AutismKB 2.0

Annotation Detail for GRIN3A


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Basic Information Top
Gene Symbol:GRIN3A ( FLJ45414,NMDAR-L,NR3A )
Gene Full Name: glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Band: 9q31.1
Quick LinksEntrez ID:116443; OMIM: 606650; Uniprot ID:NMD3A_HUMAN; ENSEMBL ID: ENSG00000198785; HGNC ID: 16767
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
No data
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Desease Name
Citalopram/adverse effects*
REPRODUCTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIN3A mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRIN3A mRNAdecreases expression 19440498
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIN3A mRNAincreases expression 19440498
17452286
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists results in decreased expression of GRIN3A proteindecreases expression 17550430
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 5.0816611668 17119214 11874814
MESH:D008107 Liver Diseases Chlorpyrifos 3.1515991261
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.4515081274
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.2911874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.7617119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.966418539
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB00193 antagonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
DB00333 antagonist Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
DB00392 antagonist Ethopropazine Antiparkinson Agents;Antidyskinetics
DB00514 antagonist Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
DB00659 antagonist Acamprosate Alcohol Deterrents
DB00721 antagonist Procaine Anesthetics;Local Anesthetics;Anesthetics, Local
DB00898 antagonist Ethanol Anti-Infective Agents, Local;Solvents;Central Nervous System Depressants;Disinfectants
DB00915 antagonist Amantadine Antiviral Agents;Dopamine Agents;Antiparkinson Agents;Analgesics, Non-Narcotic
DB00949 antagonist Felbamate Anticonvulsants;Neuroprotective Agents;Antiepileptic Agents
DB01043 antagonist Memantine Dopamine Agents;Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Excitatory Amino Acid Antagonists
DB01159 inhibitor Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
DB01161 antagonist Chloroprocaine Anesthetics, Local
DB01173 antagonist Orphenadrine Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics
DB01221 antagonist Ketamine Analgesics;General Anesthetics;Excitatory Amino Acid Antagonists;Anesthetics, Dissociative
DB01520 antagonist Tenocyclidine Neuroprotective Agents;Anesthetics, Dissociative
DB01549 - Rolicyclidine Hallucinogens
DB03575 antagonist Phencyclidine Enzyme Inhibitors;Hallucinogens;Excitatory Amino Acid Antagonists
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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