AutismKB 2.0

Annotation Detail for LRRC3B


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Basic Information Top
Gene Symbol:LRRC3B ( LRP15,MGC102927 )
Gene Full Name: leucine rich repeat containing 3B
Band: 3p24.1
Quick LinksEntrez ID:116135; OMIM: NA; Uniprot ID:LRC3B_HUMAN; ENSEMBL ID: ENSG00000179796; HGNC ID: 28105
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LRRC3B mRNAaffects expression 17562736
C014347 decitabine [decitabine affects the methylation of LRRC3B promoter] which affects the expression of LRRC3B mRNAaffects expression|affects methylation 18815942
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of LRRC3B promoter] which affects the expression of LRRC3B mRNAaffects cotreatment|affects expression|affects methylation 18757430
C014347 decitabine [decitabine results in decreased methylation of LRRC3B promoter] which results in increased expression of LRRC3B mRNAdecreases methylation|increases expression 18377727
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of LRRC3B promoter] which affects the expression of LRRC3B mRNAaffects cotreatment|affects expression|affects methylation 18757430
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001943 Breast Neoplasms decitabine 2.5318320071 19208741
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6919215824
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D003110 Colonic Neoplasms decitabine 2.3917616700
MESH:D015179 Colorectal Neoplasms marker/mechanism 18815942
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6817562736 15968718 11529661 14725611 10915739 17522070 12594235 16081117 12540782 11421492 19164858 16781746 19923254 12958197 11287661 16177239 14550746 12705907 10774834 19416960 18713872 14986274 16393943 11461765 10663392 19085960 19370779 16109766 11743745 19739265 2444490 11834606 12153990 16227642 16485898 12392966 19420014 18071297 15619225 11739529 17906064
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004701 Endocrine Gland Neoplasms decitabine 17.1419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 17.1419294695
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D005909 Glioblastoma trichostatin A 4.1018801729
MESH:D006258 Head and Neck Neoplasms decitabine 3.7719215824
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007248 Infertility, Male decitabine 3.4817581917
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007938 Leukemia decitabine 3.2519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.4919117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.4718206229 19010910 18704418 18460780 19387464 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.4718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.3318055864
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 16611625 19460945 12587719 12969438 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008223 Lymphoma decitabine 3.7319470736
MESH:D008545 Melanoma decitabine 3.9117785578 16505122
MESH:D008545 Melanoma trichostatin A 3.9116505122
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009101 Multiple Myeloma decitabine 8.7018172295
MESH:D009101 Multiple Myeloma trichostatin A 8.7018172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.6018608210 19157545 16882708 19010910
MESH:D009369 Neoplasms decitabine 2.8919470736 19116145 17925555
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010051 Ovarian Neoplasms decitabine 5.6319331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.6319331143
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010190 Pancreatic Neoplasms decitabine 6.1019294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 6.1019294695
MESH:D055728 Primary Myelofibrosis decitabine 14.7017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 14.7017616702
MESH:D011471 Prostatic Neoplasms trichostatin A 3.9718798265 19789329
MESH:D012208 Rhabdomyosarcoma decitabine 4.9319155313
MESH:D013274 Stomach Neoplasms marker/mechanism 18757430
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.6717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8517616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D014604 Uveal Neoplasms decitabine 5.7817785578
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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