AutismKB 2.0

Annotation Detail for KCTD12


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Basic Information Top
Gene Symbol:KCTD12 ( C13orf2,FLJ33073,KIAA1778,PFET1,PFETIN )
Gene Full Name: potassium channel tetramerisation domain containing 12
Band: 13q22.3
Quick LinksEntrez ID:115207; OMIM: 610521; Uniprot ID:KCD12_HUMAN; ENSEMBL ID: ENSG00000178695; HGNC ID: 14678
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KCTD12 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of KCTD12 mRNAdecreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KCTD12 mRNAdecreases expression 20064835
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of KCTD12 mRNAdecreases expression 15289156
D002117 Calcitriol Calcitriol results in increased expression of KCTD12 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of KCTD12 mRNAdecreases expression 15289156
D005472 Fluorouracil Fluorouracil results in decreased expression of KCTD12 mRNAdecreases expression 17039268
C056507 gemcitabine gemcitabine results in decreased expression of KCTD12 mRNAdecreases expression 17039268
D019833 Genistein Genistein results in decreased expression of KCTD12 mRNAdecreases expression 15289156
D007213 Indomethacin Indomethacin results in decreased expression of KCTD12 mRNAdecreases expression 16984733
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of KCTD12 mRNAincreases expression 15120970
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KCTD12 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of KCTD12 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of KCTD12 mRNAdecreases expression 18445702
17426115
D020849 Raloxifene Raloxifene affects the expression of KCTD12 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of KCTD12 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCTD12 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.496195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 17.2419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 17.2420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 17.2411473722
MESH:D000230 Adenocarcinoma Fluorouracil 17.2417638652
MESH:D000230 Adenocarcinoma Genistein 17.2411473722
MESH:D000230 Adenocarcinoma Indomethacin 17.2416537180
MESH:D000236 Adenoma Benzo(a)pyrene 6.906695378
MESH:D000236 Adenoma Indomethacin 6.9011497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.2917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.2916434500
MESH:D000419 Albuminuria Raloxifene 4.6317451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4317225004
MESH:D000544 Alzheimer Disease Indomethacin 4.4917627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 4.4915800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D000740 Anemia Fluorouracil 3.7415504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.8810231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.8519183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.8510388637
MESH:D018771 Arthralgia Indomethacin 5.232160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8311248219
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001477 Bartter Syndrome Indomethacin 5.0210684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.1016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1019483382
MESH:D001929 Brain Edema Indomethacin 5.0911481608
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D002545 Brain Ischemia Indomethacin 4.4712524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.0820146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 7.0811237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 7.0817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 7.0817289903 16675129 12948864 17261762 17018787 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 7.0819217205 18608205 15136595 16110121 16557594 18357371 16595493
MESH:D001943 Breast Neoplasms gemcitabine 7.0817039268 18382427
MESH:D001943 Breast Neoplasms Genistein 7.0816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Indomethacin 7.0817401462
MESH:D001943 Breast Neoplasms Raloxifene 7.0817595753 15758505 17261762 15572757 17952589 17893378 17049068 16912660 17242785 17440819 16837676 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 7.0819288272 18815881 21138602 20544844 16273361 18855134 19410462 15565566 17261762 11161223 19103187 19155303 21152245 19011961 19200415 15668708 19244106 17893378 17242785 18351453 19059307 18425577 17440819 19189212 20390343 19189210 19487384 19084267 16873071 19289846 17049068 20135344 20859285 19142967 20065188 18629630 16818667 19115204 20005174 16202921 18997820 19221464 18821012 19066611 18984771
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002056 Burns Indomethacin 4.7510459503
MESH:D002100 Cachexia Indomethacin 5.0615625704 16537180 11239499 15141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 3.5917121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.063084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 20.0615073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 20.0615948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.0616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 20.0617971768 16332177 16799960 17045692 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 20.0616924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 20.0616391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 20.0617173139 1701930 20935162 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 20.0616924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.7811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.4018791128 14736730 11352223
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7918695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.7917341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.9020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.9011237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.9016757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.9015482327 12636206
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5917572228
MESH:D002318 Cardiovascular Diseases Genistein 7.5716332659
MESH:D002318 Cardiovascular Diseases Raloxifene 7.5715775269
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1818566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.182727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D002764 Cholecystitis Indomethacin 5.2311181007
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9516510598 17287894 15001691 16340194 17725105 17018589 18772588 17169374 17016597 17172411
MESH:D003110 Colonic Neoplasms Genistein 5.9517182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.9515637740 15786552 15936596 15625704 11260862 15963497
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5220501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5215148649 14970324 20501625 18383874 18448328 15289873 16282729 17594712 16524972 17094418 16331619 18949393 17695437 18288408 18802399 16391804 17401013 17016601 16303861 17255274 18509181 17454858
