AutismKB 2.0

Annotation Detail for CKB


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Basic Information Top
Gene Symbol:CKB ( B-CK,CKBB )
Gene Full Name: creatine kinase, brain
Band: 14q32.33
Quick LinksEntrez ID:1152; OMIM: 123280; Uniprot ID:KCRB_HUMAN; ENSEMBL ID: ENSG00000166165; HGNC ID: 1991
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6158creatine-phosphate biosynthesis
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1791Neuropathy
2053Colon cancer
2205Uveitis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CKB mRNAincreases expression 20406850
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of CKB mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of CKB mRNAaffects expression 17562736
D020106 Acrylamide Acrylamide results in decreased activity of CKB proteindecreases activity 15038071
D020106 Acrylamide Acrylamide results in decreased activity of CKB proteindecreases activity 15038071
D013196 Dihydrotestosterone Dihydrotestosterone results in increased activity of CKB proteinincreases activity 16621514
D013196 Dihydrotestosterone Glucose inhibits the reaction [Dihydrotestosterone results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D013196 Dihydrotestosterone Dihydrotestosterone results in increased activity of CKB proteinincreases activity 17029789
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CKB mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of CKB mRNAincreases expression 16648578
C004541 biochanin A biochanin A results in increased activity of CKB proteinincreases activity 16621514
C006780 bisphenol A bisphenol A results in increased expression of CKB mRNAincreases expression 12075121
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNAaffects cotreatment|decreases expression 12634122
C459604 candoxin candoxin results in decreased expression of CKB mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CKB mRNAincreases expression 17484886
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNAaffects cotreatment|decreases expression 12634122
D003513 Cycloheximide Cycloheximide inhibits the reaction [Estradiol results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D003513 Cycloheximide Cycloheximide inhibits the reaction [Methoxychlor results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D016572 Cyclosporine Cyclosporine results in decreased expression of CKB mRNAdecreases expression 20106945
D003609 Dactinomycin Dactinomycin inhibits the reaction [Estradiol results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D003609 Dactinomycin Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of CKB protein]decreases reaction|increases expression 7839363
C004742 daidzein daidzein results in increased activity of CKB proteinincreases activity 16621514
C004742 daidzein Glucose inhibits the reaction [daidzein results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CKB mRNAincreases expression 16636312
D004317 Doxorubicin Doxorubicin results in increased expression of CKB proteinincreases expression 15764680
D004958 Estradiol Estradiol results in increased activity of CKB proteinincreases activity 16621514
D004958 Estradiol Glucose inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of CKB mRNAaffects cotreatment|increases expression 17404688
D004958 Estradiol Cycloheximide inhibits the reaction [Estradiol results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D004958 Estradiol Dactinomycin inhibits the reaction [Estradiol results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D004958 Estradiol Estradiol results in increased activity of CKB proteinincreases activity 17029789
D004958 Estradiol Estradiol results in increased expression of CKB proteinincreases expression 7839363
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 17029789
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 17029789
D004958 Estradiol Vitamin D analog promotes the reaction [Estradiol results in increased activity of CKB protein]increases activity|increases reaction 17029789
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CKB mRNAincreases expression 16174780
12072388
17942748
19400957
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CKB mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CKB mRNAaffects expression 17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CKB mRNAincreases expression 16174780
12655037
16140622
12075121
19400957
D005472 Fluorouracil CKB protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C056507 gemcitabine gemcitabine results in decreased expression of CKB mRNAdecreases expression 17039268
D019833 Genistein Genistein results in increased activity of CKB proteinincreases activity 16621514
D019833 Genistein Glucose inhibits the reaction [Genistein results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D019833 Genistein Genistein results in increased expression of CKB mRNAincreases expression 12075121
D005947 Glucose Glucose inhibits the reaction [daidzein results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D005947 Glucose Glucose inhibits the reaction [Dihydrotestosterone results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D005947 Glucose Glucose inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D005947 Glucose Glucose inhibits the reaction [Genistein results in increased activity of CKB protein]decreases reaction|increases activity 16621514
D005947 Glucose Glucose results in increased activity of CKB proteinincreases activity 16621514
C511402 Grape Seed Proanthocyanidins Grape Seed Proanthocyanidins affects the expression of CKB proteinaffects expression 16414080
C010176 halofuginone halofuginone results in increased expression of CKB mRNAincreases expression 17180598
D007657 Ketone Bodies Ketone Bodies results in increased expression of CKB mRNAincreases expression 16807920
