AutismKB 2.0

Annotation Detail for CISH


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Basic Information Top
Gene Symbol:CISH ( CIS,CIS-1,G18,SOCS )
Gene Full Name: cytokine inducible SH2-containing protein
Band: 3p21.2
Quick LinksEntrez ID:1154; OMIM: 602441; Uniprot ID:CISH_HUMAN; ENSEMBL ID: ENSG00000114737; HGNC ID: 1984
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
No data
Pathway IDPathway Name
200015GMCSF-mediated signaling events
200082IL2-mediated signaling events
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
No data
No data
Desease Name
Tuberculosis, susceptibility to
Bacteremia, susceptibility to
Malaria, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of CISH mRNAdecreases expression 15618236
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CISH mRNAincreases expression 18648102
C017572 4-nitrotoluene 4-nitrotoluene results in decreased expression of CISH mRNAdecreases expression 15618236
D000082 Acetaminophen Acetaminophen results in decreased expression of CISH mRNAdecreases expression 15618236
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CISH mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of CISH mRNAincreases expression 15929907
C006780 bisphenol A bisphenol A results in increased expression of CISH mRNAincreases expression 20678512
C007262 deoxynivalenol deoxynivalenol results in increased expression of CISH mRNAincreases expression 19625342
D004317 Doxorubicin CISH mRNA affects the susceptibility to Doxorubicinaffects response to substance 16044152
D004958 Estradiol Estradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]affects cotreatment|decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CISH mRNAaffects cotreatment|increases expression 17942748
D005054 Eugenol Eugenol results in decreased expression of CISH mRNAdecreases expression 15618236
D019833 Genistein Genistein inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]decreases reaction|increases expression 12072388
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of CISH mRNAincreases expression 15159207
D001556 Lindane Lindane results in decreased expression of CISH mRNAdecreases expression 17785943
C005223 methyleugenol methyleugenol results in decreased expression of CISH mRNAdecreases expression 15618236
C002950 methylformamide methylformamide analog results in decreased expression of CISH mRNAdecreases expression 17040096
C002950 methylformamide methylformamide results in decreased expression of CISH mRNAdecreases expression 17040096
C030957 methylmercury II methylmercury II results in increased expression of CISH mRNAincreases expression 17905399
D009151 Mustard Gas Mustard Gas results in increased expression of CISH mRNAincreases expression 15674844
D010076 Oxazepam Oxazepam results in decreased expression of CISH mRNAdecreases expression 15618236
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CISH mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CISH mRNAdecreases expression 18445702
C025299 polyphenols polyphenols results in decreased expression of CISH mRNAdecreases expression 16293270
D020849 Raloxifene Raloxifene inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]decreases reaction|increases expression 12072388
C488333 Ro 65-7199 Ro 65-7199 affects the expression of CISH mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of CISH mRNAaffects expression 14610520
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CISH mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CISH mRNAincreases expression 19933214
C025643 vinclozolin vinclozolin affects the methylation of CISH geneaffects methylation 15933200
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Doxorubicin 9.6917418594
MESH:D000230 Adenocarcinoma Estradiol 9.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6914692618
MESH:D000230 Adenocarcinoma Genistein 9.6911473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.623712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1512661182
MESH:D000419 Albuminuria Doxorubicin 10.7321441931
MESH:D000419 Albuminuria Raloxifene 10.7317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.4915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000741 Anemia, Aplastic Benzene 4.2017661222 11369114 14761424
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4619015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001249 Asthma Mustard Gas 2.6410378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001768 Blister Mustard Gas 4.9319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0016183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4714601052
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001930 Brain Injuries Raloxifene 4.2516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms Benzene 6.7711921183 17162533
MESH:D001943 Breast Neoplasms bisphenol A 6.7717123778
MESH:D001943 Breast Neoplasms Doxorubicin 6.7716595493 18628466 17426702 15939500 16115903 16096432 16322301 15692762 18234424 15136595 15668708 16826403 15567936 15994142 11325840 16264153 16935488 15993339 15634643 18382427 17369602 18695136 19526202 17983394
MESH:D001943 Breast Neoplasms Estradiol 6.7716675129 19861407 17289903 17018787 12948864 14630087 18497071 17261762
MESH:D001943 Breast Neoplasms Genistein 6.7716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Hexachlorobenzene 6.7715061365 12709520
MESH:D001943 Breast Neoplasms Lindane 6.7714688026
MESH:D001943 Breast Neoplasms methyleugenol 6.7711921183
MESH:D001943 Breast Neoplasms Raloxifene 6.7716912660 15775269 15758505 17049068 15572757 17242785 17893378 17261762 17440819 17595753 16837676 17952589
