AutismKB 2.0

Annotation Detail for ADCY8


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Basic Information Top
Gene Symbol:ADCY8 ( AC8,ADCY3,HBAC1 )
Gene Full Name: adenylate cyclase 8 (brain)
Band: 8q24.22
Quick LinksEntrez ID:114; OMIM: 103070; Uniprot ID:ADCY8_HUMAN; ENSEMBL ID: ENSG00000155897; HGNC ID: 239
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04742Taste transduction
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200004Endothelins
200011LPA receptor mediated events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNAaffects cotreatment|decreases expression 18164116
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]affects binding|decreases reaction|increases activity 19922557
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of ADCY8 mRNAaffects cotreatment|increases expression 18636392
D016572 Cyclosporine Cyclosporine results in decreased expression of ADCY8 mRNAdecreases expression 20106945
D003976 Diazinon Diazinon results in decreased expression of ADCY8 mRNAdecreases expression 17452286
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNAaffects cotreatment|decreases expression 18164116
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of ADCY8 mRNAaffects cotreatment|increases expression 18636392
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 proteinaffects binding|increases activity 19922557
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.888986270
MESH:D055371 Acute Lung Injury Chlorine 4.5820601635
MESH:D000236 Adenoma beta-Naphthoflavone 7.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 7.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2416434500 19052882 17162532 17620307 18056438 19061943
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.6716487989
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001714 Bipolar Disorder Carbamazepine 4.2417594078 20046352
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8715516495 17626835 18417511 19059883 18315731 14754758 16777450
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8719335982 19171122 19394651 21159647 3581430 19539802 19107877 18393292 19383236 20007298 16698587 17138121 17428255 19052882 18494052 20727157 20935162 16288022 16540662 19822196 16830150 16779866 20101231 19701751 18785209 18210153 16807293 16935385 20512989 17978847 18978308 17761372 19519916 17173139 17162532 20214788 20084675 18506893 16681979 3084413 16878318 11831363 19208518 20524982 16569478 18056438 20432363 18691550 19919837 10672840 18971187 18665156 16328049 17055752 10737359 16502159 19418558 18788625 20514400
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1421159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.969014606
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.7511748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.5415057820 16538175 20216337 16538176
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.5517465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.5519107877
MESH:D004362 Drug Toxicity Carbamazepine 4.6320216337
MESH:D004417 Dyspnea Chlorine 11.9620016425
MESH:D004417 Dyspnea Diazinon 11.9616487989
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 5.0117654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.5419915237 20485159 18855540 16415921 16538176
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.5217275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.3515008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 4.1018234410 20417680 7988514 9014606 17178248 17465707 19700373 821787 19439326 19620853
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.4615276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 6.0619549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005076 Exanthema Carbamazepine 5.8020485159
MESH:D005234 Fatty Liver Cyclosporine 8.5319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5320387270 21071580
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Diazinon 4.8516487989
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.9410459572
MESH:D006965 Hyperplasia Carbamazepine 5.5218773962
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007248 Infertility, Male Diazinon 3.9712948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9419638242 18522880 18665156 20032147 18407596
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 5.0319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0320452335 20101389 20137499 18648771 19294768 20501860 21278145 2862719 18754104 19642983 19499222 15175105 12771043 19090486 19073162 19551842 18977376 18978307 19638242 20118626 19690152 21071580 16942905 2422723 18644402 19254457 19426721 9163691 19812893 19833225 12112319 15885732 21167192 19256749 19427195 19850985 19996281 19255062 20434301 21047994 20405173 20583210 20492335 10737359
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.6018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6017942915 18079962 21159647 19126423 18282651 18775883 18093689 18544905 19519916 18164116 18308698 19539802 18253720 16267830 17854601 17174075 3124819 19009564 16842330 19004024 2563599 9362446
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6320512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Ozone 2.638597069 7614698
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6216628512
MESH:D008607 Mental Retardation Carbamazepine 3.799014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D019964 Mood Disorders marker/mechanism 19691954
MESH:D009224 Myotonia Congenita Carbamazepine 5.8020399394
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 5.1916990009
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010018 Osteomalacia Carbamazepine 5.8017016548
MESH:D010146 Pain Carbamazepine 4.2315215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010267 Parapsoriasis Carbamazepine 6.0116538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.2617145499 17679678
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 4.7318007984 18929643 18381685
MESH:D011041 Poisoning Diazinon 4.6117603234
MESH:D011230 Precancerous Conditions Cyclosporine 9.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.672563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.469014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.229014606
MESH:D019310 Pseudolymphoma Carbamazepine 5.979591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012640 Seizures Carbamazepine 3.9516180713 19414003 15946322 16876388 9046859 16938433 9844417
MESH:D012893 Sleep Disorders Carbamazepine 5.4619414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.5215057820 18855540 16538176 19915237 20485159 19694795 16415921
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014570 Urologic Diseases Diazinon 5.6516487989
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
KEGG:04742 Taste transduction
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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