AutismKB 2.0

Annotation Detail for MAL2


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Basic Information Top
Gene Symbol:MAL2 ( - )
Gene Full Name: mal, T-cell differentiation protein 2
Band: 8q24.12
Quick LinksEntrez ID:114569; OMIM: 609684; Uniprot ID:MAL2_HUMAN; ENSEMBL ID: ENSG00000147676; HGNC ID: 13634
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAL2 mRNAaffects expression 17562736
D002794 Choline Choline affects the expression of MAL2 mRNAaffects expression 17616785
D016572 Cyclosporine Cyclosporine results in increased expression of MAL2 mRNAincreases expression 20106945
D019833 Genistein Genistein results in increased expression of MAL2 mRNAincreases expression 17341692
D007657 Ketone Bodies Ketone Bodies results in increased expression of MAL2 mRNAincreases expression 16807920
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of MAL2 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of MAL2 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAL2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Genistein 2.0516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.053084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.0516924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D002658 Developmental Disabilities Choline 4.8316818868
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7511287661 12540782 11834606 16393943 14986274 16485898 18071297 17562736 12705907 2444490 17906064 15619225 15968718 16081117 16177239 11743745 17522070 10774834 12958197 19370779 11461765 19923254 11421492 12392966 16109766 11529661 16781746 14550746 12153990 19420014 14725611 11739529 19739265 19164858 19416960 12594235 10915739 10663392 16227642 18713872 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.8215150132 16704527 16510608 15264214 15878914 16805852 15547733 15623463 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3019176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3012621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 11587558 19014921 16611625 19460945 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0814578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction Genistein 5.9617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.9619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.0117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0116411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Genistein 10.5616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5614600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311399792 11222880 11118676 11896295
MESH:D011471 Prostatic Neoplasms Genistein 3.4215256057 16925846 15378649
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3312958204 17575124
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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