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7517687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.463581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.463084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.4616023760 17876044 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.4616924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.197296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.191485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.576189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3816952015 16731534 17131338 16651473 17329180 17308081 17928571 15476868 16364871 17519947 16455267 17351982 15792986 18627295 16242529 17924179 15811867 16109756 17007740 17382496 16612575 16269455 16278810 15505089 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 6.9816332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9815775269
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.4714688030
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.147505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.419022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4115861022 16105132 17110522 16919318 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 12.4119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0116354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003110 Colonic Neoplasms Genistein 3.8717182828
MESH:D003110 Colonic Neoplasms polyphenols 3.8716293270
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D003328 Coronary Thrombosis methyleugenol 10.5816048847
MESH:D003328 Coronary Thrombosis Oxazepam 10.5816048847
MESH:D019465 Craniofacial Abnormalities Benzene 2.6015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6015322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.1214966744
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D003872 Dermatitis Benzene 4.5415902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.598970840 14531868 11298694 11906362 8156756 2524372 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.3715920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.276679447 7440962 9653073 16192314 1440618 18289764 9328219 8291058 18648102 18692083 11289319 9022650 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2712392966 16177239 12594235 12705907 10663392 19085960 14550746 15968718 17562736 17906064 10774834 11287661 12540782 16109766 16227642 10915739 16393943 16081117 11834606 18071297 19923254 14725611 11421492 11743745 12958197 18713872 16485898 11739529 19164858 11461765 19420014 19739265 12153990 16781746 14986274 19416960 2444490 11529661 17522070 15619225 19370779
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.2717416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.2719370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5611462148
MESH:D004487 Edema Mustard Gas 14.7711402378 11428647 9260866 11428631
MESH:D004487 Edema pirinixic acid 14.7712083418
MESH:D004487 Edema Raloxifene 14.7715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.7712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3915845917
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.6617359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.6618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.6611473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004890 Erythema Mustard Gas 4.939357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.9215345470
MESH:D005234 Fatty Liver pirinixic acid 11.9219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 11.9217473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7320067830
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0716417039
MESH:D005909 Glioblastoma Doxorubicin 6.8517150277
MESH:D005909 Glioblastoma Genistein 6.8516598420
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8315173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2110048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 7.3218674790 16244372 16879835 16495754 17888722 18006777 14766674 17875725 16144979 16707910 12587719 16244371 16330681
MESH:D006331 Heart Diseases Raloxifene 7.3211110106
MESH:D006333 Heart Failure Doxorubicin 6.5917481944
MESH:D006333 Heart Failure pirinixic acid 6.5920558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 8.9813678655
MESH:D006394 Hemangiosarcoma Doxorubicin 8.9815692506
MESH:D006402 Hematologic Diseases Benzene 4.4416183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly pirinixic acid 7.5216221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5215340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.2217606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Benzene 8.2017940673
MESH:D006973 Hypertension Raloxifene 8.2015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007248 Infertility, Male vinclozolin 6.1616467254
MESH:D007249 Inflammation Mustard Gas 7.738975870 11428647 9357497 16001271 17524151 11428631 9260866 11402378 11428620
MESH:D007249 Inflammation polyphenols 7.7316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7312878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 11.4616393666
MESH:D007333 Insulin Resistance Estradiol 11.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007674 Kidney Diseases Acetaminophen 9.3115629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 9.3116775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 9.3115618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9516707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.756582329
MESH:D007680 Kidney Neoplasms Estradiol 6.7515610895
MESH:D007889 Leiomyoma Raloxifene 4.2816973256
MESH:D007938 Leukemia Benzene 6.2615935818 18335105 17119257 14694614
MESH:D007938 Leukemia Genistein 6.2618980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D007951 Leukemia, Myeloid Benzene 4.1117506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6619478238
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5016417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008107 Liver Diseases Acetaminophen 6.3419784758 16611625 11587558 12969438 19014921 16610002 19460945 12587719
MESH:D008107 Liver Diseases Lindane 6.341715830
MESH:D008107 Liver Diseases polyphenols 6.3416698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 3.9616377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.9616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.186587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.1812562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.1816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 17.181423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.1812151625
