AutismKB 2.0

Annotation Detail for CHRNA4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CHRNA4 ( BFNC,EBN,EBN1,FLJ95812,NACHR,NACHRA4,NACRA4 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 4
Band: 20q13.33
Quick LinksEntrez ID:1137; OMIM: 118504; Uniprot ID:ACHA4_HUMAN; ENSEMBL ID: ENSG00000101204; HGNC ID: 1958
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1799Epilepsy
1983Down syndrome
2124Autistic disorder
2198Psychotic disorder
2221Behavior disease
Desease Name
febrile convulsions
CARDIOVASCULAR
CHEMDEPENDENCY
Seizures, Febrile
epilepsy
PSYCH
NEUROLOGICAL
alcohol-related phenotypes nicotine
chronic obstructive pulmonary disease
attentional network function
No data
Desease Name
Epilepsy, nocturnal frontal lobe, 1
Nicotine addiction, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C041594 4-nonylphenol 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
C080417 4-octylphenol 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
C109763 5-(2-azetidinylmethoxy)-2-chloropyridine 5-(2-azetidinylmethoxy)-2-chloropyridine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 17115136
C104288 A 85380 A 85380 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 17115136
D000082 Acetaminophen Acetaminophen affects the expression of CHRNA4 mRNAaffects expression 17562736
D000109 Acetylcholine 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|affects reaction|increases activity 12604691
D000109 Acetylcholine 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]affects activity|affects binding 15733544
D000109 Acetylcholine Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 12604691
15885267
D000109 Acetylcholine Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D000109 Acetylcholine bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D000109 Acetylcholine Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
D000109 Acetylcholine [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
D000109 Acetylcholine Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 11711029
D000109 Acetylcholine Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D000109 Acetylcholine Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D000109 Acetylcholine [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|decreases activity 11517245
D000109 Acetylcholine rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D000109 Acetylcholine Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D000109 Acetylcholine Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D000109 Acetylcholine Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D000109 Acetylcholine Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D000109 Acetylcholine Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 19252481
D000109 Acetylcholine Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 11812690
D000109 Acetylcholine Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 19252481
D000109 Acetylcholine Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 15885267
D000109 Acetylcholine [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]affects cotreatment|affects reaction|increases response to substance 12754307
D000109 Acetylcholine [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|affects reaction|increases response to substance 12754307
D000109 Acetylcholine [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholineaffects cotreatment|affects response to substance 12754307
D000109 Acetylcholine [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
D000109 Acetylcholine [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
D000109 Acetylcholine [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
D000109 Acetylcholine [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D000109 Acetylcholine Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|increases activity|increases reaction 11812690
D000448 Aldicarb Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRNA4 mRNAaffects expression 16483693
D001285 Atropine Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 15733544
D001285 Atropine Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D001464 Barium [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]affects cotreatment|affects reaction|increases response to substance 12754307
D001464 Barium [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
C007725 bendiocarb bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
C006780 bisphenol A bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D020001 1-Butanol 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|affects reaction|increases activity 12604691
D020001 1-Butanol 1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 12604691
D020001 1-Butanol Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 12604691
D020001 1-Butanol Mecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 12604691
D002118 Calcium [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|affects reaction|increases response to substance 12754307
D002118 Calcium [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
D002118 Calcium [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]affects cotreatment|decreases reaction|increases response to substance 12754307
D002220 Carbamazepine Carbamazepine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 12110613
D012721 Carbaryl Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