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNAaffects cotreatment|decreases expression 12634122
D008731 Methoxychlor Cycloheximide inhibits the reaction [Methoxychlor results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D008731 Methoxychlor Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of CKB protein]decreases reaction|increases expression 7839363
D008731 Methoxychlor Methoxychlor results in increased expression of CKB proteinincreases expression 7839363
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of CKB mRNAdecreases expression 12634122
D015741 Metribolone Metribolone results in increased expression of CKB proteinincreases expression 17152098
D015735 Mifepristone Mifepristone results in decreased expression of CKB mRNAdecreases expression 17584828
D005996 Nitroglycerin Nitroglycerin results in decreased expression of CKB mRNAdecreases expression 12102619
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of CKB mRNAdecreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of CKB mRNAdecreases expression 19270015
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of CKB mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of CKB mRNAincreases expression 17404688
D011374 Progesterone Progesterone affects the expression of CKB mRNAaffects expression 17251523
D011794 Quercetin Quercetin results in increased activity of CKB proteinincreases activity 16621514
D011794 Quercetin Quercetin results in decreased expression of CKB proteindecreases expression 18095365
D020849 Raloxifene Raloxifene results in increased activity of CKB proteinincreases activity 16621514
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 17029789
D015474 Isotretinoin Isotretinoin results in decreased expression of CKB mRNAdecreases expression 15982314
D012428 Ruthenium Ruthenium results in decreased activity of CKB proteindecreases activity 17109965
D012428 Ruthenium Ruthenium results in increased activity of CKB proteinincreases activity 17109965
D012643 Selenium Selenium results in increased expression of CKB mRNAincreases expression 19244175
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNAaffects cotreatment|decreases expression 12634122
D013629 Tamoxifen Tamoxifen results in increased expression of CKB mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased activity of CKB protein]decreases reaction|increases activity 17029789
D013629 Tamoxifen Tamoxifen results in increased expression of CKB mRNAincreases expression 19400957
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CKB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CKB mRNAincreases expression 15644576
D014212 Tretinoin Tretinoin metabolite results in decreased expression of CKB mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of CKB mRNAdecreases expression 15982314
D014635 Valproic Acid Valproic Acid results in increased expression of CKB mRNAincreases expression 19949822
D014807 Vitamin D Vitamin D affects the activity of CKB proteinaffects activity 17029789
D014807 Vitamin D Vitamin D analog promotes the reaction [Estradiol results in increased activity of CKB protein]increases activity|increases reaction 17029789
D014810 Vitamin E Vitamin E results in increased expression of CKB mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0114745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 16.0718769834
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.076195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.0714514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.078875741
MESH:D000015 Abnormalities, Multiple Isotretinoin 8.8418769834
MESH:D000015 Abnormalities, Multiple Valproic Acid 8.8419490988
MESH:D000138 Acidosis Ammonium Chloride 3.0318287403
MESH:D017486 Acneiform Eruptions Isotretinoin 5.7416232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.2117505938
MESH:D000152 Acne Vulgaris Isotretinoin 10.2118769834 16185265
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma daidzein 14.9711473722
MESH:D000230 Adenocarcinoma Doxorubicin 14.9717418594
MESH:D000230 Adenocarcinoma Estradiol 14.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 14.9714692618
MESH:D000230 Adenocarcinoma Fluorouracil 14.9717638652
MESH:D000230 Adenocarcinoma Genistein 14.9711473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.3317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.3316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3616712894 17306315
MESH:D000419 Albuminuria Doxorubicin 9.7921441931
MESH:D000419 Albuminuria Raloxifene 9.7917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.1915955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4115800139
MESH:D000550 Amblyopia Valproic Acid 4.6917688650
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9815469931
MESH:D000740 Anemia Fluorouracil 7.1616511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.1611748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7717084956
MESH:D000799 Angioedema Acetaminophen 3.3110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.1517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1216292516
MESH:D001249 Asthma Tretinoin 2.1716456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4515336622
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 19460635 17157402 18177632 18775368 19232924 18316065 17688650 18985861 18940202 15238991 18396377 18558336 20603192 16609825
MESH:D001327 Autoimmune Diseases Quercetin 3.8919761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9016935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.7917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.3712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.3716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.8515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.858888407
