AutismKB 2.0

Annotation Detail for CHRNA7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CHRNA7 ( CHRNA7-2,NACHRA7 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 7
Band: 15q13.3
Quick LinksEntrez ID:1139; OMIM: 118511; Uniprot ID:ACHA7_HUMAN; ENSEMBL ID: ENSG00000175344; HGNC ID: 1960
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1870Drug abuse
1966Myoclonic epilepsy, Juvenile
1983Down syndrome
2045Bipolar disorder
2053Colon cancer
2124Autistic disorder
2151Neuroblastoma
2198Psychotic disorder
2221Behavior disease
Desease Name
Alzheimer's disease
PSYCH
memory performance
NEUROLOGICAL
schizophrenia
No data
Desease Name
Schizophrenia, neurophysiologic defect in
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone binds to CHRNA7 proteinaffects binding 16835749
D000109 Acetylcholine Acetylcholine results in increased activity of CHRNA7 proteinincreases activity 16533908
D000109 Acetylcholine Barium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D000109 Acetylcholine Calcium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D000109 Acetylcholine Strontium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D000109 Acetylcholine Acetylcholine results in increased activity of CHRNA7 proteinincreases activity 15885267
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D000109 Acetylcholine Acetylcholine results in increased activity of CHRNA7 proteinincreases activity 15885267
D000109 Acetylcholine Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D000109 Acetylcholine Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
C087686 alpha-conotoxin ImI alpha-conotoxin ImI binds to and results in decreased activity of CHRNA7 proteinaffects binding|decreases activity 15542623
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRNA7 mRNAaffects expression 16483693
C408128 AR-R 17779 AR-R 17779 results in increased activity of CHRNA7 proteinincreases activity 14727003
D001464 Barium Barium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D002038 Bungarotoxins Bungarotoxins binds to and results in decreased activity of CHRNA7 proteinaffects binding|decreases activity 15542623
D002118 Calcium Calcium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D002118 Calcium Calcium binds to and affects the activity of CHRNA7 proteinaffects activity|affects binding 16641314
D004390 Chlorpyrifos Chlorpyrifos affects the expression of CHRNA7 mRNAaffects expression 18977431
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of CHRNA7 mRNAdecreases expression 17452286
D003976 Diazinon Diazinon affects the expression of CHRNA7 mRNAaffects expression 18812211
D003976 Diazinon Diazinon results in decreased expression of CHRNA7 mRNAdecreases expression 17452286
D004026 Dieldrin Dieldrin results in increased expression of CHRNA7 mRNAincreases expression 18812211
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CHRNA7 mRNAincreases expression 20360939
D000431 Ethanol Ethanol results in decreased expression of CHRNA7 mRNAdecreases expression 15353170
D007736 Kynurenic Acid Kynurenic Acid binds to and results in decreased activity of CHRNA7 proteinaffects binding|decreases activity 16457470
C054634 methyllycaconitine methyllycaconitine binds to and results in decreased activity of CHRNA7 proteinaffects binding|decreases activity 15542623
15523001
D008743 Methyl Parathion Methyl Parathion affects the expression of CHRNA7 mRNAaffects expression 18977431
C524978 N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of CHRNA7 proteindecreases activity 17873105
D009532 Nickel Nickel results in decreased expression of CHRNA7 mRNAdecreases expression 18812211
D009538 Nicotine Nicotine results in decreased expression of CHRNA7 mRNAdecreases expression 12628473
C498513 PNU-282987 PNU-282987 binds to and results in increased activity of CHRNA7 proteinaffects binding|increases activity 15523001
D013324 Strontium Strontium promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]increases activity|increases reaction 16533908
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D013750 Tetrachloroethylene Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
D014050 Toluene Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]decreases reaction|increases activity 15885267
C052342 topiramate topiramate results in decreased expression of CHRNA7 mRNAdecreases expression 16979414
D014212 Tretinoin Tretinoin results in increased expression of CHRNA7 proteinincreases expression 17203487
C118602 triethyl-(beta-4-stilbenoxyethyl)ammonium triethyl-(beta-4-stilbenoxyethyl)ammonium binds to and results in decreased activity of CHRNA7 proteinaffects binding|decreases activity 15542623
C500838 varenicline varenicline binds to and results in increased activity of [CHRNA7 protein binds to CHRNA7 protein]affects binding|increases activity 16766716
C500838 varenicline varenicline binds to and results in increased activity of CHRNA7 proteinaffects binding|increases activity 18411066
19959243
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.6917676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 9.7118287403
MESH:D000138 Acidosis Ethanol 9.7111192467
MESH:D058186 Acute Kidney Injury varenicline 5.3218984856
MESH:D055371 Acute Lung Injury Nickel 4.3716166738
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.6416176798
MESH:D000236 Adenoma Diethylnitrosamine 6.646695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.6717620307 19052882 19061943 18056438 17162532 16434500
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.4117119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.4116487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 13.8015451039 15451040
MESH:D020268 Alcohol-Induced Disorders, Nervous System varenicline 13.8018411066
MESH:D000437 Alcoholism topiramate 9.7318552399 19331489 17925516