D012721 Carbaryl Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CHRNA4 mRNAaffects expression 12734012
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNAaffects cotreatment|increases expression 18636392
C004712 cytisine cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 20331614
C004712 cytisine cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 17115136
D003976 Diazinon Diazinon affects the expression of CHRNA4 mRNAaffects expression 18812211
D004006 Dichlorvos Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D004026 Dieldrin Dieldrin affects the expression of CHRNA4 mRNAaffects expression 18812211
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D004079 Dihydro-beta-Erythroidine Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 12604691
D004079 Dihydro-beta-Erythroidine Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 20100906
C082748 epibatidine Tretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction 17203487
C082748 epibatidine epibatidine binds to CHRNA4 proteinaffects binding 17203487
C082748 epibatidine Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein]affects binding|increases reaction 17203487
C082748 epibatidine epibatidine analog binds to and affects the activity of [CHRNA4 protein binds to CHRNB2 protein]affects activity|affects binding 20038125
C082748 epibatidine epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 20038125
C036251 EPTC EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
C036251 EPTC EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D004958 Estradiol Estradiol binds to CHRNA4 proteinaffects binding 11517245
D004958 Estradiol [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
D004997 Ethinyl Estradiol Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 11711029
D004997 Ethinyl Estradiol Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|increases activity 11517245
C052034 fenoxycarb fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 14644616
C052034 fenoxycarb fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHRNA4 mRNA]affects reaction|decreases expression 15016801
D005702 Galantamine Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 15733544
D005702 Galantamine Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D008464 Mecamylamine Mecamylamine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 12604691
C524978 N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 17873105
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]affects cotreatment|decreases reaction|increases expression 15551346
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 proteinincreases expression 15551346
D009532 Nickel Nickel results in decreased expression of CHRNA4 mRNAdecreases expression 18812211
D009538 Nicotine [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]affects cotreatment|decreases reaction|increases expression 15551346
D009538 Nicotine Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 19252481
D009538 Nicotine Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 19252481
C490152 N-methyl-5-(3-(5-isopropoxypyridinyl))-4-penten-2-amine N-methyl-5-(3-(5-isopropoxypyridinyl))-4-penten-2-amine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 20167427
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNAaffects cotreatment|increases expression 18636392
D010830 Physostigmine Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 15733544
D010830 Physostigmine Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D011374 Progesterone [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|affects cotreatment|decreases activity 11517245
D001074 Propoxur Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]affects binding|decreases activity 14644616
C059514 resveratrol resveratrol results in increased expression of CHRNA4 mRNAincreases expression 12569576
C072506 rivastigmine rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 15733544
C072506 rivastigmine rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 15733544
D012601 Scopolamine Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]affects binding 15733544
D012601 Scopolamine Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D012643 Selenium Selenium results in increased expression of CHRNA4 mRNAincreases expression 19244175
D013619 Tacrine Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|increases reaction 15733544
D013629 Tamoxifen Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
C419442 TC 2559 TC 2559 binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 17115136
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction|increases activity 15885267
D014212 Tretinoin Tretinoin inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]affects binding|decreases reaction 17203487
D014212 Tretinoin Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein]affects binding|increases reaction 17203487
D014212 Tretinoin Tretinoin results in decreased expression of CHRNA4 mRNAdecreases expression 17203487
D014212 Tretinoin Tretinoin results in decreased expression of CHRNA4 proteindecreases expression 17203487
D014403 Tubocurarine Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]affects activity|affects binding|decreases reaction 11711029
D014403 Tubocurarine Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]affects activity|affects binding|decreases reaction|increases reaction 11711029
