AutismKB 2.0

Annotation Detail for GBP4


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Basic Information Top
Gene Symbol:GBP4 ( Mpa2 )
Gene Full Name: guanylate binding protein 4
Band: 1p22.2
Quick LinksEntrez ID:115361; OMIM: 612466; Uniprot ID:GBP4_HUMAN; ENSEMBL ID: ENSG00000162654; HGNC ID: 20480
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GBP4 mRNAaffects expression 17484886
D010126 Ozone Ozone results in decreased expression of GBP4 mRNAdecreases expression 17095637
C006253 pirinixic acid pirinixic acid results in decreased expression of GBP4 mRNAdecreases expression 18445702
C017947 sodium arsenite sodium arsenite results in increased expression of GBP4 mRNAincreases expression 17350061
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.319612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5117306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6215570426
MESH:D001249 Asthma Ozone 2.7216373670 17854713
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9618417511 14754758 19059883 16777450 18315731 17626835 15516495
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2615721981 3786805 15673190 16124888 16227642 10355542 15700767 16097048 18705752 16011737 16192424 16050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2018788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2017306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2219524636 20056578
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1111566570 17522070 15998439 21278145 6623471 4309450 6884620 15968718 7179309 7440962 3786805 19085960 7120509 2869522 10092053 9327722 3732212 16177239 15027814 16227642 19336974 10915739
MESH:D004362 Drug Toxicity Zidovudine 4.2615040536
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.4517595544 12631006 16239168 12795759 16045604 15959796 19224547 61145
MESH:D005234 Fatty Liver pirinixic acid 15.4520131406 19236843
MESH:D005234 Fatty Liver Zidovudine 15.4518299183
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006402 Hematologic Diseases Zidovudine 5.1212579204
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19176532 18467677 19772884
MESH:D015658 HIV Infections Zidovudine 3.6511698656 17358032 20032539 11141242 11363243
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male sodium arsenite 3.2115346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases sodium arsenite 2.9820008137
MESH:D007680 Kidney Neoplasms Zidovudine 4.0912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7920370541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 16943688 11903743 21278145 16239168 17334410 17174718 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4117944888 12667390 17900296 18251166 14716833 12389079 18395095 18429990 12609069 17823541 16097048 18395914 15057751 14620537 17922224 18156304 18705752 18277467 18166357 16248980 16638106 14716496 18481824 18412020 18420326 18472332 16033810 17698563 18263696 15673190 14724832 12632514 20821823 17708605 15893842 18210741 15650968 18006644 17640975 17525996 10355542 14748882 12958196 15818738 15996030 18472094 15052691 18054572 13678700 14512876 18418968 17557913 12741479 16136751 11481614 18376398 12586293 12649538 18205269 17761835 18339082 17481882 18187930 15931870 15362042 12666154 17565644 17805973 12445421 15338365 17766677 12898905 16011737 17869086 16116963 15730626 15123356 16027843 17721639 16015684 17976157 15925388 18317297 15370692 15876570 12445418 12632512 12546737 16192424 17714472 17631135 15959796 18279442
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1517285989 16964402 16246199 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0819294768
MESH:D008113 Liver Neoplasms pirinixic acid 8.0815890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 8.0816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8115583823 12014681
MESH:D008171 Lung Diseases Ozone 8.2819066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 8.2819095001
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Ozone 3.778597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 3.7717306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Zidovudine 3.7718800350
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.4517358032
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 5.4517405874
MESH:D009369 Neoplasms sodium arsenite 5.4511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5215276417 17306315
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D011014 Pneumonia Ozone 4.9318007984 18929643 18381685
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.8418572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6217306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014625 Vaginal Neoplasms Zidovudine 5.2412579204
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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