AutismKB 2.0

Annotation Detail for CHRNG


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Basic Information Top
Gene Symbol:CHRNG ( ACHRG,MGC133376 )
Gene Full Name: cholinergic receptor, nicotinic, gamma
Band: 2q37.1
Quick LinksEntrez ID:1146; OMIM: 100730; Uniprot ID:ACHG_HUMAN; ENSEMBL ID: ENSG00000196811; HGNC ID: 1967
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Multiple pterygium syndrome, lethal type
Escobar syndrome
Myasthenia gravis, neonatal transient
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRNG mRNAaffects expression 16483693
D002330 Carmustine Carmustine results in decreased expression of CHRNG mRNAdecreases expression 15980968
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of CHRNG mRNAdecreases expression 18812211
D003976 Diazinon Diazinon results in decreased expression of CHRNG mRNAdecreases expression 17452286
D005419 Flavonoids Flavonoids results in decreased expression of CHRNG mRNAdecreases expression 18035473
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.0317119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.0316487989
MESH:D001932 Brain Neoplasms Carmustine 4.7316187019
MESH:D004417 Dyspnea Diazinon 5.4116487989
MESH:D005909 Glioblastoma Carmustine 4.1416187019
MESH:D006505 Hepatitis Diazinon 5.0116487989
MESH:D007248 Infertility, Male Diazinon 4.0416466525 12948887
MESH:D007249 Inflammation Flavonoids 2.8017296493
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D008545 Melanoma Carmustine 2.9012393984
OMIM:265000 MULTIPLE PTERYGIUM SYNDROME, ESCOBAR VARIANT marker/mechanism
OMIM:253290 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE marker/mechanism
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3915081274
MESH:D011041 Poisoning Diazinon 4.7517603234
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1217119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.5016611668 17119214
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.706418539
MESH:D014570 Urologic Diseases Diazinon 5.8916487989
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26499
    • No data
    Releated disease ID Related disease Name
    PA152238425Multiple Pterygium Syndrome
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00674 allosteric modulator Galantamine Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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