MESH:D008171 Lung Diseases Mustard Gas 3.3018161513 18702808
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5814698565
MESH:D008175 Lung Neoplasms Benzene 4.6712562636
MESH:D008175 Lung Neoplasms Doxorubicin 4.6717418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 4.678781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6711884234 19555203
MESH:D008223 Lymphoma Benzene 7.3117584886 17119257
MESH:D008223 Lymphoma Doxorubicin 7.3116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D008288 Malaria marker/mechanism
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2112562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 17.3311921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.3315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.3311807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.3312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental methyleugenol 17.3311921183
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008545 Melanoma Doxorubicin 2.2616827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008654 Mesothelioma Doxorubicin 2.9717638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009101 Multiple Myeloma Benzene 7.0817119195
MESH:D009101 Multiple Myeloma Raloxifene 7.0816497877
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.4513678655
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009203 Myocardial Infarction Doxorubicin 8.9319429709 15857846
MESH:D009203 Myocardial Infarction Genistein 8.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1716411023
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.543581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.5418259882
MESH:D009369 Neoplasms Lindane 4.8916818664 12807735
MESH:D009369 Neoplasms pirinixic acid 4.8917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009401 Nephrosis Doxorubicin 4.5416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8115640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 21.6411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 21.6411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.6416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.6414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.976679447
MESH:D009436 Neural Tube Defects Benzene 6.9715643154
MESH:D009447 Neuroblastoma Doxorubicin 3.1515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D009503 Neutropenia Mustard Gas 3.7616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.504026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.5015612468 17178637 15913788 17479406 15727169 15576619 16737584 17119257 15935809
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010024 Osteoporosis Genistein 6.8719401787
MESH:D010024 Osteoporosis Raloxifene 6.8717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.4416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.4415579764 17893378 17823083 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Benzene 7.5512562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.5519401270
MESH:D010051 Ovarian Neoplasms Genistein 7.5519005980
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010300 Parkinson Disease Eugenol 4.3217329831
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D011041 Poisoning Mustard Gas 3.5915727166
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.379918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.3718163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.9210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9211118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.9218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915749863 18437689 16888761 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Lindane 1.8912661182 14688026
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16220300 16536755
MESH:D011472 Prostatitis vinclozolin 4.7018629315
MESH:D011537 Pruritus Ethinyl Estradiol 8.7616919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.7618058305
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8417720292 17894541 17266442 10334151 17620002
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012509 Sarcoma Doxorubicin 3.7916767912 15625365 17710206 17203757 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012640 Seizures Lindane 3.4715475178 12842176 7539098
MESH:D012871 Skin Diseases Mustard Gas 2.6612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Doxorubicin 5.3315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3416767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D013274 Stomach Neoplasms Benzene 2.4112562636
MESH:D013276 Stomach Ulcer Eugenol 4.7718543354
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616045194 16684133
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0217997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Benzene 4.7310850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.691399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.6917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 12.9419048282
MESH:D013978 Tibial Fractures Raloxifene 12.9419048282
MESH:D014376 Tuberculosis marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.898074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.8917653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.8917572228
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014594 Uterine Neoplasms Benzene 8.8412562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017638931 17334414 16364871 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
Pathway ID Pathway Name
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26521
    • No data
    Releated disease ID Related disease Name
    PA443767Communicable Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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