AutismKB 2.0

Annotation Detail for AGAP1


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Basic Information Top
Gene Symbol:AGAP1 ( CENTG2,GGAP1,KIAA1099,MGC71657 )
Gene Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Band: 2q37.2
Quick LinksEntrez ID:116987; OMIM: 608651; Uniprot ID:AGAP1_HUMAN; ENSEMBL ID: ENSG00000157985; HGNC ID: 16922
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of AGAP1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of AGAP1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGAP1 mRNAdecreases expression 19150397
20382639
C025643 vinclozolin vinclozolin affects the expression of AGAP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001321 Autistic Disorder marker/mechanism 15892143
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9921507988 12907637 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6216530937
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.9718177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9721137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.968603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5018816296 20464547 20064080 17053015 20869020 20135361 18569708 6695378 18520028
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
Pathway ID Pathway Name
KEGG:04144 Endocytosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26412
    • No data
    Releated disease ID Related disease Name
    PA444119Eye Diseases
    PA446225Eye Diseases, Hereditary
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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