AutismKB 2.0

Annotation Detail for CHRNA2


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Basic Information Top
Gene Symbol:CHRNA2 ( - )
Gene Full Name: cholinergic receptor, nicotinic, alpha 2 (neuronal)
Band: 8p21.2
Quick LinksEntrez ID:1135; OMIM: 118502; Uniprot ID:ACHA2_HUMAN; ENSEMBL ID: ENSG00000120903; HGNC ID: 1956
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
No data
No data
Desease Name
Epilepsy, nocturnal frontal lobe, type 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C043958 2-butanol 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D000109 Acetylcholine 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D000109 Acetylcholine Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]affects binding|increases reaction|increases transport 11821649
D000109 Acetylcholine CHRNA2 gene mutant form affects the susceptibility to Acetylcholineaffects response to substance 19383498
D000109 Acetylcholine crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D000109 Acetylcholine tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRNA2 mRNAaffects expression 16483693
D001464 Barium 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D001464 Barium 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D001464 Barium 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D001464 Barium 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D001464 Barium Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]affects binding|increases reaction|increases transport 11821649
D001464 Barium [CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Bariumaffects binding|increases transport 11821649
D001464 Barium crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D001464 Barium isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D001464 Barium n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D001464 Barium tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
C095105 bexarotene bexarotene results in increased expression of CHRNA2 mRNAincreases expression 16648578
D020001 1-Butanol 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNAaffects cotreatment|decreases expression 20360939
D002220 Carbamazepine CHRNA2 gene mutant form affects the susceptibility to Carbamazepineaffects response to substance 19383498
D002995 Clofibric Acid Clofibric Acid affects the expression of CHRNA2 mRNAaffects expression 17602206
C007153 crotonyl alcohol crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
D003976 Diazinon Diazinon results in decreased expression of CHRNA2 mRNAdecreases expression 18812211
D003976 Diazinon Diazinon results in increased expression of CHRNA2 mRNAincreases expression 17452286
D004026 Dieldrin Dieldrin results in decreased expression of CHRNA2 mRNAdecreases expression 18812211
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNAaffects cotreatment|decreases expression 20360939
D005419 Flavonoids Flavonoids results in increased expression of CHRNA2 mRNAincreases expression 18035473
C040507 isobutyl alcohol isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|affects reaction|increases reaction|increases transport 11821649
D009532 Nickel Nickel results in decreased expression of CHRNA2 mRNAdecreases expression 18812211
D009538 Nicotine CHRNA2 gene mutant form affects the susceptibility to Nicotineaffects response to substance 19383498
C024999 n-pentanol n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CHRNA2 mRNAincreases expression 16221955
C006253 pirinixic acid pirinixic acid results in increased expression of CHRNA2 mRNAincreases expression 17426115
18301758
C006253 pirinixic acid pirinixic acid results in increased expression of CHRNA2 mRNAincreases expression 12832660
D019840 2-Propanol 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D000433 1-Propanol 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|increases reaction|increases transport 11821649
D020002 tert-Butyl Alcohol tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]affects binding|decreases reaction|increases reaction|increases transport 11821649
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.398986270
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D055371 Acute Lung Injury Nickel 8.7716166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.7718653653
MESH:D000236 Adenoma Diethylnitrosamine 2.766695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5916434500 19052882 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5916434500
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.1816487989
MESH:D000544 Alzheimer Disease Nicotine 3.2516627626
MESH:D001259 Ataxia 1-Butanol 5.447820390
MESH:D001714 Bipolar Disorder Carbamazepine 4.0617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0119483382
MESH:D001943 Breast Neoplasms bexarotene 2.0816818667 16344269
MESH:D001943 Breast Neoplasms Dieldrin 2.0815770527 11859874
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0817474063
MESH:D001943 Breast Neoplasms Nickel 2.0815986119
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8316698587 16681979 20084675 20727157 19394651 20101231 19335982 19383236 3581430 18665156 18978308 10737359 17428255 20432363 18785209 16878318 16807293 18971187 20935162 19208518 16540662 18393292 16830150 17055752 11831363 20514400 19519916 19919837 20524982 20512989 19701751 18691550 21159647 10672840 19171122 16502159 19539802 16328049 20007298 19052882 17173139 19418558 19822196 16935385 17138121 19107877 17978847 17761372 18506893 18056438 16779866 18210153 16288022 16569478 18494052 17162532 18788625 3084413 20214788
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1816247446
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7521159647 7505956 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5619052882
MESH:D002779 Cholestasis pirinixic acid 2.7119176532
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.949014606
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.8019470301 17100760 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003877 Dermatitis, Contact Nickel 4.492952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1620387270
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.2911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3216538176 16538175 15057820 20216337
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.2117465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2119107877
MESH:D004362 Drug Toxicity Carbamazepine 4.3420216337
MESH:D004417 Dyspnea Diazinon 4.6516487989
MESH:D020821 Dystonic Disorders Nicotine 5.7717881519
MESH:D004487 Edema perfluorooctanoic acid 6.5317259670 12083418
MESH:D004487 Edema pirinixic acid 6.5312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.5917654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1116415921 19915237 18855540 16538176 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.0617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.8217116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 3.927988514 821787 20417680 19620853 17178248 19439326 18234410 19700373 9014606 17465707
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.207750514
