AutismKB 2.0

Annotation Detail for SLC22A9


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Basic Information Top
Gene Symbol:SLC22A9 ( FLJ23666,HOAT4,OAT4,OAT7,UST3H,ust3 )
Gene Full Name: solute carrier family 22 (organic anion transporter), member 9
Band: 11q12.3
Quick LinksEntrez ID:114571; OMIM: 607579; Uniprot ID:S22A9_HUMAN; ENSEMBL ID: ENSG00000149742; HGNC ID: 16261
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C020922 4-O-methyl-12-O-tetradecanoylphorbol 13-acetate 4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in decreased activity of SLC22A9 proteindecreases activity 17341544
D000082 Acetaminophen Acetaminophen results in decreased activity of SLC22A9 proteindecreases activity 12388633
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC22A9 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC22A9 mRNAaffects expression 16483693
D000838 Anions Tetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D001241 Aspirin Aspirin results in decreased activity of SLC22A9 proteindecreases activity 12388633
C081643 candesartan candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C077793 candesartan cilexetil candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC22A9 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC22A9 mRNAdecreases expression 20106945
D019314 Dehydroepiandrosterone Sulfate Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D004008 Diclofenac Diclofenac results in decreased activity of SLC22A9 proteindecreases activity 12388633
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC22A9 mRNAaffects cotreatment|affects expression 17602206
C017296 estrone sulfate candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate EXP3174 inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C017296 estrone sulfate SLC22A9 protein results in increased uptake of estrone sulfateincreases uptake 17132213
C017296 estrone sulfate valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
C066026 EXP3174 EXP3174 inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D007052 Ibuprofen Ibuprofen results in decreased activity of SLC22A9 proteindecreases activity 12388633
D007052 Ibuprofen SLC22A9 protein results in increased uptake of Ibuprofenincreases uptake 12388633
D007213 Indomethacin Indomethacin results in decreased activity of SLC22A9 proteindecreases activity 12388633
D007213 Indomethacin SLC22A9 protein results in increased uptake of Indomethacinincreases uptake 12388633
D007660 Ketoprofen Ketoprofen results in decreased activity of SLC22A9 proteindecreases activity 12388633
D007660 Ketoprofen SLC22A9 protein results in increased uptake of Ketoprofenincreases uptake 12388633
D001556 Lindane Lindane affects the expression of SLC22A9 mRNAaffects expression 17785943
D019808 Losartan Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D008528 Mefenamic Acid Mefenamic Acid results in decreased activity of SLC22A9 proteindecreases activity 12388633
D009288 Naproxen Naproxen results in decreased activity of SLC22A9 proteindecreases activity 12388633
D010615 Phenacetin Phenacetin results in decreased activity of SLC22A9 proteindecreases activity 12388633
D015240 Phorbol 12,13-Dibutyrate Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 proteinaffects localization 17341544
D015240 Phorbol 12,13-Dibutyrate Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 proteindecreases activity 17341544
D015240 Phorbol 12,13-Dibutyrate Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]affects localization|decreases reaction 17341544
D015240 Phorbol 12,13-Dibutyrate Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein]decreases activity|decreases reaction 17341544
D010894 Piroxicam Piroxicam results in decreased activity of SLC22A9 proteindecreases activity 12388633
C047681 pranlukast pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D011339 Probenecid Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
D011374 Progesterone Progesterone affects the localization of SLC22A9 proteinaffects localization 17341544
D011374 Progesterone Progesterone results in decreased activity of SLC22A9 proteindecreases activity 17341544
