AutismKB 2.0

Annotation Detail for FBXO32


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Basic Information Top
Gene Symbol:FBXO32 ( FLJ32424,Fbx32,MAFbx,MGC33610 )
Gene Full Name: F-box protein 32
Band: 8q24.13
Quick LinksEntrez ID:114907; OMIM: 606604; Uniprot ID:FBX32_HUMAN; ENSEMBL ID: ENSG00000156804; HGNC ID: 16731
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200091FoxO family signaling
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of FBXO32 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FBXO32 mRNAdecreases expression 18648102
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 18346979
D000638 Amiodarone Amiodarone results in increased expression of FBXO32 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FBXO32 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of FBXO32 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FBXO32 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of FBXO32 mRNAincreases expression 16474171
D004041 Dietary Fats Dietary Fats results in decreased expression of FBXO32 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in decreased expression of FBXO32 mRNAdecreases expression 16002434
D004317 Doxorubicin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 18346979
D004317 Doxorubicin AKT1 protein inhibits the reaction [Doxorubicin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 18346979
D004317 Doxorubicin Doxorubicin results in increased expression of FBXO32 mRNAincreases expression 18346979
D004958 Estradiol Estradiol results in increased expression of FBXO32 mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of FBXO32 mRNAincreases expression 16474171
C002963 geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
C002963 geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
C002963 geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
C002963 geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of FBXO32 mRNAincreases expression 17131360
D008148 Lovastatin geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
D008148 Lovastatin geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
D008148 Lovastatin Lovastatin results in increased expression of FBXO32 mRNAincreases expression 19406843
D008148 Lovastatin geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
D008148 Lovastatin geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
D008148 Lovastatin Lovastatin results in increased expression of FBXO32 mRNAincreases expression 19406843
D008148 Lovastatin Lovastatin results in increased expression of FBXO32 proteinincreases expression 19406843
D008148 Lovastatin Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
D008148 Lovastatin Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
D008798 Mevalonic Acid Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]decreases reaction|increases expression 19406843
D008798 Mevalonic Acid Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]decreases reaction|increases expression 19406843
C095716 N-acetyl-S-geranylgeranyl-cysteine N-acetyl-S-geranylgeranyl-cysteine results in increased expression of FBXO32 mRNAincreases expression 19406843
C095716 N-acetyl-S-geranylgeranyl-cysteine N-acetyl-S-geranylgeranyl-cysteine results in increased expression of FBXO32 proteinincreases expression 19406843
C041786 palm oil palm oil results in decreased expression of FBXO32 mRNAdecreases expression 18042831
C032208 perilla alcohol perilla alcohol results in increased expression of FBXO32 mRNAincreases expression 19406843
C032208 perilla alcohol perilla alcohol results in increased expression of FBXO32 proteinincreases expression 19406843
C032208 perilla alcohol perilla alcohol results in increased expression of FBXO32 mRNAincreases expression 19406843
C032208 perilla alcohol perilla alcohol results in increased expression of FBXO32 proteinincreases expression 19406843
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of FBXO32 mRNAincreases expression 16474171
D018038 Sodium Selenite Sodium Selenite results in increased expression of FBXO32 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FBXO32 mRNAincreases expression 18495758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FBXO32 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FBXO32 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8911850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.8817418594
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Genistein 9.8811473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.313712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.316695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0617306315
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6720041841 18218290 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.8316835338 12569548 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 3.7415238619
MESH:D050197 Atherosclerosis Arsenic 3.1612928151 19371607
MESH:D001281 Atrial Fibrillation Amiodarone 3.7919698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8711289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.5819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5514601052
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.6217123778
MESH:D001943 Breast Neoplasms Calcitriol 4.6211237771
MESH:D001943 Breast Neoplasms Dietary Fats 4.6220435547
MESH:D001943 Breast Neoplasms Doxorubicin 4.6217369602 19526202 11325840 15939500 16935488 16264153 15668708 16096432 16595493 18628466 15994142 18695136 17426702 16826403 16322301 15993339 17983394 15136595 18382427 15692762 16115903 18234424 15567936 15634643
MESH:D001943 Breast Neoplasms Estradiol 4.6216675129 17018787 12948864 14630087 17289903 18497071 17261762 19861407
MESH:D001943 Breast Neoplasms Genistein 4.6216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5115504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.627296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.6216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.6218059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.6216924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.317296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.3116201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4715504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.4711237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.476189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4316952015 15476868 16278810 16269455 17928571 17382496 17007740 18627295 17924179 15505089 16455267 16731534 15792986 16651473 15811867 16364871 16612575 17519947 17329180 17308081 17131338 16109756 16242529 17974986 17351982
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.8015710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.8016243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 7.1615738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 7.1616332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.1818022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9318974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.317505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.3118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.049022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6015894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0412621046 16354765 15668235 15340226 8697196
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8818802399 18259882
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8815531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5616140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6611906362 2524372 14531868 18759878 8970840 8156756 11298694 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.352952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6516285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.5418289764 9653073 18692083 1440618 8291058 7440962 9022650 6482804 16192314 6679447 11289319 9328219 18648102
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.5415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.5417416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.5415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5420420201
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3418367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7915138306
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.9517359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.9518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.9511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2417637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.233581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Amiodarone 7.5214986274
