AutismKB 2.0

Annotation Detail for CHRND


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Basic Information Top
Gene Symbol:CHRND ( ACHRD,CMS2A,FCCMS,SCCMS )
Gene Full Name: cholinergic receptor, nicotinic, delta
Band: 2q37.1
Quick LinksEntrez ID:1144; OMIM: 100720; Uniprot ID:ACHD_HUMAN; ENSEMBL ID: ENSG00000135902; HGNC ID: 1965
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Brain lesion load
IMMUNE
Desease Name
Brain lesion load
Desease Name
Multiple pterygium syndrome, lethal type
Myasthenic syndrome, fast-channel congenital
Myasthenic syndrome, slow-channel congenital
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRND mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos affects the expression of CHRND mRNAaffects expression 18812211
D003976 Diazinon Diazinon affects the expression of CHRND mRNAaffects expression 17452286
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of CHRND geneincreases mutagenesis 16495775
D005419 Flavonoids Flavonoids results in decreased expression of CHRND mRNAdecreases expression 18035473
C010176 halofuginone halofuginone results in decreased expression of CHRND mRNAdecreases expression 17180598
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma Ethylnitrosourea 3.886695378
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 10.7617119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 10.7616487989
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1914991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5916651633 16357521 16436596 15144691 18412241
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9316003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.5017160924
MESH:D004417 Dyspnea Diazinon 5.3216487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.5018357618
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0216436596
MESH:D005910 Glioma Ethylnitrosourea 3.5918412241 16357521 16651633
MESH:D006505 Hepatitis Diazinon 4.9516487989
MESH:D006965 Hyperplasia halofuginone 5.6611874485
MESH:D007248 Infertility, Male Diazinon 4.0212948887 16466525
MESH:D007249 Inflammation Flavonoids 2.7917296493
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2017379185
MESH:D008103 Liver Cirrhosis halofuginone 4.1817180598
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 2.9814739098 18458672 16489207 11172339 12175628
MESH:D008107 Liver Diseases Chlorpyrifos 3.1315991261
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316019985 6695378 16271038 17703301
MESH:D008223 Lymphoma Ethylnitrosourea 4.1615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.4715375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7018041768 10767621 10838139
MESH:D008579 Meningioma Ethylnitrosourea 6.5017943659
OMIM:253290 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE marker/mechanism
OMIM:608930 MYASTHENIC SYNDROME, CONGENITAL, FAST-CHANNEL marker/mechanism
OMIM:601462 MYASTHENIC SYNDROME, CONGENITAL, SLOW-CHANNEL marker/mechanism
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.8216707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.8816003739 17160924 16651423
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3715081274
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.5017160924
MESH:D011041 Poisoning Diazinon 4.7017603234
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.0516611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.4116611668 17119214
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.616418539
MESH:D012871 Skin Diseases halofuginone 3.5711874485
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.6215790496
MESH:D014570 Urologic Diseases Diazinon 5.8016487989
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26497
    • No data
    Releated disease ID Related disease Name
    PA152238425Multiple Pterygium Syndrome
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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