D020156 Salicylic Acid Salicylic Acid results in decreased activity of SLC22A9 proteindecreases activity 12388633
D020156 Salicylic Acid SLC22A9 protein results in increased uptake of Salicylic Acidincreases uptake 12388633
D019311 Staurosporine Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]affects localization|decreases reaction 17341544
D019311 Staurosporine Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein]decreases activity|decreases reaction 17341544
D013467 Sulindac Sulindac results in decreased activity of SLC22A9 proteindecreases activity 12388633
D013752 Tetracycline SLC22A9 protein results in increased export of Tetracyclineincreases export 11855680
D013752 Tetracycline SLC22A9 protein results in increased uptake of Tetracyclineincreases uptake 11855680
D013752 Tetracycline Tetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D014212 Tretinoin Tretinoin results in increased expression of SLC22A9 mRNAincreases expression 16604517
C081489 valsartan valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]decreases reaction|increases uptake 17132213
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.1514745880
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D058186 Acute Kidney Injury Diclofenac 18.227897758
MESH:D058186 Acute Kidney Injury Ibuprofen 18.226375363
MESH:D058186 Acute Kidney Injury Naproxen 18.227897758
MESH:D058186 Acute Kidney Injury Sulindac 18.227897758
MESH:D000230 Adenocarcinoma Ibuprofen 6.8910697514
MESH:D000230 Adenocarcinoma Indomethacin 6.8916537180
MESH:D000230 Adenocarcinoma Sulindac 6.8911910360
MESH:D000236 Adenoma Diethylnitrosamine 10.2210737359 6695378
MESH:D000236 Adenoma Indomethacin 10.2211497255
MESH:D000236 Adenoma Sulindac 10.2210223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.5619052882 16434500 17162532 18056438 17620307 19061943
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3111535846 12394442 16460482 17611924 19003578 11874996 15623613
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0412661182
MESH:D000419 Albuminuria Losartan 5.5212586211
MESH:D000505 Alopecia Tretinoin 3.3515955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0217225004
MESH:D000544 Alzheimer Disease Ibuprofen 4.4218351690
MESH:D000544 Alzheimer Disease Indomethacin 4.4215579461 17627676
MESH:D000707 Anaphylaxis Ibuprofen 4.919532969
MESH:D000740 Anemia Phenacetin 4.622444515
MESH:D000743 Anemia, Hemolytic Phenacetin 4.9517082564 1949026 17698508
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.5310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.5410388637
MESH:D018771 Arthralgia Indomethacin 4.822160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.8716412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.4711248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4716292516
MESH:D001249 Asthma pranlukast 5.2720332717
MESH:D001249 Asthma Tretinoin 5.2716456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 9.8420485159 12372130
MESH:D055963 Asthma, Aspirin-Induced pranlukast 9.8419667532
MESH:D050197 Atherosclerosis Losartan 4.2910821809
MESH:D001321 Autistic Disorder Acetaminophen 2.6618445737
MESH:D001321 Autistic Disorder Dehydroepiandrosterone Sulfate 2.6615820420
MESH:D001471 Barrett Esophagus Tretinoin 4.0816935849
MESH:D001477 Bartter Syndrome Indomethacin 4.6510684365
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3116197459 16206674
MESH:D001913 Bowen's Disease Sulindac 5.0111207687
MESH:D001929 Brain Edema Indomethacin 4.6811481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 3.9315845082 15380490 15665606
MESH:D002545 Brain Ischemia Ibuprofen 9.4415837124
MESH:D002545 Brain Ischemia Indomethacin 9.4412524144
MESH:D001932 Brain Neoplasms Aspirin 4.1215481559
MESH:D001943 Breast Neoplasms Aspirin 4.4315161893
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4317474063
MESH:D001943 Breast Neoplasms estrone sulfate 4.4317261762
MESH:D001943 Breast Neoplasms Indomethacin 4.4317401462
MESH:D001943 Breast Neoplasms Lindane 4.4314688026
MESH:D001943 Breast Neoplasms Progesterone 4.4317614352 15562024 16175315