D014520 Urethane Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]affects binding|increases activity|increases reaction 11812690
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 20331614
20388087
20373480
20207347
C500838 varenicline varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|decreases activity 20100906
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 16766716
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]affects binding|increases activity 20072781
17115136
20038125
19967529
18411066
20451547
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9714745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 3.998986270
MESH:D000138 Acidosis Ammonium Chloride 3.0018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3717505938
MESH:D058186 Acute Kidney Injury resveratrol 7.7916538975
MESH:D058186 Acute Kidney Injury varenicline 7.7918984856
MESH:D055371 Acute Lung Injury Chlorine 7.9620601635
MESH:D055371 Acute Lung Injury Nickel 7.9616166738
MESH:D000230 Adenocarcinoma Estradiol 8.7211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.7214692618
MESH:D000230 Adenocarcinoma Fluorouracil 8.7217638652
MESH:D000230 Adenocarcinoma Urethane 8.7218316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.1315814487
MESH:D000236 Adenoma resveratrol 6.1315688382
MESH:D000236 Adenoma Urethane 6.1310530776 10822126 17093202 16926031 17195641 6695378 11497255
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.6616487989
MESH:D000382 Agricultural Workers' Diseases Dichlorvos 11.6616611668 17119214 12661182
MESH:D000382 Agricultural Workers' Diseases EPTC 11.6611874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System varenicline 6.3418411066
MESH:D000437 Alcoholism Mecamylamine 9.0620201817
MESH:D000437 Alcoholism varenicline 9.0620201817
MESH:D000505 Alopecia Tretinoin 3.1615955085
MESH:D000544 Alzheimer Disease Galantamine 13.7616914529 17414243
MESH:D000544 Alzheimer Disease Nicotine 13.7616627626
MESH:D000544 Alzheimer Disease Ozone 13.7615513908
MESH:D000544 Alzheimer Disease resveratrol 13.7616162502 16183991
MESH:D000544 Alzheimer Disease rivastigmine 13.7617542500
MESH:D000544 Alzheimer Disease Tacrine 13.7612725862
MESH:D000647 Amnesia Scopolamine 6.3116946593
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9415469931
MESH:D000740 Anemia Fluorouracil 3.2215504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 3.2710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.1315885639
MESH:D001169 Arthritis, Experimental resveratrol 10.1317115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.1316412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1016292516
MESH:D001249 Asthma Ozone 4.2617854713 16373670
MESH:D001249 Asthma Tretinoin 4.2616456186
MESH:D001259 Ataxia 1-Butanol 5.067820390
MESH:D050197 Atherosclerosis resveratrol 2.9216873680 17967414
MESH:D001321 Autistic Disorder marker/mechanism 15046869
MESH:D001321 Autistic Disorder Acetaminophen 2.7718445737
MESH:D001321 Autistic Disorder Galantamine 2.7717069550
MESH:D001471 Barrett Esophagus Tretinoin 3.8616935849
MESH:D001480 Basal Ganglia Diseases Dichlorvos 5.4115303389
MESH:D001714 Bipolar Disorder Carbamazepine 3.8220046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.1016197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.3611985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7617868700
MESH:D001930 Brain Injuries Progesterone 3.7115665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 3.7217600658
MESH:D001943 Breast Neoplasms Atropine 8.5912762645
MESH:D001943 Breast Neoplasms bisphenol A 8.5917123778
MESH:D001943 Breast Neoplasms Dieldrin 8.5915770527 11859874
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.5917129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 8.5912948864 18497071 16675129 14630087 17261762 17018787 19861407 17289903
MESH:D001943 Breast Neoplasms Fluorouracil 8.5916595493 19217205 15136595 16110121 16557594 18357371 18608205
MESH:D001943 Breast Neoplasms Nickel 8.5915986119
MESH:D001943 Breast Neoplasms Progesterone 8.5915562024 16175315 17614352
MESH:D001943 Breast Neoplasms resveratrol 8.5917534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 8.5918984771 16818667 16873071 19059307 19289846 18997820 19288272 19244106 20005174 18821012 20390343 18855134 21138602 17242785 19103187 18629630 19487384 20065188 17261762 16273361 17440819 19066611 20859285 19142967 20544844 19221464 18425577 19189212 19200415 20135344 19410462 15668708 21152245 15565566 19115204 19189210 17049068 19084267 16202921 18351453 19155303 11161223 19011961 18815881 17893378
MESH:D001943 Breast Neoplasms Tetrachloroethylene 8.5915986119
MESH:D001943 Breast Neoplasms Tretinoin 8.5916443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2315516495 18315731 14754758 17626835 16777450 19059883 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0216813970
MESH:D002100 Cachexia Ozone 4.1716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2310355542 15700767 16192424 15721981 16124888 15673190 16050911 16227642 16011737 18705752 3786805 16097048
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0916051944
