AutismKB 2.0

Annotation Detail for C1QTNF6


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Basic Information Top
Gene Symbol:C1QTNF6 ( CTRP6,ZACRP6 )
Gene Full Name: C1q and tumor necrosis factor related protein 6
Band: 22q12.3
Quick LinksEntrez ID:114904; OMIM: NA; Uniprot ID:C1QT6_HUMAN; ENSEMBL ID: ENSG00000133466; HGNC ID: 14343
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00408Type I diabetes mellitus
No data
Desease Name
type 1 diabetes
IMMUNE
Desease Name
Type 1 diabetes
Vitiligo
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015001 arsenite arsenite results in decreased expression of C1QTNF6 mRNAdecreases expression 19716837
C015001 arsenite arsenite results in increased methylation of C1QTNF6 promoterincreases methylation 19716837
C447119 bazedoxifene acetate bazedoxifene acetate results in decreased expression of C1QTNF6 mRNAdecreases expression 19914376
D002104 Cadmium Cadmium results in decreased expression of C1QTNF6 mRNAdecreases expression 19716837
D002104 Cadmium Cadmium results in increased methylation of C1QTNF6 promoterincreases methylation 19716837
C014347 decitabine [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of C1QTNF6 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
C014347 decitabine decitabine inhibits the reaction [sodium arsenite affects the methylation of C1QTNF6 promoter]affects methylation|decreases reaction 18448484
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of C1QTNF6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of C1QTNF6 mRNAincreases expression 17942748
D015735 Mifepristone Mifepristone results in increased expression of C1QTNF6 mRNAincreases expression 17584828
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of C1QTNF6 promoteraffects acetylation|affects methylation 18448484
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of C1QTNF6 mRNAdecreases expression 18448484
19716837
C406082 monomethylarsonous acid monomethylarsonous acid results in increased methylation of C1QTNF6 promoterincreases methylation 19716837
C017947 sodium arsenite [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of C1QTNF6 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
C017947 sodium arsenite decitabine inhibits the reaction [sodium arsenite affects the methylation of C1QTNF6 promoter]affects methylation|decreases reaction 18448484
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of C1QTNF6 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite sodium arsenite results in decreased expression of C1QTNF6 mRNAdecreases expression 18448484
D013629 Tamoxifen Tamoxifen affects the expression of C1QTNF6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of C1QTNF6 mRNAincreases expression 17942748
C012589 trichostatin A [decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of C1QTNF6 promoter]affects cotreatment|affects methylation|decreases reaction 18448484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D050197 Atherosclerosis Cadmium 3.7215687053
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms decitabine 1.8719208741 18320071
MESH:D001943 Breast Neoplasms Tamoxifen 1.8717893378 17440819 18815881 16873071 18855134 19288272 19221464 15565566 19115204 20005174 18629630 18425577 19011961 17261762 16202921 19200415 19142967 20544844 19084267 15668708 19189212 17049068 19189210 21152245 19059307 19487384 18997820 20859285 11161223 19410462 19244106 19289846 18821012 21138602 18351453 18984771 19066611 20390343 16818667 19155303 19103187 16273361 17242785 20135344 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1217306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9219215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cadmium 12.0417332340
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 12.0419716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.0419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9811677210 16105132 17333356 16919318 17110522 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 16354765 15340226 12621046 8697196
MESH:D003110 Colonic Neoplasms arsenite 4.0715037631
MESH:D003110 Colonic Neoplasms decitabine 4.0717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 18978792
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.7719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.7719294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1320544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Mifepristone 9.5916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.599294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenite 14.0118296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0115345470
MESH:D005234 Fatty Liver Tamoxifen 14.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis arsenite 9.4118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma trichostatin A 3.9218801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5819215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 15340226 16959395 8697196 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male decitabine 11.7717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.7717937319
MESH:D007248 Infertility, Male sodium arsenite 11.7715346721 12646999
MESH:D007249 Inflammation Tamoxifen 5.1119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Cadmium 6.7016322080 16226777 16962696
MESH:D007674 Kidney Diseases sodium arsenite 6.7020008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007938 Leukemia decitabine 3.1318980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.1417236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3518460780 18206229 17679729 18704418 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.4918296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008113 Liver Neoplasms sodium arsenite 7.6915276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 7.6916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms arsenite 4.9816809336
MESH:D008175 Lung Neoplasms sodium arsenite 4.9817077188 16712894 15276417 19931552 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 4.9818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9811884234 19555203
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma decitabine 7.5417785578 16505122
MESH:D008545 Melanoma sodium arsenite 7.5419082730 16487513
MESH:D008545 Melanoma Tamoxifen 7.5412393984 19393235
MESH:D008545 Melanoma trichostatin A 7.5416505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D009101 Multiple Myeloma decitabine 7.9918172295
MESH:D009101 Multiple Myeloma trichostatin A 7.9918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4619010910 19157545 18608210 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms decitabine 5.4319470736 17925555 19116145
MESH:D009369 Neoplasms sodium arsenite 5.4311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D010051 Ovarian Neoplasms decitabine 11.7219259094 19331143
MESH:D010051 Ovarian Neoplasms Mifepristone 11.7216525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.7217306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 11.7219331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.8319294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.8319294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.5815687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 13.0217616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.0217616702
MESH:D011471 Prostatic Neoplasms Cadmium 2.1317075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1315067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1319789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5519155313
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4117431481
MESH:D012878 Skin Neoplasms sodium arsenite 5.7918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4317967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.4219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 12.4220375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.4216712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.4216712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms decitabine 5.1317785578
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25633
    • No data
    Releated disease ID Related disease Name
    PA443888Diabetes Mellitus, Type 1
    PA446047Vitiligo
    PA443886Diabetes Mellitus
    PA443888Diabetes Mellitus, Type 1
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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