MESH:D001943 Breast Neoplasms Sulindac 4.4316642371
MESH:D001943 Breast Neoplasms Tretinoin 4.4316443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2516813970
MESH:D002056 Burns Indomethacin 4.3710459503
MESH:D002100 Cachexia Ibuprofen 11.5315141370
MESH:D002100 Cachexia Indomethacin 11.5311239499 16537180 15141370 15625704
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.213084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.2121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.2118978308 20514400 16540662 19394651 16830150 11831363 18971187 19822196 20432363 17978847 16698587 16569478 17162532 19539802 20101231 19208518 16681979 17761372 18494052 17428255 20512989 17138121 10737359 19171122 16502159 3084413 20007298 20935162 18788625 18785209 19418558 17055752 19383236 16288022 19107877 16779866 16878318 16807293 18056438 3581430 18691550 19052882 18665156 19919837 20524982 18393292 16328049 19519916 20727157 20214788 10672840 16935385 20084675 18210153 19701751 17173139 21159647 19335982 18506893
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.2116391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.211917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0118791128 11352223 14736730
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2117341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.5115482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5116096774 16051514
MESH:D006332 Cardiomegaly Losartan 7.3012586211 15969258
MESH:D006332 Cardiomegaly valsartan 7.3019597038
MESH:D009202 Cardiomyopathies valsartan 4.2216247790
MESH:D002318 Cardiovascular Diseases valsartan 4.0711230374
MESH:D002386 Cataract Acetaminophen 6.5610977129
MESH:D002386 Cataract Tretinoin 6.5617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.8312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.8321159647 2727394 17174075 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2516129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4019052882
MESH:D002764 Cholecystitis Indomethacin 4.8211181007
MESH:D002779 Cholestasis Cyclosporine 2.6719486331
MESH:D002822 Choriocarcinoma Tretinoin 4.8116461808
MESH:D002972 Cleft Palate Tretinoin 2.529407595
MESH:D003092 Colitis Tretinoin 3.3717035595
MESH:D003110 Colonic Neoplasms Aspirin 7.8912411196
MESH:D003110 Colonic Neoplasms Indomethacin 7.8915786552 15625704 11260862 15637740 15936596 15963497
MESH:D003110 Colonic Neoplasms Piroxicam 7.8915824018
MESH:D003110 Colonic Neoplasms Sulindac 7.8912902858 12458338
MESH:D015179 Colorectal Neoplasms Aspirin 3.5317047198
MESH:D015179 Colorectal Neoplasms Indomethacin 3.5312606626 17054584 18059344 11197048
MESH:D015179 Colorectal Neoplasms Sulindac 3.5311197048 18059344 10666051 11076880
MESH:D003324 Coronary Artery Disease valsartan 3.7717719468
MESH:D018352 Coronavirus Infections Indomethacin 5.3717302372
MESH:D003384 Coxsackievirus Infections valsartan 5.5020392896
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.809664655 10589399 9125849 9211117 8800419 9142499 14991402 9224671 16925845 17551590
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.3211508273
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1120387270
MESH:D003928 Diabetic Nephropathies valsartan 4.5111427623 18630688
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.8512861449 17621415
MESH:D003967 Diarrhea Indomethacin 3.487907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6819739265 19420014 12958197 15968718 11421492 19164858 12540782 16081117 17906064 11739529 18071297 12594235 10915739 10663392 11529661 16109766 11461765 16393943 17522070 12392966 14550746 16227642 14725611 16485898 16781746 17562736 12705907 12153990 19416960 18713872 11287661 11743745 2444490 19923254 10774834 19085960 14986274 15619225 11834606 19370779 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.6819107877
MESH:D056486 Drug-Induced Liver Injury Tetracycline 5.6817522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 12.1018446180 16133044 18450898
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 12.1017190690 18043480 16133044 18446180 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.8217329845 17045617 11535926 10671773 11991626 11595431 16699067 17151854 11595415 17202747 17351913
