AutismKB 2.0

Annotation Detail for TWF2


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Basic Information Top
Gene Symbol:TWF2 ( A6RP,A6r,PTK9L )
Gene Full Name: twinfilin, actin-binding protein, homolog 2 (Drosophila)
Band: 3p21.2
Quick LinksEntrez ID:11344; OMIM: 607433; Uniprot ID:TWF2_HUMAN; ENSEMBL ID: ENSG00000173366,ENSG00000247596; HGNC ID: 9621
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TWF2 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of TWF2 mRNAaffects expression 17562736
D008628 Mercury Mercury results in decreased expression of TWF2 mRNAdecreases expression 16823088
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 5.5216634805
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5710334427
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.066135515
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.6718551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.4316823706
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0512540782 19370779 11287661 16485898 11739529 16393943 11743745 16227642 10663392 16781746 12153990 12958197 14550746 11834606 11529661 2444490 12705907 16109766 17906064 19923254 10915739 19739265 10774834 14986274 17562736 14725611 19420014 18713872 19164858 19085960 15619225 19416960 12594235 16177239 18071297 11461765 15968718 12392966 17522070 11421492 16081117
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007674 Kidney Diseases Acetaminophen 7.0015629191 12587719
MESH:D007674 Kidney Diseases Mercury 7.0017934191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.3616705839
MESH:D008107 Liver Diseases Acetaminophen 1.7112969438 11587558 19014921 12587719 16610002 19784758 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.287678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.792876786 6135515 2876784
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.607678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8816049721
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8218551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.0610091137
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162407429
    • No data
    Releated disease ID Related disease Name
    PA444859Malaria
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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