MESH:D002277 Carcinoma Fluorouracil 3.1217121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.743084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.7418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 14.7416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.7416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.7418930000 17971768 16332177 17088986 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.7416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.7416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.741917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4217123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0316675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.7318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.4316757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.4316227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.4316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1217572228
MESH:D002318 Cardiovascular Diseases resveratrol 3.0715458977
MESH:D002386 Cataract Acetaminophen 6.0410977129
MESH:D002386 Cataract Tretinoin 6.0417460283
MESH:D002418 Cattle Diseases Dichlorvos 5.0814651886
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.3818566989
MESH:D002493 Central Nervous System Diseases Dichlorvos 5.2012670839
MESH:D002547 Cerebral Palsy Toluene 5.289294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0216129372
MESH:D002779 Cholestasis Ethinyl Estradiol 2.4516919318 17333356 17681005 11677210 16105132 17110522 15861022
MESH:D002822 Choriocarcinoma Tretinoin 4.5816461808
MESH:D002972 Cleft Palate Tretinoin 5.489407595
MESH:D002972 Cleft Palate Urethane 5.4812810352
MESH:D003072 Cognition Disorders Scopolamine 5.7419527754
MESH:D003092 Colitis resveratrol 12.8616474422
MESH:D003092 Colitis Selenium 12.8617936198
MESH:D003092 Colitis Tretinoin 12.8617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.4717287894 17725105 16340194 15001691 17169374 16510598 18772588 17016597 17018589 17172411
MESH:D003110 Colonic Neoplasms resveratrol 3.4716338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5116303861 17016601 17454858 17401013 18802399 17255274 17695437 16331619 16282729 17594712 16524972 17094418 20501625 15148649 18383874 16391804 18509181 18288408 18949393 18448328 14970324 15289873
MESH:D015179 Colorectal Neoplasms resveratrol 2.5116550006
MESH:D003128 Coma Dichlorvos 5.4215303389
MESH:D003327 Coronary Disease resveratrol 3.3716507316
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.679014606
MESH:D019465 Craniofacial Abnormalities Toluene 3.679294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6716925845 10589399 9224671 9664655 9211117 17551590 9125849 14991402 8800419 9142499
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0212952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.2316733453
MESH:D003643 Death Toluene 5.096431079
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8119031437
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.4319470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.122952479
MESH:D002658 Developmental Disabilities marker/mechanism 20805988
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3116873680
MESH:D003928 Diabetic Nephropathies Estradiol 12.2619279558
MESH:D003928 Diabetic Nephropathies resveratrol 12.2616286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.2619279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9417187935
MESH:D003967 Diarrhea Atropine 4.4310867622
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.8911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.0416538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.3412153990 12594235 10774834 19164858 14725611 17522070 16781746 19923254 12540782 2444490 18713872 11421492 16393943 15968718 16485898 15619225 11529661 19420014 11739529 16109766 11743745 16227642 10663392 10915739 12392966 19739265 17562736 11287661 12705907 19416960 19370779 18071297 14550746 12958197 19085960 11461765 14986274 16081117 16177239 11834606 17906064
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 7.3417465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.349327722 3786805 2869522 7120509 16227642 19336974 17522070 19085960 7440962 16177239 10915739 11566570 4309450 15968718 7179309 15998439 15027814 3732212 10092053 6623471 21278145 6884620
MESH:D056486 Drug-Induced Liver Injury Selenium 7.3415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5219426721
MESH:D004362 Drug Toxicity Carbamazepine 4.0320216337
MESH:D004381 Duodenal Ulcer Atropine 4.7611595415
MESH:D004417 Dyspnea Chlorine 8.7620016425
MESH:D004417 Dyspnea Diazinon 8.7616487989
MESH:D004421 Dystonia rivastigmine 6.0118029952
MESH:D020821 Dystonic Disorders Nicotine 5.3617881519
MESH:D004487 Edema resveratrol 2.898985016
MESH:D004489 Edema, Cardiac Tretinoin 3.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 23.0717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 23.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.0717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 23.0717872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.0719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.1316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.6015700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 14.6019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 14.6017893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 14.6016569247