MESH:D004487 Edema Aspirin 23.1817259670
MESH:D004487 Edema Diclofenac 23.1816273134
MESH:D004487 Edema Indomethacin 23.188273558 19703484 7907874 16100529 7990266 8985016 10653021
MESH:D004487 Edema Ketoprofen 23.187990266
MESH:D004487 Edema Piroxicam 23.187907874
MESH:D004487 Edema Staurosporine 23.188273558
MESH:D004489 Edema, Cardiac Tretinoin 4.1218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4617692515
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8916569247
MESH:D004715 Endometriosis Ibuprofen 25.5415652904
MESH:D004715 Endometriosis Indomethacin 25.5415652904
MESH:D004715 Endometriosis Naproxen 25.5415652904
MESH:D004715 Endometriosis Progesterone 25.5416134523
MESH:D004715 Endometriosis Sulindac 25.5415652904
MESH:D019446 Endotoxemia Ibuprofen 9.7311545620
MESH:D019446 Endotoxemia Indomethacin 9.7318509659
MESH:D004751 Enteritis candesartan 10.9817763956
MESH:D004751 Enteritis Indomethacin 10.9810567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6517980183
MESH:D004802 Eosinophilia Indomethacin 8.6611298111
MESH:D004802 Eosinophilia pranlukast 8.6611514498
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7716302075
MESH:D004938 Esophageal Neoplasms Indomethacin 7.1411005569
MESH:D004938 Esophageal Neoplasms Piroxicam 7.1415878914
MESH:D004938 Esophageal Neoplasms Sulindac 7.1412235107
MESH:D005124 Eye Abnormalities Tretinoin 3.3316938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 11.4719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.4721071580 20387270
MESH:D005234 Fatty Liver Tetracycline 11.4716917069 19224547
MESH:D005334 Fever Ibuprofen 8.5916997862
MESH:D005334 Fever Indomethacin 8.5911852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.1414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.7919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.5510962813
MESH:D005355 Fibrosis Cyclosporine 18.5212168785 12639820
MESH:D005355 Fibrosis Indomethacin 18.5217994277
MESH:D005355 Fibrosis Tretinoin 18.5217994277
MESH:D005355 Fibrosis valsartan 18.5216893502
MESH:D005499 Folliculitis Indomethacin 4.8211298111
MESH:D005756 Gastritis Acetaminophen 9.9916983495
MESH:D005756 Gastritis Indomethacin 9.9915046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6911910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Aspirin 10.7712870263
MESH:D005909 Glioblastoma Indomethacin 10.7712870263
MESH:D005909 Glioblastoma Tretinoin 10.7717312396
MESH:D005910 Glioma Indomethacin 3.0918371953 16487511
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.2216928621
MESH:D005923 Glomerulosclerosis, Focal Segmental candesartan 9.6616687628
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 9.6611849393
MESH:D006073 Gout Indomethacin 5.0111248219
MESH:D006261 Headache Aspirin 4.6115240983
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.1615482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8116084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7114991402 9664655
MESH:D006333 Heart Failure Losartan 7.4610979640
MESH:D006333 Heart Failure valsartan 7.4619027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2715633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3615135802
MESH:D006521 Hepatitis, Chronic Diclofenac 5.3314986274
MESH:D012001 Hyperacusis Aspirin 5.4215240983
MESH:D006930 Hyperalgesia Acetaminophen 11.5416870215
MESH:D006930 Hyperalgesia Indomethacin 11.5412727271
MESH:D006930 Hyperalgesia Tretinoin 11.5416870215
MESH:D034321 Hyperamylasemia Indomethacin 5.3717883296
MESH:D017588 Hyperandrogenism Dehydroepiandrosterone Sulfate 6.1917392600
MESH:D006940 Hyperemia Indomethacin 4.6612524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2416778211
MESH:D006949 Hyperlipidemias Indomethacin 3.8517546600
MESH:D006973 Hypertension Cyclosporine 8.2010903974
MESH:D006973 Hypertension Losartan 8.2012586211 14597852 10090350 12512695 15969258
MESH:D006973 Hypertension valsartan 8.2016475468 12850387 11427623 20102058 12692753 18390891 18344623 10903974
