parkinson Disease Dieldrin 3.4711181820 11445065 17291500 16809432 16112328
MESH:D020734 Parkinsonian Disorders Tropicamide 5.6217594079
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D011041 Poisoning Atropine 9.0417849254 18072136
MESH:D011041 Poisoning Diazinon 9.0417603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411896295 11399792 11118676 11222880
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4816611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.7417119214 16611668
MESH:D012640 Seizures Atropine 4.2812660363 11218047 17157343
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.946418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.271977408
MESH:D013276 Stomach Ulcer Atropine 4.6111595415
MESH:D013742 Tetanus Vecuronium Bromide 7.012903605
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.0115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D014202 Tremor Atropine 11.4417594079
MESH:D014202 Tremor Tropicamide 11.4419467297 17594079
MESH:D014570 Urologic Diseases Diazinon 5.1316487989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26486
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00340 antagonist Metixene Antiparkinson Agents;Muscarinic Antagonists
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00376 antagonist Trihexyphenidyl Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists
    DB00420 binder Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00496 antagonist Darifenacin Muscarinic Antagonists;Urinary antispasmodics
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00572 antagonist Spascupreel Tablets Mydriatics;Bronchodilator Agents;Adjuvants, Anesthesia;Muscarinic Antagonists;Anti-Arrhythmia Agents;Parasympatholytics
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00725 antagonist Debiline H Anti-Ulcer Agents;Antispasmodics;Antimuscarinics
    DB00747 antagonist Scopolamine Mydriatics;Adjuvants, Anesthesia;Muscarinic Antagonists;Antispasmodics;Cholinergic Antagonists;Antimuscarinics;Adjuvants
    DB00767 antagonist Benzquinamide Antiemetics;Antipsychotics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00785 antagonist Cryptenamine Antihypertensive Agents
    DB00835 antagonist Tantapp Elixir Anti-Allergic Agents;Histamine H1 Antagonists
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01036 antagonist Tolterodine Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents;Genitourinary Smooth Muscle Relaxants
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01591 antagonist Solifenacin Muscarinic Antagonists;Antispasmodics;Anti-Incontinence Agents
    DB06702 antagonist Fesoterodine Antispasmodics;Anti-Incontinence Agents;Antimuscarinics;Genitourinary Smooth Muscle Relaxants
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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