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 10.5114601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.5114601052
MESH:D001862 Bone Resorption bisphenol A 3.3911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8017868700
MESH:D001930 Brain Injuries Progesterone 9.2515845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 9.2516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.3517150277
MESH:D001943 Breast Neoplasms Acrylamide 14.6518183576 16253758
MESH:D001943 Breast Neoplasms bexarotene 14.6516818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 14.6517123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 14.6515324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 14.6516322301 15939500 16935488 19526202 16264153 15136595 15567936 16826403 15634643 18234424 16595493 18382427 18695136 17369602 17426702 16096432 15993339 18628466 15692762 11325840 16115903 17983394 15994142 15668708
MESH:D001943 Breast Neoplasms Estradiol 14.6512948864 19861407 17289903 17018787 16675129 17261762 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 14.6515136595 18608205 19217205 16557594 16595493 16110121 18357371
MESH:D001943 Breast Neoplasms gemcitabine 14.6517039268 18382427
MESH:D001943 Breast Neoplasms Genistein 14.6516873071 16541309 17200150
MESH:D001943 Breast Neoplasms Grape Seed Proanthocyanidins 14.6520146248
MESH:D001943 Breast Neoplasms Progesterone 14.6516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 14.6518628248
MESH:D001943 Breast Neoplasms Raloxifene 14.6517242785 16912660 15775269 17595753 17440819 16837676 17261762 15758505 17893378 15572757 17952589 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 14.6518855134 19155303 16202921 11161223 19103187 19288272 16273361 19115204 18351453 20135344 19059307 19084267 19142967 15565566 17049068 19200415 19244106 19189210 19487384 19221464 18984771 17261762 16818667 21152245 17440819 17893378 18425577 18815881 20005174 18629630 18997820 20544844 18821012 15668708 20065188 19189212 19289846 19011961 19410462 20859285 20390343 17242785 21138602 19066611 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 14.6520435547
MESH:D001943 Breast Neoplasms Tretinoin 14.6516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0616813970
MESH:D002105 Cadmium Poisoning Quercetin 5.0116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.2316227642 18705752 10355542 16097048 15673190 16124888 15721981 16050911 3786805 16011737 15700767 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.2316050911
MESH:D002276 Carcinoid Tumor Doxorubicin 10.5616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.5616051944
MESH:D002277 Carcinoma Fluorouracil 6.7917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6216168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 29.6216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.623084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 29.6218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 29.6216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 29.6216023760 17876044 18059187 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 29.6216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 29.6216799960 18930000 17088986 17045692 17971768 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 29.6216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 29.626705139 1701930 20935162 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 29.6212508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 29.6217306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 29.6216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 29.621917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0216247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4417234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.771485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.7718695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.376189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.3716757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 12.3711237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.3718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.3716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.9717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.9717572228
MESH:D006332 Cardiomegaly Quercetin 5.7619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.7618670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.1716651473 17519947 17329180 17308081 16731534 17007740 15811867 16612575 16952015 15476868 15505089 17382496 16269455 16455267 17351982 17924179 16109756 17928571 15792986 16242529 16278810 17974986 18627295 16364871 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7416243910 17334414
MESH:D002318 Cardiovascular Diseases daidzein 10.1816332659
MESH:D002318 Cardiovascular Diseases Genistein 10.1816332659
MESH:D002318 Cardiovascular Diseases Raloxifene 10.1815775269
MESH:D002386 Cataract Acetaminophen 6.1310977129
MESH:D002386 Cataract Tretinoin 6.1317460283
MESH:D002418 Cattle Diseases Acrylamide 4.9112510666
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.146135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.1412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.1418566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 17.142727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.1420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.744080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002779 Cholestasis Cyclosporine 6.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4517333356 17681005 17110522 11677210 15861022 16919318 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.6216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.9416354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 4.949407595
MESH:D003072 Cognition Disorders Raloxifene 4.1015800139
