AutismKB 2.0

Annotation Detail for FLYWCH2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FLYWCH2 ( - )
Gene Full Name: FLYWCH family member 2
Band: 16p13.3
Quick LinksEntrez ID:114984; OMIM: NA; Uniprot ID:FWCH2_HUMAN; ENSEMBL ID: ENSG00000162076; HGNC ID: 25178
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FLYWCH2 mRNAdecreases expression 18648102
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FLYWCH2 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FLYWCH2 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of FLYWCH2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1715565566 19115204 19289846 19011961 19487384 19221464 20859285 18855134 20005174 18815881 16873071 17893378 17261762 19142967 21138602 18629630 19059307 18351453 18984771 19189210 19200415 19189212 20390343 16202921 15668708 19084267 17049068 11161223 20065188 19155303 18997820 20135344 21152245 16273361 18821012 17242785 19244106 17440819 19288272 19066611 19410462 20544844 19103187 16818667 18425577
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.123581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 15.129022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 15.1215861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 15.1219176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3518759878 11906362 8156756 2524372 12868966 11298694 8970840 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0418692083 9653073 7440962 6679447 18289764 16192314 11289319 8291058 6482804 18648102 9022650 9328219 1440618
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.6819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2920544844 19155303 17893378 16202921
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6415345470
MESH:D005234 Fatty Liver pirinixic acid 15.6420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 15.6414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006529 Hepatomegaly pirinixic acid 3.5516221962 18467677 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.556582329
MESH:D007680 Kidney Neoplasms Tamoxifen 8.5518625569
MESH:D008064 Lipidoses Tamoxifen 3.4317567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4118564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.8415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.8416684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.751399818 3712494 6587162 598648
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8616827153 19196722 19196723 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.133581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219189210 19196722 19200415
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.816482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D013088 Spermatocele Ethinyl Estradiol 14.1116709447
MESH:D013088 Spermatocele Tamoxifen 14.1116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.191399818 6587162 6582329 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.468074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.468653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved