AutismKB 2.0

Annotation Detail for OSBPL8


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Basic Information Top
Gene Symbol:OSBPL8 ( DKFZp686A11164,MGC126578,MGC133203,MST120,MSTP120,ORP8,OSBP10 )
Gene Full Name: oxysterol binding protein-like 8
Band: 12q14
Quick LinksEntrez ID:114882; OMIM: 606736; Uniprot ID:OSBL8_HUMAN; ENSEMBL ID: ENSG00000091039; HGNC ID: 16396
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OSBPL8 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of OSBPL8 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of OSBPL8 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBPL8 mRNAdecreases expression 19150397
20018196
D003024 Clozapine Clozapine results in increased expression of OSBPL8 mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in increased expression of OSBPL8 mRNAincreases expression 14647396
C004648 testosterone enanthate testosterone enanthate affects the expression of OSBPL8 mRNAaffects expression 17440010
D013752 Tetracycline Tetracycline results in decreased expression of OSBPL8 mRNAdecreases expression 16917069
D014635 Valproic Acid Valproic Acid results in increased expression of OSBPL8 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000380 Agranulocytosis Clozapine 5.3116160616 14617031 12649775
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Haloperidol 2.2318080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.2317507914 20603192 17688650 18177632 18558336 19460635 15238991 18775368 18985861 16609825 18316065 19232924 17157402 18940202 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 2.9715553829 16217749 14691202 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002375 Catalepsy Haloperidol 5.191977408 15215559
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D003072 Cognition Disorders Clozapine 5.2217123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7517688650 8888407 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 11.6715213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.6720210726
MESH:D003704 Dementia Haloperidol 4.7811575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0116402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8715331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6412540782 12392966 12153990 12958197 11743745 19085960 10915739 15968718 11529661 16781746 19370779 14986274 19420014 16081117 12705907 11834606 18713872 19739265 2444490 16227642 12594235 19416960 17906064 11461765 10663392 18071297 17562736 16393943 14550746 11421492 19923254 16109766 15619225 16177239 11287661 10774834 19164858 17522070 16485898 14725611 11739529
MESH:D056486 Drug-Induced Liver Injury Tetracycline 6.6417522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.641733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Clozapine 4.3316402076
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4816530937
MESH:D005234 Fatty Liver arsenic trioxide 14.5315073043
MESH:D005234 Fatty Liver Tetracycline 14.5319224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 14.5314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006948 Hyperkinesis Clozapine 5.1916046005
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0120471514 16467208 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416891316 16823087 9834237 15336539 19642359 16330433 19035177 17217047 19075265 16966277 15748426 19225113 17712046 11161223 16112521 17869043 12712474 17649720 11468182 12679006 15213294 12018890 17107899 15622746 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Clozapine 4.1017567588
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 16611625 12969438 12587719 19460945 19784758 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7821137059 20195826
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4611798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4618816296 20064080 18569708 18520028 20464547 20869020 20135361 17053015 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D001523 Mental Disorders Clozapine 9.3316856516
MESH:D001523 Mental Disorders Haloperidol 9.3316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5819142101
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2511468182 14977855 19549372 19417148 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7817596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009395 Nephritis, Interstitial Tetracycline 5.109884423
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7510525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.7516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Clozapine 3.0618515891 19142110
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.7511026799
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D017096 Prion Diseases Tetracycline 5.7010903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1317292933
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 5.2111575062
MESH:D011618 Psychotic Disorders Clozapine 9.6415331141
MESH:D011618 Psychotic Disorders Haloperidol 9.6411575062
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Clozapine 5.8817667964 17726453 16141801 18855531 18806925 17123785 20168265 19369910 11151749 20452607 20521320 20521326 20107430 11763009 20580759
MESH:D012559 Schizophrenia Haloperidol 5.8818513383 20107430 19369910 1830565
MESH:D012559 Schizophrenia Valproic Acid 5.8815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.873137016 11738929 11044598 15475178 14763951 17978042 1511512 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9420210726
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2720435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D015430 Weight Gain Clozapine 4.6517502770 16141801 20107430 20521320 20564506 16402076
MESH:D015431 Weight Loss Clozapine 5.3617933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32832
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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