MESH:D005234 Fatty Liver Dietary Fats 7.5217967931 18296743 19004024 19551842
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Lipopolysaccharides 3.889205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.876705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Dietary Fats 8.1218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1220067830
MESH:D005534 Foot Diseases Arsenic 5.416392382
MESH:D005909 Glioblastoma Doxorubicin 7.0117150277
MESH:D005909 Glioblastoma Genistein 7.0116598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.897505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4315692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3816879835 17875725 14766674 16495754 16144979 16244372 18674790 18006777 17888722 16244371 12587719 16707910 16330681
MESH:D006333 Heart Failure Doxorubicin 3.2517481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.376705139
MESH:D006529 Hepatomegaly Amiodarone 8.0415265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.2817606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 8.709751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.7021332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3217050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7915034207
MESH:D006973 Hypertension Arsenic 5.049931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.4116093927
MESH:D007037 Hypothyroidism Amiodarone 4.3617991464 18020914
MESH:D007249 Inflammation Dietary Fats 7.8920412841
MESH:D007249 Inflammation Lipopolysaccharides 7.8917237260 17963957 12878042 17255318 9205823
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8912200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.8616393666
MESH:D007333 Insulin Resistance Dietary Fats 16.8618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.8616393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 16.8614714311
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4917255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.878074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007642 Keratosis Arsenic 4.8416930632 12749816
MESH:D007674 Kidney Diseases Doxorubicin 5.9115369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 5.9115618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.956582329
MESH:D007680 Kidney Neoplasms Estradiol 6.9515610895
MESH:D007938 Leukemia Genistein 2.9518980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4517339181
MESH:D007970 Leukopenia Lipopolysaccharides 4.5515821434
MESH:D008064 Lipidoses Amiodarone 3.4017567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8018296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5517823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5512878042
MESH:D008107 Liver Diseases Arsenic 2.5111134558
MESH:D008113 Liver Neoplasms Arsenic 7.0916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.0920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.39598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.3917085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 13.391423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.2712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3318516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.8621114838
MESH:D008175 Lung Neoplasms Arsenic 4.7117976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7118816296 20064080 18569708 18520028 20464547 6695378 20869020 20135361 17053015
MESH:D008175 Lung Neoplasms Doxorubicin 4.7117418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7119555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.3516098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.4715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4711807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.4714578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Doxorubicin 2.2716827129
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D052016 Mucositis Doxorubicin 4.6417415656
MESH:D009181 Mycoses Amiodarone 4.7517974566 12754197
MESH:D009203 Myocardial Infarction Doxorubicin 5.7715857846 19429709
MESH:D009203 Myocardial Infarction Genistein 5.7717141266
MESH:D017202 Myocardial Ischemia Arsenic 8.6015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1317141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.6418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1011141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009401 Nephrosis Doxorubicin 4.6216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8715640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 22.2316427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 22.2311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 22.2316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.2314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.056679447
MESH:D009436 Neural Tube Defects Arsenic 7.0516620997
MESH:D009447 Neuroblastoma Doxorubicin 3.1915555623
MESH:D020078 Neurogenic Inflammation Arsenic 4.2317056641
MESH:D009765 Obesity Dietary Fats 2.2519632207 21332399 20518802 18674790 18457598 17217161 16723640 20132043 11836018
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.294026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.873988306
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.6717306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.6719401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6719005980
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.337296757
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3416702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8415371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.326228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.4012224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0011399792 11896295 11222880 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.9116140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.9116740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.9116289102 18247401 15754350 16644109 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.9116888761 16868541 15749863 15897917 16729912 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.9116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.9116925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.9115721890
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.9118760546
MESH:D011507 Proteinuria Arsenic 3.8621343184
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12490602 12832656
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.263692021
MESH:D012509 Sarcoma Doxorubicin 3.8617710206 15625365 17203757 16767912 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0914601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9318724381
MESH:D012871 Skin Diseases Arsenic 2.7116759981 19834688 17453740 15952646 16702368 17050553 16353154 6392382 17938729 17548696 18709164
MESH:D012878 Skin Neoplasms Arsenic 13.0017029826 17050553 17976673 19538983 15504454 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.0019755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.0015692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.0016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4216767912 17203757 15625365
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.1818087811
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316045194 16684133
MESH:D013610 Tachycardia Amiodarone 4.1411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0419225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0315821434
MESH:D013959 Thyroid Diseases Amiodarone 11.5519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.887505956 6582329 3712494 6587162 1399818
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.8816010429 17909728
MESH:D013971 Thyrotoxicosis Amiodarone 4.7119584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D016171 Torsades de Pointes Amiodarone 4.0417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.468074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.4611144890 17306315 19322015 19429237 17976673 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.4617653716
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014652 Vascular Diseases Arsenic 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0717678736 17638931 17334414 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D015430 Weight Gain Dietary Fats 3.6116723640
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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