AutismKB 2.0

Annotation Detail for CHRNA3


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Basic Information Top
Gene Symbol:CHRNA3 ( LNCR2,MGC104879,NACHRA3,PAOD2 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 3
Band: 15q25.1
Quick LinksEntrez ID:1136; OMIM: 118503; Uniprot ID:ACHA3_HUMAN; ENSEMBL ID: ENSG00000080644; HGNC ID: 1957
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1983Down syndrome
2066Lung cancer
Desease Name
CARDIOVASCULAR
CHEMDEPENDENCY
nicotine dependence
CANCER
lung adenocarcinoma
chronic obstructive pulmonary disease
lung cancer
smoking
Desease Name
Nicotine dependence
Lung adenocarcinoma
Chronic obstructive pulmonary disease
Smoking behavior
Lung cancer
Desease Name
Lung cancer susceptibility 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C041594 4-nonylphenol 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
C041594 4-nonylphenol 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
C080417 4-octylphenol 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D000109 Acetylcholine 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|increases activity 15885267
D000109 Acetylcholine bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D000109 Acetylcholine Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D000109 Acetylcholine Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D000109 Acetylcholine Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|increases activity 15885267
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRNA3 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
C006780 bisphenol A bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D012721 Carbaryl Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
D012721 Carbaryl Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D003976 Diazinon Diazinon results in decreased expression of CHRNA3 mRNAdecreases expression 17452286
18812211
D004026 Dieldrin Dieldrin results in decreased expression of CHRNA3 mRNAdecreases expression 18812211
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D004054 Diethylstilbestrol Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D004298 Dopamine CHRNA3 protein results in increased secretion of Dopamineincreases secretion 15542623
C082748 epibatidine epibatidine binds to CHRNA3 proteinaffects binding 17203487
C082748 epibatidine Tretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]affects binding|increases reaction 17203487
C036251 EPTC EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
C036251 EPTC EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D004958 Estradiol Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D004958 Estradiol Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction 11711029
C052034 fenoxycarb fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
C052034 fenoxycarb fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D008464 Mecamylamine Mecamylamine binds to and results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|decreases activity 20100906
C524978 N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|decreases activity 17873105
D009532 Nickel Nickel results in decreased expression of CHRNA3 mRNAdecreases expression 18812211
D009538 Nicotine Nicotine results in decreased expression of CHRNA3 mRNAdecreases expression 12628473
D009538 Nicotine Nicotine results in increased activity of CHRNA3 proteinincreases activity 19483072
C008655 N'-nitrosonornicotine N'-nitrosonornicotine binds to CHRNA3 proteinaffects binding 16835749
18385738
D013629 Tamoxifen 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D013629 Tamoxifen bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D013629 Tamoxifen Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D013629 Tamoxifen Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D013629 Tamoxifen Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]affects activity|affects binding|decreases reaction 11711029
D013629 Tamoxifen Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]affects activity|affects binding|decreases reaction 11711029
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CHRNA3 mRNAincreases expression 19465110
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014212 Tretinoin Tretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]affects binding|increases reaction 17203487
D014212 Tretinoin Tretinoin results in increased expression of CHRNA3 mRNAincreases expression 17203487
D014212 Tretinoin Tretinoin results in increased expression of CHRNA3 proteinincreases expression 17203487
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]affects binding|increases activity 16766716
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]affects binding|increases activity 16766716
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury varenicline 5.3418984856
MESH:D055371 Acute Lung Injury Nickel 4.3916166738
MESH:D000230 Adenocarcinoma Estradiol 4.0411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.0016487989
MESH:D000382 Agricultural Workers' Diseases EPTC 9.0011874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System varenicline 6.7018411066
MESH:D000437 Alcoholism Mecamylamine 10.0020201817
MESH:D000437 Alcoholism varenicline 10.0020201817
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Nicotine 3.2416627626
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D001943 Breast Neoplasms bisphenol A 5.6217123778
MESH:D001943 Breast Neoplasms Dieldrin 5.6211859874 15770527
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.6217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 5.6214630087 12948864 17289903 17261762 18497071 19861407 17018787 16675129
MESH:D001943 Breast Neoplasms Nickel 5.6215986119
MESH:D001943 Breast Neoplasms Tamoxifen 5.6211161223 17049068 19084267 17242785 19011961 18821012 15668708 19142967 20135344 16818667 19115204 16273361 18629630 16202921 19155303 16873071 18815881 19410462 20859285 19103187 15565566 19059307 19189212 20005174 20390343 18855134 19200415 18984771 19221464 19066611 21152245 19244106 17261762 18351453 19288272 17440819 19189210 19487384 20544844 20065188 17893378 21138602 18425577 18997820 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 5.6215986119
MESH:D001943 Breast Neoplasms Tretinoin 5.6216443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.3116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.311917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6318566989
MESH:D002547 Cerebral Palsy Toluene 5.649294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7211677210 15861022 16919318 17110522 17681005 17333356 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.478697196 12621046 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Toluene 3.769294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.769142499 10589399 9211117 9664655 16925845 14991402 8800419 17551590 9125849 9224671
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3516002989 12952375
MESH:D003643 Death Toluene 5.456431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7517244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.442952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2519279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004417 Dyspnea Diazinon 4.5916487989
MESH:D020821 Dystonic Disorders Nicotine 5.7217881519
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.6715700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.6718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.6716202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 16.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D005076 Exanthema varenicline 6.2318574013
