AutismKB 2.0

Annotation Detail for GBP5


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Basic Information Top
Gene Symbol:GBP5 ( GBP-5 )
Gene Full Name: guanylate binding protein 5
Band: 1p22.2
Quick LinksEntrez ID:115362; OMIM: 611467; Uniprot ID:GBP5_HUMAN; ENSEMBL ID: ENSG00000154451; HGNC ID: 19895
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GBP5 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of GBP5 mRNAaffects expression 18414638
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GBP5 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5915322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 6.0817306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9612569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4812928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.8015504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.173084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1717306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7815504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.5218640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.7415738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.7316973168 18022660
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2516354765 15340226 8697196 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8912958197 15619225 17906064 17562736 16781746 11529661 14725611 12594235 11834606 19164858 16081117 16393943 11461765 14550746 14986274 12392966 19416960 19420014 10774834 18713872 12705907 19370779 11421492 11739529 15968718 16485898 19085960 11743745 16109766 12540782 18071297 19923254 17522070 2444490 16227642 10915739 16177239 19739265 10663392 12153990 11287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D005534 Foot Diseases Arsenic 6.436392382
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9116354765 8697196 18606429 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.9017050553
MESH:D006973 Hypertension Arsenic 5.6816076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6818670907 18850075
MESH:D006987 Hypesthesia Arsenic 6.4316093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007642 Keratosis Arsenic 5.7316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.8217339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.3612969438 16610002 19784758 16611625 19014921 11587558 19460945 12587719
MESH:D008107 Liver Diseases Arsenic 4.3611134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 5.0116368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.0116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Arsenic 2.5119168569 17306315 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5119555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D017202 Myocardial Ischemia Arsenic 10.2415371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 10.2412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D009436 Neural Tube Defects Arsenic 3.7216620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.9017056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8517306315
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.7616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.7315371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 3.5416140617
MESH:D011507 Proteinuria Arsenic 4.5321343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012871 Skin Diseases Arsenic 2.8319834688 16353154 16759981 17453740 6392382 17938729 15952646 17548696 17050553 18709164 16702368
MESH:D012878 Skin Neoplasms Arsenic 6.2917029826 17976673 16251483 17050553 19538983 15504454
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2916192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9519322015 17306315 17976673 19429237 11144890 15987713 18640142
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D014652 Vascular Diseases Arsenic 5.4817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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