OMIM:610353 EPILEPSY, NOCTURNAL FRONTAL LOBE, TYPE 4 marker/mechanism 19383498
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.9715276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.5719549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D005076 Exanthema Carbamazepine 5.3120485159
MESH:D005234 Fatty Liver Diethylnitrosamine 7.2220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 7.2220131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006505 Hepatitis Diazinon 4.4316487989
MESH:D006529 Hepatomegaly perfluorooctanoic acid 8.203609246
MESH:D006529 Hepatomegaly pirinixic acid 8.2016221962 18467677 19176532 19772884
MESH:D015658 HIV Infections Nickel 3.7417263646
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.7312083418
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6010459572
MESH:D006965 Hyperplasia Carbamazepine 5.0618773962
MESH:D007247 Infertility, Female Dieldrin 4.7910630421
MESH:D007248 Infertility, Male Diazinon 3.7212948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 11.4218785209
MESH:D007249 Inflammation Flavonoids 11.4217296493
MESH:D007249 Inflammation Nickel 11.4216166738
MESH:D007249 Inflammation perfluorooctanoic acid 11.4212083418
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4510783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.4615369732
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.8916766008
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.088812269
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7418665156 19638242 20032147 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0617034775
MESH:D008113 Liver Neoplasms Clofibric Acid 13.6717602206
MESH:D008113 Liver Neoplasms Dieldrin 13.678742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.6720492335 19254457 2422723 19090486 2862719 18977376 19642983 15885732 21047994 19812893 21071580 15175105 21167192 20434301 9163691 20501860 19256749 18644402 19996281 18754104 19255062 19850985 20583210 20452335 20405173 20101389 10737359 19551842 19073162 20118626 19690152 19294768 21278145 18978307 19833225 18648771 16942905 19427195 12112319 19638242 20137499 19499222 19426721 12771043
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.6718709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 13.6715890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.5421159647 18253720 18544905 16842330 18079962 9362446 18775883 17942915 19539802 18308698 2563599 3124819 19004024 19519916 17854601 18282651 17174075 18164116 19009564 19126423 16267830 18093689
MESH:D008175 Lung Neoplasms bexarotene 2.6817849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6820970405 21163286 20512841 6695378
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5316628512
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0011161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.3115591091 19196723 19196722
MESH:D008607 Mental Retardation Carbamazepine 3.679014606
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009224 Myotonia Congenita Carbamazepine 5.3120399394
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.513581430 9029167
MESH:D009369 Neoplasms Dieldrin 8.098820588
MESH:D009369 Neoplasms Nicotine 8.0916365874
MESH:D009369 Neoplasms pirinixic acid 8.0917405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.6319196722
MESH:D009389 Neovascularization, Pathologic Nicotine 4.8416365874
MESH:D009421 Nervous System Malformations Carbamazepine 4.7616990009
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.809802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010018 Osteomalacia Carbamazepine 5.3117016548
MESH:D010146 Pain Carbamazepine 3.9115215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3716540662
MESH:D010267 Parapsoriasis Carbamazepine 5.5516538176
MESH:D010300 Parkinson Disease Dieldrin 3.4716809432 17291500 16112328 11445065 11181820
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.7717679678 17145499
MESH:D011041 Poisoning Diazinon 4.2117603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.422563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.009014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.799014606
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.7917132714
MESH:D019310 Pseudolymphoma Carbamazepine 5.4512752131 9591791
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.149413022
MESH:D012640 Seizures Carbamazepine 6.4615946322 9046859 16180713 9844417 16876388 16938433 19414003
MESH:D012640 Seizures Nicotine 6.4617873105
MESH:D012893 Sleep Disorders Carbamazepine 4.9719414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.0619915237 16538176 19694795 15057820 20485159 18855540 16415921
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.877505956
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6216720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.3018305452 18041664 15735609 17979512
MESH:D014570 Urologic Diseases Diazinon 5.1316487989
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26489
    • No data
    Releated disease ID Related disease Name
    PA445876Tobacco Use Disorder
    PA152238518Epilepsy, Autosomal Dominant Nocturnal Frontal Lobe
    Releated drug ID Related drug Name
    PA448687bupropion
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00184 agonist Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00411 agonist Carbachol Cardiotonic Agents;Analgesics, Non-Narcotic;Cholinergic Agonists;Miotics
    DB00416 antagonist Metocurine Iodide Anesthetics, Local;Neuromuscular Nondepolarizing Agents
    DB00483 inhibitor Gallamine Triethiodide Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB00514 antagonist Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
    DB00565 blocker Cisatracurium Besylate Neuromuscular Blocking Agents
    DB00657 blocker Mecamylamine Antihypertensive Agents;Nicotinic Antagonists;Ganglionic Blockers
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00721 antagonist Procaine Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00728 antagonist Rocuronium Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents
    DB00732 blocker Atracurium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB00810 antagonist Biperiden Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Parasympatholytics
    DB01135 antagonist Doxacurium chloride Neuromuscular Nondepolarizing Agents
    DB01199 antagonist Tubocurarine Skeletal Muscle Relaxants;Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01226 antagonist Mivacurium Neuromuscular Nondepolarizing Agents
    DB01245 partial agonist Decamethonium Neuromuscular Depolarizing Agents
    DB01334 antagonist Doxacurium Neuromuscular Nondepolarizing Agents
    DB01336 antagonist Metocurine Neuromuscular Nondepolarizing Agents
    DB01337 antagonist Pancuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01338 antagonist Pipecuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    DB01339 antagonist Vecuronium Neuromuscular Nondepolarizing Agents;Nicotinic Antagonists
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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