AutismKB 2.0

Annotation Detail for GRIN3B


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Basic Information Top
Gene Symbol:GRIN3B ( NR3B )
Gene Full Name: glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
Band: 19p13.3
Quick LinksEntrez ID:116444; OMIM: 606651; Uniprot ID:NMD3B_HUMAN; ENSEMBL ID: ENSG00000116032; HGNC ID: 16768
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GRIN3B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIN3B mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRIN3B mRNAdecreases expression 19440498
D004026 Dieldrin Dieldrin affects the expression of GRIN3B mRNAaffects expression 19440498
D006220 Haloperidol Haloperidol results in increased expression of GRIN3B mRNAincreases expression 15860345
D008727 Methotrexate GRIN3B protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009532 Nickel Nickel results in increased expression of GRIN3B mRNAincreases expression 19440498
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.6412039119
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury Nickel 4.8916166738
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.7417119214 11874814 16611668
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1517286800
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001943 Breast Neoplasms Dieldrin 2.3015770527 11859874
MESH:D001943 Breast Neoplasms Methotrexate 2.3016978400
MESH:D001943 Breast Neoplasms Nickel 2.3015986119
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002375 Catalepsy Haloperidol 5.3115215559 1977408
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6612039119 9562676
MESH:D003550 Cystic Fibrosis Methotrexate 4.5019747007
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1520210726
MESH:D003704 Dementia Haloperidol 4.8611575062
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.3019470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.942952479
MESH:D003882 Dermatomyositis Methotrexate 5.4520191521
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516393943 16081117 19370779 11834606 18713872 14986274 11743745 16781746 17562736 10915739 10663392 12705907 11739529 17906064 12594235 19739265 11529661 16227642 19164858 11461765 2444490 17522070 19923254 12153990 16485898 12540782 14550746 18071297 19420014 12958197 10774834 19416960 15619225 11421492 12392966 15968718 19085960 16177239 14725611 11287661 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006086 Graft vs Host Disease Methotrexate 5.5116518429
MESH:D015658 HIV Infections Nickel 3.9417263646
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007247 Infertility, Female Dieldrin 5.2410630421
MESH:D007249 Inflammation Nickel 3.5516166738
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007805 Language Development Disorders Methotrexate 5.419562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.8314986274
MESH:D008107 Liver Diseases Acetaminophen 4.4619014921 12587719 19784758 16610002 12969438 16611625 19460945 11587558
MESH:D008107 Liver Diseases Chlorpyrifos 4.4615991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Dieldrin 3.429539021 8742319
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4618516814
MESH:D008223 Lymphoma Methotrexate 4.1417352296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D001523 Mental Disorders Haloperidol 4.4016856516
MESH:D052016 Mucositis Methotrexate 5.6817488658
MESH:D009369 Neoplasms Dieldrin 3.588820588
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3415081274
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Dieldrin 3.6116112328 11181820 16809432 17291500 11445065
MESH:D011565 Psoriasis Methotrexate 3.5117410198
MESH:D011595 Psychomotor Agitation Haloperidol 5.3111575062
MESH:D011618 Psychotic Disorders Haloperidol 4.4411575062
MESH:D051437 Renal Insufficiency Methotrexate 5.0717352296
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.9916611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.3316611668 17119214
MESH:D012559 Schizophrenia Haloperidol 2.8319369910 18513383 1830565 20107430
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.536418539
MESH:D013576 Syndactyly Methotrexate 5.369562676
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.0420210726
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28984
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    DB01159 inhibitor Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
    DB01173 antagonist Orphenadrine Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics
    DB01520 antagonist Tenocyclidine Neuroprotective Agents;Anesthetics, Dissociative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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