AutismKB 2.0

Annotation Detail for ADCY9


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Basic Information Top
Gene Symbol:ADCY9 ( AC9,FLJ12046 )
Gene Full Name: adenylate cyclase 9
Band: 16p13.3
Quick LinksEntrez ID:115; OMIM: 603302; Uniprot ID:ADCY9_HUMAN; ENSEMBL ID: ENSG00000162104; HGNC ID: 240
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04062Chemokine signaling pathway
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200004Endothelins
200011LPA receptor mediated events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P05731GABA-B receptor II signaling
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
No data
Desease Name
Partial epilepsies
Body mass index
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADCY9 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ADCY9 mRNAaffects expression 17562736
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of ADCY9 mRNAincreases expression 12558987
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ADCY9 mRNAdecreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADCY9 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADCY9 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ADCY9 mRNAdecreases expression 15336504
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]affects binding|decreases reaction|increases activity 19922557
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of ADCY9 mRNAincreases expression 17452286
D003474 Curcumin Curcumin results in decreased expression of ADCY9 mRNAdecreases expression 15713895
D016572 Cyclosporine Cyclosporine results in decreased expression of ADCY9 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ADCY9 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADCY9 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY9 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of ADCY9 mRNAdecreases expression 19219653
D005557 Formaldehyde Formaldehyde results in increased expression of ADCY9 mRNAincreases expression 14756816
C041786 palm oil palm oil results in decreased expression of ADCY9 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of ADCY9 mRNAdecreases expression 15375163
D012402 Rotenone Rotenone results in increased expression of ADCY9 mRNAincreases expression 19013527
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 proteinaffects binding|increases activity 19922557
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADCY9 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY9 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.428986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4215322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.9911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.9920464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9914692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.9917638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.2616611668 17119214 11874814
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6015590663
MESH:D000740 Anemia Fluorouracil 8.4216511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.6215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7216807698
MESH:D050197 Atherosclerosis Curcumin 3.2718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Curcumin 4.4019761891
MESH:D001714 Bipolar Disorder Carbamazepine 4.0920046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.8016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D002545 Brain Ischemia Curcumin 4.2516770732
MESH:D001932 Brain Neoplasms Curcumin 3.8617596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9320146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 2.9318593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 2.9320435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.9316110121 18608205 18357371 16557594 19217205 16595493 15136595
MESH:D001943 Breast Neoplasms Formaldehyde 2.9315986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5916051944
MESH:D002277 Carcinoma Curcumin 13.5618593918
MESH:D002277 Carcinoma Fluorouracil 13.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.4516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.453084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.4514691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.4516332177 17088986 16799960 17971768 17045692 18930000
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4420419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.4418462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.4417066447 16757204 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.3512371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 12.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9617110522 11677210 15861022 17333356 17681005 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 12.9619176532
MESH:D016770 Ciliophora Infections Formaldehyde 5.5612113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 15668235 16354765 12621046 15340226
MESH:D003092 Colitis Curcumin 4.0918200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.4718809619
MESH:D003110 Colonic Neoplasms Curcumin 3.8819359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8816510598 15001691 17725105 17172411 16340194 17287894 18772588 17016597 17018589 17169374
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5320501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5317454858 17401013 16524972 15289873 16303861 17594712 18509181 17094418 20501625 15148649 17695437 14970324 16331619 17016601 18802399 18383874 18949393 17255274 18288408 18448328 16391804 16282729
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.8118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.869014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.6315932584 14996049 15059100 12081698 16958921
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3418403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.9318204486
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3611748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3516538176 15057820 16538175 20216337
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7810663392 10915739 16485898 11461765 11529661 16781746 12392966 17906064 12594235 11739529 16393943 16081117 12153990 19416960 19164858 11287661 2444490 19739265 12540782 16109766 17562736 12705907 19923254 18071297 14550746 11743745 19370779 18713872 11421492 14725611 11834606 10774834 12958197 14986274 15619225 19420014 17522070 15968718 16227642 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 8.7817465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Carbamazepine 8.1820216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1811462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9617351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 9.1017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1716538176 19915237 18855540 16415921 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.1217275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.8915008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 3.957988514 9014606 18234410 20417680 17178248 17465707 19439326 19700373 821787 19620853
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.277750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.0415276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.6419549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.2112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.2116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.2115173087 16481741 17638652 16337965 16785472
MESH:D005076 Exanthema Carbamazepine 5.3820485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005141 Eyelid Diseases Formaldehyde 6.3014996049
MESH:D005234 Fatty Liver arsenic trioxide 29.6715073043
MESH:D005234 Fatty Liver Curcumin 29.6719297423
MESH:D005234 Fatty Liver Cyclosporine 29.6719224547
MESH:D005234 Fatty Liver Dietary Fats 29.6718296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.6715345470
MESH:D005234 Fatty Liver pirinixic acid 29.6719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005355 Fibrosis Curcumin 20.4518705752
MESH:D005355 Fibrosis Cyclosporine 20.4512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.4518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4520067830
MESH:D005393 Fish Diseases Formaldehyde 5.5312113305