MESH:D004715 Endometriosis Progesterone 3.2716134523
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3017923197
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.7219915237 16415921 16538176 18855540 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 4.6617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.4016628512 15008574 17116037
MESH:D004827 Epilepsy Carbamazepine 3.687988514 9014606 17178248 19620853 18234410 17465707 20417680 19700373 19439326 821787
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 4.807750514
MESH:D017034 Epilepsy, Frontal Lobe marker/mechanism 12823585 17881519
OMIM:600513 EPILEPSY, NOCTURNAL FRONTAL LOBE, TYPE 1 marker/mechanism
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.5615276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.1619549232
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.2916481741 16337965 16785472 15173087 17638652
MESH:D005076 Exanthema Carbamazepine 10.9820485159
MESH:D005076 Exanthema varenicline 10.9818574013
MESH:D005124 Eye Abnormalities Tretinoin 3.159664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 10.1817595544 19224547 16045604 12631006 16239168 12795759 15959796 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.1815345470
MESH:D005234 Fatty Liver Tamoxifen 10.1814986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.9916513791 16611131 15751030 16534752 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.9916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 6.9818705752
MESH:D005355 Fibrosis Tretinoin 6.9817994277
MESH:D005739 Gas Poisoning Chlorine 4.4320016425
MESH:D005756 Gastritis Acetaminophen 3.1016983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3816452187
MESH:D005909 Glioblastoma Tretinoin 2.6317312396
MESH:D005910 Glioma Fluorouracil 2.6216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.4715162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.589664655 14991402
MESH:D006331 Heart Diseases Urethane 3.8416046796
MESH:D006333 Heart Failure Selenium 2.7117162251
MESH:D006505 Hepatitis Carbon Tetrachloride 7.8419110552 19900420
MESH:D006505 Hepatitis Diazinon 7.8416487989
MESH:D006558 Herpes Genitalis Estradiol 4.4515709030
MESH:D006561 Herpes Simplex resveratrol 3.6216876885
MESH:D015658 HIV Infections Nickel 3.5017263646
MESH:D006734 Horse Diseases Dichlorvos 5.4216402567
MESH:D019584 Hot Flashes Estradiol 3.1817088409
MESH:D006930 Hyperalgesia Acetaminophen 6.1316870215
MESH:D006930 Hyperalgesia Tretinoin 6.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9716899240
MESH:D006937 Hypercholesterolemia resveratrol 3.5017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0116778211
MESH:D006941 Hyperesthesia Dichlorvos 6.1112563396
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.2510459572
MESH:D006949 Hyperlipidemias resveratrol 3.5116873680
MESH:D006965 Hyperplasia Carbamazepine 9.4718773962
MESH:D006965 Hyperplasia Diethylstilbestrol 9.4712960047 14722030
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5415338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8117488730
MESH:D007003 Hypoglycemia varenicline 5.5518346160
MESH:D007021 Hypospadias Diethylstilbestrol 9.4116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.6515869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.6517600658
MESH:D007246 Infertility Diethylstilbestrol 3.8215036965
MESH:D007247 Infertility, Female Dieldrin 8.5610630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.5612013081
MESH:D007248 Infertility, Male Diazinon 5.6412948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.6417937319
MESH:D007249 Inflammation Nickel 9.4016166738
MESH:D007249 Inflammation Progesterone 9.4015869954
MESH:D007249 Inflammation resveratrol 9.4016366677
MESH:D007249 Inflammation Tamoxifen 9.4019457130
MESH:D007251 Influenza, Human resveratrol 9.1716624496
MESH:D007251 Influenza, Human Selenium 9.1716624496
MESH:D007333 Insulin Resistance bisphenol A 6.1516393666
MESH:D007333 Insulin Resistance Estradiol 6.1516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.2217994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.3917551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Scopolamine 6.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 8.2012587719 15629191
MESH:D007674 Kidney Diseases Dichlorvos 8.2016798900
MESH:D007674 Kidney Diseases Estradiol 8.2015618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.3816518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.0016762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 14.0015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.0016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0018625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.4716316344
MESH:D007859 Learning Disorders Diethylstilbestrol 8.5417184923
MESH:D007859 Learning Disorders Scopolamine 8.5419426756 19182383
MESH:D007938 Leukemia Tretinoin 2.4717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.4816087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.4817368321 17506722 16766008 17294898 15748426 17649720 17712046 17301526 16331271 19029980 19642359 12679006 9834237 17217047 17361223 16935935 16788101 19225113 17339181 16823087 19075265 16140955 19035177 16891316 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.899224671