MESH:D003092 Colitis Selenium 7.7917936198
MESH:D003092 Colitis Tretinoin 7.7917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.1517016597 15001691 17287894 17725105 17172411 16510598 17169374 17018589 16340194 18772588
MESH:D003110 Colonic Neoplasms Genistein 5.1517182828
MESH:D003110 Colonic Neoplasms Quercetin 5.1517191121 19056647 16640504 19440933 11134977 15741050 17148506
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.1718802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.1717454858 14970324 17401013 18448328 15148649 17695437 16331619 17255274 18509181 16524972 20501625 17094418 18383874 16391804 16282729 18802399 16303861 18949393 15289873 17594712 17016601 18288408
MESH:D015179 Colorectal Neoplasms Quercetin 3.1718095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6114669216 17141729
MESH:D019465 Craniofacial Abnormalities Isotretinoin 8.459879862 18769834
MESH:D019465 Craniofacial Abnormalities lead acetate 8.4519769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.4510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.4516925845 14991402 9142499 17551590 9224671 9664655 9211117 10589399 8800419 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 8.458888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 8.4519769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0512952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.5018551238
MESH:D007644 Darier Disease Fluorouracil 4.2616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7217474826
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3019496084
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.3316647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.3316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.3317107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.4419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.4415920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.4419279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9817187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7618713872 11287661 11743745 11834606 11739529 17906064 12392966 12705907 12594235 14986274 19164858 14550746 15619225 16227642 10774834 12958197 19420014 14725611 16109766 10915739 17562736 12153990 19085960 19416960 19923254 18071297 2444490 10663392 19370779 19739265 16177239 12540782 16081117 11529661 16393943 11461765 15968718 11421492 16485898 16781746 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.762869522 21278145 6884620 16227642 15027814 3732212 11566570 19085960 19336974 16177239 10092053 10915739 7179309 7440962 15968718 3786805 17522070 4309450 9327722 15998439 6623471 7120509
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.7617416283
MESH:D056486 Drug-Induced Liver Injury Selenium 15.7615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.761733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5619426721
MESH:D004362 Drug Toxicity Doxorubicin 6.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7911462148
MESH:D004421 Dystonia Phenobarbital 8.821851702
MESH:D004421 Dystonia Valproic Acid 8.821851702
MESH:C538011 Eales disease Vitamin E 4.179068938
MESH:D004487 Edema Raloxifene 5.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.1518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.8312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.8317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.8315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.8319031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.1416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.1416402032
MESH:D016889 Endometrial Neoplasms daidzein 29.5711473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 29.5715700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 29.5717359293
MESH:D016889 Endometrial Neoplasms Estradiol 29.5718566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 29.5711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 29.5719155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 29.5716569247
MESH:D004715 Endometriosis Mifepristone 12.6816134523
MESH:D004715 Endometriosis Progesterone 12.6816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.689294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6218037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.083659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.0817275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.1911558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 8.193922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.6920417680
MESH:D004827 Epilepsy Valproic Acid 5.6918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.386401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.387562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.597750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.597750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.733659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.733659116
MESH:D007172 Erectile Dysfunction daidzein 4.5214972507
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2216337965 15173087 17638652 16481741 16785472
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.2216704527 15878914 16805852 15264214 16510608 15547733 15547721 15150132 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.5016938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.6119224547 15959796 61145 17595544 16239168 12795759 16045604 12631006
MESH:D005234 Fatty Liver Cyclosporine 24.6119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.6115345470
MESH:D005234 Fatty Liver Raloxifene 24.6117473493
MESH:D005234 Fatty Liver Tamoxifen 24.6119224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 24.6114986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.0916611131 16002989 16513791 15751030 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3516575769