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.329664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.0715345470
MESH:D005234 Fatty Liver Tamoxifen 7.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.7915751030 16611131 16534752 16513791 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.7916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9320067830
MESH:D005355 Fibrosis Tretinoin 7.9317994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7416452187
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.179664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Diazinon 4.3716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D015658 HIV Infections Nickel 3.7117263646
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2314722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8318850075 18670907
MESH:D007003 Hypoglycemia varenicline 5.8618346160
MESH:D007021 Hypospadias Diethylstilbestrol 10.5516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.5516569931 16945680
MESH:D007022 Hypotension Dopamine 4.826740701
MESH:D007246 Infertility Diethylstilbestrol 4.1515036965
MESH:D007247 Infertility, Female Dieldrin 9.6410630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.6412013081
MESH:D007248 Infertility, Male Diazinon 6.4912948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4917937319
MESH:D007249 Inflammation Nickel 7.7816166738
MESH:D007249 Inflammation Tamoxifen 7.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 6.9916393666
MESH:D007333 Insulin Resistance Estradiol 6.9916393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3017551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.4715618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.4916762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 11.4915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.4918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8617184923
MESH:D007938 Leukemia Tretinoin 2.6717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219075265 17506722 17649720 17294898 17712046 16823087 17361223 16788101 9834237 12679006 19035177 17217047 16891316 19029980 16140955 17107899 19642359 17301526 15748426 17339181 16766008 19225113 17368321 16331271 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Tamoxifen 3.0115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7218397230 16248980
MESH:D008107 Liver Diseases Tetrachloroethylene 3.6617267091
MESH:D008113 Liver Neoplasms Dieldrin 10.109539021 8742319
MESH:D008113 Liver Neoplasms Diethylstilbestrol 10.1016712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.1016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.1016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9312151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 5.937955063
MESH:D008175 Lung Neoplasms marker/mechanism 18385738
MESH:D008175 Lung Neoplasms Tamoxifen 2.1818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1811884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5317203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5311731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tamoxifen 3.1612393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008569 Memory Disorders varenicline 5.5818411066 20207347
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008607 Mental Retardation Toluene 3.589294310
MESH:D019964 Mood Disorders varenicline 6.2118567975
MESH:D019957 Motor Skills Disorders Toluene 5.049294310
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Dieldrin 14.708820588
MESH:D009369 Neoplasms Diethylstilbestrol 14.7015313581
MESH:D009369 Neoplasms Nicotine 14.7016365874
MESH:D009369 Neoplasms Tetrachloroethylene 14.7011911487
MESH:D009369 Neoplasms Tretinoin 14.7016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 9.6617289903
MESH:D009389 Neovascularization, Pathologic Nicotine 9.6616365874
MESH:D009421 Nervous System Malformations bisphenol A 28.5916427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.5911399458
MESH:D009421 Nervous System Malformations Estradiol 28.5916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 28.599125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.5819401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5816936753
MESH:D010146 Pain Tretinoin 6.9916870215
MESH:D010146 Pain varenicline 6.9920167427
MESH:D010190 Pancreatic Neoplasms EPTC 5.8819142867
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.8815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010259 Paranoid Disorders varenicline 7.0519489343
MESH:D010300 Parkinson Disease Dieldrin 3.4511181820 16112328 17291500 16809432 11445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4616977796 15687265
MESH:D011041 Poisoning Diazinon 4.1617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.0610548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.0611222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1215046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.119413022
MESH:D012135 Respiratory Sounds EPTC 5.8611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016116481 16283617
MESH:D012640 Seizures Mecamylamine 9.6012660363
MESH:D012640 Seizures Nicotine 9.6017873105
MESH:D012640 Seizures Toluene 9.606431079 9294310
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.2316467112
MESH:D013088 Spermatocele Diethylstilbestrol 18.9016709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.9016709447
MESH:D013088 Spermatocele Tamoxifen 18.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D013274 Stomach Neoplasms N'-nitrosonornicotine 3.1818456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.1817261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716045194 16684133
MESH:D013733 Testicular Diseases Toluene 4.7510514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism 20418890 20372150
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5811259349 16785264 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 12.0917979512 18305452 15735609 18041664
MESH:D014029 Tobacco Use Disorder varenicline 12.0920388087 20331614 20373480 18984856 16766716 19967529 20207347
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 4.9416452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.9416712894 8653321 17572228
MESH:D014570 Urologic Diseases Diazinon 5.0616487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.9016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9016129372
MESH:D014591 Uterine Diseases bisphenol A 13.1114652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.1114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2316002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA113
    • No data
    Releated disease ID Related disease Name
    PA447178Pulmonary Disease, Chronic Obstructive
    PA444818Lung Neoplasms
    PA445876Tobacco Use Disorder
    PA445876Tobacco Use Disorder
    PA445208Pain
    PA444818Lung Neoplasms
    PA153619833Peripheral Vascular Diseases
    Releated drug ID Related drug Name
    PA164712872Local Anesthetics
    PA448031acetylcholine
    PA451784trimethaphan
    PA450626nicotine
    PA452604xenobiotics
    PA164781343varenicline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00184 agonist Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00848 agonist Levamisole Antirheumatic Agents;Antinematodal Agents;Adjuvants, Immunologic
    DB01090 antagonist Pentolinium Antihypertensive Agents;Nicotinic Antagonists;Ganglionic Blockers
    DB01156 antagonist Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01227 other/unknown Levomethadyl Acetate Narcotics;Analgesics, Opioid
    DB01273 partial agonist Varenicline Nicotinic Agonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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