MESH:D006974 Hypertension, Malignant valsartan 6.0611560862
MESH:D006984 Hypertrophy Ibuprofen 4.6716672835
MESH:D007077 Ileal Diseases Indomethacin 4.6810574470 18306037
MESH:D007079 Ileitis Indomethacin 5.0110647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Ibuprofen 13.0416133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 13.0416133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007249 Inflammation Diclofenac 29.6516273134
MESH:D007249 Inflammation Diethylnitrosamine 29.6518785209
MESH:D007249 Inflammation Ibuprofen 29.653291741
MESH:D007249 Inflammation Indomethacin 29.653291741 12568917 7812673
MESH:D007249 Inflammation Losartan 29.6512586211
MESH:D007249 Inflammation Naproxen 29.653291741
MESH:D007249 Inflammation pranlukast 29.6519129732
MESH:D007249 Inflammation Progesterone 29.6515869954
MESH:D007249 Inflammation Sulindac 29.653291741
MESH:D007410 Intestinal Diseases Indomethacin 14.7911686837 17994277 10210152 11713966 15831440 18236018 15610444 17329856 11855677
MESH:D007410 Intestinal Diseases pranlukast 14.7918236018
MESH:D007410 Intestinal Diseases Tretinoin 14.7917994277
MESH:D007414 Intestinal Neoplasms Piroxicam 9.6610213222
MESH:D007414 Intestinal Neoplasms Sulindac 9.6610223192 12584176 12663524 12628509 10213222 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.6711245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 5.0215241188
MESH:D007511 Ischemia pranlukast 5.8519129732
MESH:D007569 Jaw Abnormalities Tretinoin 3.6017551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.6816133968 18306037 10574470
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Acetaminophen 12.8712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.878314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 12.8717190690
MESH:D007674 Kidney Diseases valsartan 12.8716893502 10903974 12164870
MESH:D007680 Kidney Neoplasms Cyclosporine 2.4712371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6311703811 12228301 10320625
MESH:D007938 Leukemia Tretinoin 2.6017143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6810785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4019285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.8318360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9319029980 19075265 19225113 17506722 17107899 16788101 16331271 12679006 16766008 16891316 17301526 17649720 17217047 9834237 17339181 17712046 15748426 16823087 16935935 17361223 19035177 17294898 16140955 17368321 19642359
MESH:D007964 Leukocytosis Indomethacin 5.0216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3717980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.079224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3711479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6418522880 20032147 19638242 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0112468960
MESH:D008106 Liver Cirrhosis, Experimental candesartan cilexetil 6.3414620537
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.3418194892
MESH:D008106 Liver Cirrhosis, Experimental Losartan 6.3412445418 15573910 17900296
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3418397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 6.3415619341 15504291 16872305
MESH:D008107 Liver Diseases Acetaminophen 17.9219460945 12587719 19784758 12969438 19014921 16610002 11587558 16611625
MESH:D008107 Liver Diseases Diclofenac 17.9216867024 14566034
MESH:D008107 Liver Diseases Diethylnitrosamine 17.9217034775
MESH:D008107 Liver Diseases Lindane 17.921715830
MESH:D008107 Liver Diseases Naproxen 17.9216867024
MESH:D008107 Liver Diseases Piroxicam 17.9216867024
MESH:D008107 Liver Diseases Sulindac 17.9214986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 6.759163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Clofibric Acid 6.7517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 6.752422723 19833225 19255062 12112319 2862719 20492335 19850985 20452335 19642983 19690152 19090486 18644402 19294768 20101389 20434301 19254457 19551842 19073162 21071580 18977376 18978307 9163691 20501860 19812893 19996281 19638242 15885732 18754104 21167192 15175105 16942905 18648771 19427195 19256749 20583210 20137499 20118626 21047994 12771043 19499222 20405173 19426721 21278145 10737359