MESH:D008064 Lipidoses Tamoxifen 2.7417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.4816943688 17174718 11408273 16221502 11903743 17157831 16239168 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.2218263696 18412020 16011737 17698563 17976157 17823541 15052691 18006644 14748882 17761835 15893842 18376398 18472094 18429990 17869086 15925388 16136751 18279442 15931870 15370692 17922224 18054572 18277467 17721639 15959796 16027843 17481882 18418968 16638106 15730626 15650968 17805973 12649538 12546737 18472332 15818738 17525996 12632514 16033810 16015684 18166357 14716496 18339082 10355542 16097048 17714472 18187930 15673190 15362042 18205269 18481824 18210741 15123356 18395914 17766677 17557913 12609069 12445418 17900296 15338365 18395095 12389079 14724832 14620537 16192424 12898905 12632512 18251166 17631135 18156304 18420326 13678700 15876570 17708605 17640975 12666154 17565644 14512876 14716833 16248980 17944888 18317297 16116963 15057751 18705752 11481614 12445421 12667390 20821823 12958196 15996030 12741479 12586293
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.2214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.2218564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.2216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 5.6216611625 19014921 12969438 12587719 19784758 19460945 16610002 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.6216964402 16246199 17285989 15830285 15720792
MESH:D008107 Liver Diseases Tetrachloroethylene 5.6217267091
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.7716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.7716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.0519294768
MESH:D008113 Liver Neoplasms Dieldrin 18.058742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.0516712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 18.0516603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms resveratrol 18.0519073162 20405173 19321006 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 18.0516684651
MESH:D008113 Liver Neoplasms Urethane 18.0516391232 17093202 17559639
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.3215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 5.327955063
MESH:D008171 Lung Diseases Ozone 2.9919066396 8266340
MESH:D055370 Lung Injury Ozone 3.3020417186
MESH:D008175 Lung Neoplasms Fluorouracil 4.2115246190
MESH:D008175 Lung Neoplasms Ozone 4.218597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 4.2118625569
MESH:D008175 Lung Neoplasms Urethane 4.2111807781 10530776 11544531 16788158 17255336 10997738 12765245 16926031 10779650 17195641 16337739 17093202 12957351 11323394 15902970 12117781 6695378 11246140 16289808 11062179 11992545 7750092 16204055 11497255 11893704 15136453 15166089 14587096 10822126 11074608 12466968 11307925 16007126 11552296 16391232
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2315086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.3816628512
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5815166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.0615700306
MESH:D016393 Lymphoma, B-Cell resveratrol 3.7817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4114749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9416002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.1315688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.1319428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.7817203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.7811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.7811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 14.7815318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.7819196722 16827153 14580682 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 10.7319453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7319453300
MESH:D008527 Medulloblastoma Tretinoin 2.5317453147
MESH:D008545 Melanoma N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 6.2816487513
MESH:D008545 Melanoma resveratrol 6.2817992120
MESH:D008545 Melanoma Tamoxifen 6.2819393235 12393984
MESH:D008545 Melanoma Tretinoin 6.2816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008569 Memory Disorders Scopolamine 9.1519426756 19527754 19182383 15957009
MESH:D008569 Memory Disorders varenicline 9.1518411066 20207347
MESH:D008591 Meningomyelocele Tretinoin 3.8716940565
MESH:D008607 Mental Retardation Carbamazepine 5.779014606
MESH:D008607 Mental Retardation Toluene 5.779294310
MESH:D008654 Mesothelioma Selenium 2.5415107826
MESH:D008659 Metabolic Diseases resveratrol 3.8717112576
MESH:D008679 Metaplasia Ozone 4.5310496685
MESH:D019964 Mood Disorders varenicline 5.8618567975
MESH:D009041 Motion Sickness Scopolamine 5.961613127
MESH:D016472 Motor Neuron Disease Dichlorvos 5.7611282359
MESH:D019957 Motor Skills Disorders Toluene 4.719294310
MESH:D009062 Mouth Neoplasms Fluorouracil 3.1918986760 16757204
MESH:D009101 Multiple Myeloma resveratrol 3.0617164350 16490592 17049120 14749477 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3017962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7317596541
MESH:D009203 Myocardial Infarction resveratrol 2.7717125593 16525036 16317513 17188708 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 3.5517125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8416810080
MESH:D009205 Myocarditis resveratrol 4.1917322642
