Annotation Detail for TOP1MT
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of TOP1MT mRNA | affects expression | 21346803
|
| D004041 |
Dietary Fats |
Dietary Fats results in decreased expression of TOP1MT mRNA | decreases expression | 18042831
|
| C041786 |
palm oil |
palm oil results in decreased expression of TOP1MT mRNA | decreases expression | 18042831
|
| D018038 |
Sodium Selenite |
Sodium Selenite results in increased expression of TOP1MT mRNA | increases expression | 18175754
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D001161 |
Arteriosclerosis |
|
Dietary Fats |
4.45 | 15238619 |
| MESH:D001943 |
Breast Neoplasms |
|
Dietary Fats |
2.24 | 20435547 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.79 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.03 | 6135515 |
| MESH:D019457 |
Chromosome Breakage |
|
Sodium Selenite |
5.31 | 15894690 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.58 | 18551238 |
| MESH:D003920 |
Diabetes Mellitus |
|
Sodium Selenite |
4.15 | 16285004 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.28 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Sodium Selenite |
4.28 | 15131321 |
| MESH:D050171 |
Dyslipidemias |
|
Dietary Fats |
3.73 | 18367378 |
| MESH:D005234 |
Fatty Liver |
|
Dietary Fats |
3.66 | 17967931 19551842 19004024 18296743 |
| MESH:D005355 |
Fibrosis |
|
Dietary Fats |
4.08 | 18296743 |
| MESH:D006937 |
Hypercholesterolemia |
|
Dietary Fats |
4.02 | 21332399 |
| MESH:D006949 |
Hyperlipidemias |
|
Dietary Fats |
4.08 | 21332399 |
| MESH:D007249 |
Inflammation |
|
Dietary Fats |
2.60 | 20412841 |
| MESH:D007333 |
Insulin Resistance |
|
Dietary Fats |
8.30 | 18457598 11836018 |
| MESH:D007333 |
Insulin Resistance |
|
Sodium Selenite |
8.30 | 14714311 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.32 | 16705839 |
| MESH:D008103 |
Liver Cirrhosis |
|
Dietary Fats |
3.07 | 18296743 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.27 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 2876786 6135515 2876784 |
| MESH:D016393 |
Lymphoma, B-Cell |
|
Sodium Selenite |
4.52 | 14737004 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.49 | 18551238 7678174 |
| MESH:D009765 |
Obesity |
|
Dietary Fats |
2.36 | 21332399 11836018 18674790 20132043 17217161 18457598 16723640 20518802 19632207 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.83 | 16049721 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Sodium Selenite |
3.33 | 18760546 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.79 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.41 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.95 | 10091137 |
| MESH:D015430 |
Weight Gain |
|
Dietary Fats |
4.11 | 16723640 |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB00762 |
antagonist |
Irinotecan |
Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic |
| DB01030 |
antagonist |
Topotecan |
Antineoplastic Agents;Enzyme Inhibitors |
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