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.308603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.3018775883 21159647 18093689 18308698 18544905 19009564 18079962 18282651 3124819 18253720 17942915 19126423 18164116 2563599 17174075 16267830 17854601 19519916 16842330 19539802 9362446 19004024
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.1514755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.1521163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Indomethacin 6.1511053908 16537180 11497255
MESH:D008175 Lung Neoplasms Piroxicam 6.1515824018 11195469
MESH:D008175 Lung Neoplasms Sulindac 6.1515713900 19359593
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 5.7610697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.7617203775 11408345
MESH:D008382 Marfan Syndrome Losartan 5.7319430350
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma Sulindac 3.4316642371
MESH:D008545 Melanoma Tretinoin 3.4316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008591 Meningomyelocele Tretinoin 4.0916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008708 Methemoglobinemia Phenacetin 4.641949026 16296465 4834387 3537620
MESH:D008881 Migraine Disorders Aspirin 16.1315240983
MESH:D008881 Migraine Disorders candesartan 16.1318759728
MESH:D008881 Migraine Disorders Indomethacin 16.1311903285
MESH:D008881 Migraine Disorders Naproxen 16.1318803445
MESH:D009062 Mouth Neoplasms Indomethacin 3.7312636206
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8817596541
MESH:D009203 Myocardial Infarction Aspirin 6.2212692751
MESH:D009203 Myocardial Infarction Losartan 6.2212692751
MESH:D009205 Myocarditis pranlukast 6.1611514498
MESH:D009325 Nausea Aspirin 4.8715240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.493581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.4911239499 11053908 16537180
MESH:D009369 Neoplasms Lindane 7.6616818664 12807735
MESH:D009369 Neoplasms Piroxicam 7.6616684565
MESH:D009369 Neoplasms Tretinoin 7.6616946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 3.8110663608 15625704
MESH:D009395 Nephritis, Interstitial Ibuprofen 9.876375363
MESH:D009395 Nephritis, Interstitial Tetracycline 9.879884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0019348381 18481113
MESH:D009410 Nerve Degeneration Ibuprofen 4.1310961664
MESH:D009421 Nervous System Malformations Tretinoin 3.469125849
MESH:D009436 Neural Tube Defects Tretinoin 2.839142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 17.8718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 17.8720387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 17.8712349958
MESH:D019636 Neurodegenerative Diseases Sulindac 17.8716850258 17266991
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7720387270
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.826374098
MESH:D010003 Osteoarthritis Aspirin 16.297009135
MESH:D010003 Osteoarthritis Diclofenac 16.2918287210
MESH:D010003 Osteoarthritis Ibuprofen 16.297009135
MESH:D010003 Osteoarthritis Indomethacin 16.297009135
MESH:D010051 Ovarian Neoplasms Progesterone 4.5417393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5416936753
MESH:D010146 Pain Acetaminophen 32.7516870215
MESH:D010146 Pain Aspirin 32.756995502 6363464
MESH:D010146 Pain Diclofenac 32.7513679232
MESH:D010146 Pain Ibuprofen 32.753291741
MESH:D010146 Pain Indomethacin 32.7517440234 13679232 17627676 3291741
MESH:D010146 Pain Naproxen 32.753291741
MESH:D010146 Pain Sulindac 32.753291741
MESH:D010146 Pain Tretinoin 32.7516870215
MESH:D010149 Pain, Postoperative Ibuprofen 10.3216678543
MESH:D010149 Pain, Postoperative Indomethacin 10.3212538197 18702446
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.3516540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 11.3512384795
MESH:D010190 Pancreatic Neoplasms Sulindac 11.3516820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.3515976015
MESH:D010195 Pancreatitis Indomethacin 3.6117883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8312349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3711903285
