AutismKB 2.0

Annotation Detail for ACOT7


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Basic Information Top
Gene Symbol:ACOT7 ( ACH1,ACT,BACH,CTE-II,LACH,LACH1,MGC1126,RP1-120G22.10,hBACH )
Gene Full Name: acyl-CoA thioesterase 7
Band: 1p36.31
Quick LinksEntrez ID:11332; OMIM: 602587; Uniprot ID:BACH_HUMAN; ENSEMBL ID: ENSG00000097021; HGNC ID: 24157
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5972stearate biosynthesis I (animals)
PWY-5148acyl-CoA hydrolysis
Pathway IDPathway Name
hsa01040Biosynthesis of unsaturated fatty acids
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
Desease Name
CARDIOVASCULAR
QT interval
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of ACOT7 mRNAaffects expression 18343893
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACOT7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ACOT7 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACOT7 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ACOT7 mRNAincreases expression 15003993
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of ACOT7 mRNAaffects cotreatment|affects expression 18636392
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOT7 mRNAaffects cotreatment|affects expression 17602206
D004041 Dietary Fats Dietary Fats results in increased expression of ACOT7 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOT7 mRNAaffects cotreatment|affects expression 17602206
D005472 Fluorouracil ACOT7 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D007657 Ketone Bodies Ketone Bodies results in increased expression of ACOT7 mRNAincreases expression 16807920
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of ACOT7 mRNAaffects cotreatment|affects expression 18636392
C041786 palm oil palm oil results in increased expression of ACOT7 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACOT7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ACOT7 mRNAincreases expression 17426115
18301758
15375163
C006253 pirinixic acid pirinixic acid results in increased expression of ACOT7 mRNAincreases expression 16940010
D011374 Progesterone Progesterone affects the expression of ACOT7 mRNAaffects expression 17251523
C037219 quinoline quinoline analog results in increased expression of ACOT7 proteinincreases expression 18645022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACOT7 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACOT7 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ACOT7 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACOT7 mRNAincreases expression 15328365
19684285
16960034
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury Chlorine 9.0920601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.0918653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4217638652
MESH:D000236 Adenoma Diethylnitrosamine 2.846695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2417620307 17162532 19061943 18056438 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Fluorouracil 8.6217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Dietary Fats 2.3320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3317474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.3319217205 18608205 18357371 15136595 16110121 16557594 16595493
MESH:D001943 Breast Neoplasms Progesterone 2.3317614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6618417511 14754758 18315731 17626835 15516495 19059883 16777450
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6716051944
MESH:D002277 Carcinoma Fluorouracil 8.1317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.863084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.8617055752 20514400 18978308 3084413 18691550 16569478 18665156 19052882 19919837 18210153 19208518 16328049 19107877 20727157 16681979 16502159 19418558 18393292 17162532 18788625 20512989 16878318 10672840 17761372 20101231 16935385 19383236 20214788 18494052 21159647 18971187 17428255 20432363 19822196 18056438 20007298 10737359 19519916 19335982 19701751 16807293 18785209 16288022 19394651 17173139 16779866 16540662 17978847 20084675 20524982 11831363 19171122 17138121 16830150 18506893 20935162 19539802 16698587 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.8617045692 17971768 16332177 18930000 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular quinoline 8.86598648
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.4916280240 17066447 18986760 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.656135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.657505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 15340226 16354765 15668235 8697196
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2315001691 17018589 16510598 17016597 17725105 16340194 17172411 17169374 17287894 18772588
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017016601 18802399 17594712 18383874 14970324 17454858 15289873 16303861 18949393 20501625 18288408 18509181 17401013 17695437 15148649 16524972 16331619 18448328 17094418 16282729 17255274 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9016393943 16781746 11743745 18713872 12540782 19739265 10774834 11287661 14550746 14725611 17562736 18071297 11529661 12705907 19370779 10663392 16485898 19416960 12392966 11461765 11739529 10915739 12153990 2444490 11421492 16109766 12594235 11834606 16227642 16081117 16177239 12958197 19164858 15968718 19923254 19420014 14986274 17906064 17522070 15619225 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7617692515
MESH:D004715 Endometriosis Progesterone 8.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4415173087 16481741 17638652 16785472 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Dietary Fats 13.0017967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 13.0020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.0020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Dietary Fats 8.5818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5820067830
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3718337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 6.9411294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006390 Hemangioendothelioma quinoline 5.90598648
MESH:D006394 Hemangiosarcoma quinoline 4.97598648
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2219176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2216120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16959395 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007249 Inflammation Dietary Fats 11.8720412841
MESH:D007249 Inflammation Diethylnitrosamine 11.8718785209
MESH:D007249 Inflammation Progesterone 11.8715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.8712878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.2011836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.4216705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.4216985049
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6018522880 20032147 18407596 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1312878042
MESH:D008107 Liver Diseases Acetaminophen 3.8919014921 16611625 11587558 19784758 16610002 12969438 19460945 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.897678174
MESH:D008113 Liver Neoplasms Clofibric Acid 17.8917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.8918644402 19499222 18754104 10737359 18977376 20405173 20452335 19996281 19812893 19255062 19294768 19833225 2862719 21047994 18978307 19256749 19090486 19638242 18648771 20137499 19254457 19073162 20434301 21278145 20101389 19427195 15175105 9163691 21071580 19426721 20118626 20492335 19850985 20583210 19551842 12112319 19642983 12771043 15885732 16942905 2422723 19690152 21167192 20501860
MESH:D008113 Liver Neoplasms Fluorouracil 17.8915113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 17.8920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.8916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.712876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.719362446 17942915 18308698 18164116 19004024 18093689 19519916 19126423 17854601 3124819 21159647 18253720 16842330 18282651 17174075 18775883 2563599 19539802 18079962 19009564 18544905 16267830
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7112151625
MESH:D008171 Lung Diseases Ozone 3.368266340 19066396
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.846695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 4.8415246190
MESH:D008175 Lung Neoplasms Ozone 4.848597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8511408345 17203775
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6118986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.857678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.253581430 9029167
MESH:D009362 Neoplasm Metastasis quinoline 6.25598648
MESH:D009369 Neoplasms Fluorouracil 4.9518600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009765 Obesity Dietary Fats 4.4221332399 18674790 20518802 19632207 11836018 16723640 20132043 18457598 17217161
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4116049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5216525653 17393432
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3015113037 16929163 19003803 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D011014 Pneumonia Ozone 4.3918007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4218626508 19082440
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9918286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5218551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.568532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.2716503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4915786421 17522103 17172411 18567086 16424979 16951190 17498489 18396642 19084572 19015929
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8616803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
Pathway ID Pathway Name
KEGG:01040 Biosynthesis of unsaturated fatty acids
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142672655
    • No data
    Releated disease ID Related disease Name
    PA446329Motor Neuron Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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