MESH:D015179 Colorectal Neoplasms Indomethacin 3.5212606626 17054584 18059344 11197048
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D018352 Coronavirus Infections Indomethacin 5.7817302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5916002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Estradiol 15.1719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.1717308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.1719279558
MESH:D003967 Diarrhea Indomethacin 3.837237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.5912705907 19370779 10915739 15619225 11461765 10663392 14986274 12153990 11287661 16485898 19416960 2444490 11421492 19923254 10774834 12540782 15968718 11739529 16109766 11743745 19085960 19164858 12958197 18713872 18071297 16393943 19739265 12594235 17522070 14550746 16227642 17562736 17906064 11529661 11834606 19420014 16177239 12392966 16081117 16781746 14725611
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.2018043480 17190690 18446180 16133044 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.1717151854 17202747 11535926 16699067 17329845 11991626 17045617 11595415 11595431 10671773 17351913
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema Indomethacin 11.757907874 19703484 16100529 7990266 8985016 10653021 8273558
MESH:D004487 Edema pirinixic acid 11.7512083418
MESH:D004487 Edema Raloxifene 11.7515860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.6815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.6815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.6819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.0616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.9516804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 17.9519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 17.9511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.9520544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Indomethacin 4.1715652904
MESH:D019446 Endotoxemia Indomethacin 4.5518509659
MESH:D004751 Enteritis Indomethacin 4.8110567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0217980183
MESH:D004802 Eosinophilia Indomethacin 4.0911298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.4912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.4916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.4916337965 16481741 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 10.4911005569
MESH:D005234 Fatty Liver arsenic trioxide 19.0515073043
MESH:D005234 Fatty Liver pirinixic acid 19.0520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 19.0517473493
MESH:D005234 Fatty Liver Tamoxifen 19.0514986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.2616002989 16611131 16534752 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.2616709447
MESH:D005334 Fever Indomethacin 4.1411852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005354 Fibrosarcoma Indomethacin 4.9410962813
MESH:D005355 Fibrosis Indomethacin 4.1117994277
MESH:D005499 Folliculitis Indomethacin 5.2311298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Acetaminophen 11.3616983495
MESH:D005756 Gastritis Indomethacin 11.3615046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0016452187
MESH:D005909 Glioblastoma Genistein 7.4716598420
MESH:D005909 Glioblastoma Indomethacin 7.4712870263
MESH:D005910 Glioma Fluorouracil 6.2816145905
MESH:D005910 Glioma Indomethacin 6.2818371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3111849393
MESH:D006073 Gout Indomethacin 5.4011248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.0615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.0615482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6720471113
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6015633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.7215135802
MESH:D006529 Hepatomegaly Phenobarbital 8.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 8.6218467677 16221962 19176532 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006930 Hyperalgesia Acetaminophen 7.9016870215
MESH:D006930 Hyperalgesia Indomethacin 7.9012727271
MESH:D034321 Hyperamylasemia Indomethacin 5.7817883296
MESH:D006940 Hyperemia Indomethacin 5.0612524144
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Indomethacin 4.1917546600
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4812960047 14722030
MESH:D006973 Hypertension Raloxifene 2.8717577099 15787275
MESH:D007021 Hypospadias Diethylstilbestrol 4.6216002989
MESH:D007077 Ileal Diseases Indomethacin 5.0910574470 18306037
MESH:D007079 Ileitis Indomethacin 5.4016133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4316133044
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007249 Inflammation Indomethacin 5.353291741 7812673 12568917
MESH:D007249 Inflammation Tamoxifen 5.3519457130
MESH:D007333 Insulin Resistance Estradiol 7.2616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007410 Intestinal Diseases Indomethacin 4.3711686837 17329856 17994277 15831440 15610444 11713966 18236018 10210152 11855677
MESH:D019586 Intracranial Hypertension Indomethacin 5.4315241188
MESH:D007579 Jejunal Diseases Indomethacin 5.0918306037 10574470 16133968
MESH:D007674 Kidney Diseases Acetaminophen 10.1912587719 15629191
MESH:D007674 Kidney Diseases Estradiol 10.1915618244
MESH:D007674 Kidney Diseases Indomethacin 10.1917190690
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.0014681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 18.0015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 18.0016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 18.0018625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9310320625 12228301 11703811
MESH:D007938 Leukemia arsenic trioxide 6.4815070760
MESH:D007938 Leukemia Genistein 6.4817468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.6314633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.6310785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1016467208 16968895 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.1018360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2316966277 16823087 19225113 17107899 15336539 9834237 17869043 11468182 15622746 17649720 15748426 19642359 12018890 19035177 17217047 19075265 16891316 12712474 11161223 17712046 15213294 16112521 16331271 16330433 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D007964 Leukocytosis Indomethacin 5.4316537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.7817980183
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.7811479899
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7817823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.7818194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.7818564211
MESH:D008107 Liver Diseases Acetaminophen 3.9516611625 12969438 11587558 19014921 12587719 19784758 16610002 19460945
