AutismKB 2.0

Annotation Detail for ADPRHL1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADPRHL1 ( ARH2 )
Gene Full Name: ADP-ribosylhydrolase like 1
Band: 13q34
Quick LinksEntrez ID:113622; OMIM: 610620; Uniprot ID:ARHL1_HUMAN; ENSEMBL ID: ENSG00000153531; HGNC ID: 21303
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADPRHL1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ADPRHL1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ADPRHL1 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in increased expression of ADPRHL1 mRNAincreases expression 18042831
C071192 entacapone entacapone binds to ADPRHL1 proteinaffects binding 19783845
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADPRHL1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ADPRHL1 mRNAaffects cotreatment|decreases expression 17942748
C041786 palm oil palm oil results in increased expression of ADPRHL1 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of ADPRHL1 mRNAincreases expression 18158353
D013629 Tamoxifen Tamoxifen affects the expression of ADPRHL1 mRNAaffects expression 17555576
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of ADPRHL1 mRNAdecreases expression 15601916
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ADPRHL1 mRNAaffects cotreatment|decreases expression 17942748
C066340 tolcapone tolcapone binds to ADPRHL1 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.007525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0014514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.4711080934
MESH:D000544 Alzheimer Disease entacapone 5.2920150427
MESH:D000544 Alzheimer Disease tolcapone 5.2920150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2117460149
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001919 Bradycardia Phenylephrine 4.7015306635
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.8319288272 16202921 19189210 18629630 17893378 18855134 20390343 15565566 18815881 20544844 19410462 11161223 19011961 20005174 17261762 15668708 21138602 19142967 19115204 18351453 19221464 18425577 19189212 19155303 19084267 18984771 17242785 19289846 20859285 19103187 16818667 20135344 19244106 17049068 19066611 19487384 20065188 18997820 18821012 16873071 21152245 16273361 17440819 19059307 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Phenylephrine 7.0715728586 11179087 11754973 17124262 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0716120746 18850075 18670907
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6314694615
MESH:D002386 Cataract Acetaminophen 7.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9515861022 17110522 16105132 17333356 11677210 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003866 Depressive Disorder entacapone 9.037768276
MESH:D003866 Depressive Disorder tolcapone 9.037768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.0010440460
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.7021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7017562736 12705907 12392966 14725611 16081117 16781746 11834606 11529661 16393943 11287661 15968718 12540782 17522070 17906064 16177239 19739265 10774834 10915739 16227642 14550746 19370779 12153990 16485898 11739529 19416960 19420014 19085960 18713872 16109766 19164858 12958197 12594235 14986274 15619225 11421492 10663392 11461765 11743745 18071297 2444490 19923254
MESH:D056486 Drug-Induced Liver Injury entacapone 15.7019783845
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7020420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 15.7016604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.5711455177
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1119155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 15.3019578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 15.3019578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Dietary Fats 13.7618296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7615345470
MESH:D005234 Fatty Liver Tamoxifen 13.7619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Phenylephrine 5.4312717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4318670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6612791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 8.5920412841
MESH:D007249 Inflammation Tamoxifen 8.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1711836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7016705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7018625569
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 16610002 12969438 11587558 19460945 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.607678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.6016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.952876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.017678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3116723640 17217161 18457598 20132043 18674790 20518802 19632207 11836018 21332399
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4816049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.4814694615
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010300 Parkinson Disease entacapone 6.4819783845 19578428 11586115 20334432 17089403
MESH:D010300 Parkinson Disease tolcapone 6.488635184 20216409 1977408 9754991 18328768 9708959 20334432 9305320 11586115 9333106 11432539 7566641 11746615 10651109 19578428 17089403 19783845 9591521 8739811 16758261 11793426
MESH:D020734 Parkinsonian Disorders entacapone 5.5018722529
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012852 Sinusitis Phenylephrine 4.867327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 15.3019578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 15.3019578428
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.178653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo tolcapone 5.3210573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved