AutismKB 2.0

Annotation Detail for TLCD1


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Basic Information Top
Gene Symbol:TLCD1 ( - )
Gene Full Name: TLC domain containing 1
Band: 17q11.2
Quick LinksEntrez ID:116238; OMIM: NA; Uniprot ID:TLCD1_HUMAN; ENSEMBL ID: ENSG00000160606; HGNC ID: 25177
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TLCD1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of TLCD1 mRNAdecreases expression 19420014
D000638 Amiodarone Amiodarone results in decreased expression of TLCD1 mRNAdecreases expression 17991464
D004041 Dietary Fats Dietary Fats results in decreased expression of TLCD1 mRNAdecreases expression 18042831
D007657 Ketone Bodies Ketone Bodies results in decreased expression of TLCD1 mRNAdecreases expression 16807920
C041786 palm oil palm oil results in decreased expression of TLCD1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of TLCD1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1120041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.1919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.1919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1212594235 12153990 19085960 12540782 15968718 17906064 19370779 11743745 16485898 18071297 11461765 11739529 10915739 11287661 16081117 10663392 12958197 18713872 15619225 11529661 19416960 12705907 19164858 14550746 19923254 14986274 16393943 17562736 14725611 16109766 17522070 2444490 16781746 12392966 19420014 11834606 16227642 19739265 16177239 10774834 11421492
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1218218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver Amiodarone 15.1214986274
MESH:D005234 Fatty Liver Dietary Fats 15.1219004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 15.1220131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Amiodarone 10.0015265979
MESH:D006529 Hepatomegaly pirinixic acid 10.0019772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Amiodarone 10.278137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 10.2721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007037 Hypothyroidism Amiodarone 4.9318020914 17991464
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8911836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8916306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D008064 Lipidoses Amiodarone 3.7317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16611625 16610002 12969438 12587719 19014921 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 16377806 20007298
MESH:D008133 Long QT Syndrome Amiodarone 3.8211989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009181 Mycoses Amiodarone 5.4212754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 4.6411836018 20518802 20132043 18457598 17217161 16723640 18674790 21332399 19632207
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9511597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.6511989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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