AutismKB 2.0

Annotation Detail for PTPMT1


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Basic Information Top
Gene Symbol:PTPMT1 ( DUSP23,FLJ46081,MOSP,PLIP )
Gene Full Name: protein tyrosine phosphatase, mitochondrial 1
Band: 11p11.2
Quick LinksEntrez ID:114971; OMIM: 609538; Uniprot ID:PTPM1_HUMAN; ENSEMBL ID: ENSG00000110536; HGNC ID: 26965
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTPMT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PTPMT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PTPMT1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PTPMT1 mRNAincreases expression 19150397
D010615 Phenacetin Phenacetin results in increased expression of PTPMT1 mRNAincreases expression 17698508
C030299 phenylhydrazine phenylhydrazine results in increased expression of PTPMT1 mRNAincreases expression 17698508
D013752 Tetracycline Tetracycline results in decreased expression of PTPMT1 mRNAdecreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000740 Anemia Phenacetin 10.792444515
MESH:D000740 Anemia phenylhydrazine 10.792444515
MESH:D000743 Anemia, Hemolytic Phenacetin 12.0117698508 17082564 1949026
MESH:D000743 Anemia, Hemolytic phenylhydrazine 12.0117084956 17082564 17698508
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5918713872 16485898 19420014 16081117 12540782 10774834 11529661 10915739 19164858 12958197 19739265 12705907 19416960 16393943 14550746 11287661 19923254 19085960 12594235 12392966 11739529 17522070 10663392 15968718 11461765 16109766 12153990 11421492 11743745 16177239 2444490 16781746 15619225 19370779 14725611 16227642 11834606 18071297 17906064 17562736 14986274
MESH:D056486 Drug-Induced Liver Injury Tetracycline 9.5917522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Tetracycline 4.3316917069 19224547
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16611625 19460945 12587719 19784758 11587558 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876784 2876786 6135515
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008708 Methemoglobinemia Phenacetin 5.251949026 16296465 3537620 4834387
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009395 Nephritis, Interstitial Tetracycline 5.239884423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.8811026799
MESH:D017096 Prion Diseases Tetracycline 5.8110903871
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013436 Sulfhemoglobinemia Phenacetin 7.00978859
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 9.0311144890
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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