MESH:D009216 Myopia Atropine 4.6312601066
MESH:D009224 Myotonia Congenita Carbamazepine 4.9020399394
MESH:D009349 Nematode Infections Dichlorvos 5.5616402567
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3019410462
MESH:D009369 Neoplasms Dieldrin 19.298820588
MESH:D009369 Neoplasms Diethylstilbestrol 19.2915313581
MESH:D009369 Neoplasms Fluorouracil 19.2918239605 16928823 18600527
MESH:D009369 Neoplasms Nicotine 19.2916365874
MESH:D009369 Neoplasms Tetrachloroethylene 19.2911911487
MESH:D009369 Neoplasms Tretinoin 19.2916594593 16946489
MESH:D009369 Neoplasms Urethane 19.2915625555
MESH:D009374 Neoplasms, Experimental resveratrol 7.788985016
MESH:D009374 Neoplasms, Experimental Urethane 7.7815582191
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 8.4917289903
MESH:D009389 Neovascularization, Pathologic Nicotine 8.4916365874
MESH:D009410 Nerve Degeneration Dichlorvos 4.4611282359 17850875
MESH:D009422 Nervous System Diseases marker/mechanism 20805988
MESH:D009421 Nervous System Malformations bisphenol A 25.0916427766 11399458
MESH:D009421 Nervous System Malformations Carbamazepine 25.0916990009
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.0911399458
MESH:D009421 Nervous System Malformations Estradiol 25.0916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 25.099125849
MESH:D009436 Neural Tube Defects Tretinoin 2.679142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.5818514411
MESH:D019636 Neurodegenerative Diseases Dichlorvos 11.5816635102
MESH:D019636 Neurodegenerative Diseases resveratrol 11.5817652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.8817929310
MESH:D020258 Neurotoxicity Syndromes Aldicarb 11.2715081274
MESH:D020258 Neurotoxicity Syndromes Dichlorvos 11.2712186780
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 11.2716436463
MESH:D010018 Osteomalacia Carbamazepine 4.9017016548
MESH:D010024 Osteoporosis Calcium 3.4217882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7317513867
MESH:D010049 Ovarian Diseases bisphenol A 4.4211985600
MESH:D010051 Ovarian Neoplasms Estradiol 9.5619401270
MESH:D010051 Ovarian Neoplasms Progesterone 9.5616525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 9.5616936753
MESH:D010051 Ovarian Neoplasms Urethane 9.5616391232
MESH:D010146 Pain 5-(2-azetidinylmethoxy)-2-chloropyridine 16.4120167427
MESH:D010146 Pain Acetaminophen 16.4116870215
MESH:D010146 Pain Carbamazepine 16.4115215642
MESH:D010146 Pain Tretinoin 16.4116870215
MESH:D010146 Pain varenicline 16.4120167427
MESH:D010190 Pancreatic Neoplasms EPTC 10.5519142867
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.5516929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 10.5511504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.5515976015
MESH:D010195 Pancreatitis Dichlorvos 4.3816258382
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1611578682
MESH:D010259 Paranoid Disorders varenicline 6.6819489343
MESH:D010267 Parapsoriasis Carbamazepine 5.1516538176
MESH:D010300 Parkinson Disease Dieldrin 3.2916112328 11181820 16809432 17291500 11445065
MESH:D010302 Parkinson Disease, Secondary Dichlorvos 5.0612645970
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.3617145499 17679678
MESH:D010538 Peritonitis Ozone 3.5816369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 10.2916977796 15687265
MESH:D010911 Pituitary Neoplasms Urethane 10.2916391232
MESH:D010954 Plasmacytoma Selenium 4.3115087411
MESH:D011014 Pneumonia Ozone 3.8318929643 18007984 18381685
MESH:D011041 Poisoning Atropine 21.5017849254 18072136
MESH:D011041 Poisoning Diazinon 21.5017603234
MESH:D011041 Poisoning Dichlorvos 21.5016036766 15303389 12460839 18072136 17157343 17603234
MESH:D011041 Poisoning Galantamine 21.5016914529
MESH:D011041 Poisoning Physostigmine 21.5017157343
MESH:D011115 Polyneuropathies Dichlorvos 5.0712563396
MESH:D011248 Pregnancy Complications Carbamazepine 4.609014606
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.7310548101
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 18.739014606
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.7317184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.7316679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0016740699
MESH:D011471 Prostatic Neoplasms Dichlorvos 2.0012661182
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0015046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.0016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0019082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 2.0017675339 17804756 17636462 17718901 16731767 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0015067354
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7516919318 15861022
MESH:D019310 Pseudolymphoma Carbamazepine 5.029591791 12752131
MESH:D011625 Pterygium Tretinoin 4.2316723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2210548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5318286688 15538739 18722050 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0116325855
MESH:D015427 Reperfusion Injury resveratrol 2.9717520802 16314181 17058453 15827377 16317513
MESH:D012120 Respiration Disorders Chlorine 4.6418579056
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 3.869413022
MESH:D012131 Respiratory Insufficiency Dichlorvos 5.1115303389 17350689
MESH:D012135 Respiratory Sounds Dichlorvos 9.0717119214 16611668