MESH:D005317 Fetal Growth Retardation lead acetate 9.5319769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 9.538888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.6919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.6919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 22.2918705752
MESH:D005355 Fibrosis Cyclosporine 22.2912639820 12168785
MESH:D005355 Fibrosis Quercetin 22.2919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.2920067830
MESH:D005355 Fibrosis Tretinoin 22.2917994277
MESH:D005756 Gastritis Acetaminophen 3.1416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.0616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.0616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.698708960
MESH:D005909 Glioblastoma biochanin A 18.4916598420
MESH:D005909 Glioblastoma Doxorubicin 18.4917150277
MESH:D005909 Glioblastoma Genistein 18.4916598420
MESH:D005909 Glioblastoma Quercetin 18.4919804834
MESH:D005909 Glioblastoma Tretinoin 18.4917312396
MESH:D005910 Glioma Fluorouracil 5.4016145905
MESH:D005910 Glioma Quercetin 5.4017643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006261 Headache Nitroglycerin 4.6511554966 11284996
MESH:D006258 Head and Neck Neoplasms Doxorubicin 10.8415692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 10.8418337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.8416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.3911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.3914991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 9.3916080930
MESH:D006331 Heart Diseases Doxorubicin 10.8116244371 16707910 16144979 12587719 18674790 16330681 14766674 17888722 16879835 16495754 18006777 16244372 17875725
MESH:D006331 Heart Diseases Grape Seed Proanthocyanidins 10.8112587719
MESH:D006331 Heart Diseases Raloxifene 10.8111110106
MESH:D006333 Heart Failure Doxorubicin 6.1117481944
MESH:D006333 Heart Failure Selenium 6.1117162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4315692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1019900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 6.7416109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.7416120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5016863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4915709030
MESH:D006689 Hodgkin Disease Doxorubicin 6.0217606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.0212676792
MESH:D019584 Hot Flashes Estradiol 8.2617088409
MESH:D019584 Hot Flashes Vitamin E 8.2614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.3417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5115340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.2316870215
MESH:D006930 Hyperalgesia Tretinoin 6.2316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0516778211
MESH:D006943 Hyperglycemia Quercetin 3.5718262572 11834736
MESH:D006965 Hyperplasia Diethylstilbestrol 9.6012960047 14722030
MESH:D006965 Hyperplasia halofuginone 9.6011874485
MESH:D006973 Hypertension Cyclosporine 13.9510903974
MESH:D006973 Hypertension daidzein 13.9517169123
MESH:D006973 Hypertension Quercetin 13.9518356687
MESH:D006973 Hypertension Raloxifene 13.9515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 13.9518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5715338365
MESH:D017379 Hypertrophy, Left Ventricular marker/mechanism 11406506
MESH:D007021 Hypospadias Diethylstilbestrol 9.5316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.5316945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8915869954
MESH:D007246 Infertility Diethylstilbestrol 3.8515036965
MESH:D007247 Infertility, Female Acrylamide 8.7711020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.7712013081
MESH:D007248 Infertility, Male Acrylamide 13.1612507653 15355880 15749267 11020651
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.1617937319
MESH:D007248 Infertility, Male Methoxychlor 13.1611955947 16467254
MESH:D007248 Infertility, Male sodium arsenite 13.1612646999 15346721
MESH:D007249 Inflammation Progesterone 6.5815869954
MESH:D007249 Inflammation Tamoxifen 6.5819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.5812878042 12200463
MESH:D007251 Influenza, Human Quercetin 15.5116624496
MESH:D007251 Influenza, Human Selenium 15.5116624496
MESH:D007251 Influenza, Human Vitamin E 15.5116624496
MESH:D007333 Insulin Resistance bisphenol A 6.2416393666
MESH:D007333 Insulin Resistance Estradiol 6.2416627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.2617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.3615992940 17551590
MESH:D007627 Keloid Quercetin 4.4417086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9015604871
MESH:D007674 Kidney Diseases Acetaminophen 32.8115629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 32.8116962696
MESH:D007674 Kidney Diseases Cyclosporine 32.8110903974 8314463 18776723
MESH:D007674 Kidney Diseases Doxorubicin 32.8116775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 32.8115618244
MESH:D007674 Kidney Diseases Grape Seed Proanthocyanidins 32.8112587719
MESH:D007674 Kidney Diseases Quercetin 32.8116962696
MESH:D007674 Kidney Diseases sodium arsenite 32.8120008137
MESH:D007674 Kidney Diseases Vitamin E 32.8112488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.4116707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.4116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.5216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 23.5215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 23.5215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.5216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 23.5218625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5517184923
MESH:D007889 Leiomyoma Raloxifene 4.0116973256
MESH:D007938 Leukemia Genistein 8.8718980019 17468513
