AutismKB 2.0

Annotation Detail for C1QTNF4


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Basic Information Top
Gene Symbol:C1QTNF4 ( CTRP4,ZACRP4 )
Gene Full Name: C1q and tumor necrosis factor related protein 4
Band: 11p11.2
Quick LinksEntrez ID:114900; OMIM: NA; Uniprot ID:C1QT4_HUMAN; ENSEMBL ID: ENSG00000172247; HGNC ID: 14346
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004041 Dietary Fats Dietary Fats results in increased expression of C1QTNF4 mRNAincreases expression 18042831
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of C1QTNF4 mRNAincreases expression 15919760
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of C1QTNF4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QTNF4 mRNAaffects cotreatment|increases expression 17942748
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of C1QTNF4 mRNAincreases expression 15919760
C041786 palm oil palm oil results in increased expression of C1QTNF4 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of C1QTNF4 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of C1QTNF4 mRNAaffects expression 19136022
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QTNF4 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.9218653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.9218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.946705139 17173139 20935162 1701930 20007298
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3311677210 16105132 17681005 16919318 17333356 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 15668235 16354765 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 12.2017637181 18509659
MESH:D019446 Endotoxemia Lipopolysaccharides 12.2015328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 14.5119004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5115345470
MESH:D005234 Fatty Liver pirinixic acid 14.5119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever endotoxin, Escherichia coli 10.5216997862
MESH:D005334 Fever Lipopolysaccharides 10.529205823 11852909
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 16.2516109766
MESH:D006529 Hepatomegaly pirinixic acid 16.2519176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.2516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16354765 15340226 18606429 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Dietary Fats 9.0120412841
MESH:D007249 Inflammation Lipopolysaccharides 9.0112878042 17963957 17237260 17255318 9205823
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0112878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0621047994
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.8119482888 15975961 19812893 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 7.8120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8116984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.2618308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2612151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity Dietary Fats 4.6018674790 21332399 11836018 18457598 20132043 16723640 19632207 17217161 20518802
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.8911605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11399792 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures Phenobarbital 2.8411442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.9718063050
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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