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6118462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Curcumin 3.4217596214
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.7718829502 18462866
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.7718337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9719772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9716120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9517701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006937 Hypercholesterolemia Curcumin 8.9618704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.9621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6510459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006965 Hyperplasia Carbamazepine 5.1218773962
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Curcumin 8.0817151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 8.0820412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0812878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1718200517 18596194
MESH:D007333 Insulin Resistance Dietary Fats 7.0518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0516306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.1410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 5.6315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.6310903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.9816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9816985049
MESH:D007889 Leiomyoma Curcumin 4.4918555241
MESH:D007938 Leukemia arsenic trioxide 6.3715070760
MESH:D007938 Leukemia Curcumin 6.3718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.4917077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.4916106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216467208 19850784 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1619642359 11161223 11468182 15336539 16112521 17217047 19035177 16330433 17107899 19225113 12679006 16331271 17869043 12018890 17649720 16966277 17712046 15748426 16891316 19075265 9834237 15213294 16823087 12712474 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.4316882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.4316106398
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8318296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.4018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4012878042
MESH:D008107 Liver Diseases Acetaminophen 6.5416611625 12969438 12587719 11587558 19460945 19014921 16610002 19784758
MESH:D008107 Liver Diseases Chlorpyrifos 6.5415991261
MESH:D008107 Liver Diseases Curcumin 6.5416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 13.8814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8821137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 13.8817045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 13.8815890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.6220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4819825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4820464547 18569708 18520028 18816296 17053015 20135361 20869020 6695378 20064080
MESH:D008175 Lung Neoplasms Curcumin 6.4816243823 19359593 18462866
MESH:D008175 Lung Neoplasms Fluorouracil 6.4815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5416628512
MESH:D008223 Lymphoma Curcumin 3.5218462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6116173963
MESH:D008545 Melanoma Curcumin 2.4017885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008569 Memory Disorders Curcumin 4.0717263510
MESH:D008607 Mental Retardation Carbamazepine 3.709014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009041 Motion Sickness Dextroamphetamine 5.441613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3016757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2315949261 14977855 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma Curcumin 7.2319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D009224 Myotonia Congenita Carbamazepine 5.3820399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.0416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.0418495463
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9611141357
MESH:D009369 Neoplasms Fluorouracil 7.9616928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 7.9617405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4512497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.8118619942 17356569 15790535
MESH:D009421 Nervous System Malformations Carbamazepine 9.6416990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5518462866
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 8.1115081274
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 8.1116436463
MESH:D009669 Nose Neoplasms Formaldehyde 5.264038687
MESH:D009765 Obesity Curcumin 7.3119297423
MESH:D009765 Obesity Dietary Fats 7.3118674790 17217161 19632207 20518802 21332399 11836018 18457598 20132043 16723640
MESH:D009765 Obesity pirinixic acid 7.3120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3512819281 16049721
MESH:D010018 Osteomalacia Carbamazepine 5.3817016548
MESH:D010024 Osteoporosis Curcumin 3.4218719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9616624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 4.9618462866 19020741
MESH:D010146 Pain Acetaminophen 6.7616870215
MESH:D010146 Pain Carbamazepine 6.7615215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.5315580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.5319401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.5319003803 16929163 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010267 Parapsoriasis Carbamazepine 5.6116538176
MESH:D010300 Parkinson Disease Rotenone 2.9519232380 18191903 16412576 16140633 18619942 19114014 15451049 11445065 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 4.0015795934 15927086 15574749 18197244
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.8417679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011248 Pregnancy Complications Carbamazepine 5.069014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.579014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5711896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.1111398177 15129424 18226269 12497104 10851300 18156803 18769126
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1118626508 19082440
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 5.529591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.4519168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9316160472 18286688 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9418379247 10666014
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.5517119214 16611668 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8116611668 17119214
MESH:D012509 Sarcoma Curcumin 4.0418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.7814979077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1318551238
MESH:D012640 Seizures Carbamazepine 6.1319414003 9046859 16876388 9844417 16938433 16180713 15946322
MESH:D018805 Sepsis Curcumin 4.0018389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.016418539
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1610029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.168532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1616192470
MESH:D012893 Sleep Disorders Carbamazepine 5.0419414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.1216538176 15057820 19915237 19694795 18855540 20485159 16415921
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.322093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3217522103 16424979 18396642 19084572 18567086 17498489 19015929 15786421 17172411 16951190
MESH:D013276 Stomach Ulcer Curcumin 3.4219188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0219014326
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9116280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.6616049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6620435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6617053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.6618593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.1818462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    Releated drug ID Related drug Name
    PA450121isoproterenol
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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