AutismKB 2.0

Annotation Detail for DHRS1


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Basic Information Top
Gene Symbol:DHRS1 ( DKFZp586I0523,FLJ14250,FLJ25430,MGC20204,SDR19C1 )
Gene Full Name: dehydrogenase/reductase (SDR family) member 1
Band: 14q12
Quick LinksEntrez ID:115817; OMIM: 610410; Uniprot ID:DHRS1_HUMAN; ENSEMBL ID: ENSG00000157379; HGNC ID: 16445
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DHRS1 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of DHRS1 mRNAaffects expression 17562736
D003474 Curcumin Curcumin results in decreased expression of DHRS1 mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of DHRS1 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DHRS1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DHRS1 mRNAincreases expression 16443690
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DHRS1 mRNAincreases expression 19933214
D014810 Vitamin E Vitamin E results in increased expression of DHRS1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Curcumin 2.1318593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D002277 Carcinoma Curcumin 9.0318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 16354765 15668235 15340226 8697196
MESH:D003092 Colitis Curcumin 4.5318200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5419359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5918403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5917107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.2618204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7814550746 14725611 17562736 16177239 10663392 15968718 15619225 16081117 19370779 19416960 11739529 12705907 11529661 18071297 16393943 12958197 12392966 11461765 12540782 19739265 10774834 11743745 18713872 16781746 12153990 10915739 19420014 16109766 16485898 19085960 12594235 11287661 19923254 17906064 11421492 17522070 2444490 19164858 14986274 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Curcumin 14.8219297423
MESH:D005234 Fatty Liver Cyclosporine 14.8219224547
MESH:D005234 Fatty Liver pirinixic acid 14.8219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Curcumin 16.9918705752
MESH:D005355 Fibrosis Cyclosporine 16.9912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.9920067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Curcumin 3.6417596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8318462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0016080930
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007249 Inflammation Curcumin 5.5116956363 18403477 17151092
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3018596194 18200517
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.8610903974 8314463 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.8612488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Curcumin 3.3618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.1718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1716169303
MESH:D008107 Liver Diseases Acetaminophen 4.2916610002 12969438 11587558 16611625 19460945 19784758 12587719 19014921
MESH:D008107 Liver Diseases Curcumin 4.2916956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Curcumin 3.6019359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.6011062179
MESH:D008223 Lymphoma Curcumin 3.7818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009101 Multiple Myeloma Curcumin 3.7019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9812497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Curcumin 4.7919297423
MESH:D009765 Obesity pirinixic acid 4.7920558911
MESH:D010024 Osteoporosis Curcumin 3.6218719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8818462866 19020741
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0117440100 19196508 19401701
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 3.3912497104 18226269 11398177 15129424 18156803 10851300 18769126
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3915084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013276 Stomach Ulcer Curcumin 3.7719188055 16631530
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9818593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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