MESH:D000437 Alcoholism varenicline 9.7320201817
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease marker/mechanism 18071042
MESH:D000544 Alzheimer Disease Nicotine 3.2316627626
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D001008 Anxiety Disorders Ethanol 3.8311141031
MESH:D001169 Arthritis, Experimental Tretinoin 2.9416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder marker/mechanism 15046869
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.4016206674 16197459
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.8820146248
MESH:D001943 Breast Neoplasms Dieldrin 2.8815770527 11859874
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8817474063
MESH:D001943 Breast Neoplasms Nickel 2.8815986119
MESH:D001943 Breast Neoplasms Tetrachloroethylene 2.8815986119
MESH:D001943 Breast Neoplasms Tretinoin 2.8816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.4619919837 17761372 16681979 18210153 18788625 19701751 20214788 16288022 16878318 16935385 18056438 17138121 20514400 3084413 18971187 16502159 20432363 16569478 10737359 19052882 17055752 20524982 18665156 20007298 10672840 19208518 19418558 19539802 18691550 17173139 20512989 17978847 19519916 18393292 20084675 19822196 19335982 18506893 19394651 16328049 3581430 20727157 18978308 19171122 18785209 16807293 16779866 16540662 21159647 20101231 11831363 16830150 17162532 17428255 19107877 19383236 20935162 16698587 18494052
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.4615289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.461917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2316051514 16096774
MESH:D006332 Cardiomegaly Ethanol 3.3119332462
MESH:D002386 Cataract Tretinoin 2.9617460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7017174075 7505956 21159647 2727394
MESH:D002547 Cerebral Palsy Toluene 5.629294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0115650499
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4919052882
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Ethanol 5.8415513904
MESH:D002972 Cleft Palate Tretinoin 5.849407595
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8919302082 15513904 15451039 15451040 10194807 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Toluene 3.899294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.899125849 10589399 9664655 16925845 9142499 17551590 9211117 14991402 9224671 8800419
MESH:D003643 Death Toluene 5.446431079
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7317100760 17244072 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.422952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7720387270
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 4.7716979414
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9019107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 3.9011566570
MESH:D004417 Dyspnea Diazinon 4.5716487989
MESH:D020821 Dystonic Disorders Nicotine 5.7017881519
MESH:D004489 Edema, Cardiac Tretinoin 4.2418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9616569247
MESH:D004827 Epilepsy topiramate 4.2119148780
OMIM:600669 EPILEPSY, IDIOPATHIC GENERALIZED marker/mechanism 19136953
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.0416499746
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.7016704527
MESH:D005076 Exanthema varenicline 6.2118574013
MESH:D005124 Eye Abnormalities Tretinoin 3.4116938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 7.3621071580 20387270
MESH:D005234 Fatty Liver Ethanol 7.3619236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0716946407 10194807 15513904 15451040
MESH:D005355 Fibrosis Tretinoin 3.2917994277
MESH:D005756 Gastritis Ethanol 4.4615046732
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7814991402 9664655
MESH:D006505 Hepatitis Diazinon 4.3616487989
MESH:D015658 HIV Infections Nickel 3.7017263646
MESH:D006930 Hyperalgesia Ethanol 7.4118783367
MESH:D006930 Hyperalgesia Tretinoin 7.4116870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D007003 Hypoglycemia varenicline 5.8518346160
MESH:D007247 Infertility, Female Dieldrin 4.7310630421
MESH:D007248 Infertility, Male Diazinon 3.6716466525 12948887
MESH:D007249 Inflammation Diethylnitrosamine 5.0818785209
MESH:D007249 Inflammation Nickel 5.0816166738
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Ethanol 9.6415513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.6417551590 15992940
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8116316344
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0117339181 17506722 19075265 16331271 17294898 16766008 16823087 17217047 16788101 16140955 17107899 12679006 19035177 17712046 17649720 17368321 19642359 15748426 19029980 9834237 16891316 17361223 19225113 16935935 17301526
MESH:D017880 Limb Deformities, Congenital Ethanol 7.7817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.789224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4020032147 18665156 18522880 18407596 19638242
MESH:D008103 Liver Cirrhosis Ethanol 6.4015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.6318166357
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6318397230 16248980
MESH:D008107 Liver Diseases Chlorpyrifos 6.5315991261
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5317034775
MESH:D008107 Liver Diseases Tetrachloroethylene 6.5317267091
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317347304 17207112
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.2415890375
MESH:D008113 Liver Neoplasms Dieldrin 7.249539021 8742319
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.2420452335 19073162 18648771 20405173 20137499 20492335 12771043 10737359 18644402 15885732 21278145 2862719 20101389 21047994 19427195 19642983 19638242 21071580 16942905 21167192 19294768 19996281 19254457 19255062 18977376 9163691 18754104 20583210 19812893 19850985 15175105 19833225 12112319 19256749 19690152 20434301 19499222 18978307 19426721 20501860 19090486 19551842 20118626 2422723