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 22.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.0921137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 22.0915890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 22.0917045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 22.0919812893 21047994 19482888 15975961 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 22.0916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 22.0916684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0820377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.081399818 18308698 17172636 6150874 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.646695378 20464547 20064080 18569708 17053015 18816296 20869020 18520028 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 6.6415246190
MESH:D008175 Lung Neoplasms Indomethacin 6.6416537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tamoxifen 6.6418625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.0917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.0914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.0919196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.8619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.8619453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9417671175
MESH:D008881 Migraine Disorders Indomethacin 3.6911903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 14.5516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 14.5516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 14.5512636206
MESH:D009101 Multiple Myeloma arsenic trioxide 7.4819417148 14977855 11468182 19549372 15949261
MESH:D009101 Multiple Myeloma Raloxifene 7.4816497877
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616105982 16882451
MESH:D009203 Myocardial Infarction Genistein 5.7117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.3017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.3016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009362 Neoplasm Metastasis Indomethacin 5.9916537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.9811141357
MESH:D009369 Neoplasms Diethylstilbestrol 11.9815313581
MESH:D009369 Neoplasms Fluorouracil 11.9818239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 11.9817405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.1810663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.7111399458
MESH:D009421 Nervous System Malformations Estradiol 16.7111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 16.7116427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1310525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4818514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.4812349958
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.236374098
MESH:D010003 Osteoarthritis Indomethacin 3.687009135
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010024 Osteoporosis Genistein 7.3919401787
MESH:D010024 Osteoporosis Raloxifene 7.3917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.2516169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.2517893378 17823083 15579764 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 7.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 7.9519005980
MESH:D010146 Pain Acetaminophen 6.8716870215
MESH:D010146 Pain Indomethacin 6.8717627676 13679232 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.7412538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.4815580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.4816500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms gemcitabine 12.4811504793 18992248 17440100 18383843 16929163
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.4816965848
MESH:D010195 Pancreatitis Indomethacin 3.9515028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.7816537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.7811903285
MESH:D010437 Peptic Ulcer Indomethacin 5.2011148446
MESH:D010518 Periodontitis Indomethacin 4.9817225004
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7115687265 16977796
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D047928 Premature Birth Indomethacin 5.1717000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.1617184923
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.9819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9817292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.9816289102 12479363 18247401 16644109 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.9817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.9816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.9819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.9815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Raloxifene 2.9815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.9815067354
MESH:D011507 Proteinuria Indomethacin 4.1911849393
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0416160472 15538739 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012640 Seizures Phenobarbital 2.713137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3819755658 10029692
MESH:D013088 Spermatocele Diethylstilbestrol 12.0616709447 16002989
MESH:D013088 Spermatocele Tamoxifen 12.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013272 Stomach Diseases Indomethacin 4.4710486359 16280098 17207306 10192188 15472012 16113693 10215738 18209964 17160473 16184426 15038085 18545984 17638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7720155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7717172411 17522103 19015929 18396642 17498489 16424979 16951190 15786421 19084572 18567086
MESH:D013274 Stomach Neoplasms Indomethacin 4.7715609394
MESH:D013276 Stomach Ulcer Indomethacin 3.6116631530 18087811 12077510 11145282 17977527 12498302 18193104 18726076 17918041 16755016 10878458 18209962 17135157 11595431 18543354 12467913 17895592 18237397 1323529 11595415 11906479 11729361 10423059 16169175 16150113 14567935 15138204 17657623 15104355 16934674 16397915 12787963 10750652 16252198 17627676 18299717 18431645 18181030 15255614 11523592 12500499 17654042
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.1919014326
MESH:D013964 Thyroid Neoplasms Indomethacin 12.1911352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.191399818
MESH:D013978 Tibial Fractures Estradiol 13.9219048282
MESH:D013978 Tibial Fractures Raloxifene 13.9219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D014456 Ulcer Indomethacin 4.9410574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.9312845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.9317053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.9316452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.9317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.9316712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.6716175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6716803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816002989 16513791
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D014839 Vomiting Indomethacin 4.8111897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25512
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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