AutismKB 2.0

Annotation Detail for OSBPL6


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Basic Information Top
Gene Symbol:OSBPL6 ( FLJ36583,MGC59642,ORP6 )
Gene Full Name: oxysterol binding protein-like 6
Band: 2q31.2
Quick LinksEntrez ID:114880; OMIM: 606734; Uniprot ID:OSBL6_HUMAN; ENSEMBL ID: ENSG00000079156; HGNC ID: 16388
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of OSBPL6 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of OSBPL6 mRNAdecreases expression 20406850
C006632 arsenic trioxide arsenic trioxide results in increased expression of OSBPL6 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBPL6 mRNAdecreases expression 20382639
D014635 Valproic Acid Valproic Acid results in increased expression of OSBPL6 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3519825857 11798837
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9818775368 18985861 17688650 17507914 19232924 18558336 20603192 17157402 16609825 18316065 18177632 18940202 18396377 19460635 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.2317594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0416206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1616705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1616217749 15553829 14691202 15073043 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.446135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7810525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.788888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.643659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.917562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7012903497
MESH:D005234 Fatty Liver arsenic trioxide 9.1815073043
MESH:D005234 Fatty Liver Valproic Acid 9.1819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0819850784 20471514 16467208 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4317869043 16112521 11161223 16891316 15622746 15748426 16966277 12712474 15213294 19075265 12679006 17107899 16823087 17649720 16330433 19642359 17217047 17712046 19225113 9834237 11468182 16331271 15336539 12018890 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.977678174
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9714682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.652876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008881 Migraine Disorders Valproic Acid 3.4418803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3515949261 19417148 14977855 19549372 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.0216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.0217596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009436 Neural Tube Defects arsenic trioxide 8.0610525206
MESH:D009436 Neural Tube Defects Valproic Acid 8.0616359493 8888407
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4916624393 12452020 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7218551238
MESH:D012640 Seizures Valproic Acid 6.723137016 16876388 11044598 11738929 1511512 14763951 15475178 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4716049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4711780464 20435036 12973940 12845720
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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