MESH:D007938 Leukemia Quercetin 8.8717468513
MESH:D007938 Leukemia Tretinoin 8.8717143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6216085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.6119850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.6116294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 5.6120368581
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8016823087 15748426 17506722 16766008 16788101 16935935 17361223 16140955 17294898 19029980 9834237 17301526 12679006 19225113 19075265 19642359 17649720 17217047 17712046 17107899 16891316 16331271 17368321 17339181 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.929224671
MESH:D008064 Lipidoses Tamoxifen 2.7715342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.3721278145 16943688 16239168 11408273 17157831 16221502 11903743 17174718 17334410
MESH:D008103 Liver Cirrhosis halofuginone 9.3717180598
MESH:D008103 Liver Cirrhosis Phenobarbital 9.3721047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 16.3018277467 15959796 12445418 18418968 12546737 12958196 15925388 18263696 15730626 18420326 18006644 12632512 12649538 13678700 15673190 18376398 17557913 12445421 15370692 18156304 17481882 15996030 14620537 14716833 12898905 15052691 12632514 15818738 14512876 17714472 18472332 12586293 17869086 16192424 16136751 15123356 16638106 17761835 12389079 16033810 14748882 17708605 18412020 16097048 15338365 18279442 17922224 17525996 17805973 18429990 15931870 17631135 17698563 12741479 18210741 17976157 18054572 17640975 18472094 18339082 16248980 17721639 18395914 12609069 15650968 17766677 14724832 16011737 16116963 12667390 14716496 10355542 15893842 15362042 18317297 15876570 17823541 18251166 20821823 18205269 16015684 18187930 15057751 17900296 12666154 18395095 18481824 16027843 18166357 18705752 11481614 17944888 17565644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 16.3016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 16.3014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 16.3017823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 16.3011172339 16489207 12175628 14739098 18458672
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 16.3012741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 16.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 16.3012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 16.3018397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 16.3016169303
MESH:D008107 Liver Diseases Acetaminophen 8.0612969438 12587719 19784758 16610002 19460945 11587558 19014921 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.0616246199 15830285 17285989 15720792 16964402
MESH:D008107 Liver Diseases Grape Seed Proanthocyanidins 8.0612587719
MESH:D008107 Liver Diseases Phenobarbital 8.0619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.567678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.5619294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 25.5615890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 25.5616603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 25.5615975961 8742319 19073162 19482888 19812893 21047994
MESH:D008113 Liver Neoplasms Quercetin 25.5618980244
MESH:D008113 Liver Neoplasms sodium arsenite 25.5616712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 25.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.892876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.8912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 18.8916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.891399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.8919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.8912151625
MESH:D008171 Lung Diseases Grape Seed Proanthocyanidins 10.4512587719
MESH:D008171 Lung Diseases sodium arsenite 10.4519095001
MESH:D008171 Lung Diseases Vitamin E 10.4516863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7217228818
MESH:D008175 Lung Neoplasms bexarotene 13.6717849452
MESH:D008175 Lung Neoplasms Doxorubicin 13.676189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 13.6715246190
MESH:D008175 Lung Neoplasms Isotretinoin 13.6715899809
MESH:D008175 Lung Neoplasms Quercetin 13.6716280456
MESH:D008175 Lung Neoplasms sodium arsenite 13.6717077188 19931552 17306315 16712894 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 13.6718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.6719555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 13.6711062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6215166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.4615700306
MESH:D008223 Lymphoma Doxorubicin 6.4616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.3617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0515621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6311161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2419428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 23.0915591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 23.0915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 23.0911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 23.0912929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 23.0911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 23.0915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 23.0919196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 10.8619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.8619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5517453147
MESH:D008545 Melanoma Doxorubicin 13.5316827129
MESH:D008545 Melanoma Glucose 13.5314993021
MESH:D008545 Melanoma Isotretinoin 13.5317237267
MESH:D008545 Melanoma Ruthenium 13.5317210701
MESH:D008545 Melanoma sodium arsenite 13.5319082730 16487513
MESH:D008545 Melanoma Tamoxifen 13.5319393235 12393984