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0911026799
MESH:D010437 Peptic Ulcer Indomethacin 4.8111148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.2011156591
MESH:D010518 Periodontitis Indomethacin 4.5717225004
MESH:D020795 Photophobia Aspirin 5.4215240983
MESH:D011230 Precancerous Conditions Cyclosporine 8.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.002563599
MESH:D047928 Premature Birth Indomethacin 4.7917000239
MESH:D017096 Prion Diseases Tetracycline 5.0710903871
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.1017409433
MESH:D011471 Prostatic Neoplasms Lindane 4.1012661182 14688026
MESH:D011507 Proteinuria candesartan 25.5216687628
MESH:D011507 Proteinuria Ibuprofen 25.526375363
MESH:D011507 Proteinuria Indomethacin 25.5211849393
MESH:D011507 Proteinuria Tretinoin 25.5216636307
MESH:D011507 Proteinuria valsartan 25.5217664856 12164870 18344623
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011625 Pterygium Tretinoin 4.4516723453
MESH:D011658 Pulmonary Fibrosis valsartan 3.6817241526
MESH:D051437 Renal Insufficiency Losartan 5.1915728788
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7916116481 16283617
MESH:D012220 Rhinitis Aspirin 8.7012372130
MESH:D012220 Rhinitis pranlukast 8.7020332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012640 Seizures Lindane 3.4012842176 15475178 7539098
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.9312269725
MESH:D012878 Skin Neoplasms Tretinoin 2.4516467112
MESH:D013119 Spinal Cord Injuries Progesterone 3.9415862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 4.0815472012 10192188 10486359 18545984 17160473 16280098 10215738 17638125 16113693 16184426 18209964 17207306 15038085
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2318456281
MESH:D013274 Stomach Neoplasms Indomethacin 3.2315609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.2317261132
MESH:D013276 Stomach Ulcer Indomethacin 7.0911906479 18726076 18431645 12787963 14567935 16169175 10750652 18209962 16150113 16934674 17627676 17977527 16252198 17657623 12077510 11729361 15138204 17654042 15255614 16631530 12500499 11595415 12498302 18087811 11145282 18181030 10423059 11595431 15104355 18299717 17918041 18193104 16397915 17895592 18543354 10878458 12467913 1323529 17135157 16755016 18237397 11523592
MESH:D013276 Stomach Ulcer Piroxicam 7.0915309881
MESH:D020521 Stroke Aspirin 4.1116403987
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.21978859
MESH:D013927 Thrombosis Aspirin 4.2317672075
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.567505956
MESH:D013964 Thyroid Neoplasms Indomethacin 10.5618791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 10.5616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.4916051514
MESH:D014376 Tuberculosis Tretinoin 3.0216040207
MESH:D014456 Ulcer Indomethacin 4.5517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 3.6811144890
MESH:D014581 Urticaria Acetaminophen 13.2010982225
MESH:D014581 Urticaria Aspirin 13.2020485159 10982225
MESH:D014581 Urticaria Piroxicam 13.2010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.3816129372
MESH:D014594 Uterine Neoplasms Sulindac 4.2818645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.2616752155
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.8519057314
MESH:D020257 Ventricular Remodeling valsartan 5.3619027736
MESH:D014820 Vitiligo Tretinoin 3.7316761959
MESH:D014839 Vomiting Indomethacin 4.4011897121
MESH:D009396 Wilms Tumor Tretinoin 3.6816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38102
    • Releated gene ID Related gene Name
    PA38102SLC22A9
    No data
    Releated drug ID Related drug Name
    PA450268losartan
    PA10384antiinflammatory and antirheumatic products, non-steroids
    PA449957ibuprofen
    PA449982indomethacin
    PA450149ketoprofen
    PA450428methotrexate
    PA450932phenylbutazone
    PA450985piroxicam
    PA451106probenecid
    PA452621antineoplastic agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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