MESH:D012135 Respiratory Sounds EPTC 9.0711874814
MESH:D012140 Respiratory Tract Diseases Dichlorvos 4.9216611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5816116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012640 Seizures Atropine 22.0817157343 11218047 12660363
MESH:D012640 Seizures Carbamazepine 22.089844417 19414003 9046859 15946322 16938433 16180713 16876388
MESH:D012640 Seizures Dichlorvos 22.0817157343 12660363
MESH:D012640 Seizures Mecamylamine 22.0812660363
MESH:D012640 Seizures Nicotine 22.0817873105
MESH:D012640 Seizures Physostigmine 22.0817157343
MESH:D012640 Seizures Toluene 22.089294310 6431079
MESH:D012878 Skin Neoplasms resveratrol 7.9715837718 8985016
MESH:D012878 Skin Neoplasms Tretinoin 7.9716467112
MESH:D012878 Skin Neoplasms Urethane 7.9711807781
MESH:D012893 Sleep Disorders Carbamazepine 4.5619414003
MESH:D013088 Spermatocele Diethylstilbestrol 16.8016002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.8016709447
MESH:D013088 Spermatocele Tamoxifen 16.8016709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.9916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.9919457130
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.6619915237 16538176 19694795 15057820 20485159 16415921 18855540
MESH:D013274 Stomach Neoplasms Dichlorvos 3.2011397402
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2016951190 19084572 19015929 15786421 18567086 17172411 18396642 16424979 17522103 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 3.2017261132
MESH:D013276 Stomach Ulcer Atropine 4.2611595415
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9816321402
MESH:D013322 Strongyloidiasis Dichlorvos 5.5614651886
MESH:D019966 Substance-Related Disorders bisphenol A 3.4216045194 16684133
MESH:D013733 Testicular Diseases Toluene 4.3910048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6715669648
MESH:D013964 Thyroid Neoplasms Tretinoin 2.6017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.1119048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.3116785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 10.9518305452 18041664 15735609 17979512
MESH:D014029 Tobacco Use Disorder varenicline 10.9518984856 20388087 20331614 20207347 16766716 20373480 19967529
MESH:D014062 Tongue Neoplasms Fluorouracil 13.7316280240
MESH:D014062 Tongue Neoplasms resveratrol 13.7316227395
MESH:D014062 Tongue Neoplasms Tretinoin 13.7316051514
MESH:D014202 Tremor Atropine 5.1517594079
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 4.3716712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.378653321 17572228 16712894
MESH:D014570 Urologic Diseases Diazinon 4.7016487989
MESH:D014581 Urticaria Acetaminophen 2.4610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.6016175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.6016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 18.6017473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.6016129372
MESH:D014591 Uterine Diseases bisphenol A 11.9014652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 12.9715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 12.9714692618
MESH:D014594 Uterine Neoplasms resveratrol 12.9717044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.0316752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916002989 16513791
MESH:D019043 Vascular Neoplasms Urethane 5.3310620525
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7517488730
MESH:D014820 Vitiligo Tretinoin 3.5216761959
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014985 Xerophthalmia Scopolamine 6.3117120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26490
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA443853Dementia
    PA446098Dementia, Vascular
    PA447127Lewy Body Disease
    PA446858Neurodegenerative Diseases
    PA445876Tobacco Use Disorder
    PA444818Lung Neoplasms
    Releated drug ID Related drug Name
    PA164712423Anticholinesterases
    PA449726galantamine
    PA450626nicotine
    PA452604xenobiotics
    PA164781343varenicline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00184 agonist Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00237 antagonist Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 antagonist Trianal-C 1/2 Capsule Analgesics
    DB00306 antagonist Talbutal Analgesics
    DB00312 antagonist Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00418 antagonist Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00463 antagonist Metharbital Anticonvulsants
    DB00599 antagonist Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00794 antagonist Primidone Anticonvulsants;Barbiturates
    DB00849 antagonist Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB01174 antagonist Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01273 partial agonist Varenicline Nicotinic Agonists
    DB01351 antagonist Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 antagonist Aprobarbital
    DB01353 antagonist Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 antagonist Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 antagonist Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 antagonist Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 antagonist Barbituric acid derivative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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