AutismKB 2.0

Annotation Detail for HELQ


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Basic Information Top
Gene Symbol:HELQ ( HEL308,MGC20604 )
Gene Full Name: helicase, POLQ-like
Band: 4q21.23
Quick LinksEntrez ID:113510; OMIM: 606769; Uniprot ID:HELQ_HUMAN; ENSEMBL ID: ENSG00000163312; HGNC ID: 18536
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HELQ mRNAincreases expression 18687144
D016572 Cyclosporine Cyclosporine results in decreased expression of HELQ mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8512371664
MESH:D002779 Cholestasis Cyclosporine 3.2819486331
MESH:D005234 Fatty Liver Cyclosporine 3.4019224547
MESH:D005355 Fibrosis Cyclosporine 3.9012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 5.118708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.3115720958
MESH:D006973 Hypertension Cyclosporine 2.2410903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.5115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.588314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1712371664
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.7817365036
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3318303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.8616801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.5117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7518481113 19348381
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.6610923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.6912371664
MESH:D011565 Psoriasis Cyclosporine 2.3516882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1717365031 17322281 17975199 15814490
MESH:D014605 Uveitis Cyclosporine 5.051336536
MESH:D014985 Xerophthalmia Cyclosporine 5.5117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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