AutismKB 2.0

Annotation Detail for U2AF2


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Basic Information Top
Gene Symbol:U2AF2 ( U2AF65 )
Gene Full Name: U2 small nuclear RNA auxiliary factor 2
Band: 19q13.43
Quick LinksEntrez ID:11338; OMIM: 191318; Uniprot ID:U2AF2_HUMAN; ENSEMBL ID: ENSG00000063244; HGNC ID: 23156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500570Cleavage of Growing Transcript in the Termination Region
500928Transport of Mature mRNA derived from an Intron-Containing Transcript
500105mRNA 3'-end processing
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of U2AF2 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of U2AF2 mRNAincreases expression 17879257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0720127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.443712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.446695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.8419183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.0911289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9817474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.787296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1520419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5518759878 8970840 2524372 11298694 14531868 11906362 12868966 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.102952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.069653073 9328219 6482804 1440618 18692083 16192314 18289764 6679447 11289319 7440962 8291058 9022650 18648102
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.683581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8720471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.099022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1821137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.803712494 598648 6587162 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718569708 20464547 18816296 20869020 6695378 18520028 20135361 20064080 17053015
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5716381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3611141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.926482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.261399818 3712494 7505956 6582329 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
REACT:78 Post-Elongation Processing of the Transcript
KEGG:03040 Spliceosome
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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