MESH:D008545 Melanoma Tretinoin 13.5316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0519513568
MESH:D008591 Meningomyelocele Tretinoin 3.9116940565
MESH:D008654 Mesothelioma Doxorubicin 5.5017638057
MESH:D008654 Mesothelioma Selenium 5.5015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2516801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.253537620
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.3617671175
MESH:D008881 Migraine Disorders Valproic Acid 2.8118803445 18765137
MESH:D020326 Migraine without Aura Nitroglycerin 4.6214659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0215792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0115863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.2218986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.2617415656
MESH:D009101 Multiple Myeloma Raloxifene 3.0616497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.558888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.3217596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.3217596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.6119429709 15857846
MESH:D009203 Myocardial Infarction Genistein 11.6117141266
MESH:D009203 Myocardial Infarction Nitroglycerin 11.6114729435
MESH:D009203 Myocardial Infarction Quercetin 11.6119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.9116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.9117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.9119207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9517484760
MESH:D009232 Myxoma Raloxifene 5.0116343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.3418551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.0818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.0819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3219410462
MESH:D009369 Neoplasms Diethylstilbestrol 12.7115313581
MESH:D009369 Neoplasms Fluorouracil 12.7116928823 18600527 18239605
MESH:D009369 Neoplasms Quercetin 12.7115185748
MESH:D009369 Neoplasms sodium arsenite 12.7111559025
MESH:D009369 Neoplasms Tretinoin 12.7116594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.1620056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.1519196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.1519196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2117289903
MESH:D009401 Nephrosis Doxorubicin 4.2516636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.8118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.8115640375 16889571
MESH:D009410 Nerve Degeneration Acrylamide 4.2912387366 12387367 11264303
MESH:D009422 Nervous System Diseases Acrylamide 4.5412164553 12507653
MESH:D009421 Nervous System Malformations bisphenol A 31.7811399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 31.7811399458
MESH:D009421 Nervous System Malformations Estradiol 31.7816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 31.7816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 31.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 31.789125849
MESH:D009436 Neural Tube Defects sodium arsenite 10.0812854658
MESH:D009436 Neural Tube Defects Tretinoin 10.089142499
MESH:D009436 Neural Tube Defects Valproic Acid 10.088888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 6.3815555623
MESH:D009447 Neuroblastoma Isotretinoin 6.3817368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4418514411
MESH:D020078 Neurogenic Inflammation Quercetin 3.8717929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0716436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9816049721
MESH:D010018 Osteomalacia Phenobarbital 3.8417016548
MESH:D010024 Osteoporosis Genistein 10.1519401787
MESH:D010024 Osteoporosis Raloxifene 10.1517882678 19059307 15775268
MESH:D010024 Osteoporosis Vitamin D 10.1517882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 14.0816169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 14.0819495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 14.0817823083 17893378 15758505 15579764
MESH:D012516 Osteosarcoma Doxorubicin 3.6915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4611985600
MESH:D010051 Ovarian Neoplasms Estradiol 19.9019401270
MESH:D010051 Ovarian Neoplasms Genistein 19.9019005980
MESH:D010051 Ovarian Neoplasms Mifepristone 19.9016525653
MESH:D010051 Ovarian Neoplasms Progesterone 19.9017393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 19.9019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.9015276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 19.9016936753
MESH:D010146 Pain Acetaminophen 5.1816870215
MESH:D010146 Pain Tretinoin 5.1816870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.0019003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms gemcitabine 14.0011504793 17440100 16929163 18992248 18383843
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.0016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 14.0016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.0015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.6111510240
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6217983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1515687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.3515087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6217638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.7512371664
MESH:D011230 Precancerous Conditions Phenobarbital 12.752563599
MESH:D011230 Precancerous Conditions Quercetin 12.7519056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 24.8910548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 24.8917184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 24.8918769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 24.8911896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 24.8920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9820887781
MESH:D011471 Prostatic Neoplasms biochanin A 4.5812111696