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0919126423 19519916 18544905 2563599 18164116 19009564 18775883 19539802 18253720 16267830 18079962 19004024 18093689 17174075 16842330 9362446 17942915 3124819 18308698 18282651 21159647 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 6.097955063
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.7514755239 19931552 15172992 9255578 18508827 16061637 17139156 18813816 12438228 15893417 16401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7521163286 6695378 20970405 20512841
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008569 Memory Disorders Ethanol 9.6215451040 18411066
MESH:D008569 Memory Disorders varenicline 9.6218411066 20207347
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008607 Mental Retardation Toluene 3.579294310
MESH:D008881 Migraine Disorders topiramate 4.4218803445 16942474 18759728 18765137
MESH:D019964 Mood Disorders varenicline 6.1918567975
MESH:D019957 Motor Skills Disorders Toluene 5.029294310
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.489029167 3581430
MESH:D009369 Neoplasms Dieldrin 11.138820588
MESH:D009369 Neoplasms Nicotine 11.1316365874
MESH:D009369 Neoplasms Tetrachloroethylene 11.1311911487
MESH:D009369 Neoplasms Tretinoin 11.1316594593 16946489
MESH:D009389 Neovascularization, Pathologic Nicotine 4.7716365874
MESH:D009421 Nervous System Malformations Tretinoin 3.569125849
MESH:D009436 Neural Tube Defects Tretinoin 2.919142499
MESH:D019954 Neurobehavioral Manifestations marker/mechanism 19898479
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 8.3215081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 8.3219784758
MESH:D010018 Osteomalacia Strontium 6.5216815919
MESH:D010024 Osteoporosis Calcium 3.6417882678
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2816936753
MESH:D010146 Pain Tretinoin 6.9416870215
MESH:D010146 Pain varenicline 6.9420167427
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.7112384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7116540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.7112384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7115976015
MESH:D010259 Paranoid Disorders varenicline 7.0319489343
MESH:D010300 Parkinson Disease Dieldrin 3.4417291500 11181820 11445065 16809432 16112328
MESH:D011041 Poisoning Diazinon 8.7717603234
MESH:D011041 Poisoning Methyl Parathion 8.7717603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.362563599
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.109413022
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4117119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6617119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012640 Seizures Ethanol 17.079754883
MESH:D012640 Seizures Kynurenic Acid 17.0716457470
MESH:D012640 Seizures Nicotine 17.0717873105
MESH:D012640 Seizures Toluene 17.076431079 9294310
MESH:D012640 Seizures topiramate 17.0716499746
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.866418539
MESH:D012878 Skin Neoplasms Tretinoin 2.5016467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3018456281
MESH:D013274 Stomach Neoplasms Ethanol 3.3018456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3017261132
MESH:D013276 Stomach Ulcer Ethanol 3.3316755016 9562338 11906479 17189318 17918041 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.069754883
MESH:D013733 Testicular Diseases Toluene 4.7310514026 10048760
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.607505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6017045167 16026305
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5616785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 12.0317979512 18305452 18041664 15735609
MESH:D014029 Tobacco Use Disorder varenicline 12.0316766716 18984856 20388087 20331614 20373480 20207347 19967529
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D014570 Urologic Diseases Diazinon 5.0516487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA114
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    PA443319Alzheimer Disease
    PA447278Depression
    PA447216Schizophrenia
    PA445208Pain
    PA444818Lung Neoplasms
    PA445876Tobacco Use Disorder
    Releated drug ID Related drug Name
    PA164712872Local Anesthetics
    PA448031acetylcholine
    PA448976choline
    PA451784trimethaphan
    PA452604xenobiotics
    PA450626nicotine
    PA164781343varenicline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00184 agonist Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00237 antagonist Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 antagonist Trianal-C 1/2 Capsule Analgesics
    DB00306 antagonist Talbutal Analgesics
    DB00312 antagonist Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00418 antagonist Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00463 antagonist Metharbital Anticonvulsants
    DB00599 antagonist Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00794 antagonist Primidone Anticonvulsants;Barbiturates
    DB00849 antagonist Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB01174 antagonist Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01273 agonist Varenicline Nicotinic Agonists
    DB01351 antagonist Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 antagonist Aprobarbital
    DB01353 antagonist Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 antagonist Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 antagonist Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 antagonist Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 antagonist Barbituric acid derivative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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