AutismKB 2.0

Annotation Detail for MRPL54


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Basic Information Top
Gene Symbol:MRPL54 ( L54mt,MRP-L54 )
Gene Full Name: mitochondrial ribosomal protein L54
Band: 19p13.3
Quick LinksEntrez ID:116541; OMIM: 611858; Uniprot ID:RM54_HUMAN; ENSEMBL ID: ENSG00000183617; HGNC ID: 16685
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MRPL54 mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MRPL54 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MRPL54 mRNAincreases expression 17942748
D010126 Ozone Ozone results in increased expression of MRPL54 mRNAincreases expression 12763052
C006253 pirinixic acid pirinixic acid results in increased expression of MRPL54 mRNAincreases expression 18301758
D012645 Selenomethionine Selenomethionine affects the expression of MRPL54 mRNAaffects expression 17222674
D043343 Testosterone Propionate Testosterone Propionate results in increased expression of MRPL54 mRNAincreases expression 15601916
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9015516495 16777450 17626835 14754758 18315731 19059883 18417511
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.5719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.5717110522 16919318 17333356 16105132 11677210 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 14.5719176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 12868966 8970840 8156756 14531868 18759878 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0218692083 9653073 18289764 7440962 1440618 18648102 11289319 6482804 8291058 9328219 16192314 6679447 9022650
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5015345470
MESH:D005234 Fatty Liver pirinixic acid 8.5020131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19176532 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.6620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.693712494 598648 6587162 1399818
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5618816296 18569708 20464547 17053015 20064080 20869020 6695378 18520028 20135361
MESH:D008175 Lung Neoplasms Ozone 2.568597069 7614698
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011014 Pneumonia Ozone 4.7918929643 18007984 18381685
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 3712494 7505956 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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