MESH:D011471 Prostatic Neoplasms bisphenol A 4.5816740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.5815046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.5815749863 16888761 18437689 16868541 16729912 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 4.5816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.5819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 4.5816925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Quercetin 4.5814715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 4.5815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.5816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.5815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 4.5815084515
MESH:D011507 Proteinuria Tretinoin 3.1216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.4012752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.4012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.3918769834
MESH:D011625 Pterygium Tretinoin 4.2616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2610548101
MESH:D011693 Purpura Raloxifene 5.0115770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5615538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.7117922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.2416116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.2419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012509 Sarcoma Doxorubicin 3.5316767912 15675481 17203757 17710206 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Dactinomycin 9.0314601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.0314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2617846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.0116862918
MESH:D012559 Schizophrenia Valproic Acid 1.9915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 7.7018551238
MESH:D012640 Seizures Phenobarbital 7.7011442880 16876388 3137016 4039156
MESH:D012640 Seizures Valproic Acid 7.7017978042 16876388 3137016 14763951 15475178 11044598 11738929 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 4.296407741
MESH:D012871 Skin Diseases halofuginone 4.7711874485
MESH:D012871 Skin Diseases Vitamin E 4.7718709164
MESH:D012878 Skin Neoplasms Doxorubicin 15.0315692506
MESH:D012878 Skin Neoplasms Glucose 15.0314993021
MESH:D012878 Skin Neoplasms sodium arsenite 15.0318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.0316192470
MESH:D012878 Skin Neoplasms Tretinoin 15.0316467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0516767912 15625365 17203757
MESH:D013088 Spermatocele Diethylstilbestrol 17.0216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.0216709447
MESH:D013088 Spermatocele Tamoxifen 17.0216709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.1216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.1219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.1712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.1719490988
MESH:D013158 Splenic Diseases Grape Seed Proanthocyanidins 5.9612587719
MESH:D013226 Status Epilepticus Valproic Acid 4.0012833885
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms Fluorouracil 3.1017172411 17522103 15786421 16424979 19084572 18396642 16951190 17498489 18567086 19015929
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.1012958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 3.1017261132
MESH:D020521 Stroke Raloxifene 7.3116837676
MESH:D020521 Stroke Vitamin E 7.3116517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.4616045194 16684133
MESH:D013733 Testicular Diseases Acrylamide 4.7015864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.6716010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.671399818
MESH:D013964 Thyroid Neoplasms Tretinoin 9.6716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 11.9219048282
MESH:D013978 Tibial Fractures Raloxifene 11.9219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.3016280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.3016051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.6917262798
MESH:D014376 Tuberculosis Tretinoin 2.8816040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.993119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 20.5116049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 20.5116452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 20.5117653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 20.5116720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 20.5117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 20.5116452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 20.518653321 17572228 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.138888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7910091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.8616175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.8616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 18.8611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.8616129372
MESH:D014591 Uterine Diseases bisphenol A 12.0214652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.8115809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0716752155
MESH:D014605 Uveitis Cyclosporine 3.451336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9216513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.9017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7117638931 17678736 17334414 16364871
MESH:D014820 Vitiligo Tretinoin 3.5616761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D009396 Wilms Tumor Tretinoin 3.5216287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9017120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00148 ligand Creatine Dietary supplement;Micronutrient
DB04184 - Acetate Ion Indicators and Reagents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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